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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Pasilow 50 Capsule is used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis conditions and in the treatment of psoriasis. It contains Cyclosporine, which works by suppressing the body's immune system. Thereby, prevents organ rejection. It helps decrease pain and swelling, thus providing relief from the symptoms of rheumatoid arthritis. In some cases, it may cause headache, vomiting nausea, high blood pressure, loss of appetite (feeling unwell and upset stomach), and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

CYCLOSPORINE-50MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Pasilow 50 Capsule

Pasilow 50 Capsule belongs to the class of medicines called 'immunosuppressants' used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis conditions and in the treatment of psoriasis. Organ rejection occurs when patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Pasilow 50 Capsule contains 'cyclosporine' which works by suppressing the body's immune system. Thereby, prevents organ rejection. It helps decrease pain and swelling, thus providing relief from the symptoms of rheumatoid arthritis.

Take Pasilow 50 Capsule as prescribed. You are advised to take Pasilow 50 Capsule for as long as your doctor has prescribed it for you depending on your medical conditions. In some cases, Pasilow 50 Capsule may cause headache, vomiting nausea, high blood pressure, loss of appetite (feeling unwell and upset stomach), and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before taking Pasilow 50 Capsule inform your doctor if you have any allergy, kidney disease, uncontrolled high blood pressure, or any type of cancer. Consult your doctor before taking Pasilow 50 Capsule if you are pregnant or breastfeeding. Pasilow 50 Capsule increases the risk of infections and skin cancer. Therefore, stay cautious and avoid prolonged exposure to sunlight. Inform your doctor about your health condition and medicines you are taking to rule out any unpleasant side effects.

Uses of Pasilow 50 Capsule

Prevent organ rejection, Rheumatoid arthritis, psoriasis (a skin disease that causes itchy and dry patches).

Directions for Use

Swallow Pasilow 50 Capsule as a whole with a glass of water; do not break or chew the tablet/capsule.

Medicinal Benefits

Pasilow 50 Capsule belongs to the class of medicines called 'immunosuppressant' used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis and is used in the treatment of severe cases of skin diseases such as eczema, psoriasis and atopic dermatitis, nephrotic syndrome (kidney disease), and eye problems such as endogenous uveitis and Behçet's uveitis. Cyclosporine works by suppressing the body's immune system. Thereby, prevents organ rejection. Also, it reduces the function of the cells that cause inflammation, especially in the joint tissues. Thereby, decreasing pain, inflammation, slowing down the joint damage and disease progression over time.

How Pasilow 50 Capsule Works

Pasilow 50 Capsule contains 'cyclosporine' which works by suppressing the body's immune system. Thereby, prevents organ rejection. It helps decrease pain and swelling, thus providing relief from the symptoms of rheumatoid arthritis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Pasilow 50 Capsule

  • Headache
  • Vomiting
  • Nausea
  • High blood pressure
  • Loss of appetite
  • Diarrhea

What if I have taken an overdose of Pasilow 50 Capsule

Do not take more than the prescribed dose of Pasilow 50 Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Pasilow 50 Capsule if you are allergic to any of the components. Let your doctor know before using Pasilow 50 Capsule if you have liver or kidney problems, high blood pressure, low levels of magnesium, and high levels of potassium. Pasilow 50 Capsule may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Before taking Pasilow 50 Capsule inform your doctor if you have any type of cancer. Do not take Pasilow 50 Capsule if you are pregnant or planning for pregnancy. Pasilow 50 Capsule should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Drug-Drug Interactions

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CiclosporinBaricitinib
Critical
CiclosporinPitavastatin
Critical

Drug-Drug Interactions

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CiclosporinBaricitinib
Critical
How does the drug interact with Pasilow 50 Capsule 5's:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Pasilow 50 Capsule 5's with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinPitavastatin
Critical
How does the drug interact with Pasilow 50 Capsule 5's:
Coadministration of pitavastatin with Pasilow 50 Capsule 5's may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Pasilow 50 Capsule 5's is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinBosentan
Critical
How does the drug interact with Pasilow 50 Capsule 5's:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Pasilow 50 Capsule 5's with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinCidofovir
Critical
How does the drug interact with Pasilow 50 Capsule 5's:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Pasilow 50 Capsule 5's with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinSimvastatin
Critical
How does the drug interact with Pasilow 50 Capsule 5's:
Combining Pasilow 50 Capsule 5's and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pasilow 50 Capsule 5's and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinRilonacept
Severe
How does the drug interact with Pasilow 50 Capsule 5's:
Co-administration of rilonacept with Pasilow 50 Capsule 5's can increase the risk of infections.

How to manage the interaction:
Taking rilonacept with Pasilow 50 Capsule 5's together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinItraconazole
Severe
How does the drug interact with Pasilow 50 Capsule 5's:
Taking Pasilow 50 Capsule 5's with itraconazole may significantly raise blood levels of Pasilow 50 Capsule 5's.

How to manage the interaction:
Although there is a interaction between cyclosporine and itraconazole can be used if a doctor prescribes them. However, consult a doctor if you have any of the following symptoms fever, sore throat, unusual bruising or bleeding, increased or reduced urination, nausea, vomiting, diarrhea, stomach discomfort, dizziness, tiredness, headache, shaking, fits, and headache. Never stop taking any medications without talking to a doctor.
CiclosporinAliskiren
Severe
How does the drug interact with Pasilow 50 Capsule 5's:
The combined use of aliskiren and Pasilow 50 Capsule 5's can significantly increase the blood levels and effects of aliskiren, which may lead to low blood pressure, hyperkalemia (high potassium levels) in the body. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythms. If you are elderly, dehydrated, or have kidney disease, diabetes, or severe heart failure, you are more prone to develop hyperkalemia while taking these medications.

How to manage the interaction:
Taking aliskiren and Pasilow 50 Capsule 5's will lead to an interaction, they can be taken together if your doctor has prescribed them. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is important to maintain proper fluid intake while taking these medications. It is advised to reduce intake of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes.
CiclosporinEverolimus
Severe
How does the drug interact with Pasilow 50 Capsule 5's:
Taking everolimus with cyclosporine may significantly increases the blood levels of everolimus.

How to manage the interaction:
Although taking everolimus and Pasilow 50 Capsule 5's together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. In case you experience any side effects like persistent cough, fever, chills, mouth ulcers, paleness of skin, or unusual bleeding or bruising, or blood in stools or urine, consult a doctor. Do not stop using any medications without talking to a doctor.
CiclosporinAmbrisentan
Severe
How does the drug interact with Pasilow 50 Capsule 5's:
When ambrisentan is taken with cyclosporine, this increases the blood levels of ambrisentan. This can increase the risk of serious side effects such as liver problems, anemia, and fluid accumulation (particularly in the lungs).

How to manage the interaction:
Co-administration of Pasilow 50 Capsule 5's with Ambrisentan can result in an interaction, but it can be taken if a doctor has advised it. If you experience any of these symptoms such as fever with shivering, pain in your joints, swelling, bleeding or bruising easily, a rash or itchy skin, not feeling hungry, feeling tired, dark color urine, looking pale, dizziness, gaining weight suddenly, or breathing problem, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit and grapefruit juice while taking Pasilow 50 Capsule 5's can increase the effects of Pasilow 50 Capsule 5's. Avoid consuming grapefruit and grapefruit juice while taking Pasilow 50 Capsule 5's.

Diet & Lifestyle Advise

  • Eat foods rich in quercetin (a flavonoid) such as apples, cherries, broccoli, spinach, and blueberries.

  • Consuming food rich in probiotics helps in developing the ing immune system against allergies.

  • Limit intake of food that might trigger allergies such as dairy products, soy, eggs, and nuts.

  • Avoid consumption of foods with excess sugar as flare-up inflammation.

  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.

  • Reducing stress and maintaining a regular sleep pattern would be helpful.

  • Avoid getting in contact with harsh soaps, detergents, and rough fabrics.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Pasilow 50 Capsule Substitute

Substitutes safety advice
  • Sandimmun Neoral 50 mg Capsule 5's

    50.86per tablet
  • Psorid 50 Capsule 5's

    57.80per tablet
  • Iminoral 50 Capsule 5's

    by AYUR

    52.02per tablet
  • Panimun Bioral 50 mg Capsule 6's

    50.60per tablet
  • Arpimune ME 50 Tablet 5's

    38.52per tablet
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Pasilow 50 Capsule. It could lead to increased dizziness.

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Pregnancy

Caution

Pasilow 50 Capsule belongs to pregnancy category C. Consult your doctor before taking Pasilow 50 Capsule if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Pasilow 50 Capsule passes into breast milk. Avoid breastfeeding while taking Pasilow 50 Capsule.

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Driving

Caution

Pasilow 50 Capsule may cause dizziness. Drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Pasilow 50 Capsule is not recommended for children as efficacy and safety have not been established.

FAQs

Pasilow 50 Capsule is used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis conditions and in the treatment of psoriasis.
Pasilow 50 Capsule acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby provides relief from rheumatoid arthritis.
If you miss a dose of Pasilow 50 Capsule, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and take the scheduled dose instead.
Diarrhoea might be a side effect of Pasilow 50 Capsule. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Yes, the use of Pasilow 50 Capsule may cause abnormal facial and body hair growth as a common side effect. Please consult your doctor if you have any concerns.
Pasilow 50 Capsule is known to suppress the immune system. As a result, it increases the risk of infections and developing cancers, especially of the skin. Therefore, avoid prolonged exposure to sunlight by wearing suitable protective clothing and use sunscreen regularly.
Pasilow 50 Capsule may cause high blood pressure. Therefore, consult the doctor before taking Pasilow 50 Capsule if you have high blood pressure.
No, Pasilow 50 Capsule is not a steroid. It is an immunosuppressant.
Pasilow 50 Capsule may cause weight gain. Follow a healthy diet and exercise regularly to maintain proper weight. Consult your doctor if you have any concerns.
Pasilow 50 Capsule may cause fatigue. Eat a healthy diet, get regular exercise, manage stress, improve sleep habits, and quit smoking. Doing these may help cope with fatigue.
Yes, your doctor will recommend certain tests to check your body’s response to Pasilow 50 Capsule.
Pasilow 50 Capsule may cause side effects like headache, vomiting nausea, high blood pressure, loss of appetite (feeling unwell and upset stomach), and diarrhoea. Talk to your doctor if you experience these side effects persistently.
Pasilow 50 Capsule should be swallowed as a whole with water; do not crush or chew it. Take the medicine at the same time each day, and maintain the same amount of time between doses and meals every day.
You are advised to take Pasilow 50 Capsule for the duration prescribed by the doctor. The duration of treatment will depend upon your condition and response to the treatment.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - PAS0062

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