Plagerine Tablet is used for the prevention of heart attack or stroke in people at high risk of heart disease. A heart attack generally refers to the blocked flow of blood to the heart because of the blockage of arteries. A heart blockage is most often a build-up of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).

Plagerine Tablet belongs to a class of medications called a blood thinner or an antiplatelet medication. Plagerine Tablet plays a vital role in preventing the formation of harmful blood clots (plaque) in your veins. It makes your blood flow easily through your veins, making it less likely to form a serious blood clot. So, an intake of Plagerine Tablet helps prevent blood clots if you have an increased risk of having severe chest pain (unstable angina or heart attack), stroke, or peripheral arterial disease (heart problem due to narrowed blood vessels).

The recommended daily dose of Plagerine Tablet is 75 mg once daily orally, with or without food. It should be swallowed whole with a glass of water. Do not chew, bite or break it. Your doctor will advise you how often you take your tablets based on your medical condition. In some cases, you may experience nosebleeds, heavier periods, bleeding gums, easy bruising, diarrhoea, stomach pain, indigestion, or heartburn. If the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Stopping a sudden intake of Plagerine Tablet may worsen your condition and increase your risk of cardiovascular death, heart attack, and stroke. Let your doctor know if you have any liver, kidney, or heart problems. Plagerine Tablet should be taken cautiously in pregnant or breastfeeding women. It should be not given to people with a bleeding disorder (haemophilia), active pathological bleeding, like a peptic ulcer, or bleeding in the brain (intracranial haemorrhage). Do not take Plagerine Tablet with aspirin or ibuprofen for pain relief while you are using Plagerine Tablet . It may increase the chance of having stomach ulcers or severe gastric bleeding.

Plagerine Tablet plays a vital role in preventing the formation of harmful blood clots in your blood vessels by making platelets (clotting agents) stick together. Thus, it helps to reduce the risk of heart attack, stroke, unstable angina (heart-related chest pain), and peripheral arterial disease (blocked or poor blood flow due to narrowed blood vessels) in heart disease patients and patients who have undergone recent heart surgery with a stent.

• Nosebleeds
• Heavier periods
• Bleeding gums
• Easy bruising
• Diarrhoea
• Stomach pain
• Indigestion  or heartburn

Indigestion medicines known as proton pump inhibitors like omeprazole should be used with caution while taking Plagerine Tablet . Prolonged use of Plagerine Tablet can cause bleeding problems (like nosebleeds, heavier periods, bleeding gums, and easy bruising). If you are going to have any surgery, discontinue taking Plagerine Tablet 5 days before the surgery. Discontinuation of Plagerine Tablet might increase the risk of heart attack, stroke, and other risks of cardiovascular events. So, do not stop taking Plagerine Tablet suddenly. If you have had a recent stroke or heart attack, stop the intake of Plagerine Tablet with painkillers like aspirin or ibuprofen, as it can increase your stomach or gastrointestinal bleeding. Purpura (blood leakage under the skin) has been observed with the use of Plagerine Tablet , including in fatal cases.

Drug-Drug Interactions: Plagerine Tablet may have interaction with other anticoagulants (e.g. warfarin, aspirin, rivaroxaban, apixaban), pain killers (e.g. ibuprofen), antidepressants (e.g. citalopram), and indigestion medicine/proton pump inhibitors (e.g. omeprazole).

Drug-Food Interactions: Plagerine Tablet may interact with Ginkgo biloba and St John’s wort plant (used as an antidepressant) and increase the risk of bleeding.

Drug-Disease Interactions: Plagerine Tablet should not be given to the people with stomach ulcers, brain haemorrhage (bleeding in your brain), haemophilia (a bleeding disorder), and liver or kidney problems.

• WARFARIN
• ASPIRIN
• RIVAROXABAN
• APIXABAN
• IBUPROFEN
• CITALOPRAM
• OMEPRAZOLE

• A low cholesterol diet and a regular exercise regime complement treatment with Plagerine Tablet effectively.
• Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.
• Replacing most of your saturated fats with unsaturated fats can reduce total cholesterol and LDL cholesterol (bad cholesterol) quickly.
• Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.
• Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.
• Quit smoking and avoid excessive intake of alcohol.

• As Plagerine Tablet tends to increase bleeding, try to avoid injuries, keep away from sharp objects, and inform your doctor if you have peptic ulcers or injuries.

A blood clot can occur in any part of the body and can lead to a heart attack, stroke, and damage to organs (even coma or death). Blood clots can reach your arteries or veins in organs like the brain, kidney, heart, lungs, and limbs. Conditions like atherosclerosis, diabetes, heart failure, irregular heartbeat (arrhythmia), and obesity/overweight can trigger excessive blood clotting in the brain and heart. On the other hand, deep vein thrombosis (blood clot in veins), peripheral artery disease (narrowed arteries due to fat deposit or blood clot), and atherosclerosis (fat built upon the walls of the arteries) can cause a blood clot in your limbs.