Luprohal 11.25 Depot Injection Combikit belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists primarily used to treat prostate cancer and endometriosis. Additionally, it is also used to treat precocious puberty (early puberty) in children. Luprohal 11.25 Depot Injection Combikit is used in combination with other medicines to treat anaemia caused by uterine fibroids.

Luprohal 11.25 Depot Injection Combikit contains Leuprolide acetate, which is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. It works by inhibiting the synthesis of the natural male hormone, testosterone in men and oestrogen in women. This process of lowering hormone levels can decrease cancer cell growth in prostate cancer and helps treat endometriosis.

Luprohal 11.25 Depot Injection Combikit will be administered by a healthcare professional. The common side effects of Luprohal 11.25 Depot Injection Combikit include hot flashes, decreased sexual interest, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach and injection site reaction. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Avoid taking Luprohal 11.25 Depot Injection Combikit if you are pregnant or breastfeeding. Both women and men using Luprohal 11.25 Depot Injection Combikit should use effective contraception. Luprohal 11.25 Depot Injection Combikit may affect fertility, hence discuss with your doctor if you have any plans to start a family in the future. Luprohal 11.25 Depot Injection Combikit is not recommended for children below two years of age. Luprohal 11.25 Depot Injection Combikit may cause dizziness, hence drive only if you are alert.

Luprohal 11.25 Depot Injection Combikit contains Leuprolide acetate, a gonadotropin-releasing hormone (GnRH) agonist. It treats prostate cancer in men, endometriosis in women and precocious puberty (early puberty) in children. Luprohal 11.25 Depot Injection Combikit is a synthetic hormone that acts similar to the GnRH, produced by the hypothalamus gland in the brain. Luprohal 11.25 Depot Injection Combikit works by lowering testosterone levels in men that help stop the growth of cancer cells in prostate cancer. Luprohal 11.25 Depot Injection Combikit reduces oestrogen (a hormone required for the development and regulation of the female reproductive system and secondary sexual characteristics) levels in women, thus helping in endometriosis.

• Weight changes
• Hot flushes
• Muscle weakness
• Bone Pain
• Loss of interest in sexual intercourse
• Tiredness
• Difficulty sleeping
• Headaches
• Nausea
• Breast tenderness
• Changes in breast size
• Mood swings
• Abdominal pain

If you are allergic to Luprohal 11.25 Depot Injection Combikit or any other medicines, please tell your doctor. Luprohal 11.25 Depot Injection Combikit is not indicated for use in pregnancy and breastfeeding women. If you are using Luprohal 11.25 Depot Injection Combikit, make sure to use reliable forms of contraception. Luprohal 11.25 Depot Injection Combikit may also affect fertility in men, hence discuss with your doctor if you have any plans to start a family in the future. Luprohal 11.25 Depot Injection Combikit is not recommended for children younger than two years of age. If you have a seizure or unusual changes in mood or behaviour, inform your doctor immediately. Before starting Luprohal 11.25 Depot Injection Combikit, let your doctor know if you have liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels. Luprohal 11.25 Depot Injection Combikit may cause QT prolongation (heart muscle takes longer than normal to recharge between beats) and may affect heart rhythm, hence heart patients should be cautious while taking Luprohal 11.25 Depot Injection Combikit. Luprohal 11.25 Depot Injection Combikit can make you feel dizzy and affects your mental ability to drive. Do not drive or operate machinery if you are not mentally alert and focused.

Drug-Drug Interaction: Luprohal 11.25 Depot Injection Combikit may interact with heart rhythm problems treating drugs (quinidine, procainamide, disopyramide, amiodarone, sotalol), steroids (dexamethasone, methylprednisolone) and antibiotics (moxifloxacin), opioid pain killers (methadone)antipsychotics and antidepressants (citalopram, escitalopram, fluoxetine, paroxetine, sertraline).

Drug-Food Interaction: No interactions found/established.

Drug-Disease Interaction: Luprohal 11.25 Depot Injection Combikit should be used with caution in cases of liver or kidney diseases, heart diseases, recent heart attack, depression, brain tumours, electrolyte imbalance, diabetes, fits, weak bones and high cholesterol levels.

• QUINIDINE
• PROCAINAMIDE
• DISOPYRAMIDE
• AMIODARONE
• SOTALOL
• DEXAMETHASONE
• METHYLPREDNISOLONE
• MOXIFLOXACIN
• METHADONE
• CITALOPRAM
• ESCITALOPRAM
• FLUOXETINE
• SERTRALINE
• PAROXETINE

• Maintain a fibre-rich diet and include fruits, vegetables and whole grains.
• Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
• Avoid grilled meat, red meat, saturated fat found in animal products, milk and dairy products.
• Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
• Eat at regular intervals.
• Opt for a diet rich in whole grains, fruits, vegetables, and low-fat dairy products.

• Your doctor may advise liver function tests to monitor your liver health since Luprohal 11.25 Depot Injection Combikit may cause increased liver enzymes (alanine aminotransferase, serum aspartate and serum transaminases).
• Luprohal 11.25 Depot Injection Combikit may cause increased serum glucose levels (hyperglycaemia), hence inform your doctor if you have diabetes before starting Luprohal 11.25 Depot Injection Combikit.
• Your doctor may advise blood tests, electrolyte levels and regular examinations of the prostate.

• It is advised to get an electrocardiogram (ECG) done timely to monitor your heart health.

Prostate cancer: It is the cancer of the prostate gland (a small gland under the bladder that secretes fluid that nourishes and protects sperm) found in men. The symptoms include difficulty in urination, pain, numbness or sexual problems. It is the most common type of cancer in men.

Endometriosis: It is a disorder in which tissue lining the uterus grows outside the uterine cavity. It commonly involves ovaries, fallopian tubes and the tissue lining the pelvis. Symptoms of endometriosis include pain and irregular periods.

Precocious Puberty: Precocious puberty occurs when a child's body changes into that of an adult or experiences puberty too soon. If puberty begins before age 8 in girls and before age 9 in boys, it is considered precocious puberty. Symptoms in a girl include first period and breast development, whereas, in a boy, it causes enlarged testicles and penis, deepening voice and facial hair.