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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Nilotirel 200 mg Capsule 28's is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia (a type of blood cancer). It contains Nilotinib, which works by blocking the action of an abnormal protein produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thus, it stops the multiplication, inhibits the growth of cancerous cells, and then causes their death.

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Composition :

NILOTINIB-200MG

Manufacturer/Marketer :

Reliance Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Nilotirel 200 mg Capsule 28's

Nilotirel 200 mg Capsule 28's belongs to the class of anticancer drugs called tyrosine kinase inhibitors used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Ph+ CML is a type of blood cancer that causes white blood cells to behave differently.

Nilotirel 200 mg Capsule 28's contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.

Take Nilotirel 200 mg Capsule 28's as prescribed. You are recommended to take Nilotirel 200 mg Capsule 28's for as long as your doctor has advised it for you based on your medical condition. Sometimes, Nilotirel 200 mg Capsule 28's may cause common side effects such as vomiting, nausea, diarrhoea, headache, constipation, tiredness, and muscle and joint pain. Most of these side effects of Nilotirel 200 mg Capsule 28's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Nilotirel 200 mg Capsule 28's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Nilotirel 200 mg Capsule 28's and for two weeks after completing the course of Nilotirel 200 mg Capsule 28's. Nilotirel 200 mg Capsule 28's is not recommended for children below one year of age. Drive only if you are alert as Nilotirel 200 mg Capsule 28's may cause dizziness or visual disorders as side effects in some people. If you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Nilotirel 200 mg Capsule 28's, contact your doctor immediately, as these might be symptoms of liver problems. 

Uses of Nilotirel 200 mg Capsule 28's

Treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML)

Directions for Use

Take this medicine on an empty stomach or as advised by the doctor. Avoid eating food for at least 2 hours before taking Nilotirel 200 mg Capsule 28's and avoid eating for at least 1 hour after taking Nilotirel 200 mg Capsule 28's. Swallow it as a whole with a glass of water. If you are unable to swallow it, open the capsule and sprinkle the contents in 1 teaspoon of applesauce and take it right away (within 15 minutes). Do not use more than one teaspoon of apple sauce for each capsule, and do not use any food other than apple sauce.

Medicinal Benefits

Nilotirel 200 mg Capsule 28's contains Nilotinib, an anticancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells. Nilotirel 200 mg Capsule 28's is used in adults and children with newly diagnosed Ph+ CML in the chronic phase and in adults with Ph+ CML in the accelerated and chronic phase who did not tolerate or no longer benefit from other treatments, including Imatinib. 

How Nilotirel 200 mg Capsule 28's Works

Nilotirel 200 mg Capsule 28's contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Nilotirel 200 mg Capsule 28's

  • Vomiting
  • Nausea
  • Diarrhoea
  • Headache
  • Constipation
  • Tiredness
  • Muscle and joint pain

What if I have taken an overdose of Nilotirel 200 mg Capsule 28's

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Nilotirel 200 mg Capsule 28's may include drowsiness and vomiting. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Nilotirel 200 mg Capsule 28's if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Nilotirel 200 mg Capsule 28's and for two weeks after completing the course of Nilotirel 200 mg Capsule 28's. Nilotirel 200 mg Capsule 28's is not recommended for children below one year of age. Nilotirel 200 mg Capsule 28's may affect the growth and development of children with chronic phase Ph+ CML. Some children and adolescents may have slower than normal growth while taking Nilotirel 200 mg Capsule 28's. Therefore, your doctor will monitor the growth of your child at regular visits. Drive only if you are alert as Nilotirel 200 mg Capsule 28's may cause dizziness or visual disorders as side effects in some people. Nilotirel 200 mg Capsule 28's may increase the risk of liver problems, especially in people with a history of liver problems. Therefore, if you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Nilotirel 200 mg Capsule 28's, contact your doctor immediately, as these might be symptoms of liver problems. Inform your doctor if you have a severe problem with lactose (milk sugar) or other sugars as Nilotirel 200 mg Capsule 28's may contain lactose. Most people who have mild or moderate lactose intolerance can take Nilotirel 200 mg Capsule 28's. Avoid taking Nilotirel 200 mg Capsule 28's if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy), inform your doctor before taking Nilotirel 200 mg Capsule 28's.

Diet & Lifestyle Advise

  • Drink nutrient-rich liquids such as juices, shakes and soups if you have trouble swallowing solid food.
  • Eat frequently by opting for 4 to 6 smaller meals a day instead of 2 to 3 big meals.
  • Consume a variety of vegetables, including legumes.
  • Eat whole grains, whole fruits, and fat-free or low-fat dairy products.
  • Include a variety of proteins in the diet, such as lean meats, poultry, seafood, soy, beans, and eggs.
  • Use healthy oils such as olive oil.
  • Drink plenty of water to keep yourself hydrated.

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS

Nilotirel 200 mg Capsule 28's Substitute

Substitutes safety advice
  • Tasigna 200 mg Capsule 4's

    by AYUR

    2054.80per tablet
  • Nelova 200 mg Capsule 28's

    73.93per tablet
  • Nilocap 200 Capsule 4's

    33.30per tablet
  • Nilosure 200 Capsule 4's

    115.42per tablet
  • Ninlib 200 mg Capsule 30's

    109.33per tablet
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Alcohol

Consult your doctor

The interaction of Nilotirel 200 mg Capsule 28's with alcohol is unknown. Please discuss with your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Nilotirel 200 mg Capsule 28's is not recommended for use during pregnancy as it may harm the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Nilotirel 200 mg Capsule 28's. Also, you are advised to use effective birth control measures during treatment with Nilotirel 200 mg Capsule 28's and for up to 2 weeks after the last dose of Nilotirel 200 mg Capsule 28's.

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Breast Feeding

Unsafe

You are recommended to avoid breastfeeding during treatment with Nilotirel 200 mg Capsule 28's and for two weeks after the final dose. Inform your doctor if you are breastfeeding.

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Driving

Caution

If you experience side effects such as dizziness or visual disorders, avoid driving or operating machinery until you are alert.

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Liver

Caution

Inform your doctor if you have liver problems before taking Nilotirel 200 mg Capsule 28's. Your doctor may adjust the dose if necessary based on your condition.

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Kidney

Consult your doctor

Limited information is available on the use of Nilotirel 200 mg Capsule 28's in patients with impaired kidney function. Therefore, if you have kidney problems, inform your doctor before taking Nilotirel 200 mg Capsule 28's.

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Children

Caution

Nilotirel 200 mg Capsule 28's is not recommended for children below 1 year of age as the safety and effectiveness were not established.

FAQs

Nilotirel 200 mg Capsule 28's is used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML).
Nilotirel 200 mg Capsule 28's contains Nilotinib, an anticancer drug. In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells.
You are not recommended to take antacids and Nilotirel 200 mg Capsule 28's at the same time. You are advised to take antacids containing magnesium hydroxide, aluminium hydroxide, and simethicone about two hours before or two hours after taking Nilotirel 200 mg Capsule 28's. However, please consult a doctor before taking other medicines with Nilotirel 200 mg Capsule 28's.
You are recommended to avoid grapefruit juice, grapefruit and any supplement containing grapefruit extract while taking Nilotirel 200 mg Capsule 28's as it may increase the amount of Nilotinib in the body and cause serious side effects.

Country of origin

India

Manufacturer/Marketer address

Surya Tower, 3rd Floor, Mall Road, Ludhiana - 141 001
Other Info - NIL0163

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