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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:38 PM IST
Penicitin Capsule is used to treat rheumatoid arthritis, Wilson's disease, cystinuria, and lead poisoning. It contains Penicillamine which works by blocking the action of certain chemical messengers responsible for inflammation, lowering cysteine levels and facilitating the removal of extra copper in the body via urine. This medicine may sometimes cause side effects such as stomach upset, diarrhoea, change in taste, loss of appetite, mouth irritation, and mouth sores. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Manufacturer/Marketer

Samarth Life Sciences Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Penicitin Capsule

Penicitin Capsule is used to treat severe rheumatoid arthritis, Wilson's disease, and cystinuria. Rheumatoid arthritis is a joint disorder in which our immune system attacks our body cells. Wilson disease is a genetic problem characterized by excess copper deposited in body parts like the eye, brain, and liver leading to metal toxicity. Cystinuria is the excess build-up of an amino acid called cystine in the urinary bladder and kidney, leading to harmful effects. 

Penicitin Capsule contains Penicillamine, which works by blocking the action of certain chemical messengers responsible for inflammation and slowing the progress of the condition with certain joint diseases. It works in Wilson's disease by binding to the extra copper in the body and causing it to leave the body through the urine. Decreasing copper levels improves liver function and mental, mood, and nerve problems (like confusion and difficulty speaking or walking) caused by Wilson's disease. Besides this, Penicitin Capsule is also used to treat cystinuria (kidney and bladder stone) and lead poisoning.

Take Penicitin Capsule exactly as prescribed by your doctor. You are advised to take Penicitin Capsule as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as protein in the urine, low blood platelets, stomach upset or throwing up, diarrhoea, change in taste, loss of appetite,  mouth irritation, and mouth sores. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Penicitin Capsule for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Do not take Penicitin Capsule if you are pregnant or planning for pregnancy, as Penicitin Capsule causes serious congenital disabilities. Penicitin Capsule should not be taken by breastfeeding mothers as it passes into breast milk. Your doctor may advise you to undergo regular blood tests, as well as kidney and liver tests, to monitor your condition. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Uses of Penicitin Capsule

Treatment of Rheumatoid arthritis, Wilson's disease, Cystinuria, and Lead poisoning.

Medicinal Benefits

Penicitin Capsule contains Penicillamine, which is primarily used to treat Wilson's disease (copper builds up in the body and may result in serious symptoms), and cystinuria (kidney stones). It is also used in combination with other treatments to treat severe rheumatoid arthritis. The treatment of rheumatoid arthritis Penicitin Capsule reduces pain, inflammation, and slow joint damage and disease progression over time; hence Penicitin Capsule is known as a disease-modifying anti-rheumatic drug (DMARD). In Wilson's disease, Penicitin Capsule works by binding to the extra copper in the body and causing it to leave the body through the urine. Decreasing copper levels improves liver function and the mental, mood, and nerve problems (such as confusion, and difficulty speaking/walking) caused by Wilson's disease. In cystinuria, it helps decrease the amount of a certain substance (cystine) by binding to that substance which can cause kidney stones and prevent it from building up and forming stones. Besides this, Penicitin Capsule is also used to treat lead poisoning.

Directions for Use

Take Penicitin Capsule as advised by the doctor. Swallow it as a whole with a glass of water; do not break, or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Penicitin Capsule

  • Protein in urine
  • Low blood platelets
  • Stomach upset 
  • Diarrhoea
  • Change in taste
  • Loss of appetite
  • Mouth irritation
  • Mouth sores

Drug Warnings

Do not take Penicitin Capsule if you are allergic (hypersensitive) to penicillamine or any of the other ingredients in it. Inform your doctor if you have severe kidney problems, lupus erythematosus (an auto-immune disorder), agranulocytosis (a low white cell blood count), aplastic anaemia (symptoms including feeling tired, breathless, having pale skin and more susceptible to infection) or thrombocytopenia (a blood disorder which causes bleeding into your skin, bruising and bleeding more than normal). Do not take Penicitin Capsule if you are pregnant or planning to get pregnant and breastfeeding. This medicine may cause harm to the unborn baby if you take it while you are pregnant. Caution should be required while taking Penicitin Capsule by elderly patients as they may be at greater risk of suffering side effects if you are taking Penicitin Capsule over a long time, especially if you are on a restricted diet, as this medicine increases the requirement for pyridoxine (Vitamin B6) so your doctor may also prescribe this vitamin for you. If you are taking iron tablets, antacids, or digoxin (used to treat heart failure), please maintain two hours gap between these tablets and Penicitin Capsule . Low blood cell counts have happened while taking Penicitin Capsule . If blood cell counts get very low, this can lead to bleeding problems, infections, or anaemia, and sometimes, these have been deadly. 

Drug Interactions

Drug-Drug Interactions: Penicitin Capsule interacts with medicine used to treat low iron levels or anaemia (carbonyl iron, heme iron polypeptide), medicine used to treat rheumatoid arthritis (gold sodium thoimalate, auranofin, aurothioglucose), a medicine used to treat heart conditions (digoxin), antacids (aluminium hydroxide, aluminium carbonate), non-steroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, indomethacin, naproxen, oxyphenbutazone, phenylbutazone), anti-malarial agents (chloroquine, hydroxychloroquine), the medicine used to treat the mental illness schizophrenia (clozapine), a medicine used in the treatment of Parkinson's disease (levodopa) medicines to treat cancers(azathioprine, cyclophosphamide),  immunosuppressive drugs (mycophenolate, cyclosporine), and zinc. 

Drug-Food Interactions: Do not take copper-containing foods like shellfish, chocolate, nuts, mushroom, and organ meats (liver pate, sweetbreads etc.)

Drug-Disease Interactions: Penicitin Capsule should not be used in people with bone marrow suppression, kidney dysfunction, liver disease, anaemia, asthma and allergies.

Drug-Drug Interactions Checker List

  • GOLD SODIUM THIOMALATE
  • DIGOXIN
  • ALUMINIUM HYDROXIDE
  • IBUPROFEN
  • INDOMETHACIN
  • NAPROXEN
  • OXYPHENBUTAZONE
  • PHENYLBUTAZONE
  • CHLOROQUINE
  • HYDROXYCHLOROQUINE
  • CLOZAPINE
  • LEVODOPA
  • AZATHIOPRINE
  • CYCLOPHOSPHAMIDE
  • MYCOPHENOLATE MOFETIL
  • CYCLOSPORINE
  • ZINC SULFATE
  • CARBONYL IRON
  • HEME IRON POLYPEPTIDE
  • AURANOFIN
  • AUROTHIOGLUCOSE
  • ZINC ACETATE
  • ZINC GLUCONATE

Habit Forming

No

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Drink plenty of fluids.

  • Limit consumption of spinach, wheat bran, nuts, beets and dairy products.

  • Avoid high salt intake and foods containing baking soda.

  • Follow work safety regulations if you are at risk of occupational exposure. Wear necessary protective gear while working and do not take any contaminated material such as clothing or work gear to home. 

  • Avoid smoking and alcohol consumption.

Special Advise

  • Your doctor may advise you to take blood and urine tests while using Penicitin Capsule to examine your health condition and ensure that this medicine treats your condition.

  • People with Wilson disease should avoid using copper-containing foods like shellfish, nuts, chocolate, mushroom, and organ meats.

  • Avoid using copper containers for drinking, cooking and eating. Ensure running water you drink should be reduced copper level up to the minimum. 

  • If you are using any nutritional supplements or herbal supplements which contains copper tell your doctor about this. Your doctor may suggest any other alternative to this. 

Disease/Condition Glossary

Rheumatoid arthritis: It is an autoimmune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty moving, and swelling.

Wilson’s disease: It is a rare genetic disorder that causes excess copper in the body. Copper plays an important role in developing healthy nerves, bones, collagen, and the skin pigment melanin. Normally, copper is absorbed from the food; the liver filters out excess copper and releases it through urine. In People with Wilson’s disease, the liver cannot remove the extra copper properly, and the extra copper then builds up in organs such as the brain, liver, and eyes.

Cystinuria: It is the condition in which the amino acid called cystine in the urine, leading to the formation of cystine stones in the kidneys, ureters, and bladder. Cystinuria symptoms are usually sharp pain in the lower back or side of the abdomen (renal colic), blood in the urine (hematuria), obstruction of the urinary tract, and infections of the urinary tract. 

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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Penicitin Capsule . It could lead to increased dizziness and drowsiness.

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Pregnancy

Unsafe

Penicitin Capsule is a pregnancy category D drug. It is not recommended to take Penicitin Capsule while you are pregnant. Penicitin Capsule may cause serious birth defects.

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Breast Feeding

Unsafe

Penicitin Capsule should not be used in breastfeeding mothers as Penicitin Capsule passes into breast milk.

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Driving

Caution

Penicitin Capsule may cause dizziness, drowsiness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Unsafe

Penicitin Capsule is not recommended for the liver patients.

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Kidney

Caution

Penicitin Capsule should be used with caution in patients with kidney diseases. Dose adjustments may be necessary.

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Children

Safe if prescribed

Penicitin Capsule should be used in children under the care of the doctor. The dose may depend on the weight and age of the child.

Country of origin

INDIA

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - PEN0238

Author Details

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FAQs

Penicitin Capsule is used to treat severe rheumatoid arthritis, Wilsons disease, and cystinuria. Rheumatoid arthritis is a joint disorder in which our immune system attacks our body cells. Wilson disease is a genetic problem characterized by excess copper deposited in body parts like the eye, brain, and liver, leading to metal toxicity. Cystinuria is the excess build-up of an amino acid called cystine in the urinary bladder and kidney, leading to harmful effects.
Penicitin Capsule works by blocking the action of certain chemical messengers that are responsible for inflammation and prevents joint stiffness, thereby provides relief from rheumatoid arthritis.
Wilson’s disease is a condition where the body cannot get rid of copper properly and cause damage the liver, brain, and other organs. Penicitin Capsule contains penicillamine that works by helping the body to remove excess copper.
Avoid taking other medicines at the same time while taking Penicitin Capsule . If you take an iron supplement, take it at least 2 hours before or after you take Penicitin Capsule . Iron can make it harder for your body to absorb Penicitin Capsule . Avoid taking mineral supplements, unless your doctor advised you to. Do not drink milk within 1 hour before or after you take Penicitin Capsule . Do not take copper-containing foods like shellfish, chocolate, nuts, mushroom, and organ meats (liver pate, sweetbreads etc.)
Penicitin Capsule may cause side-effects such as protein in urine, low blood platelets, stomach upset or throwing up, diarrhea , change in taste, loss of appetite, mouth irritation, mouth sores. These side-effects are usually mild and temporary. However, if any of these side-effects persist or get worse, inform your doctor immediately.
Penicitin Capsule should not be taken during pregnancy or if you are trying to become pregnant as Penicitin Capsule can cause birth defects, miscarriages or harm unborn babies. Avoid becoming pregnant for at least 6 months after stopping the treatment with Penicitin Capsule .

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