Nix CZ 100mg/250mg Tablet belongs to the group of medicines called muscle relaxants indicated for the relief of painful skeletal muscle spasms. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Muscle spasms are the involuntary contractions of muscles which can be painful. Musculoskeletal pain affects the bones, muscles, ligaments, tendons and nerves.

Nix CZ 100mg/250mg Tablet is a combination of two drugs: Nimesulide (NSAID) and Chlorzoxazone (Muscle relaxant). Nimesulide works by inhibiting the synthesis of prostaglandins which are responsible for pain and inflammation. Chlorzoxazone acts on the brain and spinal cord centres where it inhibits multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms or stiffness. Together, Nix CZ 100mg/250mg Tablet helps in relieving musculoskeletal pain.

You are advised to take Nix CZ 100mg/250mg Tablet for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, Nix CZ 100mg/250mg Tablet may cause common side-effects such as nausea, vomiting, diarrhoea, weakness, and stomach upset. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Nix CZ 100mg/250mg Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Nix CZ 100mg/250mg Tablet as it could increase the risk of stomach bleeding. Nix CZ 100mg/250mg Tablet may cause sleepiness and dizziness, so drive only if you are alert. Keep your doctor informed about your health condition and medicines to rule out any side-effects/interactions.

Nix CZ 100mg/250mg Tablet is a combination of two drugs, namely: Nimesulide and Chlorzoxazone. Nix CZ 100mg/250mg Tablet is used to relieve pain and stiffness caused by muscle strains and sprains. Nimesulide is an NSAID that inhibits the synthesis of prostaglandins responsible for pain and inflammation. Chlorzoxazone is a muscle relaxant that acts on the brain and spinal cord centres, where it inhibits the multisynaptic reflex involved in muscle spasms, thereby providing relief from skeletal muscle spasms or stiffness. Together, Nix CZ 100mg/250mg Tablet helps in relieving pain due to muscle spasms.

• Nausea
• Vomiting
• Diarrhoea
• Weakness
• Stomach upset
• Heart burn or abdominal cramps

Do not take Nix CZ 100mg/250mg Tablet if you are allergic to any of its contents, if you have bronchospasm, asthma or breathing problems, gastrointestinal bleeding or perforation, coagulation or bleeding problems and severe heart problems. Inform your doctor if you have heart, kidney or liver impairment. Consult your doctor if you are pregnant or breastfeeding. Nix CZ 100mg/250mg Tablet is not recommended for children as safety has not been established. Avoid consuming alcohol with Nix CZ 100mg/250mg Tablet as it could increase the risk of stomach bleeding. Nix CZ 100mg/250mg Tablet may cause sleepiness and dizziness, so drive only if you are alert. Stop taking Nix CZ 100mg/250mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Nix CZ 100mg/250mg Tablet unless prescribed.

Drug-Drug Interactions: Nix CZ 100mg/250mg Tablet may interact with blood thinners (warfarin), hypnotics (zolpidem), anti-depressant (duloxetine, escitalopram), antihistamines (diphenhydramine, cetirizine), anti-convulsant (pregabalin, topiramate), anti-hypertensive (metoprolol), pain killers (acetaminophen, hydrocodone), anti-anxiety (alprazolam), anti-psychotic (lithium), diuretic (furosemide), other muscle relaxants ( carisoprodol, cyclobenzaprine).

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have bronchospasm, asthma or breathing problems, gastrointestinal bleeding or perforation, coagulation or bleeding problems, heart, kidney, or liver dysfunction.

• WARFARIN
• ZOLPIDEM
• DULOXETINE
• ESCITALOPRAM
• DIPHENHYDRAMINE
• CETIRIZINE
• PREGABALIN
• TOPIRAMATE
• METOPROLOL
• HYDROCODONE
• ACETAMINOPHEN
• ALPRAZOLAM
• LITHIUM
• FUROSEMIDE

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.
• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
• Acupuncture, massage and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
• Avoid smoking and alcohol consumption.

• Nix CZ 100mg/250mg Tablet may rarely cause your urine to turn orange or reddish-purple. This effect is harmless and will disappear when the medication is stopped.
• If you experience bloody or tarry stools, stop using Nix CZ 100mg/250mg Tablet and consult a doctor.

Musculoskeletal pain: Musculoskeletal pain affects the bones, muscles, ligaments, tendons and nerves. It can be acute or chronic and can be localised or widespread. The pain can be mild or severe enough to interfere with your daily routine. Musculoskeletal pain could occur due to arthritis, osteoporosis, fractures, dislocations, problems with the bone structure or injury to the bones, joints, tendons, muscles and ligaments. Symptoms of musculoskeletal pain include stiffness, swelling, redness, weakness, muscle spasms or twitching, trouble moving the affected area, soreness, and cracking or popping sound at the joints.