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  3. RF-HE Tablet Kit

RF-HE Tablet Kit, Pack of 1
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

RF-HE Tablet Kit is used to treat tuberculosis (TB) caused by the bacteria mycobacterium tuberculin. It prevents or kills the bacteria and prevents its spread. It may cause common side effects like nausea, vomiting, fever, dark-coloured urine, sweating, and increased saliva. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ETHAMBUTOL-800MG + ISONIAZID-300MG + RIFAMPICIN-450MG

Manufacturer/Marketer :

Sunij Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About RF-HE Tablet Kit

RF-HE Tablet Kit belongs to the group of antibiotics called 'antituberculosis agents' used to treat tuberculosis (TB) caused by the bacteria mycobacterium tuberculin. Infectious or harmful bacteria can make you sick and reproduce quickly in your body. These harmful bacteria produce toxins which can damage tissue and make you sick. Tuberculosis (TB) usually attacks your lungs and can also spread to the brain and spine. Common signs and symptoms of TB include fever, cough (sometimes blood-tinged), weight loss, and night sweats.

RF-HE Tablet Kit contains Rifampicin, Ethambutol, and Isoniazid. Rifampicin inhibits DNA synthesis (a process required for bacterial growth and division). On the other hand, Ethambutol and Isoniazid prevent bacterial cell wall (outer covering) synthesis, which is necessary for growth. This ultimately prevents or kills the bacteria and prevents its spread.

RF-HE Tablet Kit should be taken as directed by the doctor. You may experience common side effects like nausea, vomiting, fever, dark-coloured urine, sweating, and increased saliva. Everyone need not undergo the above symptoms. If any discomfort occurs from this medicine, consult your doctor.

People with liver and kidney diseases should take RF-HE Tablet Kit only after consulting with a doctor. Pregnant women and breastfeeding mothers should take RF-HE Tablet Kit as instructed by the doctor. Do not take this medicine with alcohol, which causes drowsiness. While on the medication, your doctor advises some diagnostic and laboratory tests to know the effects of drugs on the body. Use of RF-HE Tablet Kit may also affect oral contraceptive pills, so if you are using any, please consult a doctor and ask for some other birth control methods. You may experience dark-coloured urine and yellowing of teeth after using RF-HE Tablet Kit. However, these are harmless symptoms and may go after stopping RF-HE Tablet Kit.

Uses of RF-HE Tablet Kit

Treatment of Tuberculosis (TB)

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

RF-HE Tablet Kit is an antibiotic active against the mycobacterium strain of bacteria, which causes TB infection. Rifampicin, Ethambutol, and Isoniazid prevent the bacteria's growth by interfering with the cell wall and DNA (the genetic material of bacteria) required to survive the bacteria. RF-HE Tablet Kit is active against Mycobacterium bacteria which causes TB and leprosy.

How RF-HE Tablet Kit Works

RF-HE Tablet Kit contains Rifampicin, Ethambutol, and Isoniazid. Rifampicin inhibits DNA synthesis (a process required for bacterial growth and division). On the other hand, Ethambutol and Isoniazid prevent bacterial cell wall (outer covering) synthesis, which is necessary for growth. This ultimately prevents or kills the bacteria and prevents its spread.

Storage

Store in a cool and dry place away from sunlight

Side Effects of RF-HE Tablet Kit

  • Nausea
  • Vomiting
  • Fever
  • Rash Dark-coloured urine
  • Increased salivation (drooling)

What if I have taken an overdose of RF-HE Tablet Kit

Do not take more than the prescribed dose of RF-HE Tablet Kit as it may cause overdose. The symptoms of overdose include dizziness/fainting/lightheadedness when getting up suddenly from a lying or sitting position, confusion, blurred vision, fast/pounding/irregular heartbeat, slurring of speech, severe sleepiness, low blood pressure or seizures (fits). If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

People with liver and kidney diseases should take RF-HE Tablet Kit only after consulting with a doctor. Pregnant women and breastfeeding mothers should take RF-HE Tablet Kit as instructed by the doctor. Do not take this medicine with alcohol, which causes drowsiness. While on the medication, your doctor advises some diagnostic and laboratory tests to know the effects of drugs on the body. Use of RF-HE Tablet Kit may also affect oral contraceptive pills, so please consult a doctor and ask for some other birth control methods if you are using any. You may experience dark-coloured urine and yellowing of teeth after using RF-HE Tablet Kit. However, these are harmless symptoms and may go after stopping RF-HE Tablet Kit.

Drug-Drug Interactions

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RifampicinDarunavir
Critical
RifampicinVoriconazole
Critical

Drug-Drug Interactions

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RifampicinDarunavir
Critical
How does the drug interact with RF-HE Tablet Kit:
Taking darunavir with RF-HE Tablet Kit can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and RF-HE Tablet Kit, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinVoriconazole
Critical
How does the drug interact with RF-HE Tablet Kit:
Taking Voriconazole with RF-HE Tablet Kit can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with RF-HE Tablet Kit, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinRanolazine
Critical
How does the drug interact with RF-HE Tablet Kit:
When ranolazine is taken with RF-HE Tablet Kit, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and RF-HE Tablet Kit, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinSaquinavir
Critical
How does the drug interact with RF-HE Tablet Kit:
Taking saquinavir with RF-HE Tablet Kit can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and RF-HE Tablet Kit, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinPirfenidone
Critical
How does the drug interact with RF-HE Tablet Kit:
Taking pirfenidone with RF-HE Tablet Kit can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and RF-HE Tablet Kit, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinIndinavir
Critical
How does the drug interact with RF-HE Tablet Kit:
When Indinavir is taken with RF-HE Tablet Kit, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and RF-HE Tablet Kit, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
IsoniazidLomitapide
Critical
How does the drug interact with RF-HE Tablet Kit:
When Lomitapide is taken with RF-HE Tablet Kit, RF-HE Tablet Kit may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking RF-HE Tablet Kit with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
IsoniazidRegorafenib
Critical
How does the drug interact with RF-HE Tablet Kit:
When RF-HE Tablet Kit is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with RF-HE Tablet Kit is not recommended, it taken can be taken if prescribed by the doctor.
IsoniazidLovastatin
Critical
How does the drug interact with RF-HE Tablet Kit:
When Lovastatin is taken with RF-HE Tablet Kit, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking RF-HE Tablet Kit with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
RifampicinBedaquiline
Severe
How does the drug interact with RF-HE Tablet Kit:
Taking bedaquiline with RF-HE Tablet Kit can decrease the blood levels of bedaquiline, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between bedaquiline and RF-HE Tablet Kit, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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ETHAMBUTOL-800MG+ISONIAZID-300MG+RIFAMPICIN-450MGTyramine-containing food, Caffeine containing foods/drinks
Moderate

Drug-Food Interactions

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ETHAMBUTOL-800MG+ISONIAZID-300MG+RIFAMPICIN-450MGTyramine-containing food, Caffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado, Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Consuming Tyramine containing food and Caffeine with RF-HE Tablet Kit can increase the risk of toxicity. Avoid consuming Tyramine-containing food and Caffeine with RF-HE Tablet Kit. Contact a doctor immediately if you experience any symptoms such as headache, diaphoresis, flushing, diarrhea, nausea, vomiting, tachycardia, dyspnea, and hypotension.

Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Vitamin C-rich foods such as kiwi, broccoli, and bell pepper help improve the immune system.
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help relieve a cough.
  • Avoid foods and drinks containing histamine or tyramine, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS

RF-HE Tablet Kit Substitute

Substitutes safety advice

  • AKT-3 Kit 1's

    by Others

    ₹18.00per tablet

  • MONTO 3 KIT TABLET

    by Others

    ₹2.25per tablet

  • Rhe FD Tablet 6's

    by Others

    ₹20.03per tablet

  • Rhe Kit Tablet 2's

    by Others

    ₹9.45per tablet

  • TRAC 3 TABLET

    by Others

    ₹5.40per tablet

Product Substitutes

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Alcohol

Unsafe

Consuming alcohol and RF-HE Tablet Kit causes flushing, increased heartbeat, chest pain, nausea, thirst and low blood pressure. So avoid the use of alcohol with RF-HE Tablet Kit.

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Pregnancy

Caution

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Safe if prescribed

Consult your doctor, and there is no substantial research yet on the use of RF-HE Tablet Kit in breastfeeding/nursing mothers.

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Driving

Caution

RF-HE Tablet Kit may affect your ability to drive as it produces drowiness and sleep. So, it should not be taken before driving a motor vehicle.

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Liver

Caution

Limited information was available for the use of RF-HE Tablet Kit in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using RF-HE Tablet Kit in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Limited information was available for the use of RF-HE Tablet Kit in patients suffering from kidney impairment. Please consult your doctor if you have any concerns regarding using RF-HE Tablet Kit in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

RF-HE Tablet Kit is not recommended for use in children as its safety and efficacy have not been established.

FAQs

RF-HE Tablet Kit is used to treat tuberculosis (TB) caused by the bacteria Mycobacterium tuberculin. It prevents or kills the bacteria and prevents its spread.

No, RF-HE Tablet Kit decreases the action of birth control pills. So, use other contraceptive devices or methods to avoid unwanted pregnancies. Discuss with your doctor before taking this medicine.

It is best to take RF-HE Tablet Kit on an empty stomach 1 hour before or 2 hours after meals.

The full form of DOTS is (Directly Observed Therapy Short Term). It is a defined treatment regimen initiated by the Government to cure tuberculosis. The initial treatment phase consists of 8 weeks of the four drugs, namely: Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) and Ethambutol (E). Then, the continuation phase should consist of the three drugs: Isoniazid, Rifampicin and Ethambutol, which should be given for another 16 weeks.

Yes, it may take at least 6-8 months for the treatment of TB. Remember, you should regularly take DOTS therapy as instructed by the doctor or DOTS worker provided by the government agency.

Do not Panic, as RF-HE Tablet Kit can cause bright red-orange colour urine, faeces, saliva, sputum, sweat, and tear. It won't occur as soon as you stop the use of drugs.

Taking RF-HE Tablet Kit combination tablet is convenient, helps you take your medication correctly, and reduces mistakes in administering.

The duration of taking RF-HE Tablet Kit for getting relief from the symptoms can vary depending on the individual's health condition. Generally, noticeable improvements can occur within a few days to a week after starting treatment. Follow your doctor's instructions regarding dose and duration and complete the full course as prescribed.

You will know the treatment is working when you start to feel better, experience a reduction in symptoms like coughing, fever, and fatigue, and if follow-up tests show improvement. Complete the full course of treatment even if you start feeling better.

To ensure you are fully cured of tuberculosis, your doctor will conduct follow-up tests like sputum cultures or chest X-rays. Complete the entire course of treatment and attend all follow-up appointments to ensure the infection is fully cured.

RF-HE Tablet Kit can make birth control pills less effective. Use an alternative method of contraception, such as condoms or diaphragms,while taking this medication. Discuss with your doctor for personalized advice.

Store RF-HE Tablet Kit at room temperature, away from moisture and heat. Keep out of reach of children and pets.

RF-HE Tablet Kit may cause discoloration of the urine in some individuals as it is a common side effect. However, this effect vanishes over time as the medication adapts to the body. If this symptom becomes more uncomfortable and worsens please consult a doctor for relief.

No, don't discontinue taking RF-HE Tablet Kit even if you feel well. Complete the full course of treatment as prescribed by your doctor to ensure the infection is fully cleared. If you are having any concerns please discuss them with your doctor.

RF-HE Tablet Kit can cause visual impairment, primarily due to Ethambutol in its composition. It can lead to optic neuritis, causing decreased vision, blind spots, and colour vision changes. Have regular eye tests and report any vision changes to your doctor immediately.

The common side effects of RF-HE Tablet Kit that may occur in some individuals are nausea, vomiting, fever, dark-coloured urine, sweating, and increased saliva. However, these symptoms vanish as your body adjusts to the medication. If these symptoms worsen, please consult a doctor for relief.

Country of origin

India

Manufacturer/Marketer address

T-1/B National Park, Gulbai Tekra, Ahmedabad 380 015, (India)
Other Info - RFH0001

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Author Details

Doctor imageDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:49 PM IST

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Reference

  1. https://http://www.stoptb.org/assets/documents/gdf/drugsupply/rh150_100-b_and_more.pdf
  2. https://www.medicines.org.uk/emc/product/5311/smpc#gref
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