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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

NS-Zole DSR Capsule is used to treat peptic ulcers and gastroesophageal reflux disease (GERD). It prevents the release of stomach acid and relieves symptoms of food pipe lining inflammation (esophagitis), and gastroesophageal reflux disease (GERD), or heartburn. It contains Domperidone and Pantoprazole, which work by increasing the movement of food through the stomach and the digestive tract more quickly. This helps reduce the feeling of bloating, or fullness and indigestion. It helps in reducing the stomach acid. Also, it effectively blocks the action of vomiting centre in your brain, that is responsible for inducing the feeling of nausea and vomiting.

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Manufacturer/Marketer :

Ns Pharma

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About NS-Zole DSR Capsule

NS-Zole DSR Capsule is composed of two medicines, Domperidone and Pantoprazole. Domperidone is a prokinetic and anti-nausea agent that helps to treat indigestion and stomach pain. On the other hand, Pantoprazole is a proton pump inhibitor that reduces excess stomach acid formation by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). NS-Zole DSR Capsule is a widely used medicine to treat peptic ulcers and gastroesophageal reflux disease (GERD). NS-Zole DSR Capsule prevents the release of stomach acid and relieves symptoms of food pipe lining inflammation (esophagitis), and gastroesophageal reflux disease (GERD), or heartburn.

Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and, in this way, reduces the feeling of bloating, fullness and indigestion. On the other hand, it effectively blocks the action of a vomiting centre (chemoreceptor trigger zone - CTZ) located in your brain, which is responsible for inducing the feeling of nausea and vomiting. Pantoprazole helps in reducing the stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This proton pump lies in the cells of the stomach wall and is responsible for the release of gastric acid secretion, damaging tissues in the food pipe, stomach, and duodenum.

It should be taken as prescribed by the doctor. Like all medicines, NS-Zole DSR Capsule may cause side effects, although not everybody gets them. The most common side effects of NS-Zole DSR Capsule are diarrhoea, stomach pain, flatulence (gas), dryness in the mouth, dizziness, and headache. Everyone doesn't need to experience the above side effects. In case of any discomfort, speak with your doctor.

It is recommended not to use it if you are allergic to any of its ingredients. Prolonged intake of Pantoprazole is associated with a low level of Vitamin B12 and low magnesium. Hence, a yearly test of Vitamin B12 and magnesium is required if you are taking NS-Zole DSR Capsule for the long term. Use of NS-Zole DSR Capsule is contraindicated in people with lupus (autoimmune inflammatory disease). Try to avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes).

Uses of NS-Zole DSR Capsule

Treatment of Gastroesophageal reflux disease (GERD), Heartburn due to hyperacidity, Inflammation of food pipe (esophagitis), and Peptic ulcer.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

NS-Zole DSR Capsule plays a vital role in preventing nausea, vomiting, stomach upset, stomach pain, peptic ulcer, and other conditions due to hyperacidity or acid reflux. Pantoprazole prevents the proton pump gate from producing an excessive amount of stomach acid. While Domperidone stops nausea (feeling sick) and vomiting (being sick), it blocks messages between parts of your brain called the chemoreceptor trigger zone (CTZ) and the vomiting centre.

How NS-Zole DSR Capsule Works

Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and, in this way, reduces the feeling of bloating, fullness and indigestion. On the other hand, it effectively blocks the action of a vomiting centre (chemoreceptor trigger zone - CTZ) located in your brain, which is responsible for inducing the feeling of nausea and vomiting. Pantoprazole helps in reducing the stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This proton pump lies in the cells of the stomach wall and is responsible for the release of gastric acid secretion, damaging tissues in the food pipe, stomach, and duodenum.

Side Effects of NS-Zole DSR Capsule

  • Headache
  • Diarrhoea
  • Nausea
  • Abdominal pain
  • Vomiting
  • Flatulence
  • Dizziness
  • Arthralgia (joint pain)

What if I have taken an overdose of NS-Zole DSR Capsule

Do not take more than the prescribed dose of NS-Zole DSR Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

You should avoid taking NS-Zole DSR Capsule if you are allergic to NS-Zole DSR Capsule or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, pregnant or planning for pregnancy, and breastfeeding mothers. NS-Zole DSR Capsule may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of NS-Zole DSR Capsule may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its own tissues), Vitamin B12, and magnesium deficiency. Intake of NS-Zole DSR Capsule may mask the symptoms of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool), immediately consult the doctor.

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
RabeprazoleRilpivirine
Critical

Drug-Drug Interactions

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RabeprazoleErlotinib
Critical
How does the drug interact with NS-Zole DSR Capsule 10's:
When used in combination with erlotinib, NS-Zole DSR Capsule 10's may prevent the absorption of erlotinib into the circulation, which might make erlotinib less effective in treating cancer.

How to manage the interaction:
Taking NS-Zole DSR Capsule 10's with Erlotinib is not recommended as it can result in an interaction, it should be taken only if a doctor has advised it. Do not stop using any medications without consulting a doctor.
RabeprazoleRilpivirine
Critical
How does the drug interact with NS-Zole DSR Capsule 10's:
Co-administration of NS-Zole DSR Capsule 10's can make Rilpivirine less effective by reducing its absorption in the body.

How to manage the interaction:
Taking NS-Zole DSR Capsule 10's with Rilpivirine is not recommended, but can be taken if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.
RabeprazoleClopidogrel
Severe
How does the drug interact with NS-Zole DSR Capsule 10's:
Taking Clopidogrel with NS-Zole DSR Capsule 10's can reduce the effectiveness of Clopidogrel.

How to manage the interaction:
Taking Clopidogrel and NS-Zole DSR Capsule 10's together possibly has an interaction, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to a doctor.
RabeprazoleDasatinib
Severe
How does the drug interact with NS-Zole DSR Capsule 10's:
Taking NS-Zole DSR Capsule 10's together with Dasatinib results in decreased levels of Dasatinib and its effectiveness.

How to manage the interaction:
Although taking NS-Zole DSR Capsule 10's and Dasatinib together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazolePhenytoin
Severe
How does the drug interact with NS-Zole DSR Capsule 10's:
When Phenytoin and NS-Zole DSR Capsule 10's are taken in combination, Phenytoin will reduce the concentration or impact of NS-Zole DSR Capsule 10's.

How to manage the interaction:
Although taking Phenytoin and NS-Zole DSR Capsule 10's together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleGefitinib
Severe
How does the drug interact with NS-Zole DSR Capsule 10's:
Taking NS-Zole DSR Capsule 10's together with Gefitinib results in decreased levels of gefitinib in your blood. This can result in a decreased effectiveness of gefitinib in treating the disease.

How to manage the interaction:
Although taking NS-Zole DSR Capsule 10's and Gefitinib together can possibly result in an interaction, it can be taken if your doctor has prescribed it. To lessen the effects of the interaction, it is advised that you take gefitinib 12 hours before or 12 hours after NS-Zole DSR Capsule 10's. Do not discontinue any medications without a doctor's advice.
RabeprazoleIdelalisib
Severe
How does the drug interact with NS-Zole DSR Capsule 10's:
When NS-Zole DSR Capsule 10's and Idelalisib are taken in combination, Idelalisib may increase the level or impact of NS-Zole DSR Capsule 10's.

How to manage the interaction:
Although taking NS-Zole DSR Capsule 10's and Idelalisib together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleAtazanavir
Severe
How does the drug interact with NS-Zole DSR Capsule 10's:
Co-administration of Atazanavir's blood levels and absorption can both be affected by NS-Zole DSR Capsule 10's, which decreases the atazanavir's ability to treat HIV.

How to manage the interaction:
Although taking NS-Zole DSR Capsule 10's and atazanavir together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
RabeprazoleMethotrexate
Severe
How does the drug interact with NS-Zole DSR Capsule 10's:
Co-administration of Methotrexate with NS-Zole DSR Capsule 10's can increase the blood levels and side effects of Methotrexate.

How to manage the interaction:
Although there is a possible interaction between NS-Zole DSR Capsule 10's and Methotrexate, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without consulting a doctor.
RabeprazolePazopanib
Severe
How does the drug interact with NS-Zole DSR Capsule 10's:
Taking NS-Zole DSR Capsule 10's together with Pazopanib can result in a decreased effectiveness of Pazopanib in treating the disease.

How to manage the interaction:
Although taking NS-Zole DSR Capsule 10's and Pazopanib together can result in an interaction, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
  • Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows; one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
  • Avoid taking alcohol and smoking cigarettes. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), which prevents the backflow of the stomach acid back into the food pipe.
  • Include high fibre-containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B 12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help prevent excess stomach acid production. Cranberry juice can be beneficial for peptic ulcers and H Pyroli infection.
  • Avoid regular sitting continuously, as it can increase stomach acid production. Take a break of 5 minutes in 1 hour by brisk walking or stretching.

Habit Forming

No

Therapeutic Class

ANTACIDS

NS-Zole DSR Capsule Substitute

Substitutes safety advice
  • Auspanta DSR Capsule 15's

    16.67per tablet
  • Pantocid DSR Capsule 15's

    14.67per tablet
  • Pan-D Capsule 15's

    13.86per tablet
  • Pantop-D SR Capsule 15's

    13.23per tablet
  • New Pantosec DSR Capsule 10's

    13.64per tablet
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Alcohol

Caution

It is best to avoid alcohol while taking medication.

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Pregnancy

Caution

If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. You should use this medicine only if your doctor considers the benefit for you greater than the potential risk for your unborn child or baby.

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Breast Feeding

Caution

NS-Zole DSR Capsule should be used in breastfeeding mothers only if the benefits outweigh the risks.

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Driving

Caution

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking NS-Zole DSR Capsule you should not drive or operate any machinery or vehicles.

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Liver

Caution

In patients with severe liver impairment, the liver enzymes should be monitored regularly during treatment with pantoprazole, particularly on long-term use

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Kidney

Caution

Inform your doctor before receiving the NS-Zole DSR Capsule if you have a kidney impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Safe if prescribed

NS-Zole DSR Capsule can be given safely to children provided; dose has been prescribed by a child specialist.

FAQs

NS-Zole DSR Capsule is used to treat Gastroesophageal reflux disease (GERD), Heartburn due to hyperacidity, Inflammation of food pipe (esophagitis), and Peptic ulcer.
Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and, in this way, reduces the feeling of bloating, fullness and indigestion. On the other hand, it effectively blocks the action of a vomiting centre (chemoreceptor trigger zone - CTZ) located in your brain, which is responsible for inducing the feeling of nausea and vomiting. Pantoprazole helps in reducing stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This proton pump lies in the cells of the stomach wall and is responsible for the release of gastric acid secretion, damaging tissues in the food pipe, stomach, and duodenum.
NS-Zole DSR Capsule can be safely taken as long as your doctor has prescribed it to you.
Yes, taking NS-Zole DSR Capsule for a very long time can cause calcium depletion in the body, leading to weakening of bones. Hence, a calcium and vitamin D supplement is recommended along with NS-Zole DSR Capsule to replenish calcium depletion in the body.
Yes. NS-Zole DSR Capsule can alter certain medical tests, such as those for neuroendocrine tumours (secretin stimulation test) and urine screening tests for tetrahydrocannabinol (THC). So, before undergoing such diagnostic tests, contact your doctor.
Prolonged intake of NS-Zole DSR Capsule may weaken your bone and lower your haemoglobin level. Your doctor may prescribe you Vitamin B12 to enhance haemoglobin and calcium/vitamin D/magnesium supplements for bone health.
A combination of pantoprazole and domperidone is effective and safe.
No, NS-Zole DSR Capsule is a prescribed drug with minimal side effects. Only take it if your doctor has recommended it to you for acidity.
NS-Zole DSR Capsule is an antacid medicine containing Domperidone (anti-emetic) and Pantoprazole (proton pump inhibitor). It is used to treat acidity-related conditions.
Yes, NS-Zole DSR Capsule is safe for use if taken in the dose and duration prescribed by the doctor.
Do not take NS-Zole DSR Capsule if you are allergic to any of its components. It should be used with caution in patients with liver or kidney disease.
Dry mouth could be a side-effect of NS-Zole DSR Capsule . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
NS-Zole DSR Capsule may cause diarrhoea as a side effect. Drink enough fluids and eat fibre-rich food if you experience diarrhoea. Consult the doctor if the diarrhoea persists or worsens.
Store NS-Zole DSR Capsule at room temperature, in a dry place. Keep out of sight and reach of children.
Foods/drinks that aggravate acidity like fried or spicy food, butter, oil, beverages containing caffeine, citrus fruits and alcohol should be avoided.
Alcohol may not affect NS-Zole DSR Capsule . However, it might increase acid production. Therefore, avoid alcohol consumption.
Do not discontinue NS-Zole DSR Capsule without consulting your doctor. To treat your condition effectively, keep taking NS-Zole DSR Capsule for the prescribed duration.

Country of origin

India

Manufacturer/Marketer address

Pp Talaw Road No 27, Vokhale State.
Other Info - NSZ0001

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