Oraprein-A 100mg/50mg Tablet belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) used to reduce and relieve pain, redness and inflammation (swelling) in patients suffering from osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Osteoarthritis is a disease characterized by the degeneration of cartilage and its underlying bone within a joint, as well as bony overgrowth. Ankylosing spondylitis is a rare type of arthritis that causes pain and stiffness in your spine. Rheumatoid arthritis is an autoimmune disease in which the immune system of the body attacks its own cells and causes damage, thereby causing joint pain with inflammation.

Oraprein-A 100mg/50mg Tablet is composed of two medicines: Aceclofenac and Diacerine. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Diacerine works by blocking the actions of a certain specific protein that causes swelling, pain, and degradation of cartilage at bone joints. So this Oraprein-A 100mg/50mg Tablet both in combination reduces pain and inflammation.

Take Oraprein-A 100mg/50mg Tablet as prescribed by the doctor. You can take Oraprein-A 100mg/50mg Tablet with or after food. You are advised to take Oraprein-A 100mg/50mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as nausea, vomiting, indigestion, heartburn, stomach pain, diarrhea, loss of appetite, and intense yellow urine. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Oraprein-A 100mg/50mg Tablet if you are allergic to it. Tell your doctor if you are using any other medicines other than the Oraprein-A 100mg/50mg Tablet. Inform your doctor if you are pregnant/planning to get pregnant/breastfeeding women. Oraprein-A 100mg/50mg Tablet should be used with caution in bleeding disorders, kidney diseases, liver diseases, asthma, people who are in antibiotic therapy, and heart-surgery patients.

Oraprein-A 100mg/50mg Tablet is composed of two medicines: Aceclofenac and Diacerine belong to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or pain killers used to reduce and relieve pain, redness, and inflammation (swelling) in patients suffering from osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling). Diacerine works by blocking the actions of a certain specific protein that causes swelling, and pain, and reduces friction in the joints by the building of cartilage (the soft connective tissue in the bones near the joints).

• Nausea
• Vomiting
• Indigestion
• Heartburn
• Stomach pain
• Diarrhea
• Loss of appetite
• Intense yellow urine

Do not take Oraprein-A 100mg/50mg Tablet if you are allergic to it. Tell your doctor if you are using any other medicines other than the Oraprein-A 100mg/50mg Tablet. Inform your doctor if you are pregnant/planning to get pregnant/breastfeeding women. Oraprein-A 100mg/50mg Tablet should be used with caution in bleeding disorders, kidney diseases, liver diseases, asthma, and heart-surgery patients. Oraprein-A 100mg/50mg Tablet should be used with caution in patients having irritable bowel or other associated conditions of the gastrointestinal tract due to an increase in the risk of adverse effects. Avoid consuming alcohol while taking Oraprein-A 100mg/50mg Tablet as it can increase your risk of stomach problems. Your doctor may regularly monitor your kidney function, liver function, blood sugar level, and levels of blood components if you are taking this Oraprein-A 100mg/50mg Tablet for long-term treatment. Oraprein-A 100mg/50mg Tablet should not be taken with antibiotics since the risk of gastric irritation and persistent diarrhea is significantly more.

Drug-Drug Interaction: Oraprein-A 100mg/50mg Tablet interact with antidepressants (lithium), cardiac glycoside (digoxin), antibiotic (amoxicillin), antacids (aluminium hydroxide), corticosteroids (prednisone), anti-hypertensives (enalapril, lisinopril, losartan, candesartan, hydralazine), blood-thinners (warfarin).

Drug-Food Interaction: Drugs may interact with foods rich in fibres (beans, lentils)  and phytates (grains, nuts, legumes)

Drug-Disease Interaction: Patients with liver disease, bleeding disorder, kidney disease, asthma, irritable bowel disorder, heart disease and alcoholism should not take Oraprein-A 100mg/50mg Tablet as it has a risk of causing derangement in liver functions.

• LITHIUM
• DIGOXIN
• AMOXICILLIN
• ALUMINIUM HYDROXIDE
• PREDNISONE
• ENALAPRIL
• LISINOPRIL
• CANDESARTAN
• HYDRALAZINE
• WARFARIN

• Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.

• Performing yoga may also help in improving joint flexibility and pain management.

• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

• Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.

• Follow heat or cold therapy, and apply a cold or hot compress on the joints for 15-20minutes regularly.

• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

• Acupuncture, massage and physical therapy may also be helpful.

• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

• Avoid smoking and alcohol consumption.

• The components of Oraprein-A 100mg/50mg Tablet have the tendency to cause stomach upset. Thus, it is recommended to consume Oraprein-A 100mg/50mg Tablet with meals to minimize gastric side effects. If you have a diagnosis of peptic ulcer, Oraprein-A 100mg/50mg Tablet is best avoided unless prescribed by your doctor.

• Avoid consuming alcohol while Oraprein-A 100mg/50mg Tablet as it can increase your risk of stomach problems.

Osteoarthritis: It is a degenerative joint disease in which the breakdown of a cartilage protective covering causes the two ends of the joints to come together. The lack of this protective covering causes the joints to rub against one another, causing discomfort and stiffness. Osteoarthritis signs and symptoms include pain, stiffness, swelling, and tenderness. Age is the primary cause of osteoarthritis. Osteoarthritis, also referred to as a degenerative disease because it causes the joints to wear out as a person ages, is more likely to develop as you get older. Past injuries like torn ligaments, dislocated joints, and torn cartilage are additional causes.
Rheumatoid arthritis: Joint pain and damage are caused by an auto-immune disease in which the immune system of the body attacks its own tissue. Rheumatoid arthritis symptoms include joint pain, stiffness, swelling, deformities, and loss of joint function.

Ankylosing spondylitis: The spine becomes painful and stiff as a result. The lower back is where the pain typically first appears, but it can also affect the neck, damaged joints, or other areas of the body. Reduced flexibility, which typically causes a hunched-forward posture, and pain in the back and joints are all signs of ankylosing spondylitis.