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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Jan 1, 2025 | 2:44 PM IST

Rofiplag Injection 100 ml is used to Prevent blood clots, heart attacks, and chest pain. It contains Tirofiban, an antiplatelet that prevents platelets (blood cells) from sticking together to form blood clots. Thus, it is used to prevent blood clots. It also helps blood flow to the heart and prevents heart attack and chest pain. Additionally, it may be used in patients whose heart vessels are dilated with a balloon (percutaneous coronary intervention or PCI). It is intended for use with unfractionated heparin and aspirin.

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Prescription drug

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Composition :

TIROFIBAN-5MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Rofiplag Injection 100 ml

Rofiplag Injection 100 ml belongs to a class of medicines called 'antiplatelets' (blood thinners) used to prevent blood clots. It helps to prevent heart attack and chest pain. It is intended for use with unfractionated heparin and aspirin. A blood clot is a clump of blood that has changed from a liquid to a gel-like or semisolid state. Blood clots are formed to stop bleeding that occurs due to tissue injury. Though blood clots are useful for stopping bleeding, they are harmful when abnormally formed within blood vessels as they block blood vessels and inhibit blood flow to essential organs such as the brain, heart, or lungs.

Rofiplag Injection 100 ml contains Tirofiban, a platelet aggregation inhibitor which works by preventing platelets (blood cells) from sticking together to form blood clots. Thus, it prevents blood clot formation.

Rofiplag Injection 100 ml will be administered by a healthcare professional; do not self-administer. Sometimes, Rofiplag Injection 100 ml may cause common side effects such as bleeding under the skin at the site of injection or into a muscle causing swelling, bleeding after surgery, invisible blood in stool or urine, headache or feeling sick. Most of these side effects of Rofiplag Injection 100 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Tirofiban or any other medicines, please tell your doctor. Rofiplag Injection 100 ml is not recommended for children as safety and effectiveness were not established. If you are a pregnant or breastfeeding woman, inform your doctor before receiving Rofiplag Injection 100 ml. Avoid alcohol consumption with Rofiplag Injection 100 ml as it may increase the risk of bleeding in the stomach or intestines. If you have a history of stroke or bleeding internally within the last 30 days, avoid receiving Rofiplag Injection 100 ml.

Uses of Rofiplag Injection 100 ml

Prevention of blood clots, heart attack and chest pain

Medicinal Benefits

Rofiplag Injection 100 ml contains Tirofiban, an antiplatelet which prevents platelets (blood cells) from sticking together to form blood clots. Thus, it is used to prevent blood clots. Also, it helps blood flow to the heart and prevents heart attack and chest pain. Additionally, it may be used in patients whose heart vessels are dilated with a balloon (percutaneous coronary intervention or PCI). It is intended for use with unfractionated heparin and aspirin.

Side Effects of Rofiplag Injection 100 ml

  • Bleeding under the skin at the site of injection or into a muscle causes swelling
  • Bleeding after surgery
  • Invisible blood in stool or urine
  • Headache
  • Feeling sick

Directions for Use

Rofiplag Injection 100 ml will be administered by a healthcare professional; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to Tirofiban or any other medicines, please tell your doctor. Rofiplag Injection 100 ml is not recommended for children as safety and effectiveness were not established. If you are a pregnant or breastfeeding woman, inform your doctor before receiving Rofiplag Injection 100 ml. Avoid alcohol consumption with Rofiplag Injection 100 ml as it may increase the risk of bleeding in the stomach or intestines. If you have a history of stroke or bleeding internally within the last 30 days, avoid receiving Rofiplag Injection 100 ml. If you have had cardiopulmonary resuscitation (CPR), a biopsy, or a procedure to break up kidney stones within the last 2 weeks or have been seriously injured, had a major operation or had an ulcer in the stomach or intestine within the last 3 months, had a recent spinal procedure, have history or symptoms of aortic dissection (splitting of the aorta, main artery), or had a special intravenous line inserted under your collar bone within the last 24 hours, inform your doctor before receiving Rofiplag Injection 100 ml.

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Diet & Lifestyle Advise

  • Avoid making any changes in your diet without first talking to your doctor to avoid medication interactions.
  • Include foods high in antioxidants, such as vegetables, fruits, olive oil, seeds, nuts, cocoa, and red wine, as they may lower the risk of developing blood clots.
  • Adopt an anti-inflammatory diet high in omega-3-rich foods, fruits and vegetables, and vitamin E-rich foods.
  • Drink plenty of fluids as dehydration can thicken blood leading to an increased risk of blood clot formation.
  • Do regular exercise as it helps to dissolve blood clots, especially in obese people.
  • Avoid alcohol consumption as it may increase the risk of bleeding.

Habit Forming

No

How Rofiplag Injection 100 ml Works

Rofiplag Injection 100 ml contains Tirofiban, a platelet aggregation inhibitor which works by preventing platelets (blood cells) from sticking together to form blood clots. Thus, it prevents blood clot formation.

What if I have taken an overdose of Rofiplag Injection 100 ml

Since Rofiplag Injection 100 ml is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.
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Alcohol

Unsafe

You are recommended to avoid the consumption of alcohol with Rofiplag Injection 100 ml as it may increase the risk of bleeding in the stomach or intestines.

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Pregnancy

Consult your doctor

Limited data is available on the effect of Rofiplag Injection 100 ml in pregnancy. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Rofiplag Injection 100 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Limited data is available on the effect of Rofiplag Injection 100 ml on breastfeeding mothers. Hence, if you are a nursing mother, inform your doctor before receiving Rofiplag Injection 100 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Not applicable

Due to your disease state, you will not be able to drive or operate machinery while receiving Rofiplag Injection 100 ml.

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Liver

Caution

Rofiplag Injection 100 ml is not recommended if you have severe liver disease. Therefore, if you have any liver disorder, inform your doctor before receiving Rofiplag Injection 100 ml.

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Kidney

Caution

If you have kidney disease/condition, inform your doctor before receiving Rofiplag Injection 100 ml. The dose may be adjusted in patients with severe kidney failure.

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Children

Unsafe

Rofiplag Injection 100 ml is not recommended for children as the safety and effectiveness were not established.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - ROF0052

Author Details

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Rofiplag Injection 100 ml Substitute

Substitutes safety advice
  • Aggramed 5mg Infusion 100 ml

    74.10per tablet
  • AGGRIBLOC 5MG I.V INJECTION 100ML

    83.23per tablet
  • TIROFUSE INJECTION 100ML

    38.09per tablet
  • TIROBAN 5MG INJECTION 100ML

    52.14per tablet
  • Fibroban 5Mg/100Ml Inj

    by AYUR

    69.00per tablet

FAQs

Rofiplag Injection 100 ml is used to prevent blood clots, heart attack and chest pain.
Rofiplag Injection 100 ml contains Tirofiban, a platelet aggregation inhibitor which works by preventing platelets (blood cells) from sticking together to form blood clots. Thus, it prevents blood clot formation.
Rofiplag Injection 100 ml is not recommended for patients with severe liver disease. Therefore, if you have any liver disorder, inform your doctor before receiving Rofiplag Injection 100 ml.
Yes, Rofiplag Injection 100 ml may cause bleeding. If you notice blood in urine or stool or coughing up blood, please inform your doctor immediately, as these might be signs of internal bleeding.
While taking Rofiplag Injection 100 ml, avoid medications such as NSAIDs (aspirin, ibuprofen), anticoagulants (heparin, warfarin), thrombolytic agents (streptokinase), other antiplatelet medicines (clopidogrel), and SSRIs (citalopram), as they may interact with Rofiplag Injection 100 ml and cause negative complications. Always inform your doctor about your medication and health history for personalized guidance.
Rofiplag Injection 100 ml is administered through an intravenous (IV) infusion by a healthcare professional.
You should avoid consuming alcohol while on Rofiplag Injection 100 ml since it may raise the risk of bleeding in the stomach or intestines.
Rofiplag Injection 100 ml gets to work quickly, and you may start feeling better within a few hours. As the medication rapidly prevents blood clots, you'll be on the road to recovery in no time. Follow your doctor's instructions and complete the full treatment course to ensure maximum benefits and a speedy return to health.
The common side effects of the Rofiplag Injection 100 ml may include bleeding under the skin at the site of injection or into a muscle, causing swelling, bleeding after surgery, invisible blood in stool or urine, headache, or feeling sick. Most of these side effects of Rofiplag Injection 100 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

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