NIMREST PLUS TABLET belongs to a class of painkillers called non-steroidal anti-inflammatory drugs (NSAIDs) used to relieve pain in conditions like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and dysmenorrhea. Besides this, it is also useful for dental pain, muscle pain, back pain, ear pain, and throat pain. 

NIMREST PLUS TABLET is composed of two medicines: Nimesulide and Paracetamol. NIMREST PLUS TABLET works by blocking the effect of prostaglandins, a chemical responsible for inducing pain and inflammation in the body. It also lowers the elevated body temperature by promoting heat loss (through sweating), which helps reset the hypothalamic thermostat. Together, NIMREST PLUS TABLET helps relieve pain.

Take NIMREST PLUS TABLET exactly as directed by your doctor. The most common side effects of NIMREST PLUS TABLET are loss of appetite (in case of liver condition), nausea, vomiting, abdominal pain, persistent tiredness or dark/discoloured urine. It is not necessary for everyone to experience the above side effects. In case of any discomfort, speak with your doctor.

Do not take NIMREST PLUS TABLET if you are allergic to painkillers like aspirin, ibuprofen, naproxen or diclofenac. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. NIMREST PLUS TABLET may be associated with a small increase in heart attack risk (myocardial infarction). Avoid alcohol consumption as it may damage your liver and cause increased side effects on taking this medicine. Consult your doctor if your pain, inflammation and fever symptoms do not disappear even after ten days.

NIMREST PLUS TABLET comprises nimesulide and paracetamol, primarily used to treat mild to moderate pain. NIMREST PLUS TABLET is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains. It helps treat pain by blocking the chemical messenger in the brain responsible for causing fever, pain and inflammation. Nimesulide works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. On the other hand, Paracetamol lowers the elevated body temperature and mild pain by inhibiting prostaglandin synthesis by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.

• Nausea
• Vomiting
• Loss of appetite
• Abdominal pain
• Persistent tiredness
• Dark/discoloured urine

NIMREST PLUS TABLET is contraindicated in patients with a history of hypersensitivity (allergic) reaction to NIMREST PLUS TABLET, paracetamol, nimesulide, or other pain killers. Please inform your doctor before starting NIMREST PLUS TABLET if you have an active stomach ulcer, recent gastrointestinal bleeding, asthma, recent by-pass heart surgery or severe kidney/liver impairment. Nimesulide present in NIMREST PLUS TABLET is known to affect fertility, so if you are planning for pregnancy, contact the doctor. NIMREST PLUS TABLET should be avoided in both pregnant (especially last trimester of pregnancy) and breastfeeding women, as it may pass the milk affecting the baby. Patients with heart diseases and recent stroke (bleeding in the brain) should not take NIMREST PLUS TABLET as a substitute for aspirin. It should not be given to children (below 12 years) with symptoms of fever and chills or suffering from influenza (flu) or chickenpox.

Drug-Drug Interactions: NIMREST PLUS TABLET is shown to interact with various drugs. Some of them include lithium, anticancer/antimetabolites (methotrexate), blood thinner or anticoagulant (warfarin, coumadin, aspirin), blood pressure or heart medicine, nausea medicine (metoclopramide, domperidone), diuretic/water pills (thiazides, furosemide), steroid medicine (prednisone), quinolones antibiotics (ciprofloxacin), respiratory medicines (theophyllines, ephedrine), immune system affecting medicine (cyclosporine), cholesterol-reducing medicine (colestyramine) and antidepressants (duloxetine). These drugs may affect the working of NIMREST PLUS TABLET and may alter its efficacy.

Drug-Food Interactions: Excessive intake of alcoholic beverages, caffeine-containing food or drinks like coffee, tea, chocolate, and some fizzy drinks should be avoided while taking NIMREST PLUS TABLET. Taking together may lead to drowsiness and dizziness and sleepiness.

Drug-Disease Interactions: NIMREST PLUS TABLET should not recommend for people having bleeding disorders, like haemophilia, von Willebrand disease, or low blood platelets. Besides this, it should not be given to children suffering from influenza (flu) or chickenpox. It should also be avoided in case of the presence of gastric or duodenal ulcers.

• LITHIUM
• METHOTREXATE
• WARFARIN
• COUMADIN
• ASPIRIN
• METOCLOPRAMIDE
• DOMPERIDONE
• FUROSEMIDE
• PREDNISONE
• CIPROFLOXACIN
• EPHEDRINE
• THEOPHYLLINE
• CYCLOSPORINE
• CHOLESTYRAMINE
• DULOXETINE

• Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
• Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching low,, impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
• In chronic arthritis or joint pain conditions, fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimize chemical cytokines, which ramp up inflammation.
• Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.

Inform your doctor about any bleeding disorders as nimesulide in NIMREST PLUS TABLET should be taken with care as it may interference in the functioning of platelets.

Pain: Pain can be short-term (acute) or long-term (chronic) in nature. Acute pain is, for a short time, caused by damage to the tissues of the muscle, bone or organs. At the same time, chronic pain lasts for a longer duration; it is caused by pathologies like nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction or injury. Many women have painful periods known as dysmenorrhea, most often menstrual cramps. On the other hand, osteoarthritis is a degenerative disease that results in chronic pain in joints (especially the knee) and stiffness, making daily tasks difficult.