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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Safion 50 Tablet is used to treat Parkinson's disease. It contains Safinamide which works by increasing the amount of dopamine (a chemical messenger that is needed to control movement) in the brain. In some cases, this medicine may cause side effects such as dizziness, headache, nausea, insomnia, and sleepiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

SAFINAMIDE-50MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About Safion 50 Tablet

Safion 50 Tablet is used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. Parkinson’s disease is a disorder of the central nervous system that affects movement and locomotion. It causes stiffness, shaking, and difficulty in walking, coordination and balance. 

Safion 50 Tablet contains 'safinamide', belonging to the group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

Safion 50 Tablet may cause common side effects like cough, depression, indigestion, flu-like symptoms, insomnia (difficulty sleeping), joint pain, and peripheral oedema. Most of these side effects of  Safion 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Safion 50 Tablet or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Safion 50 Tablet . If you are pregnant or breastfeeding, it is advised to inform your doctor. Safion 50 Tablet is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Safion 50 Tablet should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Safion 50 Tablet may cause serotonin syndrome when used with MAO inhibitors, antidepressants, or opioid drugs.

Uses of Safion 50 Tablet

Treatment of Parkinson's disease

Directions for Use

Swallow Safion 50 Tablet as a whole with water. Do not chew, crush or break it.

Medicinal Benefits

Safion 50 Tablet belongs to a class of drugs called antiparkinson agents, which are used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. It works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson’s disease.

How Safion 50 Tablet Works

Safion 50 Tablet contains 'safinamide', belonging to the group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Safion 50 Tablet

  • Cough
  • Depression
  • Indigestion
  • Flu-like symptoms
  • Insomnia (difficulty in sleeping)
  • Joint pain
  • Peripheral oedema

What if I have taken an overdose of Safion 50 Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

If you are known to be allergic to Safion 50 Tablet or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Safion 50 Tablet . If you are pregnant or breastfeeding, it is advised to inform your doctor. Safion 50 Tablet is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Safion 50 Tablet should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Safion 50 Tablet should be used caution with liver diseases. Safion 50 Tablet may cause serotonin syndrome when used with MAO inhibitors, antidepressants or opioid drugs. A combination of MAOIs and dextromethorphan has been reported to cause episodes of psychosis or abnormal behaviour.

Drug-Drug Interactions

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SafinamideTranylcypromine
Critical
SafinamideDesvenlafaxine
Critical

Drug-Drug Interactions

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SafinamideTranylcypromine
Critical
How does the drug interact with Safion 50 Tablet:
Taking Tranylcypromine with Safion 50 Tablet can increase the risk of high blood pressure and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safion 50 Tablet with Tranylcypromine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideDesvenlafaxine
Critical
How does the drug interact with Safion 50 Tablet:
Taking Safion 50 Tablet with Desvenlafaxine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Desvenlafaxine with Safion 50 Tablet is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideVilazodone
Critical
How does the drug interact with Safion 50 Tablet:
Taking Safion 50 Tablet with Amitriptyline can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Vilazodone with Safion 50 Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as severe confusion, hallucinations, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
SafinamideApraclonidine
Critical
How does the drug interact with Safion 50 Tablet:
Taking Safion 50 Tablet with Apraclonidine may raise blood pressure.

How to manage the interaction:
Taking Safion 50 Tablet with Apraclonidine is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not discontinue any medications without first consulting your doctor.
SafinamideVortioxetine
Critical
How does the drug interact with Safion 50 Tablet:
Taking Safion 50 Tablet with Vortioxetine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Vortioxetine with Safion 50 Tablet is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
SafinamideViloxazine
Critical
How does the drug interact with Safion 50 Tablet:
Taking Viloxazine with Safion 50 Tablet can increase the risk of high blood pressure.

How to manage the interaction:
Taking Safion 50 Tablet with Viloxazine is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not discontinue any medications without first consulting your doctor.
SafinamideDexmethylphenidate
Critical
How does the drug interact with Safion 50 Tablet:
Taking Safion 50 Tablet with Dexmethylphenidate together may increase side effects such as blood pressure elevations and increased heart rate.

How to manage the interaction:
Taking Safion 50 Tablet with Dexmethylphenidate is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms like headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat, consult a doctor. Do not stop using any medications without talking to a doctor.
SafinamideLevomilnacipran
Critical
How does the drug interact with Safion 50 Tablet:
Taking Safion 50 Tablet with levomilnacipran can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safion 50 Tablet with levomilnacipran is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideClomipramine
Critical
How does the drug interact with Safion 50 Tablet:
Taking Safion 50 Tablet with Clomipramine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Clomipramine with Safion 50 Tablet can possibly result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
SafinamideVenlafaxine
Critical
How does the drug interact with Safion 50 Tablet:
Taking Safion 50 Tablet with Venlafaxine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Safion 50 Tablet with Venlafaxine is not recommended as it can possibly result in an interaction, , but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Eating tyramine containing foods while you are taking Safion 50 Tablet can raise your blood pressure levels. Avoid Tyramine containing food while on the treatment with Safion 50 Tablet. Consult your doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not stop taking the medication without consulting a doctor.

Diet & Lifestyle Advise

  • A balanced diet is essential to show improvement in Parkinson's disease, including grains and leafy foods, as this food is rich in vitamins, fibres, and minerals. With this food, one should also include dairy items, protein-rich nourishments, for example, meat and beans, and solid fats found in nuts, olive oil, fish, and eggs in their diet. However, limit the consumption of sugar.

  • Avoid intake of high-protein foods like soy protein, fish, eggs, chicken, beef, and pork. Eat more whole-grain foods such as whole wheat bread, oatmeal, brown rice or pasta.

  • Eat more fibre-rich foods to ease constipation.

  • Drink plenty of water to avoid headaches due to dehydration.

  • Avoid the consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPARKINSON AGENTS

Safion 50 Tablet Substitute

Substitutes safety advice
  • Xafinact 50 Tablet 10's

    by AYUR

    16.02per tablet
  • Zafimove 50 Tablet 10's

    by Others

    12.47per tablet
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Alcohol

Caution

Safion 50 Tablet may cause excessive drowsiness with alcohol, decreasing alertness and affecting your vision.

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Pregnancy

Unsafe

Safion 50 Tablet may be unsafe to use during pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Safion 50 Tablet . Please consult your doctor before taking Safion 50 Tablet .

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Breast Feeding

Unsafe

Safion 50 Tablet may be unsafe to use in breastfeeding mothers. Your doctor will weigh the benefits and potential risks before prescribing Safion 50 Tablet . Please consult your doctor before taking Safion 50 Tablet .

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Driving

Caution

Safion 50 Tablet may decrease alertness, affect your vision or make you sleepy and dizzy. Do not drive if these symptoms occur.

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Liver

Caution

Safion 50 Tablet should be used with caution in patients with liver disease. A dose adjustment of Safion 50 Tablet may be needed. So please consult your doctor before taking Safion 50 Tablet .

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Kidney

Caution

Safion 50 Tablet should be used with caution in patients with kidney disease. A dose adjustment of Safion 50 Tablet may be needed. So please consult your doctor before taking Safion 50 Tablet .

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Children

Unsafe

Safion 50 Tablet is not recommended for use in children under 12 years.

FAQs

Safion 50 Tablet is used to treat the signs and symptoms of Parkinson's disease.
Safion 50 Tablet works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson’s disease.
Do not double the dosage to compensate for a missed one. One can skip the missed portion and take the next dosage at the standard time of the following day.
Yes, Safion 50 Tablet is not recommended in albinism (an inherited condition that causes a lack of colour in the skin, hair and eyes), retinal degeneration, uveitis (inflammation of the middle layer of the eye (uvea)), inherited retinopathy or severe progressive diabetic retinopathy.
Do not stop Safion 50 Tablet suddenly; it may cause side effects like confusion, stiff muscles and a high fever. So please consult your doctor before stopping the medicine.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - SAF0358

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