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Knilonat 200 Capsule is used to treat Philadelphia chromosome-positive chronic myeloid leukaemia (a type of blood cancer). It contains Nilotinib, which works by blocking the action of an abnormal protein produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thus, it stops the multiplication, inhibits the growth of cancerous cells, and then causes their death.
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About Knilonat 200 Capsule
Knilonat 200 Capsule belongs to the class of anticancer drugs called tyrosine kinase inhibitors used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Ph+ CML is a type of blood cancer that causes white blood cells to behave differently.
Knilonat 200 Capsule contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.
Take Knilonat 200 Capsule as prescribed. You are recommended to take Knilonat 200 Capsule for as long as your doctor has advised it for you based on your medical condition. Sometimes, Knilonat 200 Capsule may cause common side effects such as vomiting, nausea, diarrhoea, headache, constipation, tiredness, and muscle and joint pain. Most of these side effects of Knilonat 200 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 200 Capsule if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 200 Capsule and for two weeks after completing the course of Knilonat 200 Capsule . Knilonat 200 Capsule is not recommended for children below one year of age. Drive only if you are alert as Knilonat 200 Capsule may cause dizziness or visual disorders as side effects in some people. If you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 200 Capsule , contact your doctor immediately, as these might be symptoms of liver problems.
Uses of Knilonat 200 Capsule
Medicinal Benefits
Knilonat 200 Capsule contains Nilotinib, an anticancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells. Knilonat 200 Capsule is used in adults and children with newly diagnosed Ph+ CML in the chronic phase and in adults with Ph+ CML in the accelerated and chronic phase who did not tolerate or no longer benefit from other treatments, including Imatinib.
Side Effects of Knilonat 200 Capsule
Directions for Use
Storage
Drug Warnings
If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Knilonat 200 Capsule if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Knilonat 200 Capsule and for two weeks after completing the course of Knilonat 200 Capsule . Knilonat 200 Capsule is not recommended for children below one year of age. Knilonat 200 Capsule may affect the growth and development of children with chronic phase Ph+ CML. Some children and adolescents may have slower than normal growth while taking Knilonat 200 Capsule . Therefore, your doctor will monitor the growth of your child at regular visits. Drive only if you are alert as Knilonat 200 Capsule may cause dizziness or visual disorders as side effects in some people. Knilonat 200 Capsule may increase the risk of liver problems, especially in people with a history of liver problems. Therefore, if you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Knilonat 200 Capsule , contact your doctor immediately, as these might be symptoms of liver problems. Inform your doctor if you have a severe problem with lactose (milk sugar) or other sugars as Knilonat 200 Capsule may contain lactose. Most people who have mild or moderate lactose intolerance can take Knilonat 200 Capsule . Avoid taking Knilonat 200 Capsule if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy), inform your doctor before taking Knilonat 200 Capsule .
Therapeutic Class
Drug-Drug Interactions
Drug-Food Interactions
Diet & Lifestyle Advise
Habit Forming
How Knilonat 200 Capsule Works
What if I have taken an overdose of Knilonat 200 Capsule
Alcohol
Consult your doctor
The interaction of Knilonat 200 Capsule with alcohol is unknown. Please discuss with your doctor if you have any concerns regarding this.
Pregnancy
Unsafe
Knilonat 200 Capsule is not recommended for use during pregnancy as it may harm the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Knilonat 200 Capsule . Also, you are advised to use effective birth control measures during treatment with Knilonat 200 Capsule and for up to 2 weeks after the last dose of Knilonat 200 Capsule .
Breast Feeding
Unsafe
You are recommended to avoid breastfeeding during treatment with Knilonat 200 Capsule and for two weeks after the final dose. Inform your doctor if you are breastfeeding.
Driving
Caution
If you experience side effects such as dizziness or visual disorders, avoid driving or operating machinery until you are alert.
Liver
Caution
Inform your doctor if you have liver problems before taking Knilonat 200 Capsule . Your doctor may adjust the dose if necessary based on your condition.
Kidney
Consult your doctor
Limited information is available on the use of Knilonat 200 Capsule in patients with impaired kidney function. Therefore, if you have kidney problems, inform your doctor before taking Knilonat 200 Capsule .
Children
Caution
Knilonat 200 Capsule is not recommended for children below 1 year of age as the safety and effectiveness were not established.
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