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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Pregaba D 75/20 Capsule is used in the treatment of diabetic neuropathic pain and fibromyalgia. It contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Pregaba D 75/20 Capsule may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation.

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Synonym :

DULOXETINE HYDROCHLORIDE+PREGABALIN

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Pregaba D 75/20 Capsule

Pregaba D 75/20 Capsule belongs to an anticonvulsant class of medicines. It is used in the treatment of diabetic neuropathic pain and fibromyalgia. Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged. Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. Fibromyalgia is a chronic condition with moderate pain and tenderness all over the body resulting in fatigue and trouble sleeping.

Pregaba D 75/20 Capsule is a combination of Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Pregaba D 75/20 Capsule can be taken with or without food or as prescribed by your doctor. Pregaba D 75/20 Capsule may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist, inform your doctor.

Pregaba D 75/20 Capsule should be avoided if you are allergic to it. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or are at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). If you are pregnant or breastfeeding, inform your doctor before taking this medicine. It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies. 

Uses of Pregaba D 75/20 Capsule

Treatment of Diabetic Neuropathic Pain and Fibromyalgia

Directions for Use

Take Pregaba D 75/20 Capsule as prescribed by your doctor. Swallow it as a whole with water. It can be taken with or without food. Do not crush, break or chew it.

Medicinal Benefits

Pregaba D 75/20 Capsule contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Pregaba D 75/20 Capsule effectively treats neuropathic pain, and improves nerve conduction for proper nerve signal functioning in the body. 

How Pregaba D 75/20 Capsule Works

Pregaba D 75/20 Capsule contains Ozenoxacin, a quinolone antibiotic medicine. It works by inhibiting the protein synthesis responsible for bacterial cell growth, thereby killing the bacteria and treating bacterial infections.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Pregaba D 75/20 Capsule

  • Burning sensation
  • Drowsiness
  • Nausea
  • Constipation
  • Headache
  • Dry mouth
  • Increased sweating
  • Loss of appetite

What if I have taken an overdose of Pregaba D 75/20 Capsule

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Pregaba D 75/20 Capsule may include autonomic instability, blurred vision, coma, confusion, diarrhoea, excessive sleepiness, muscle twitching, numbness, seizures, somnolence, speech disturbances, syncope, tachycardia, and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Pregaba D 75/20 Capsule should be avoided if you are allergic to any of the components in it. Do not stop taking Pregaba D 75/20 Capsule suddenly without your doctor’s advice, as it may cause withdrawal symptoms like dizziness, tingling sensation, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, or glaucoma (an eye condition). Pregaba D 75/20 Capsule may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. It is not recommended for use in children below 18 years of age as the safety and efficacy of this medicine are not established. Pregnant or breastfeeding mothers should inform the doctor before using Pregaba D 75/20 Capsule .

Drug-Drug Interactions

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NortriptylineLinezolid
Critical
NortriptylineTranylcypromine
Critical

Drug-Drug Interactions

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NortriptylineLinezolid
Critical
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Coadministration of Pregaba D 75/20 Capsule 10's with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Pregaba D 75/20 Capsule 10's with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineTranylcypromine
Critical
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Coadministration of Pregaba D 75/20 Capsule 10's with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregaba D 75/20 Capsule 10's with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
NortriptylineZiprasidone
Critical
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Coadministration of Pregaba D 75/20 Capsule 10's with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Pregaba D 75/20 Capsule 10's with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Using Pregaba D 75/20 Capsule 10's together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Pregaba D 75/20 Capsule 10's is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
NortriptylinePotassium citrate
Critical
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Coadministration of Pregaba D 75/20 Capsule 10's with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Pregaba D 75/20 Capsule 10's with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineSelegiline
Critical
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Co-administration of Pregaba D 75/20 Capsule 10's with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Pregaba D 75/20 Capsule 10's with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineSafinamide
Critical
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Coadministration of Pregaba D 75/20 Capsule 10's with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregaba D 75/20 Capsule 10's with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
NortriptylineCyclobenzaprine
Severe
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Taking Cyclobenzaprine with Pregaba D 75/20 Capsule 10's might raise serotonin hormone levels which can increase the risk of developing side effects.

How to manage the interaction:
Taking Cyclobenzaprine with Pregaba D 75/20 Capsule 10's can possibly lead to an interaction. It can be taken if prescribed by doctor. However, if you experience fever, palpitations, excessive sweating, muscle spasm, or vomiting, contact a doctor immediately. Do not discontinue the medications without consulting a doctor.
NortriptylineFluoxetine
Severe
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Co-administration of Pregaba D 75/20 Capsule 10's with Fluoxetine can reduce the metabolism and increase the levels of Pregaba D 75/20 Capsule 10's in the body. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Pregaba D 75/20 Capsule 10's with Fluoxetine together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, dry mouth, sleepiness, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineMirtazapine
Severe
How does the drug interact with Pregaba D 75/20 Capsule 10's:
Using Pregaba D 75/20 Capsule 10's together with mirtazapine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Pregaba D 75/20 Capsule 10's with Mirtazapine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercise regularly, which helps in reducing pain.
  • Rest well, and get enough sleep.
  • Always take a warm bath, as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Pregaba D 75/20 Capsule Substitute

Substitutes safety advice
  • Maxdulin 75 mg/20 mg Capsule 10's

    21.51per tablet
  • Pregabid D 75/20 Capsule 10's

    21.47per tablet
  • Pregeb D 75/20 Capsule 10's

    23.23per tablet
  • Pregalin D 75/20 Capsule 10's

    21.60per tablet
  • Neurokem D 75 mg/20 mg Capsule 10's

    21.42per tablet
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Alcohol

Unsafe

Avoid alcohol consumption during treatment with $nmae as it may increase the risk of serious side effects and worsen your health.

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Pregnancy

Caution

If you are pregnant, especially in the last trimester or planning pregnancy, inform your doctor before taking Pregaba D 75/20 Capsule . It may cause foetal abnormalities if taken in the last trimester of pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before taking Pregaba D 75/20 Capsule . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Pregaba D 75/20 Capsule may cause drowsiness. Hence, avoid driving vehicles or operating machines after taking Pregaba D 75/20 Capsule .

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Liver

Caution

If you have liver conditions, inform your doctor before taking Pregaba D 75/20 Capsule . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have kidney conditions, inform your doctor before taking Pregaba D 75/20 Capsule . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Pregaba D 75/20 Capsule is not recommended for children below 18 years as the safety and efficacy of use for this medicine are not established. Please seek medical advice for more information.

FAQs

Pregaba D 75/20 Capsule is used in the treatment of diabetic neuropathic pain and fibromyalgia. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.
Do not stop using Pregaba D 75/20 Capsule suddenly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose based on your clinical condition.
Seek medical attention immediately if you notice any depressive thoughts while using Pregaba D 75/20 Capsule . Your doctor may change the dose or medicine to treat your condition.
Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged.
Pregaba D 75/20 Capsule contains Pregabalin and Duloxetine. Pregabalin is an anticonvulsant drug, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. Both medicines mainly work by increasing the chemical messengers in the brain responsible for regulating pain.
To manage weight gain associated with the use of Pregaba D 75/20 Capsule , maintain a balanced diet and engage in regular exercise. Use the lowest effective dose to help reduce the chances of gaining weight. Keep track of your weight and consult your doctor if you notice significant changes. They can help adjust your treatment or suggest ways to manage your weight more effectively.
Pregaba D 75/20 Capsule may cause sleepiness or drowsiness in some individuals as a mild side effect. If you experience these symptoms, it is important to avoid activities that require full alertness, such as driving or operating machinery. If drowsiness persists for a longer period, please consult your doctor.
Pregaba D 75/20 Capsule may take several weeks or longer to show its full effects. While some patients may notice improvements within the first week, it is important to continue taking the medication as prescribed to achieve the full benefits. Your doctor will likely reduce your dose gradually to avoid withdrawal symptoms.
If you forget to take Pregaba D 75/20 Capsule , take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose.
No, taking a higher dose of Pregaba D 75/20 Capsule than recommended will not necessarily make it more effective and may increase the risk of side effects. Additionally, it can become habit-forming if misused or taken in larger amounts than prescribed for a prolonged period, leading to dependence. If you feel your current dose is not effective, please consult your doctor for proper adjustments, rather than increasing the dose on your own.
It is not recommended to drink alcohol while taking Pregaba D 75/20 Capsule , as it may increase the risk of side effects such as drowsiness and dizziness. These effects impair your ability to perform tasks that require focus, so avoid driving or operating machinery while taking Pregaba D 75/20 Capsule . Always consult your doctor for personalized advice.
Pregaba D 75/20 Capsule should typically be stored in a cool and dry place, away from direct sunlight and moisture. Keep it out of reach of children.
Pregaba D 75/20 Capsule may cause common side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist or worsen, please inform your doctor.

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - PRE1473

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