Saferet-20 Tablet belongs to a class of drugs called retinoids (a synthetic form of vitamin A) primarily used to treat a severe form of acne known as nodular acne that cannot be cleared by any other treatments, including antibiotics. Nodular acne is severe acne that occurs due to excessive production of oil in the skin cells, causing swollen, red and tender lumps in the skin. Acne nodules are larger in size than typical pimples. 

Saferet-20 Tablet contains 'isotretinoin', a form of vitamin A that works by reducing sebum (skin's natural oil) production on the skin's surface by decreasing the activity and size of sebaceous glands. Thereby unblocks pores and kills acne-causing bacteria.

Take Saferet-20 Tablet as prescribed. Your doctor will advise you on how often you need to take Saferet-20 Tablet based on your medical condition. Some people may experience chapped lips, dryness of skin, eyes, nose, or lips. Most of these side effects of Saferet-20 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Saferet-20 Tablet or any other medicines, please tell your doctor. Do not take Saferet-20 Tablet if you are pregnant or breastfeeding as it may cause adverse effects on the baby. If you have depression or any suicidal thoughts while taking Saferet-20 Tablet or after stopping treatment with Saferet-20 Tablet , please consult a doctor. Avoid sun exposure while using Saferet-20 Tablet as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn.

Saferet-20 Tablet is a synthetic form of vitamin A used to treat a severe form of acne. Saferet-20 Tablet reduces sebum (skin's natural oil) production on the skin's surface by decreasing the activity and size of sebaceous glands. Thereby unblocking pores and killing acne-causing bacteria. Also, Saferet-20 Tablet reduces swelling in the skin.

• Chapped lips

• Dryness of skin, eyes, nose or lips

Do not take Saferet-20 Tablet if you are pregnant or breastfeeding as it may cause adverse effects in the baby. If you have depression or any suicidal thoughts while taking Saferet-20 Tablet or after stopping treatment with Saferet-20 Tablet , please consult a doctor. Avoid sun exposure while using Saferet-20 Tablet as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn. Do not undergo any cosmetic procedures while taking Saferet-20 Tablet and for a minimum of 6 months after stopping treatment with Saferet-20 Tablet as it may increase the risk of scarring. Inform your doctor if you have asthma, diabetes, hypervitaminosis A (high levels of vitamin A), liver or heart problems, weak bones, osteoporosis (bone loss), anorexia nervosa (an eating disorder where people eat too little), any mental problems such as psychosis (loss of contact with reality) or depression before taking Saferet-20 Tablet .

Drug-Drug Interaction: Saferet-20 Tablet may interact with anticonvulsants (phenytoin), antibiotics (doxycycline, demeclocycline, minocycline, oxytetracycline, tetracycline, eravacycline), vitamins (vitamin A).

Drug-Food Interaction: Do not use Saferet-20 Tablet with St. John's Wort (a herbal supplement used to treat depression) as it may reduce the effectiveness of hormonal contraceptive pills, raising the risk of pregnancy.

Drug-Disease Interaction: If you have asthma, diabetes, liver or heart problems, hypervitaminosis A (high levels of vitamin A), weak bones, osteoporosis (bone loss), anorexia nervosa (an eating disorder where people eat too little), any mental problems such as psychosis (loss of contact with reality) or depression before taking Saferet-20 Tablet .

• PHENYTOIN
• DOXYCYCLINE
• TETRACYCLINE
• DEMECLOCYCLINE
• MINOCYCLINE
• OXYTETRACYCLINE
• ERAVACYCLINE
• VITAMIN A

• Regular exercise can improve your mood and self-esteem though it doesn't clear acne. Take a shower immediately after finishing exercise as sweat may irritate acne.

• Avoid sun exposure while using Saferet-20 Tablet as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out to protect your skin from sunburn.

• Do regular hair wash and avoid contact of hair with the face.

• Remove the make-up completely before going to bed.

• Regular blood tests are recommended before and while taking Saferet-20 Tablet to monitor liver functioning.

• Do not donate blood while taking Saferet-20 Tablet and for one month after stopping Saferet-20 Tablet .

• Do not squeeze, pop or pick spots as it may worsen them and cause permanent scarring.

Nodular acne: It is severe acne that occurs due to excessive production of oil in the skin cells causing swollen, red and tender lumps in the skin which can be the size of pencil erasers or larger. The sebum inhibits sebaceous glands and stops oil from flowing out freely causing accumulation of sebum under the skin which increases the growth of acne-causing bacteria. Acne nodules are larger in size than typical pimples and affect the deeper layers of skin. Nodular acne can occur on the back, face and the body. If they are left untreated, it may cause permanent scars. The symptoms include long-lasting painful blemishes that feel like hard knots under the skin.