Knilonat 200 Capsule belongs to the class of anticancer drugs called tyrosine kinase inhibitors used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Ph+ CML is a type of blood cancer that causes white blood cells to behave differently.

Knilonat 200 Capsule contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.

Take Knilonat 200 Capsule as prescribed. You are recommended to take Knilonat 200 Capsule for as long as your doctor has advised it for you based on your medical condition. Sometimes, Knilonat 200 Capsule may cause common side effects such as vomiting, nausea, diarrhoea, headache, constipation, tiredness, and muscle and joint pain. Most of these side effects of Knilonat 200 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 200 Capsule if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 200 Capsule and for two weeks after completing the course of Knilonat 200 Capsule . Knilonat 200 Capsule is not recommended for children below one year of age. Drive only if you are alert as Knilonat 200 Capsule may cause dizziness or visual disorders as side effects in some people. If you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 200 Capsule , contact your doctor immediately, as these might be symptoms of liver problems. 

Knilonat 200 Capsule contains Nilotinib, an anticancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells. Knilonat 200 Capsule is used in adults and children with newly diagnosed Ph+ CML in the chronic phase and in adults with Ph+ CML in the accelerated and chronic phase who did not tolerate or no longer benefit from other treatments, including Imatinib. 

• Vomiting
• Nausea
• Diarrhoea
• Headache
• Constipation
• Tiredness
• Muscle and joint pain

If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 200 Capsule if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 200 Capsule and for two weeks after completing the course of Knilonat 200 Capsule . Knilonat 200 Capsule is not recommended for children below one year of age. Knilonat 200 Capsule may affect the growth and development of children with chronic phase Ph+ CML. Some children and adolescents may have slower than normal growth while taking Knilonat 200 Capsule . Therefore, your doctor will monitor the growth of your child at regular visits. Drive only if you are alert as Knilonat 200 Capsule may cause dizziness or visual disorders as side effects in some people. Knilonat 200 Capsule may increase the risk of liver problems, especially in people with a history of liver problems. Therefore, if you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 200 Capsule , contact your doctor immediately, as these might be symptoms of liver problems. Inform your doctor if you have a severe problem with lactose (milk sugar) or other sugars as Knilonat 200 Capsule may contain lactose. Most people who have mild or moderate lactose intolerance can take Knilonat 200 Capsule . Avoid taking Knilonat 200 Capsule if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy), inform your doctor before taking Knilonat 200 Capsule .

Drug-Drug Interaction: Knilonat 200 Capsule may interact with anti-arrhythmic drugs (disopyramide, quinidine, amiodarone, sotalol, procainamide), antibiotics (clarithromycin, moxifloxacin), antimalarial drugs (chloroquine), antipsychotics (haloperidol, pimozide), opioid analgesics (methadone, fentanyl, alfentanil), anticonvulsants (phenytoin, carbamazepine, phenobarbital), blood thinner (warfarin), anti-HIV drug (rifampicin), antifungals (itraconazole, ketoconazole, voriconazole) and immunosuppressants (cyclosporine, tacrolimus, sirolimus). Inform your doctor if you are using any medicines before taking Knilonat 200 Capsule .

Drug-Food Interaction: Avoid grapefruit juice, grapefruit and any supplement containing grapefruit extract while taking Knilonat 200 Capsule as it may increase the amount of Nilotinib in the body and cause serious side effects. Also, Knilonat 200 Capsule may interact with St. John’s wort (a herbal product used to treat depression). 

Drug-Disease Interaction: Avoid taking Knilonat 200 Capsule if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had pancreatitis, stroke or other problems due to decreased blood flow to the brain, have QTc prolongation or a family history of it, bleeding problems, irregular heartbeat, have low problems with decreased blood flow to your legs, have low levels of magnesium or potassium in blood, heart or liver problems, inform your doctor before taking Knilonat 200 Capsule .

• DISOPYRAMIDE
• QUINIDINE
• AMIODARONE
• SOTALOL
• PROCAINAMIDE
• CLARITHROMYCIN
• MOXIFLOXACIN
• CHLOROQUINE
• HALOPERIDOL
• PIMOZIDE
• METHADONE
• FENTANYL
• ALFENTANIL
• PHENYTOIN
• CARBAMAZEPINE
• PHENOBARBITAL
• WARFARIN
• RIFAMPICIN
• ITRACONAZOLE
• KETOCONAZOLE
• VORICONAZOLE
• CYCLOSPORINE
• TACROLIMUS
• SIROLIMUS

• Drink nutrient-rich liquids such as juices, shakes and soups if you have trouble swallowing solid food.
• Eat frequently by opting for 4 to 6 smaller meals a day instead of 2 to 3 big meals.
• Consume a variety of vegetables, including legumes.
• Eat whole grains, whole fruits, and fat-free or low-fat dairy products.
• Include a variety of proteins in the diet, such as lean meats, poultry, seafood, soy, beans, and eggs.
• Use healthy oils such as olive oil.
• Drink plenty of water to keep yourself hydrated.

• Knilonat 200 Capsule can cause a possibly life-threatening heart problem called QTc prolongation (causes irregular heartbeat, which may lead to sudden death). Therefore, if you faint, feel lightheaded or have an irregular heartbeat while taking Knilonat 200 Capsule , please contact your doctor immediately, as these might be symptoms of QTc prolongation.

Regular tests are recommended during treatment with Knilonat 200 Capsule :

• To monitor the number of blood cells (red blood cells, white blood cells and platelets), liver and pancreas function in the body to see how Knilonat 200 Capsule is tolerated.
• To monitor electrolytes (magnesium, potassium) in the body that are essential in the functioning of the heart.
• To check the level of fats and sugar in the blood.
• Also, ECG is recommended to check the heart rate.

Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML): It is a common form of chronic myeloid leukemia (CML) that occurs when specific chromosomes swap positions, causing an abnormality in the chromosomes, creating the Philadelphia chromosome. The abnormal chromosomes produce an abnormal protein called Bcr-Abl tyrosine kinase, which then triggers a signal to produce abnormal white blood cells in the bone marrow. CML is a type of blood cancer which makes the body produce too many abnormal white blood cells. Many people with Ph+ CML will not experience symptoms before their diagnosis. However, if symptoms do occur, they include weight loss, weakness, night sweats, extreme tiredness, feeling full after only small meals, bone pain, and easy bleeding.