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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Ranolife 500 mg ER Tablet is used alone or with other medicines to treat angina pectoris. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines. In some cases, it may cause side effects such as constipation, dizziness, headache, or feeling sick. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

RANOLAZINE-500MG

Manufacturer/Marketer :

Orris Pharmaceuticals

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Ranolife 500 mg ER Tablet

Ranolife 500 mg ER Tablet is used alone or with other medicines to treat angina pectoris. Angina pectoris is discomfort in the chest or chest pain, which generally occurs due to coronary artery disease (CAD) when an adequate amount of oxygen and blood is not reaching the heart and its muscles. It can also be due to the blockage of the heart's arteries. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines.

The active substance in Ranolife 500 mg ER Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels, through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Ranolife 500 mg ER Tablet is thought to help the heart relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Your doctor will tell you how to take the Ranolife 500 mg ER Tablet based on your medical condition. You may sometimes experience constipation, dizziness, headache, or feeling sick. Most of these side effects of Ranolife 500 mg ER Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not consume Ranolife 500 mg ER Tablet if you are allergic to any component in this medicine. Ranolife 500 mg ER Tablet should not be stopped even if you feel better for the best results, as it prevents any future harm. If you stop taking the Ranolife 500 mg ER Tablet on your own, your chest pain can come back in more severe form. If you plan to get pregnant or are pregnant or breastfeeding, please consult your doctor to avoid any unwanted harm to the baby. Some lifestyle modifications are important for best results when taking Ranolife 500 mg ER Tablet , like smoking cessation, decreasing alcohol intake, eating well, regular exercise, and managing stress. Ranolife 500 mg ER Tablet should be taken with caution if you have any liver or kidney problems. Also, inform your doctor if you are taking other medications to avoid unwanted side effects or contraindications.

Uses of Ranolife 500 mg ER Tablet

Treatment of Angina Pectoris.

Directions for Use

Swallow Ranolife 500 mg ER Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Ranolife 500 mg ER Tablet is prescribed for treating angina. Ranolife 500 mg ER Tablet is an anti-anginal medication used to treat angina pectoris. It reduces sodium ions' flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called ‘sodium-dependent calcium channels’ through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Ranolife 500 mg ER Tablet is thought to help the heart relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

How Ranolife 500 mg ER Tablet Works

The active substance in Ranolife 500 mg ER Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels, through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Ranolife 500 mg ER Tablet is thought to help the heart relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Ranolife 500 mg ER Tablet

  • Constipation
  • Dizziness
  • Headache
  • Feeling sick

What if I have taken an overdose of Ranolife 500 mg ER Tablet

Do not take more than the prescribed dose of Ranolife 500 mg ER Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, confusion, dizziness, double vision, fainting, difficulty speaking, uncontrollable shaking of a part of the body, hallucinations and burning, pain, numbness, or tingling in any part of the body. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Ranolife 500 mg ER Tablet should be taken with caution in liver/kidney disease, are pregnant, plan to become pregnant, or are breastfeeding, history of heart disease. Also, grapefruit juice should be avoided while taking Ranolife 500 mg ER Tablet . As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery. Do regular exercise to avoid the feeling of heaviness in the abdomen.

Drug-Drug Interactions

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RanolazineRifabutin
Critical
RanolazinePhenylbutazone
Critical

Drug-Drug Interactions

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RanolazineRifabutin
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
Taking Rifabutin and Ranolife 500 mg ER Tablet 10's may significantly reduce the blood levels of Ranolife 500 mg ER Tablet 10's.

How to manage the interaction:
There may be a possibility of interaction between Rifabutin and Ranolife 500 mg ER Tablet 10's, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RanolazinePhenylbutazone
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
Co-administration of Phenylbutazone and Ranolife 500 mg ER Tablet 10's may significantly reduce the blood levels of Ranolife 500 mg ER Tablet 10's, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Phenylbutazone with Ranolife 500 mg ER Tablet 10's can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
RanolazineClarithromycin
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
When Ranolife 500 mg ER Tablet 10's and Clarithromycin are taken together, significantly increases the blood levels and effects of Ranolife 500 mg ER Tablet 10's.

How to manage the interaction:
Co-administration of Clarithromycin and Ranozaline can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RanolazineCisapride
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
Co-administration of Ranolife 500 mg ER Tablet 10's with Cisapride can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ranolife 500 mg ER Tablet 10's with Ceritinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
RanolazineFosamprenavir
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
Co-administration of Fosamprenavir and Ranolife 500 mg ER Tablet 10's may significantly can occasionally cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Fosamprenavir with Ranolife 500 mg ER Tablet 10's can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineVoriconazole
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
Co-administration of Ranolife 500 mg ER Tablet 10's together with Voriconazole may significantly increase the blood levels and effects of Ranolife 500 mg ER Tablet 10's.

How to manage the interaction:
Taking Ranolife 500 mg ER Tablet 10's with Voriconazole together can result in an interaction, but it can be taken if a doctor has advised it. Consult a doctor if you experience dizziness, or fast or pounding heartbeats. Do not discontinue any medications without consulting a doctor.
RanolazineZiprasidone
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
Co-administration of Ranolife 500 mg ER Tablet 10's with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ranolife 500 mg ER Tablet 10's with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
RanolazineBexarotene
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
When Ranolife 500 mg ER Tablet 10's and Bexarotene are taken together, may reduce the blood levels and effects of Ranolife 500 mg ER Tablet 10's.

How to manage the interaction:
Taking Ranolife 500 mg ER Tablet 10's with Bexarotene together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
RanolazineMifepristone
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
When Mifepristone is taken with Ranolife 500 mg ER Tablet 10's, may cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Phenylbutazone with Ranolife 500 mg ER Tablet 10's can lead to an interaction. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineNevirapine
Critical
How does the drug interact with Ranolife 500 mg ER Tablet 10's:
Co-administration of Nevirapine with Ranolife 500 mg ER Tablet 10's may significantly reduce the blood levels of Ranolife 500 mg ER Tablet 10's. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Nevirapine with Ranolife 500 mg ER Tablet 10's is generally avoided as it can lead to an interaction, they can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the levels of Ranolife 500 mg ER Tablet 10's, and high blood levels of food can occasionally cause an irregular heart rhythm that may be serious. Grapefruit and grapefruit juice should be avoided while taking Ranolife 500 mg ER Tablet 10's if possible.

Diet & Lifestyle Advise

  • Maintain a healthy lifestyle by exercising regularly, maintaining weight, and eating a healthy diet.

  • If you suffer from kidney or liver disease, please inform your doctor before taking the Ranolife 500 mg ER Tablet .
  • Alcohol consumption along with Ranolife 500 mg ER Tablet should be avoided as it may cause excessive drowsiness and increase muscle pain.
  • As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery.

Habit Forming

No

Therapeutic Class

ANTIANGINALS

Ranolife 500 mg ER Tablet Substitute

Substitutes safety advice
  • Ranozex Tablet 10's

    17.91per tablet
  • Ranolaz 500 mg Tablet 15's

    18.96per tablet
  • Ranx 500 Tablet 15's

    20.61per tablet
  • Rancad Tablet 15's

    by AYUR

    20.73per tablet
  • Ranogard 500 Tablet 10's

    by AYUR

    9.54per tablet
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Alcohol

Safe if prescribed

Ranolife 500 mg ER Tablet does not have any reported interaction; hence, if you experience any difficulty, discuss with your doctor.

bannner image

Pregnancy

Unsafe

Ranolife 500 mg ER Tablet should not be used when pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Ranolife 500 mg ER Tablet .

bannner image

Breast Feeding

Unsafe

Ranolife 500 mg ER Tablet should not be used in nursing mothers. Please consult the doctor if you have any concerns regarding this.

bannner image

Driving

Safe if prescribed

Ranolife 500 mg ER Tablet does not have any reported interaction; hence, in case you experience any difficulty, discuss with your doctor.

bannner image

Liver

Caution

Ranolife 500 mg ER Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Ranolife 500 mg ER Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Children

Caution

Ranolife 500 mg ER Tablet is not recommended for children below the age of 18. The safety and effectiveness of Ranolife 500 mg ER Tablet have not been established in children due to limited testing of this drug on children by competent authorities worldwide.

FAQs

Ranolife 500 mg ER Tablet is used alone or with other medicines to treat angina pectoris.
The active substance in Ranolife 500 mg ER Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Ranolife 500 mg ER Tablet is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.
No, Ranolife 500 mg ER Tablet does not stop acute attacks (sudden attacks) of angina, but Ranolife 500 mg ER Tablet helps prevent a new attack.
No, alcohol should not be taken with Ranolife 500 mg ER Tablet as it may lead to unwanted side effects and increase angina attacks.
Yes, smoking (tobacco) decreases the efficacy of Ranolife 500 mg ER Tablet , especially when taken for angina (chest pain), so it should be avoided while taking Ranolife 500 mg ER Tablet .
Yes, Ranolife 500 mg ER Tablet can cause an upset stomach when taken empty stomach. So, to avoid it, Ranolife 500 mg ER Tablet should be taken with a meal for best results.
Yes, Ranolife 500 mg ER Tablet can cause drowsiness. If you feel excessively sleepy, please consult your doctor for better advice.
Some major side effects include a rapid, pounding, or irregular heartbeat, difficulty breathing, and fainting. If you encounter any of these symptoms, contact your doctor immediately.
Do not take more than the prescribed dose of Ranolife 500 mg ER Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, confusion, dizziness, double vision, fainting, difficulty speaking, uncontrollable shaking of a part of the body, hallucinations and burning, pain, numbness, or tingling in any part of the body. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.
Ranolife 500 mg ER Tablet may increase the blood levels and effects of metoprolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.
Ranolife 500 mg ER Tablet might raise metformin levels, increasing the risk of lactic acidosis. If you are prescribed ranolazine while taking metformin, discuss it with a healthcare physician. They may offer a lesser dose of metformin as a safer alternative.
You can take it if prescribed by the doctor. However, limit simvastatin to 20 mg once daily in individuals taking any dose of Ranolife 500 mg ER Tablet .

Country of origin

India

Manufacturer/Marketer address

GL-3, Building No.17,Unit-3, Ektha Society, Ghansoli, Navi Mumbai-400 701.
Other Info - RAN0223

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