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Written By , M Pharmacy
Reviewed By , MPharma., PhD
Last Updated Jan 1, 2025 | 9:32 AM IST

Pam Injection is used to treat poisoning caused by organic phosphorus pesticides or chemicals. It is also used to treat an overdose of drugs that treat myasthenia gravis. It contains Pralidoxime, a cholinesterase reactivator. It works by reactivating the enzyme cholinesterase (mainly outside the central nervous system), which has been inactivated by phosphorylation due to an organophosphate pesticide or related compound.

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Prescription drug

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Composition :

PRALIDOXIME-500MG

Manufacturer/Marketer :

TTK Healthcare Ltd

Consume Type :

PARENTERAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Pam Injection

Pam Injection belongs to the oxime class of drugs. Pralidoxime is used alone or together with atropine to treat poisoning caused by organic phosphorus pesticides or chemicals. It is also used to treat an overdose of drugs that treat myasthenia gravis.

Pam Injection contains Pralidoxime, a cholinesterase reactivator. It works by reactivating the enzyme cholinesterase (mainly outside the central nervous system), which has been inactivated by phosphorylation due to an organophosphate pesticide or related compound.

A qualified healthcare professional will administer Pam Injection. You may experience mild to moderate pain at the site of injection, blurred vision, diplopia (double vision), impaired accommodation, dizziness, headache, drowsiness, nausea, tachycardia (fast heartbeat), increased systolic and diastolic blood pressure, hyperventilation (rapid or deep breathing), and muscular weakness. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, inform your doctor.

Before taking Pam Injection, let your doctor know about all your medical conditions, sensitivities, and ongoing medications. Also, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Pam Injection may cause blurred vision and diplopia (double vision); it impacts your ability to drive or operate machinery.

Uses of Pam Injection

Treatment of Organophosphate poisoning

Medicinal Benefits

Pam Injection contains Pralidoxime, a cholinesterase reactivator that belongs to the oxime class of drugs. Pralidoxime is together with another medicine called atropine to treat poisoning caused by organic phosphorus pesticides (such as diazinon, malathion, sarin and parathion). Pralidoxime injection is also used to treat an overdose of medicines (such as neostigmine, ambenonium, and pyridostigmine) that treat myasthenia gravis. It works by reactivating the enzymes (cholinesterase) blocked by many pesticides or medicines. Poisoning with these substances or drugs weakens your muscles, including those that let you breathe. Pralidoxime is used to help you regain muscle strength.

Side Effects of Pam Injection

  • Mild to moderate pain at the site of injection
  • Blurred vision
  • Diplopia (double vision)
  • Impaired accommodation
  • Dizziness
  • Headache
  • Drowsiness
  • Nausea
  • Tachycardia 
  • Increased systolic and diastolic blood pressure
  • Rapid or deep breathing
  • Muscular weakness

Directions for Use

A qualified healthcare professional will administer Pam Injection.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Pam Injection is not recommended as an antidote for carbamate pesticide overdose since it may enhance carbaryl toxicity or known hypersensitivity to the drug. Before taking Pam Injection, inform your doctor of all your medical problems, sensitivities, and medicines. Also, let your doctor know if you are pregnant, want to become pregnant, or are breastfeeding. Do not drive or operate machinery because Pam Injection may cause diplopia (double vision), decreased accommodation, and dizziness.

Therapeutic Class

ANTIDOTES

Habit Forming

No

How Pam Injection Works

Pam Injection contains Pralidoxime, a cholinesterase reactivator. It works by reactivating the enzyme cholinesterase (mainly outside the central nervous system), which has been inactivated by phosphorylation due to an organophosphate pesticide or related compound.

What if I have taken an overdose of Pam Injection

As Pam Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away.
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Alcohol

Caution

Avoid consuming alcohol. Consult your doctor for more information.

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Pregnancy

Caution

Inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Pam Injection.

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Breast Feeding

Caution

Caution is advised. Let your doctor know if you are a nursing mother before taking Pam Injection; your doctor may suggest stopping breastfeeding for a certain period.

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Driving

Unsafe

Pam Injection may cause blurred vision and diplopia (double vision). It impacts your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before receiving Pam Injection if you have had a liver impairment/disorder history. Your doctor will weigh the benefits and potential risks before prescribing Pam Injection.

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Kidney

Caution

Caution should be exercised. Inform your doctor before receiving Pam Injection if you have had a kidney impairment/disorder history. Your doctor will weigh the benefits and potential risks before prescribing Pam Injection.

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Children

Consult your doctor

Please consult your doctor. The doctor will decide the dose based on your child's age and condition.

Country of origin

India

Manufacturer/Marketer address

6, Cathedral Road, Chennai - 600 086.
Other Info - PAM0088

Author Details

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FAQs

Pam Injection is used treat Organophosphate poisoning.
Pam Injection contains Pralidoxime, a cholinesterase reactivator. It works by reactivating the enzyme cholinesterase (mainly outside the central nervous system), which has been inactivated by phosphorylation due to an organophosphate pesticide or related compounds and medicines.
Pam Injection is an antidote Antidote for organophosphorus nerve agent poisoning, including chlorosarin, cyclosarin (GF), R-VX, tabun (GA), sarin (GB), VX, soman (GD), chlorosoman and organophosphorus pesticides.
Pralidoxime injection is also used to treat an overdose of medicines (such as neostigmine, ambenonium, and pyridostigmine) that treat myasthenia gravis.
The common side effects of Pam Injection may include mild to moderate pain at the site of injection, blurred vision, diplopia (double vision), impaired accommodation, dizziness, headache, drowsiness, nausea, tachycardia (fast heartbeat), increased systolic and diastolic blood pressure, hyperventilation (rapid or deep breathing), and muscular weakness. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, inform your doctor.
Pam Injection is a cholinesterase reactivator that belongs to the oxime class of drugs. It is used to treat poisoning caused by organic phosphorus pesticides or chemicals, often in combination with atropine.
Pam Injection is typically administered intravenously (through a vein) or intramuscularly (into a muscle). It is usually given in a hospital setting by a healthcare professional. The administration route and dosage may vary depending on the specific situation and medical guidance.

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