Plelos Clp 50mg/12.5mg Tablet belongs to the class of ‘anti-hypertensive drugs’ primarily used to treat high blood pressure (hypertension). Hypertension is a medical condition in which blood pressure is elevated persistently in the arteries. It is considered an essential risk factor for cardiovascular diseases like heart attack, stroke, myocardial infarction etc. 

Plelos Clp 50mg/12.5mg Tablet consists of two medicines, namely: Losartan and Chlorthalidone. Losartan belongs to a group of angiotensin II receptor antagonists which narrows constricted blood vessels and widens it. Thus, it lowers elevated blood pressure and increases blood flow by preventing blood vessel narrowing. Chlorthalidone belongs to thiazide diuretics (water pill) which inhibits sodium and chloride reabsorption from absorbing excess salts that cause fluid retention or build-up. Thus, it also relaxes the blood vessels to improve blood circulation and lowers raised blood pressure.  

Your doctor will decide the dosage of Plelos Clp 50mg/12.5mg Tablet based on your medical condition. In some cases, Plelos Clp 50mg/12.5mg Tablet can cause side effects like nausea, taste changes, stomach upset, diarrhoea, headache, weakness, dizziness and decreased blood pressure. Most of these side effects of Plelos Clp 50mg/12.5mg Tablet do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

If you are known to be allergic to Plelos Clp 50mg/12.5mg Tablet or any other medicines, please inform your doctor. Before taking Plelos Clp 50mg/12.5mg Tablet, let your doctor know if you have any kidney, liver problems or severe dehydration. Pregnant and breastfeeding women should consult their doctor before taking Plelos Clp 50mg/12.5mg Tablet. Please do not stop taking Plelos Clp 50mg/12.5mg Tablet on your own, leading to the recurrence of symptoms or worsening the condition. Do not consume alcohol with Plelos Clp 50mg/12.5mg Tablet as it may increase the risk of low blood pressure. Avoid driving or operating machinery if you experience dizziness.

Plelos Clp 50mg/12.5mg Tablet is an anti-hypertensive medication that treats high blood pressure (hypertension). It consists of Losartan and Chlorthalidone. Losartan is an angiotensin II receptor antagonist. It lowers the blood pressure and increases the blood flow by inhibiting angiotensin (a hormone that constricts blood vessels). Losartan is also used to treat stroke and slow down kidney damage in people with type 2 diabetes. It also increases urinary flow rate and aids in the excretion of electrolytes like chloride, magnesium, calcium and phosphate and by-products like uric acid. Chlorthalidone is a thiazide diuretic (water pill) with antihypertensive activity. It inhibits sodium and chloride reabsorption from absorbing excess salts that cause fluid retention or build-up. Chlorthalidone lowers blood pressure by decreasing the amount of blood the heart pumps (cardiac output) and reducing plasma and extracellular fluid volume (body fluids outside the cells). 

• Nausea
• Taste changes
• Stomach upset
• Diarrhoea
• Headache
• Weakness
• Dizziness
• Decreased blood pressure (hypotension)  

Complete the course strictly as suggested by the doctor, even if you feel better, to avoid disease recurrence. Let your doctor know if you have any history of heart, kidney or liver diseases, severe dehydration, high potassium levels (hyperkalaemia), low potassium levels (hypokalaemia), diabetes, high cholesterol levels, electrolyte imbalance, asthma, lupus (an autoimmune disease), gout and thyroid disorders before starting Plelos Clp 50mg/12.5mg Tablet. Pregnant women should consult their doctor before taking Plelos Clp 50mg/12.5mg Tablet. Chlorthalidone in Plelos Clp 50mg/12.5mg Tablet passes into the breast milk during breastfeeding. Hence, it is advised to inform your doctor before using Plelos Clp 50mg/12.5mg Tablet if you are a nursing mother. Avoid operating any machines or doing any work that needs mental alertness if you feel dizzy after taking Plelos Clp 50mg/12.5mg Tablet. It is advised to avoid alcohol consumption while using Plelos Clp 50mg/12.5mg Tablet to prevent dizziness and risk of low blood pressure. Plelos Clp 50mg/12.5mg Tablet is not recommended for use in patients younger than 18 years of age. 

Drug-Drug Interaction: Plelos Clp 50mg/12.5mg Tablet may interact with other blood pressure-treating medicines (lisinopril, benazepril, aliskiren), pain killers (ibuprofen, naproxen), heart-related medicines (dofetilide), birth control pills containing drospirenone, heartburn medicines (cisapride) and antidepressants (lithium).

Drug-Food Interaction: Minimize high potassium foods intake and avoid over-the-counter potassium supplements, grapefruit or juice, and alcohol. 

Drug-Disease Interaction: People with low blood pressure, heart, kidney or liver problems or severe dehydration, hyperkalaemia, hypokalaemia, high cholesterol levels, electrolyte imbalance, asthma, lupus, gout, thyroid disorders, and diabetes should consult the doctor before taking Plelos Clp 50mg/12.5mg Tablet. 

• LISINOPRIL
• BENAZEPRIL
• ALISKIREN
• IBUPROFEN
• NAPROXEN
• DOFETILIDE
• DROSPIRENONE
• CISAPRIDE
• LITHIUM

• Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
• Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
• Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
• If you are taking alcohol, use only one serving for women and two servings for men.
• Quit smoking to lower the risk of heart diseases. 
• Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
• Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
• Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

• Keep a check on your daily blood pressure, and if you notice any fluctuations, please consult a doctor. Low salt/sodium diet and regular exercise are recommended along with Plelos Clp 50mg/12.5mg Tablet for effective results.
• Thiazide diuretics like Chlorthalidone may increase serum triglyceride and cholesterol levels. Hence it is advised to monitor your cholesterol levels regularly.
• Chlorthalidone in Plelos Clp 50mg/12.5mg Tablet may interfere with specific lab tests like parathyroid test and protein-bound iodide test, hence mention that you are using Plelos Clp 50mg/12.5mg Tablet in advance to the laboratory staff.
• Your doctor may advise you to get a regular kidney function test, blood examinations for potassium levels and other electrolytes while using Plelos Clp 50mg/12.5mg Tablet to rule out any renal impairment.
• Regular monitoring of blood glucose levels is advised in diabetic patients while using Plelos Clp 50mg/12.5mg Tablet.

Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower, and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack. Additionally, high blood pressure can also cause brain damage (stroke), and kidney failure. Blood pressure is expressed as systolic and diastolic pressures. Systolic blood pressure represents the contraction and relaxation of the heart. Diastolic pressure is exerted in the blood vessels when the heart beats and is in the resting state. Ideal blood pressure should be between 90/60mmHg and 120/80mmHg. Hypertension is detected when systolic blood pressure is more than 140mmHg, and diastolic pressure is higher than 90mmHg. Some of the symptoms of hypertension include headache, nose bleed, vomiting, and chest pain.