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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Rubilon 50 mg Injection is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer. It contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, it treats cancers.

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Whats That

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Synonym :

EPIRUBICIN HYDROCHLORIDE

Composition :

EPIRUBICIN-50MG

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Rubilon 50 mg Injection

Rubilon 50 mg Injection is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer in people who have had tumor removal surgery. Rubilon 50 mg Injection is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast).

Rubilon 50 mg Injection contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Rubilon 50 mg Injection may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Rubilon 50 mg Injection. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Rubilon 50 mg Injection should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines, and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (eg, Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. Rubilon 50 mg Injection is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Rubilon 50 mg Injection is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF.

Uses of Rubilon 50 mg Injection

Treatment of Breast Cancer

Directions for Use

A trained healthcare professional will administer Rubilon 50 mg Injection. Hence, do not self-administer.

Medicinal Benefits

Rubilon 50 mg Injection contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. It is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer.

How Rubilon 50 mg Injection Works

Rubilon 50 mg Injection contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Rubilon 50 mg Injection

  • Nausea
  • Abdominal pain
  • Vomiting
  • Dizziness
  • Back pain
  • Pain at the site of injection
  • Red discoloration of urine
  • Loss of appetite
  • Mouth sores
  • Tiredness
  • Weight gain
  • Pale skin

What if I have taken an overdose of Rubilon 50 mg Injection

Since Rubilon 50 mg Injection is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Rubilon 50 mg Injection may cause sores in the mouth and throat, fever, sore throat, chills, or other signs of infection, unusual bleeding or bruising, black and tarry stools, red blood in stools, and bloody vomit or vomited material that looks like coffee grounds.

Drug Warnings

Rubilon 50 mg Injection should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (e.g., Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. Rubilon 50 mg Injection is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Rubilon 50 mg Injection is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF. Do not stop receiving Rubilon 50 mg Injection without a doctor’s advice, as it can cause serious health conditions. Rubilon 50 mg Injection is known to cause severe life-threatening haematological reactions, tissue necrosis, cardiomyopathy, secondary acute myelogenous leukaemia, and severe myelosuppression in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
EpirubicinHaloperidol
Severe

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
How does the drug interact with Rubilon 50 mg Injection 1's:
Using ziprasidone together with Rubilon 50 mg Injection 1's can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Ziprasidone with Rubilon 50 mg Injection 1's is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinHaloperidol
Severe
How does the drug interact with Rubilon 50 mg Injection 1's:
Co-administration of Rubilon 50 mg Injection 1's and Haloperidol can affect the rhythm of the heart.

How to manage the interaction:
Co-administration of Rubilon 50 mg Injection 1's and Haloperidol can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
EpirubicinEtanercept
Severe
How does the drug interact with Rubilon 50 mg Injection 1's:
When Etanercept is used with Rubilon 50 mg Injection 1's, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Rubilon 50 mg Injection 1's can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
EpirubicinGatifloxacin
Severe
How does the drug interact with Rubilon 50 mg Injection 1's:
Taking Rubilon 50 mg Injection 1's with Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Rubilon 50 mg Injection 1's with Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EpirubicinMoxifloxacin
Severe
How does the drug interact with Rubilon 50 mg Injection 1's:
Using Moxifloxacin together with Rubilon 50 mg Injection 1's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Rubilon 50 mg Injection 1's together can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heart rhythm, vomiting, dizziness, difficulty breathing, or irregular heartbeat call a doctor right away. Do not discontinue any medications without consulting a doctor.
EpirubicinTofacitinib
Severe
How does the drug interact with Rubilon 50 mg Injection 1's:
Taking Tofacitinib with Rubilon 50 mg Injection 1's may increase the risk of serious infection.

How to manage the interaction:
Co-administration of Rubilon 50 mg Injection 1's with Tofacitinib can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - make sure to call your doctor right away. Do not discontinue any medications without first consulting your doctor.
EpirubicinBaricitinib
Severe
How does the drug interact with Rubilon 50 mg Injection 1's:
Coadministration of baricitinib and Rubilon 50 mg Injection 1's can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Rubilon 50 mg Injection 1's if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
EpirubicinChloroquine
Severe
How does the drug interact with Rubilon 50 mg Injection 1's:
Using chloroquine together with Rubilon 50 mg Injection 1's can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Chloroquine and Rubilon 50 mg Injection 1's, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinDisopyramide
Severe
How does the drug interact with Rubilon 50 mg Injection 1's:
The combined use of Efavirenz and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Efavirenz and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
EpirubicinInfliximab
Severe
How does the drug interact with Rubilon 50 mg Injection 1's:
Combining Infliximab with Rubilon 50 mg Injection 1's can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Rubilon 50 mg Injection 1's together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to eat more healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.
  • Doing meditation and yoga for some time is very effective in helping cancer patients maintain a healthy attitude and body.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Rubilon 50 mg Injection Substitute

Substitutes safety advice
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  • ALRUBICIN 50MG INJECTION 25ML

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  • Adricin 50 Injection 1's

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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

Rubilon 50 mg Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Rubilon 50 mg Injection. Use reliable methods of birth control while on treatment with Rubilon 50 mg Injection.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Rubilon 50 mg Injection. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Safe

Rubilon 50 mg Injection does not affect your ability to drive. However, drive only if you are alert.

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Liver

Caution

Rubilon 50 mg Injection should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

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Children

Unsafe

Rubilon 50 mg Injection is not recommended for use in children, as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF leading to serious side effects.

FAQs

Rubilon 50 mg Injection is used to treat Breast Cancer.
Rubilon 50 mg Injection contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.
Rubilon 50 mg Injection can disrupt a woman's natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with Rubilon 50 mg Injection.
Yes, Rubilon 50 mg Injection is considered a vesicant. This means it may cause tissue blistering and damage if it leaks out of the vein during administration in some individuals. Hence, this medication must be administered by a trained healthcare professional to reduce the risk of this complication.
Rubilon 50 mg Injection is effective in treating breast cancer by slowing or stopping the growth of cancer cells. It inhibits the topoisomerase II enzyme, interfering with DNA replication and destroying cancer cells. However, like all medications, it can have side effects and interact with other drugs, so it's essential to follow your doctor's instructions to maximize effectiveness and minimize side effects.
Rubilon 50 mg Injection is a chemotherapy medication that contains the active ingredient Epirubicin, a type of anthracycline topoisomerase inhibitor, used to treat breast cancer after tumor removal surgery.
The common side effects of Rubilon 50 mg Injection may include nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the injection site. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - RUB0137

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