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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Aprovel 300mg Tablet is used for the treatment of hypertension (high blood pressure) in adults. Additionally, it is used to reduce the risk of heart attack or stroke in adults. It contains Irbesartan, which widens and relaxes blood vessels. Thus, lowers high blood pressure. In some cases, you may experience nausea, vomiting, fatigue, and orthostatic hypotension. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

IRBESARTAN-300MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Aprovel 300mg Tablet

Aprovel 300mg Tablet belongs to a group of medicines known as angiotensin II receptor blockers indicated for the treatment of hypertension (high blood pressure) in adults. Additionally, Aprovel 300mg Tablet is used to reduce the risk of heart attack or stroke in adults. Hypertension is a medical condition in which the blood pressure is elevated persistently in the arteries without any known cause. On the other hand, heart attack or stroke occurs due to blocked blood flow to the heart or brain, respectively.

Aprovel 300mg Tablet works by blocking the action of a hormone called angiotensin II in the body, which causes the narrowing of blood vessels, leading to high blood pressure. Thereby, Aprovel 300mg Tablet widens and relaxes blood vessels, lowering high blood pressure.

You can take Aprovel 300mg Tablet irrespective of food and swallow it whole with a glass of water. Do not crush, chew, or break it. Your doctor will let you how often you should take your tablets based on your medical condition. In some cases, you may experience nausea, vomiting, fatigue, and orthostatic hypotension. Most of these side effects of Aprovel 300mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Aprovel 300mg Tablet is not for pregnant women as its use during your pregnancy can cause injury and even death to your unborn baby. It is not known whether Aprovel 300mg Tablet passes into your breast milk or not. Your doctor will decide if you will take Aprovel 300mg Tablet while using Aprovel 300mg Tablet and breastfeeding together. Prolonged intake of Aprovel 300mg Tablet may cause high potassium in the blood (hyperkalemia). Avoid intake of potassium supplements with Aprovel 300mg Tablet as it may lead to high potassium levels in the blood, so the doctor may ask you to have a regular check of your potassium level. Do not consume alcohol with Aprovel 300mg Tablet as it may increase the risk of low blood pressure. Taking Aprovel 300mg Tablet with painkillers (like aspirin and ibuprofen) can increase the risk of kidney problems and reduce the efficiency of Aprovel 300mg Tablet.

Uses of Aprovel 300mg Tablet

Treatment of Hypertension, Heart failure, Prevents heart attack & heart stroke.

Directions for Use

Swallow Aprovel 300mg Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Aprovel 300mg Tablet is used to treat high blood pressure and reduce the risk of heart attack or stroke. Aprovel 300mg Tablet is an angiotensin II receptor blocker that decreases high blood pressure by widening and relaxing the blood vessels by blocks the action of a hormone called angiotensin II in the body which causes the narrowing of blood vessels leading to high blood pressure.

How Aprovel 300mg Tablet Works

Aprovel 300mg Tablet works by blocking the action of a hormone called angiotensin II in the body, which causes the narrowing of blood vessels, leading to high blood pressure. Thereby, Aprovel 300mg Tablet widens and relaxes blood vessels, lowering high blood pressure.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Aprovel 300mg Tablet

  • Nausea
  • Vomiting
  • Dizziness
  • Orthostatic hypotension
  • Fatigue

What if I have taken an overdose of Aprovel 300mg Tablet

Do not take more than the prescribed dose of Aprovel 300mg Tablet as it may cause overdose. The symptoms of overdose include low blood pressure, fast or slow heart rate. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Aprovel 300mg Tablet is not recommended for people with impaired kidney function, diabetes or severe liver problems. Aprovel 300mg Tablet may increase the risk of low blood pressure when taken with alcohol. Aprovel 300mg Tablet may cause tiredness or dizziness in some people. Make sure you are not affected before driving. Breastfeeding women are advised to consult a doctor before taking Aprovel 300mg Tablet. Avoid intake of potassium supplements with Aprovel 300mg Tablet as it may lead to high potassium levels in the blood, so the doctor may ask you to have a regular check of your potassium level. Do not consume alcohol with Aprovel 300mg Tablet as it may increase the risk of low blood pressure. Taking Aprovel 300mg Tablet with painkillers (like aspirin and ibuprofen) can increase the risk of kidney problems and reduce the efficiency of Aprovel 300mg Tablet.

Drug-Drug Interactions

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IrbesartanLofexidine
Severe
IrbesartanLisinopril
Severe

Drug-Drug Interactions

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IrbesartanLofexidine
Severe
How does the drug interact with Aprovel 300mg Tablet:
Co-administration of Aprovel 300mg Tablet with Lofexidine can decrease the low blood pressure, which may lead to side effects.

How to manage the interaction:
Taking Aprovel 300mg Tablet with Lofexidine can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - slow heart rate, headache, feeling dizzy or lightheaded, or fainting - make sure to contact a doctor right away. Avoid activities requiring mental focus like driving, operating dangerous equipment. Be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.
IrbesartanLisinopril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Lisinopril may increase potassium levels in the blood.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Lisinopril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanTizanidine
Severe
How does the drug interact with Aprovel 300mg Tablet:
Combining Tizanidine with Aprovel 300mg Tablet can increase the risk of low blood pressure.

How to manage the interaction:
Taking Aprovel 300mg Tablet with Tizanidine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - headache, dizziness, feeling lightheaded, or fainting, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
IrbesartanPotassium citrate
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Potassium citrate may increase potassium levels in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Potassium citrate together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. It is advised to reduce the intake of potassium-rich foods. Do not discontinue any medications without a doctor's advice.
IrbesartanSpironolactone
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Spironolactone may increase potassium levels in the blood, which may lead to side effects.

How to manage the interaction:
Taking Aprovel 300mg Tablet with Spironolactone can result in an interaction, it can be taken if a doctor has advised it. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feeling of heaviness in your legs, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. Do not stop taking any medication without doctors advise.
IrbesartanPotassium chloride
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Potassium chloride may increase potassium levels in the blood.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Potassium chloride together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanMoexipril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Moexipril may cause low blood pressure, kidney function impairment, and increased potassium levels in the blood.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Moexipril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanPerindopril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Perindopril may cause low blood pressure and kidney problems.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Perindopril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in the legs, or a slow or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
IrbesartanNaproxen
Severe
How does the drug interact with Aprovel 300mg Tablet:
Co-administration of Aprovel 300mg Tablet along with naproxen may result in side effects including low blood pressure, impaired kidney function.

How to manage the interaction:
There may be a possible interaction between Naproxen and Aprovel 300mg Tablet, but they can be taken together if they are prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, decreased hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, breathing difficulty, muscle pains, dizziness, confusion, and irregular heart rhythm, consult the doctor. Do not discontinue any medication without a doctor's advice.
IrbesartanCaptopril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with captopril may cause low blood pressure, kidney function impairment, and increased potassium levels in the blood.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with captopril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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IRBESARTAN-300MGPotassium rich foods
Moderate

Drug-Food Interactions

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IRBESARTAN-300MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Consuming potassium-containing substances during treatment with Aprovel 300mg Tablet can lead to high potassium levels which may result in side effects like weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs. Avoid potassium-containing salt substitutes and over-the-counter potassium supplements during Aprovel 300mg Tablet therapy.

Diet & Lifestyle Advise

  • Maintain a low-salt diet and minimize eating processed foods, as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Regular exercise, such as cycling, walking, jogging, dancing, or swimming, should be done for a minimum of 30 minutes daily.
  • Chronic stress may also cause high blood pressure. Therefore, avoid stress by changing your expectations, readjusting your reactions to certain situations, and making time for yourself to do activities that you enjoy.
  • Maintain a diet that is rich in fruits, vegetables, whole grains and low-fat dairy products.
  • Avoid smoking and alcohol intake.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Aprovel 300mg Tablet Substitute

Substitutes safety advice
  • Irovel 300 Tablet 10's

    28.08per tablet
  • XARB 300MG TABLET

    8.45per tablet
  • Debipro 300mg Tablet

    15.03per tablet
  • Sebri 300mg Tablet

    31.05per tablet
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Alcohol

Caution

Not recommended. Aprovel 300mg Tablet and alcohol together result in an abnormal decrease in blood pressure levels, thus strictly not to be taken together.

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Pregnancy

Unsafe

Not recommended in pregnant patients. Aprovel 300mg Tablet is harmful to an unborn baby, especially in the first 3 months of pregnancy. Aprovel 300mg Tablet is to be replaced with any other blood pressure-lowering drug on doctor consultation.

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Breast Feeding

Caution

Not recommended in breastfeeding patients. Enough data is not available on the usage of Aprovel 300mg Tablet in breastfeeding mothers; thus, it is replaced with any alternative blood pressure-lowering agents in doctors' consultations.

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Driving

Safe if prescribed

Aprovel 300mg Tablet is unlikely to affect your ability to drive or use heavy machines. However, occasionally, dizziness or slowness of movements may occur during the treatment of high blood pressure. If you experience these, talk to your doctor before attempting such activities.

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Liver

Caution

Aprovel 300mg Tablet has been found to affect liver function in certain cases; thus, patients with liver problems should discuss with their doctor for proper guidance regarding treatment with this medication.

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Kidney

Caution

Aprovel 300mg Tablet is not advised for patients with kidney disease as there have been cases of harmful interactions between kidney patients and Aprovel 300mg Tablet. Patients are strictly advised to consult and discuss this medication with their doctors before taking it.

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Children

Safe if prescribed

It is safe to give to children under 12 years of age. No harmful interaction has been reported in patients under 12 years of age, yet doctor's consultation is advised.

FAQs

Aprovel 300mg Tablet is indicated for the treatment of hypertension (high blood pressure) in adults. Additionally, it is used to reduce the risk of heart attack or stroke in adults.
Aprovel 300mg Tablet may increase potassium levels in the blood (hyperkalemia). Therefore, it is recommended to avoid intake of potassium supplements and foods that are rich in potassium like coconut water, bananas and broccoli.
Only on doctors consultation, a patient can take Aprovel 300mg Tablet with metformin which has been found to have a beneficial effect on kidneys in a diabetic patient with hypertension.
Not recommended in overweight patients as per studies conducted by researchers,Aprovel 300mg Tablet causes weight gain in normal individuals and thus contraindicated in overweight patients.
Take the missed dose as soon as possible. if it has been too late then a patient is advised to jump to the next dose without attempting double dose to make up for the missed dose.
Absolutely safe to be used in patients with stomach ulcers as there has been no harmful interaction between Aprovel 300mg Tablet and peptic ulcers except occasional nausea. Recently it has been found to have a protective role against stomach ulcers yet not approved for stomach diseases yet.

Country of origin

India
Other Info - AP76648

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