Nextril 50 Tablet is used to treat depression and associated anxiety with depression. Depression is a mood disorder that mainly affects a person's daily life. It leads to feelings of sadness, anger, or loss that affect the quality of life.  An anxiety disorder is a mental condition characterized by feelings of excessive fear or worry that affect an individual's daily activities. 

Nextril 50 Tablet contains benzodiazepine named Tofisopam, primarily used to treat depression. It works by increasing the action of a chemical messenger in the brain known as GABA (gamma-amino-butyric-acid), which suppresses the excessive and abnormal activity of nerve cells in the brain. As a result, this reduces tension, creates a feeling of well-being, relieves anxiety, helps you sleep better, and increases your energy levels so that you can perform daily activities. It also, in turn, improves the quality of life.

Take Nextril 50 Tablet as prescribed by your doctor. You are advised to take Nextril 50 Tablet for as long as your doctor has prescribed it for you, depending upon your medical condition. In some cases, you may experience loss of appetite, dryness in the mouth, nausea, insomnia (difficulty in sleeping), and headache. Most of these side effects of Nextril 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Nextril 50 Tablet has a very high potential for habit-forming, so take it only in the dose and duration prescribed by your doctor. Do not abruptly stop taking Nextril 50 Tablet as it might lead to nausea, aggressive behavior, anxiety, confusion. Inform your doctor if you feel better, and accordingly, the dose will be adjusted. It is known to cause drowsiness, so do not operate any machinery or drive a car, as it requires mental focus. Please inform your doctor if you are pregnant, planning to get pregnant, or breastfeeding as it a pregnancy category D drug. Also, alcohol consumption should be avoided as it might increase the drowsiness effect and cause excessive sleepiness.

Nextril 50 Tablet contains an 'anti-depression medication', Tofisopam, primarily used to treat depression and associated anxiety with depression. It works by increasing the action of a chemical messenger known as GABA (gamma-amino-butyric-acid), which suppresses the excessive and abnormal activity of nerve cells in the brain. As a result, this reduces tension, creates a feeling of well-being, relieves anxiety, helps you sleep better, and increases your energy levels so that you can perform daily activities. It also, in turn, improves the quality of life.

• Loss of appetite
• Dryness in mouth
• Nausea
• Insomnia (difficulty in sleeping)
• Headache
• Constipation
• Stomach discomfort
• Drowsiness

Do not take Nextril 50 Tablet if you are allergic to benzodiazepines or any ingredient of Nextril 50 Tablet . Nextril 50 Tablet has a very high potential for habit-forming, so take it only in dose and duration prescribed by your doctor. Do not abruptly stop taking Nextril 50 Tablet as it might lead to nausea, aggressive behavior, anxiety, confusion. Inform your doctor if you feel better, and accordingly, the dose will be adjusted. It is known to cause drowsiness, so do not operate any machinery or drive a car as it requires mental focus. Please inform your doctor if you are pregnant, planning to get pregnant, or breastfeeding. Also, alcohol consumption should be avoided as it might increase the drowsiness effect and cause excessive sleepiness.

Drug-Drug Interaction: This medicine may have interactions with other benzodiazepines (bromazepam, diazepam, lorazepam), antianxiety or antiepileptic medicines (like carbamazepine, fluvoxamine, phenobarbital, phenytoin, primidone), antifungal drugs (ketoconazole, itraconazole, voriconazole, fluconazole), acidity medicine (aluminum hydroxide, calcium carbonate, omeprazole, cimetidine), immuno-suppressant (cyclosporine), heart medicines (digoxin, digitoxin, isoniazid).

Drug-Food Interaction: Nextril 50 Tablet may interact with a multivitamin, multi-mineral, or other herbal supplements. So, if you are using any of the OTC items, please tell your doctor. Also, avoid consumption of alcohol and caffeine contains beverages like tea, coffee.

Drug-Disease Interaction: Nextril 50 Tablet is known to interact in patients with glaucoma (increased eye pressure), epilepsy, respiratory problems (asthma), liver or kidney problems, social phobia.

• DIAZEPAM
• LORAZEPAM
• CARBAMAZEPINE
• FLUVOXAMINE
• PHENOBARBITAL
• PHENYTOIN
• PRIMIDONE
• KETOCONAZOLE
• ITRACONAZOLE
• VORICONAZOLE
• FLUCONAZOLE
• ALUMINIUM HYDROXIDE
• CALCIUM CARBONATE
• OMEPRAZOLE
• CIMETIDINE
• CYCLOSPORINE
• DIGOXIN
• ISONIAZID

• Do regular exercise, which can help lower anxiety by releasing endorphins and improving your sleep and self-image.
• Find humour in your daily life. Try to watch light-hearted shows to help relieve stress.
• You can try increasing your mindfulness by including yoga, meditation, mindfulness-based cognitive therapy, and mindfulness-based stress reduction.
• Drink enough water to stay hydrated, and limit or avoid alcohol and caffeine to relieve anxiety.
• Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating a lot of simple carbohydrates found in processed foods.
• Herbs like turmeric, ginger, and chamomile have anti-inflammatory properties. Including these in meals can reduce inflammation caused by anxiety disorders.
• Reduce your alcohol, caffeine, added sugar, high salt, and high fat intake. Especially trans-fat may help also help reduce inflammation.
• Antioxidants, such as ashwagandha, omega-3 fatty acids, green tea, and lemon balm, can be included in your daily diet.
• Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

• Nextril 50 Tablet causes drowsiness. Avoid doing activities that require your complete focus and attention, like driving when on this drug.
• An abrupt stoppage of Nextril 50 Tablet can lead to significant withdrawal symptoms. Always discuss decreasing the dosage with your doctor before completely stopping its usage.
• Avoid consuming alcohol while on this medication, as it can lead to dangerous side effects.
• Nextril 50 Tablet is unsafe for usage if you're pregnant or are planning to get pregnant. Discuss with your doctor about changing/replacing the medicine with safer alternatives in such situations.
• To avoid getting addicted to Nextril 50 Tablet , take it only in prescribed quantities and only as directed by your doctor. Do not self-medicate.

Depression: Depression is considered a serious mental disorder that can lead to worsening of the condition if not treated. It is a mood disorder that mainly affects a person's daily life. It leads to feelings of sadness, anger, or loss that affect the quality of life. It can lead to low productivity at work.

Anxiety: High levels of anxiety can cause panic attacks, with intense feelings of nervousness, fear, and sudden onset of sweating, hyperventilation, fast heartbeat, and flushing of the skin. Anxiety disorders are different from feelings of anxiety and feeling nervous, which involve excessive anxiety, fear, or worry. Fear can arise due to anxiety and emotional response to an immediate threat related to more staying to fight or leaving to escape danger. Fear before getting ready for the surgery is also a part of the short-term anxiety. Anxiety disorders can affect an individual’s job performance, school work, and personal relationships.