Zafimove 50 Tablet is used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. Parkinson’s disease is a disorder of the central nervous system that affects movement and locomotion. It causes stiffness, shaking, and difficulty in walking, coordination and balance. 

Zafimove 50 Tablet contains 'safinamide', belonging to the group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

Zafimove 50 Tablet may cause common side effects like cough, depression, indigestion, flu-like symptoms, insomnia (difficulty sleeping), joint pain, and peripheral oedema. Most of these side effects of  Zafimove 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Zafimove 50 Tablet or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Zafimove 50 Tablet . If you are pregnant or breastfeeding, it is advised to inform your doctor. Zafimove 50 Tablet is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Zafimove 50 Tablet should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Zafimove 50 Tablet may cause serotonin syndrome when used with MAO inhibitors, antidepressants, or opioid drugs.

Zafimove 50 Tablet belongs to a class of drugs called antiparkinson agents, which are used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. It works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson’s disease.

• Cough
• Depression
• Indigestion
• Flu-like symptoms
• Insomnia (difficulty in sleeping)
• Joint pain
• Peripheral oedema

If you are known to be allergic to Zafimove 50 Tablet or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Zafimove 50 Tablet . If you are pregnant or breastfeeding, it is advised to inform your doctor. Zafimove 50 Tablet is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Zafimove 50 Tablet should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Zafimove 50 Tablet should be used caution with liver diseases. Zafimove 50 Tablet may cause serotonin syndrome when used with MAO inhibitors, antidepressants or opioid drugs. A combination of MAOIs and dextromethorphan has been reported to cause episodes of psychosis or abnormal behaviour.

Drug-Drug Interaction: Zafimove 50 Tablet may interact with other medicines like pain killers (diclofenac, tramadol), antidepressant medications (fluoxetine, bupropion, amitryptiline), antibiotics (balofloxacin, ciprofloxacin), anti-epileptics (carbamazepine), statins (rosuvastatin, pitavastatin, pravastatin), anti-cancer (methotrexate, topotecan), antidiabetic (glyburide), antitussive (dextromethorphan), opioid-medications (meperidine, methadone, propoxyphene), MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine),

Drug-Food Interaction: Zafimove 50 Tablet may interact with foods that are high in tyramine, such as aged cheeses, fava beans, soy sauce, herring, pickled or processed meats, fish, and meats that are aged, dried, smoked, or fermented. Eating tyramine while taking this drug can raise your blood pressure which could cause life-threatening side effects. It may also interact with alcohol and St. John's wort.

Drug-Disease Interaction: The use of Zafimove 50 Tablet is strictly restricted if a patient is already dealing with liver diseases, albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy.

• DICLOFENAC
• TRAMADOL
• FLUOXETINE
• BUPROPION
• AMITRIPTYLINE
• BALOFLOXACIN
• CIPROFLOXACIN
• CARBAMAZEPINE
• ROSUVASTATIN
• PITAVASTATIN
• PRAVASTATIN
• METHOTREXATE
• GLYBURIDE
• MEPERIDINE
• METHADONE
• PROPOXYPHENE
• ISOCARBOXAZID
• LINEZOLID
• METHYLENE BLUE
• MOCLOBEMIDE
• PHENELZINE
• PROCARBAZINE
• RASAGILINE
• SELEGILINE
• TRANYLCYPROMINE
• DEXTROMETHORPHAN
• TOPOTECAN

• A balanced diet is essential to show improvement in Parkinson's disease, including grains and leafy foods, as this food is rich in vitamins, fibres, and minerals. With this food, one should also include dairy items, protein-rich nourishments, for example, meat and beans, and solid fats found in nuts, olive oil, fish, and eggs in their diet. However, limit the consumption of sugar.

• Avoid intake of high-protein foods like soy protein, fish, eggs, chicken, beef, and pork. Eat more whole-grain foods such as whole wheat bread, oatmeal, brown rice or pasta.

• Eat more fibre-rich foods to ease constipation.

• Drink plenty of water to avoid headaches due to dehydration.

• Avoid the consumption of alcohol as it may increase drowsiness.

• Talk to your doctor if you develop hallucinations or other changes in your behaviour.

Parkinson’s disease: It is a disorder of the central nervous system that affects movement due to damage of nerve cells in the brain, which reduces the levels of dopamine and leads to symptoms such as stiffness, tremors in one hand, shaking, difficulty in walking, coordination and balance. This condition can last for many years or a lifetime. Treatment with medicines and physiotherapy may help control the symptoms and provide a quality life for as long as possible.