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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Cyclophil ME 50 Tablet is used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis conditions and in the treatment of psoriasis. It contains Cyclosporine, which works by suppressing the body's immune system. Thereby, prevents organ rejection. It helps decrease pain and swelling, thus providing relief from the symptoms of rheumatoid arthritis. In some cases, it may cause headache, vomiting nausea, high blood pressure, loss of appetite (feeling unwell and upset stomach), and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

CYCLOSPORINE-50MG

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Cyclophil ME 50 Tablet

Cyclophil ME 50 Tablet belongs to the class of medicines called 'immunosuppressants' used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis conditions and in the treatment of psoriasis. Organ rejection occurs when patient’s immune system recognizes the donor organ as foreign and tries to eliminate it.

Cyclophil ME 50 Tablet contains 'cyclosporine' which works by suppressing the body's immune system. Thereby, prevents organ rejection. It helps decrease pain and swelling, thus providing relief from the symptoms of rheumatoid arthritis.

Take Cyclophil ME 50 Tablet as prescribed. You are advised to take Cyclophil ME 50 Tablet for as long as your doctor has prescribed it for you depending on your medical conditions. In some cases, Cyclophil ME 50 Tablet may cause headache, vomiting nausea, high blood pressure, loss of appetite (feeling unwell and upset stomach), and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before taking Cyclophil ME 50 Tablet inform your doctor if you have any allergy, kidney disease, uncontrolled high blood pressure, or any type of cancer. Consult your doctor before taking Cyclophil ME 50 Tablet if you are pregnant or breastfeeding. Cyclophil ME 50 Tablet increases the risk of infections and skin cancer. Therefore, stay cautious and avoid prolonged exposure to sunlight. Inform your doctor about your health condition and medicines you are taking to rule out any unpleasant side effects.

Uses of Cyclophil ME 50 Tablet

Prevent organ rejection, Rheumatoid arthritis, psoriasis (a skin disease that causes itchy and dry patches).

Directions for Use

Swallow Cyclophil ME 50 Tablet as a whole with a glass of water; do not break or chew the tablet/capsule.

Medicinal Benefits

Cyclophil ME 50 Tablet belongs to the class of medicines called 'immunosuppressant' used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis and is used in the treatment of severe cases of skin diseases such as eczema, psoriasis and atopic dermatitis, nephrotic syndrome (kidney disease), and eye problems such as endogenous uveitis and Behçet's uveitis. Cyclosporine works by suppressing the body's immune system. Thereby, prevents organ rejection. Also, it reduces the function of the cells that cause inflammation, especially in the joint tissues. Thereby, decreasing pain, inflammation, slowing down the joint damage and disease progression over time.

How Cyclophil ME 50 Tablet Works

Cyclophil ME 50 Tablet contains 'cyclosporine' which works by suppressing the body's immune system. Thereby, prevents organ rejection. It helps decrease pain and swelling, thus providing relief from the symptoms of rheumatoid arthritis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Cyclophil ME 50 Tablet

  • Headache
  • Vomiting
  • Nausea
  • High blood pressure
  • Loss of appetite
  • Diarrhea

What if I have taken an overdose of Cyclophil ME 50 Tablet

Do not take more than the prescribed dose of Cyclophil ME 50 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Cyclophil ME 50 Tablet if you are allergic to any of the components. Let your doctor know before using Cyclophil ME 50 Tablet if you have liver or kidney problems, high blood pressure, low levels of magnesium, and high levels of potassium. Cyclophil ME 50 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of severe conditions such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Before taking Cyclophil ME 50 Tablet inform your doctor if you have any type of cancer. Do not take Cyclophil ME 50 Tablet if you are pregnant or planning for pregnancy. Cyclophil ME 50 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and medicines to rule out any unpleasant side effects.

Drug-Drug Interactions

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CiclosporinSimvastatin
Critical
CiclosporinBosentan
Critical

Drug-Drug Interactions

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CiclosporinSimvastatin
Critical
How does the drug interact with Cyclophil ME 50 Tablet 5's:
Combining Cyclophil ME 50 Tablet 5's and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Cyclophil ME 50 Tablet 5's and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinBosentan
Critical
How does the drug interact with Cyclophil ME 50 Tablet 5's:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Cyclophil ME 50 Tablet 5's with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinCidofovir
Critical
How does the drug interact with Cyclophil ME 50 Tablet 5's:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophil ME 50 Tablet 5's with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinBaricitinib
Critical
How does the drug interact with Cyclophil ME 50 Tablet 5's:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Cyclophil ME 50 Tablet 5's with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinPitavastatin
Critical
How does the drug interact with Cyclophil ME 50 Tablet 5's:
Coadministration of pitavastatin with Cyclophil ME 50 Tablet 5's may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Cyclophil ME 50 Tablet 5's is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinRepaglinide
Severe
How does the drug interact with Cyclophil ME 50 Tablet 5's:
Coadministration of repaglinide and Cyclophil ME 50 Tablet 5's can increase the blood levels and effects of repaglinide.

How to manage the interaction:
Although taking repaglinide together with Cyclophil ME 50 Tablet 5's can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact a doctor immediately if you experience headache, dizziness, drowsiness, anxiety, weakness, shaking, nausea, hunger, sweating, and palpitation. Do not discontinue any medicine without consulting a doctor.
CiclosporinOrlistat
Severe
How does the drug interact with Cyclophil ME 50 Tablet 5's:
Coadministration of Cyclophil ME 50 Tablet 5's with Orlistat can reduce the levels and effects of Cyclophil ME 50 Tablet 5's.

How to manage the interaction:
Although there is a possible interaction between Orlistat and Cyclophil ME 50 Tablet 5's, you can take these medicines together when prescribed by your doctor. Do not stop using any medications without talking to a doctor.
CiclosporinEverolimus
Severe
How does the drug interact with Cyclophil ME 50 Tablet 5's:
Taking everolimus with cyclosporine may significantly increases the blood levels of everolimus.

How to manage the interaction:
Although taking everolimus and Cyclophil ME 50 Tablet 5's together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. In case you experience any side effects like persistent cough, fever, chills, mouth ulcers, paleness of skin, or unusual bleeding or bruising, or blood in stools or urine, consult a doctor. Do not stop using any medications without talking to a doctor.
CiclosporinDarunavir
Severe
How does the drug interact with Cyclophil ME 50 Tablet 5's:
Co-administration of darunavir with Cyclophil ME 50 Tablet 5's may increase the blood levels of Cyclophil ME 50 Tablet 5's.

How to manage the interaction:
Although there is a possible interaction, darunavir can be taken with Cyclophil ME 50 Tablet 5's if prescribed by the doctor. Consult the prescriber if you experience side effects such as diarrhea, nausea, vomiting, abdominal pain, dizziness, weakness, headache, shaking, fits, fever, sore throat, unusual bruising or bleeding, and increased or decreased urination. Do not discontinue the medication without a doctor's advice.
CiclosporinPosaconazole
Severe
How does the drug interact with Cyclophil ME 50 Tablet 5's:
Coadministration of posaconazole and Cyclophil ME 50 Tablet 5's together can enhance the effects of Cyclophil ME 50 Tablet 5's.

How to manage the interaction:
Although using posaconazole and Cyclophil ME 50 Tablet 5's together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor immediately if you experience any symptoms such as nausea, dizziness, weakness, vomiting, diarrhea, abdominal pain, or headache. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat foods rich in quercetin (a flavonoid) such as apples, cherries, broccoli, spinach, and blueberries.

  • Consuming food rich in probiotics helps in developing the ing immune system against allergies.

  • Limit intake of food that might trigger allergies such as dairy products, soy, eggs, and nuts.

  • Avoid consumption of foods with excess sugar as flare-up inflammation.

  • Include fruits, vegetables, whole grains, healthy fats and fish in your diet.

  • Reducing stress and maintaining a regular sleep pattern would be helpful.

  • Avoid getting in contact with harsh soaps, detergents, and rough fabrics.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Cyclophil ME 50 Tablet Substitute

Substitutes safety advice
  • Sandimmun Neoral 50 mg Capsule 5's

    50.86per tablet
  • Psorid 50 Capsule 5's

    57.80per tablet
  • Iminoral 50 Capsule 5's

    by AYUR

    52.02per tablet
  • Panimun Bioral 50 mg Capsule 6's

    50.60per tablet
  • Arpimune ME 50 Tablet 5's

    38.52per tablet
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Cyclophil ME 50 Tablet. It could lead to increased dizziness.

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Pregnancy

Caution

Cyclophil ME 50 Tablet belongs to pregnancy category C. Consult your doctor before taking Cyclophil ME 50 Tablet if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Cyclophil ME 50 Tablet passes into breast milk. Avoid breastfeeding while taking Cyclophil ME 50 Tablet.

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Driving

Caution

Cyclophil ME 50 Tablet may cause dizziness. Drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Cyclophil ME 50 Tablet is not recommended for children as efficacy and safety have not been established.

FAQs

Cyclophil ME 50 Tablet is used to prevent organ rejection after a transplant. Also, it helps to reduce the pain/inflammation in rheumatoid arthritis conditions and in the treatment of psoriasis.
Cyclophil ME 50 Tablet acts as an immunosuppressant, which helps in reducing inflammation and prevents joint stiffness, thereby provides relief from rheumatoid arthritis.
If you miss a dose of Cyclophil ME 50 Tablet, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and take the scheduled dose instead.
Diarrhoea might be a side effect of Cyclophil ME 50 Tablet. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Yes, the use of Cyclophil ME 50 Tablet may cause abnormal facial and body hair growth as a common side effect. Please consult your doctor if you have any concerns.
Cyclophil ME 50 Tablet is known to suppress the immune system. As a result, it increases the risk of infections and developing cancers, especially of the skin. Therefore, avoid prolonged exposure to sunlight by wearing suitable protective clothing and use sunscreen regularly.
Cyclophil ME 50 Tablet may cause high blood pressure. Therefore, consult the doctor before taking Cyclophil ME 50 Tablet if you have high blood pressure.
No, Cyclophil ME 50 Tablet is not a steroid. It is an immunosuppressant.
Cyclophil ME 50 Tablet may cause weight gain. Follow a healthy diet and exercise regularly to maintain proper weight. Consult your doctor if you have any concerns.
Cyclophil ME 50 Tablet may cause fatigue. Eat a healthy diet, get regular exercise, manage stress, improve sleep habits, and quit smoking. Doing these may help cope with fatigue.
Yes, your doctor will recommend certain tests to check your body’s response to Cyclophil ME 50 Tablet.
Cyclophil ME 50 Tablet may cause side effects like headache, vomiting nausea, high blood pressure, loss of appetite (feeling unwell and upset stomach), and diarrhoea. Talk to your doctor if you experience these side effects persistently.
Cyclophil ME 50 Tablet should be swallowed as a whole with water; do not crush or chew it. Take the medicine at the same time each day, and maintain the same amount of time between doses and meals every day.
You are advised to take Cyclophil ME 50 Tablet for the duration prescribed by the doctor. The duration of treatment will depend upon your condition and response to the treatment.

Country of origin

INDIA

Manufacturer/Marketer address

20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - CYC0052

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