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Reviewed By Santoshini Reddy G , M Pharmacy
Last Updated Jan 1, 2025 | 2:46 PM IST
PR-Lupro Injection is a gonadotropin-releasing hormone medicine used in the treatment of prostate cancer, endometriosis and precocious puberty. This medicine works by inhibiting the synthesis of the testosterone in men and oestrogen in women, thereby lowers the hormone levels. Common side effects include hot flashes, decreased sexual interest, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach and injection site reaction.
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Prescription drug

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Manufacturer/Marketer :

Orca Healthcare Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Jan-27

About PR-Lupro Injection

PR-Lupro Injection belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists primarily used to treat prostate cancer and endometriosis. Additionally, it is also used to treat precocious puberty (early puberty) in children. PR-Lupro Injection is used in combination with other medicines to treat anaemia caused by uterine fibroids.

PR-Lupro Injection contains Leuprolide acetate, which is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. It works by inhibiting the synthesis of the natural male hormone, testosterone in men and oestrogen in women. This process of lowering hormone levels can decrease cancer cell growth in prostate cancer and helps treat endometriosis.

PR-Lupro Injection will be administered by a healthcare professional. The common side effects of PR-Lupro Injection include hot flashes, decreased sexual interest, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach and injection site reaction. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Avoid taking PR-Lupro Injection if you are pregnant or breastfeeding. Both women and men using PR-Lupro Injection should use effective contraception. PR-Lupro Injection may affect fertility, hence discuss with your doctor if you have any plans to start a family in the future. PR-Lupro Injection is not recommended for children below two years of age. PR-Lupro Injection may cause dizziness, hence drive only if you are alert.

Uses of PR-Lupro Injection

Treatment of Prostate cancer, Endometriosis and Precocious puberty

Medicinal Benefits

PR-Lupro Injection contains Leuprolide acetate, a gonadotropin-releasing hormone (GnRH) agonist. It treats prostate cancer in men, endometriosis in women and precocious puberty (early puberty) in children. PR-Lupro Injection is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. PR-Lupro Injection works by lowering testosterone levels in men that help stop the growth of cancer cells in prostate cancer. PR-Lupro Injection reduces oestrogen (a hormone required for the development and regulation of the female reproductive system and secondary sexual characteristics) levels in women, thus helping in endometriosis.

Side Effects of PR-Lupro Injection

  • Weight changes
  • Hot flushes
  • Muscle weakness
  • Bone Pain
  • Loss of interest in sexual intercourse
  • Tiredness
  • Difficulty sleeping
  • Headaches
  • Nausea
  • Breast tenderness
  • Changes in breast size
  • Mood swings
  • Abdominal pain

Directions for Use

PR-Lupro Injection will be administered by a healthcare professional. Do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to PR-Lupro Injection or any other medicines, please tell your doctor. PR-Lupro Injection is not indicated for use in pregnancy and breastfeeding women. If you are using PR-Lupro Injection, make sure to use reliable forms of contraception. PR-Lupro Injection may also affect fertility in men, hence discuss with your doctor if you have any plans to start a family in the future. PR-Lupro Injection is not recommended for children younger than two years of age. If you have a seizure or unusual changes in mood or behaviour, inform your doctor immediately. Before starting PR-Lupro Injection, let your doctor know if you have liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels. PR-Lupro Injection may cause QT prolongation (heart muscle takes longer than normal to recharge between beats) and may affect heart rhythm, hence heart patients should be cautious while taking PR-Lupro Injection. PR-Lupro Injection can make you feel dizzy and affects your mental ability to drive. Do not drive or operate machinery if you are not mentally alert and focused.

Therapeutic Class

HORMONES

Diet & Lifestyle Advise

  • Maintain a fibre-rich diet and include fruits, vegetables and whole grains.
  • Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
  • Avoid grilled meat, red meat, saturated fat found in animal products, milk and dairy products.
  • Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
  • Eat at regular intervals.
  • Opt for a diet rich in whole grains, fruits, vegetables, and low-fat dairy products.

Habit Forming

No

How PR-Lupro Injection Works

PR-Lupro Injection contains Leuprolide acetate, which is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. It works by inhibiting the synthesis of the natural male hormone, testosterone in men and oestrogen in women. This process of lowering hormone levels can decrease cancer cell growth in prostate cancer and helps treat endometriosis.

What if I have taken an overdose of PR-Lupro Injection

The overdose of PR-Lupro Injection is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with PR-Lupro Injection, please inform your doctor immediately.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking PR-Lupro Injection to avoid unpleasant side-effects. Alcohol intake, along with PR-Lupro Injection, may cause increased dizziness.

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Pregnancy

Unsafe

PR-Lupro Injection is a pregnancy category X drug. PR-Lupro Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Women of childbearing potential must use an effective method of contraception while taking PR-Lupro Injection. Please consult your doctor if you have any concerns regarding this.

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Breast Feeding

Unsafe

PR-Lupro Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

PR-Lupro Injection causes dizziness and affects your ability to drive. Do not drive or operate machinery if you experience any unmanageable side effects with PR-Lupro Injection.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking PR-Lupro Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking PR-Lupro Injection. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Children

Caution

PR-Lupro Injection is not recommended in children younger than two years of age and should be used with caution and only if absolutely warranted in children under 12.

Country of origin

India

Manufacturer/Marketer address

10/15, Visvanathan Street, Srinivasa Avenue, Ra Puram, Mylapore, Chennai-600028, Tamil Nadu, India
Other Info - PRL0003

Author Details

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FAQs

PR-Lupro Injection belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists primarily used to treat prostate cancer and endometriosis. It is also used to treat precocious puberty (early puberty) in children and in combination with other medicines to treat anaemia caused by uterine fibroids.
PR-Lupro Injection contains Leuprolide acetate, a synthetic hormone that helps reduce the testosterone and oestrogen hormones in men and women, respectively. This process of lowering hormone levels can decrease cancer cell growth in prostate cancer in men and shrinks endometriosis in women.
PR-Lupro Injection affects the hair, making it thin which further causes loss of hair. Hair reduction possibly happens due to the estrogen lowering effect of PR-Lupro Injection. These effects are not long-lasting and may return after some time. If you have any concerns, contact your doctor for further advice.
PR-Lupro Injection may cause impotence and affect fertility in men. It is advised to speak to your doctor if you plan to have a family in the future before starting PR-Lupro Injection.
PR-Lupro Injection should be used with caution in diabetic patients as it may increase the risk of high blood sugar levels. Therefore, regular monitoring of blood sugar levels is recommended while taking PR-Lupro Injection and inform your doctor if you have diabetes before taking PR-Lupro Injection.
PR-Lupro Injection may worsen your mood disorders like depression. Hence it is advised to use PR-Lupro Injection only when you are free from any kind of mental problems. Please consult your doctor for more information.
PR-Lupro Injection may cause osteoporosis (bone thinning) due to the reduction of estrogen in the body. Regular bone density tests may help you monitor osteoporosis. Contact your doctor if you observe any sign of tendon pain or swelling while taking PR-Lupro Injection.
PR-Lupro Injection is not recommended for patients suffering from heart rhythm problems such as arrhythmia (irregular heartbeat) as it may increase the risk of cardiac disease. Therefore, inform your doctor if you have any heart problems before taking PR-Lupro Injection.
PR-Lupro Injection is not a chemotherapy medication. PR-Lupro Injection belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists primarily used to treat prostate cancer and endometriosis.
PR-Lupro Injection may stop periods because it alters reproductive hormones in females. Additionally, people treated with PR-Lupro Injection may experience menstruation or spotting in the first 2 months. If bleeding persists beyond 2 months, consult your doctor.
Yes, PR-Lupro Injection is a hormonal medicine. Leuprolide acetate is a pregnancy category X drug. It should not be used during pregnancy because it may cause harm to the foetus.
PR-Lupro Injection may increase the risk of high blood sugar levels. Therefore, it should be used with caution in diabetic patients. Consult your doctor if you notice any changes in blood sugar levels.
The common side effects of PR-Lupro Injection include hot flashes, decreased sexual interest, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach, and injection site reaction. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

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Keep Refrigerated. Do not freeze.