Pantoprazole+domperidone
About Pantoprazole+domperidone
Domperidone+pantoprazole is composed of two medicines, Domperidone and Pantoprazole. Domperidone is a prokinetic and anti-nausea agent that helps to treat indigestion and stomach pain. On the other hand, Pantoprazole is a proton pump inhibitor that reduces excess stomach acid formation by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). Domperidone+pantoprazole is a widely used medicine to treat peptic ulcers and gastroesophageal reflux disease (GERD). Domperidone+pantoprazole prevents the release of stomach acid and relieves symptoms of food pipe lining inflammation (esophagitis), and gastroesophageal reflux disease (GERD), or heartburn.
Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and, in this way, reduces the feeling of bloating, fullness and indigestion. On the other hand, it effectively blocks the action of a vomiting centre (chemoreceptor trigger zone - CTZ) located in your brain, which is responsible for inducing the feeling of nausea and vomiting. Pantoprazole helps in reducing the stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This proton pump lies in the cells of the stomach wall and is responsible for the release of gastric acid secretion, damaging tissues in the food pipe, stomach, and duodenum.
It should be taken as prescribed by the doctor. Like all medicines, Domperidone+pantoprazole may cause side effects, although not everybody gets them. The most common side effects of Domperidone+pantoprazole are diarrhoea, stomach pain, flatulence (gas), dryness in the mouth, dizziness, and headache. Everyone doesn't need to experience the above side effects. In case of any discomfort, speak with your doctor.
It is recommended not to use it if you are allergic to any of its ingredients. Prolonged intake of Pantoprazole is associated with a low level of Vitamin B12 and low magnesium. Hence, a yearly test of Vitamin B12 and magnesium is required if you are taking Domperidone+pantoprazole for the long term. Use of Domperidone+pantoprazole is contraindicated in people with lupus (autoimmune inflammatory disease). Try to avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes).
Uses of Pantoprazole+domperidone
Medicinal Benefits
Domperidone+pantoprazole plays a vital role in preventing nausea, vomiting, stomach upset, stomach pain, peptic ulcer, and other conditions due to hyperacidity or acid reflux. Pantoprazole prevents the proton pump gate from producing an excessive amount of stomach acid. While Domperidone stops nausea (feeling sick) and vomiting (being sick), it blocks messages between parts of your brain called the chemoreceptor trigger zone (CTZ) and the vomiting centre.
Directions for Use
Side Effects of Pantoprazole+domperidone
- Headache
- Diarrhoea
- Nausea
- Abdominal pain
- Vomiting
- Flatulence
- Dizziness
- Arthralgia (joint pain)
Drug Warnings
You should avoid taking Domperidone+pantoprazole if you are allergic to Domperidone+pantoprazole or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, pregnant or planning for pregnancy, and breastfeeding mothers. Domperidone+pantoprazole may interact with a blood thinner (warfarin), antifungal (ketoconazole), anti-HIV drug (atazanavir, nelfinavir), iron supplements, ampicillin antibiotic, anti-cancer drug (methotrexate). Let your doctor know if you are taking these medicines. Prolonged intake of Domperidone+pantoprazole may cause lupus erythematosus (an inflammatory condition in which the immune system attacks its own tissues), Vitamin B12, and magnesium deficiency. Intake of Domperidone+pantoprazole may mask the symptoms of gastric cancer, so if you have any severe stomach pain or gastric bleeding (blood in mucous or stool), immediately consult the doctor.
Drug Interactions
Drug-Drug Interactions: Domperidone+pantoprazole may interact with a blood thinner (e.g. clopidogrel, warfarin), antifungal (e.g. ketoconazole, voriconazole, itraconazole, posaconazole), anti-HIV drug (e.g. atazanavir, nelfinavir), iron supplements, antibiotic (e.g. ampicillin, rifampicin), heart medicine (e.g. digoxin) and anti-cancer drug (e.g. methotrexate). Let your doctor know if you are taking these medicines.
Drug-Food Interactions: Domperidone+pantoprazole interacts with St John's wort plant that is used as an anti-depressant. This plant may affect the working of Domperidone+pantoprazole. So avoid its intake with Domperidone+pantoprazole.
Drug-Disease Interactions: Domperidone+pantoprazole should not be given in patients with C. difficile-induced colitis, liver disease, bone fractures, low Vitamin B12 (anaemia), and low magnesium (hypomagnesemia).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionIt is best to avoid alcohol while taking medication.
Pregnancy
cautionIf you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. You should use this medicine only if your doctor considers the benefit for you greater than the potential risk for your unborn child or baby.
Breast Feeding
cautionDomperidone+pantoprazole should be used in breastfeeding mothers only if the benefits outweigh the risks.
Driving
cautionDrive only if you are physically stable and mentally focussed, If you experience drowsiness after taking Domperidone+pantoprazole you should not drive or operate any machinery or vehicles.
Liver
cautionIn patients with severe liver impairment, the liver enzymes should be monitored regularly during treatment with pantoprazole, particularly on long-term use
Kidney
cautionInform your doctor before receiving the Domperidone+pantoprazole if you have a kidney impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.
Children
safe if prescribedDomperidone+pantoprazole can be given safely to children provided; dose has been prescribed by a child specialist.
Habit Forming
Diet & Lifestyle Advise
- Avoid intake of acid or heartburn-triggering foods or drinks like onions, peppermint, chocolate, caffeinated beverages, citrus fruits or juices, tomatoes and high-fat and spicy foods.
- Before going to sleep, try to raise your bedhead so that your head and chest are higher than your feet. Do not use piles of pillows; one raised block is fine. This will not allow the stomach acid to backflow through your food pipe.
- Avoid taking alcohol and smoking cigarettes. Alcohol can raise the level of production of stomach acid leading to heartburn and acid reflux. On the other hand, nicotine smoking damages the valve (sphincter), which prevents the backflow of the stomach acid back into the food pipe.
- Include high fibre-containing foods, berries, cherries, leafy green veggies (kale, spinach) and black peppers in your meal. These foods are full of antioxidants, calcium and vitamin B 12 that can help cope with the long-term effects of the medicine. Fermented dairy products like miso, sauerkraut, and kimchi contain probiotics which help prevent excess stomach acid production. Cranberry juice can be beneficial for peptic ulcers and H Pyroli infection.
- Avoid regular sitting continuously, as it can increase stomach acid production. Take a break of 5 minutes in 1 hour by brisk walking or stretching.
Patients Concern
Disease/Condition Glossary
Acidity: Normally a thick layer of mucous protects the stomach against its own acid secretion. But, in the long run, it gets eroded by excessive stomach acid production, leading to complications like GERD, peptic ulcer, and Zollinger-Ellison syndrome. Gastroesophageal reflux disease (GERD) is a gastrointestinal disorder that occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn. On the other hand, a peptic ulcer is a painful condition followed by the development of sores or ulcers in the stomach lining or duodenum (the first part of the small intestine). Zollinger-Ellison syndrome is a rare condition in which a gastrin-secreting tumour of the pancreas causes excessive acid production, leading to peptic ulcers.
FAQs
Domperidone+pantoprazole is used to treat Gastroesophageal reflux disease (GERD), Heartburn due to hyperacidity, Inflammation of food pipe (esophagitis), and Peptic ulcer.
Domperidone works by increasing the movement of food through the stomach and the digestive tract more quickly and, in this way, reduces the feeling of bloating, fullness and indigestion. On the other hand, it effectively blocks the action of a vomiting centre (chemoreceptor trigger zone - CTZ) located in your brain, which is responsible for inducing the feeling of nausea and vomiting. Pantoprazole helps in reducing stomach acid by blocking the actions of an enzyme (H+/K+ ATPase or gastric proton pump). This proton pump lies in the cells of the stomach wall and is responsible for the release of gastric acid secretion, damaging tissues in the food pipe, stomach, and duodenum.
Domperidone+pantoprazole can be safely taken as long as your doctor has prescribed it to you.
Yes, taking Domperidone+pantoprazole for a very long time can cause calcium depletion in the body, leading to weakening of bones. Hence, a calcium and vitamin D supplement is recommended along with Domperidone+pantoprazole to replenish calcium depletion in the body.
Yes. Domperidone+pantoprazole can alter certain medical tests, such as those for neuroendocrine tumours (secretin stimulation test) and urine screening tests for tetrahydrocannabinol (THC). So, before undergoing such diagnostic tests, contact your doctor.
Prolonged intake of Domperidone+pantoprazole may weaken your bone and lower your haemoglobin level. Your doctor may prescribe you Vitamin B12 to enhance haemoglobin and calcium/vitamin D/magnesium supplements for bone health.
A combination of pantoprazole and domperidone is effective and safe.
No, Domperidone+pantoprazole is a prescribed drug with minimal side effects. Only take it if your doctor has recommended it to you for acidity.
Domperidone+pantoprazole is an antacid medicine containing Domperidone (anti-emetic) and Pantoprazole (proton pump inhibitor). It is used to treat acidity-related conditions.
Yes, Domperidone+pantoprazole is safe for use if taken in the dose and duration prescribed by the doctor.
Do not take Domperidone+pantoprazole if you are allergic to any of its components. It should be used with caution in patients with liver or kidney disease.
Dry mouth could be a side-effect of Domperidone+pantoprazole. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.
Domperidone+pantoprazole may cause diarrhoea as a side effect. Drink enough fluids and eat fibre-rich food if you experience diarrhoea. Consult the doctor if the diarrhoea persists or worsens.
Store Domperidone+pantoprazole at room temperature, in a dry place. Keep out of sight and reach of children.
Foods/drinks that aggravate acidity like fried or spicy food, butter, oil, beverages containing caffeine, citrus fruits and alcohol should be avoided.
Alcohol may not affect Domperidone+pantoprazole. However, it might increase acid production. Therefore, avoid alcohol consumption.
Do not discontinue Domperidone+pantoprazole without consulting your doctor. To treat your condition effectively, keep taking Domperidone+pantoprazole for the prescribed duration.
