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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Phoscan 50mg Tablet is used to treat cancer and nephrotic syndrome (kidney disease). It contains Cyclophosphamide that stops the growth and multiplication of cancer cells. In some cases, this medicine may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Manufacturer/Marketer :

Enrico Pharmaceuticals

Consume Type :

ORAL

Return Policy :

Not Returnable

About Phoscan 50mg Tablet

Phoscan 50mg Tablet is used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia,  nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Phoscan 50mg Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
 
Phoscan 50mg Tablet contains ‘Cyclophosphamide’, an alkylating agent that damages the genetic material of cancer cells to stop their growth and multiplication. Thus, Phoscan 50mg Tablet helps treat cancer by killing the cancer cells.
 
You are advised to take Phoscan 50mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Do not be reluctant to talk with your doctor if you experience any of these side effects persistently.
 
Do not take Phoscan 50mg Tablet if you are allergic to any of its components; or if you have bladder obstruction or other urination problems. Avoid taking Phoscan 50mg Tablet if you are pregnant or breastfeeding. Phoscan 50mg Tablet may cause dizziness, so drive only if you are alert. Phoscan 50mg Tablet should be given to children only if prescribed by the doctor. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Phoscan 50mg Tablet

Phoscan 50mg Tablet is used to treat Cancer and nephrotic syndrome (kidney disease).

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush or chew it.Oral liquid: Check the label for directions before use and take the prescribed dose using the dosing syringe or medicine spoon.

Medicinal Benefits

Phoscan 50mg Tablet belongs to the group of anti-cancer medicines used to treat malignant diseases such as Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma(cancer of plasma cells), Burkitt’s lymphoma, leukaemia (blood cancer), neuroblastoma (nerve tissue cancer), retinoblastoma (eye cancer), adenocarcinoma of the ovary (ovarian cancer), mycosis fungoides (T-cell lymphoma), rhabdomyosarcoma (soft tissue cancer), osteosarcoma (bone cancer), and breast carcinoma. Additionally, Phoscan 50mg Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in pediatric patients. Phoscan 50mg Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Phoscan 50mg Tablet helps to treat cancer by killing the cancer cells.

How Phoscan 50mg Tablet Works

Phoscan 50mg Tablet contains ‘Cyclophosphamide’, an alkylating agent that damages the genetic material of cancer cells to stop their growth and multiplication. Thus, Phoscan 50mg Tablet helps treat cancer by killing the cancer cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Phoscan 50mg Tablet

  • Fever
  • Nausea
  • Vomiting
  • Diarrhoea
  • Hair loss
  • Low blood cell count
  • Abdominal pain

What if I have taken an overdose of Phoscan 50mg Tablet

Take Phoscan 50mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include black/tarry stools, red urine, unusual bleeding/bruising, unusual tiredness/weakness, signs of infection (sore throat, cough, fever), chest pain, and swelling in the ankles, feet or legs. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Phoscan 50mg Tablet if you are allergic to any of its contents; or have urinary flow obstruction, bone marrow suppression, or infections. Talk to your doctor if you have myelosuppression, immunosuppression, infections, diabetes, heart, lung, liver, or kidney problems. Inform your doctor if you are receiving any radiotherapy or chemotherapy. Avoid taking Phoscan 50mg Tablet if you are pregnant or breastfeeding. Phoscan 50mg Tablet may cause dizziness, so drive only if you are alert. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
CyclophosphamideNalidixic acid
Critical

Drug-Drug Interactions

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CyclophosphamideCidofovir
Critical
How does the drug interact with Phoscan 50mg Tablet:
Co-administration of Phoscan 50mg Tablet and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideNalidixic acid
Critical
How does the drug interact with Phoscan 50mg Tablet:
Co-administration of Nalidixic acid with Phoscan 50mg Tablet may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Phoscan 50mg Tablet and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideThiotepa
Severe
How does the drug interact with Phoscan 50mg Tablet:
When Thiotepa is taken with Phoscan 50mg Tablet, can increase the blood levels or add to the medication side effects of Phoscan 50mg Tablet.

How to manage the interaction:
Although taking Thiotepa and Phoscan 50mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
CyclophosphamideThalidomide
Severe
How does the drug interact with Phoscan 50mg Tablet:
Taking Phoscan 50mg Tablet with Thalidomide may increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction, Phoscan 50mg Tablet can be taken with Thalidomide if prescribed by the doctor. However, consult the doctor if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, and/or pain, redness, or swelling in an arm or leg. Do not discontinue any medications without a doctor's advice.
CyclophosphamideLidocaine
Severe
How does the drug interact with Phoscan 50mg Tablet:
Taking Lidocaine with Phoscan 50mg Tablet may increase the risk of methemoglobinemia (a rare condition that can lead to oxygen deprivation in tissues and vital organs due to reduced oxygen-carrying capacity of the blood).

How to manage the interaction:
Although there is a possible interaction, Phoscan 50mg Tablet can be taken with lidocaine if prescribed by the doctor. However, consult the doctor if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not discontinue the medication without consulting a doctor.
CyclophosphamideCladribine
Severe
How does the drug interact with Phoscan 50mg Tablet:
The combined use of Cladribine with Phoscan 50mg Tablet can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Cladribine with Phoscan 50mg Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, contact a doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not discontinue any medications without consulting a doctor.
CyclophosphamideTeriflunomide
Severe
How does the drug interact with Phoscan 50mg Tablet:
Co-administration of Phoscan 50mg Tablet with Teriflunomide can increase the risk of side effects.

How to manage the interaction:
Although taking Phoscan 50mg Tablet and Teriflunomide together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any symptoms like fever, chills, sore throat, or muscle aches, it's best to contact a doctor right away. Other symptoms to watch out for include diarrhea, shortness of breath, weight loss, or pain during urination. Do not discontinue any medications without consulting a doctor.
CyclophosphamideBusulfan
Severe
How does the drug interact with Phoscan 50mg Tablet:
Co-administration of Phoscan 50mg Tablet with Busulfan can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Busulfan and Phoscan 50mg Tablet, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
CyclophosphamideCertolizumab
Severe
How does the drug interact with Phoscan 50mg Tablet:
When Phoscan 50mg Tablet is taken with Certolizumab, may increase the risk or severity of infections.

How to manage the interaction:
There may be a possibility of interaction between Phoscan 50mg Tablet and Certolizumab, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
CyclophosphamideTenofovir disoproxil
Severe
How does the drug interact with Phoscan 50mg Tablet:
Coadministration of Tenofovir disoproxil with Phoscan 50mg Tablet may increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction, Phoscan 50mg Tablet can be taken with Tenofovir disoproxil if prescribed by the doctor. Consult the doctor if you experience signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, herbs, and spices.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.
  • Stay protected from the sun. Avoid tanning beds and cover up with clothing, sunscreen, and sunglasses.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Phoscan 50mg Tablet Substitute

Substitutes safety advice
  • Cycloxan Tablet 10's

    3.66per tablet
  • Adcyclo 50 Tablet 10's

    3.51per tablet
  • Endoxan Tablet 10's

    3.83per tablet
  • Endoxan Tablet 10's

    3.83per tablet
  • Eldamide 50mg Tablet

    2.03per tablet
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Alcohol

Consult your doctor

It is not known if alcohol affects Phoscan 50mg Tablet. Please consult your doctor.

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Pregnancy

Unsafe

Cyclophosphamide belongs to pregnancy category D. Phoscan 50mg Tablet should not be taken during pregnancy as it might cause fetal harm. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnant.

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Breast Feeding

Unsafe

Phoscan 50mg Tablet passes into breastmilk. Avoid breastfeeding while taking Phoscan 50mg Tablet.

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Driving

Caution

Phoscan 50mg Tablet may cause dizziness. Drive or operate heavy machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Phoscan 50mg Tablet should be used with caution in patients with renal impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Phoscan 50mg Tablet should be given to children only if prescribed by a doctor.

FAQs

Phoscan 50mg Tablet is used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia, nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Phoscan 50mg Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
Phoscan 50mg Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Phoscan 50mg Tablet helps to treat cancer by killing the cancer cells.
Do not stop taking Phoscan 50mg Tablet on your own. You are advised to take Phoscan 50mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Phoscan 50mg Tablet.
Phoscan 50mg Tablet might interfere with oogenesis (development of ovum) and spermatogenesis (development of sperm) and could impair fertility. Before starting treatment with Phoscan 50mg Tablet, talk to your doctor regarding cryopreservation/freezing of eggs/sperm if you consider becoming parents.
Phoscan 50mg Tablet might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding, or bruising or if the wounds do not heal properly.
No, it is not safe to father a child while taking Phoscan 50mg Tablet. Use effective contraception while taking Phoscan 50mg Tablet and for at least four months after treatment. Women of childbearing age taking Phoscan 50mg Tablet should use highly effective contraceptives while taking Phoscan 50mg Tablet up to 1 year after the treatment.
Phoscan 50mg Tablet might cause myelosuppression/bone marrow suppression leading to a decrease in white blood cells. This could lead to an increased risk of infections. Regular blood tests while taking Phoscan 50mg Tablet are advised.
During treatment with Phoscan 50mg Tablet, stay protected from sun and avoid excessive sun exposure. It’s best to use sunscreen, sunglasses and protective clothing to prevent skin damage, if your immune system is weakened.
Cancer treatments like chemotherapy and radiation therapy can increase the chance of developing other cancers, which may appear years after treatment with Phoscan 50mg Tablet. The use of Phoscan 50mg Tablet is associated with a higher risk of bladder cancer. Rarely, it may also increase the risk of other cancers like acute leukaemia, and ureter cancer.
Phoscan 50mg Tablet is a chemotherapy medicine which belongs to the class of alkylating agents. It works by destroying cancer cells.
Yes, Phoscan 50mg Tablet may be used to treat nephrotic syndrome in children, especially in cases where the condition has not improved, or has recurred after using other medications. It is also an option for children who have experienced severe side effects from other treatments. However, its safety and effectiveness for nephrotic syndrome in adults have not been established.
Phoscan 50mg Tablet may cause weight loss due to decreased appetite and may be due to underlying cancer. Consult a doctor if you experience significant weight loss.
Phoscan 50mg Tablet may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. However, if these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Shop No. 6, 2nd Floor, Om Shanti Co- Op. Hsg. Soc. 42/44, Babu Genu Road, Kalbadevi Mumbai Mh 400002 In
Other Info - PH65059

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