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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Musran ER 400 mg Tablet is used to treat mild to moderate pain in osteoarthritis and rheumatoid arthritis. It contains Etodolac, which works by reducing the production of a chemical known as prostaglandin, responsible for inducing pain and inflammation in the body. In some cases, you may experience certain common side effects such as stomach pain, diarrhoea, indigestion, headache, loss of appetite, nausea and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

ETODOLAC-400MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Musran ER 400 mg Tablet

Musran ER 400 mg Tablet is used to treat mild to moderate pain in osteoarthritis and rheumatoid arthritis. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering (cartilage). Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage.

 

Musran ER 400 mg Tablet works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

 

Take Musran ER 400 mg Tablet with or after food. You are advised to take Musran ER 400 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as stomach pain, diarrhoea, indigestion, headache, loss of appetite, nausea and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you should talk to your doctor if you experience these side effects persistently.

 

Consult your doctor before taking Musran ER 400 mg Tablet if you are pregnant or breastfeeding; your doctor will prescribe Musran ER 400 mg Tablet only if the benefits outweigh the risks. Musran ER 400 mg Tablet may cause drowsiness and dizziness, so drive with caution. Musran ER 400 mg Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Musran ER 400 mg Tablet as it could lead to increased drowsiness and dizziness. It could also increase the risk of stomach bleeding.

Uses of Musran ER 400 mg Tablet

Treatment of Osteoarthritis, Rheumatoid arthritis

Directions for Use

Take Musran ER 400 mg Tablet with or after food. Swallow it as a whole with a glass of water. Do not crush, chew or break the tablet/capsule.

Medicinal Benefits

Musran ER 400 mg Tablet works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Thus, Musran ER 400 mg Tablet helps treat pain associated with osteoarthritis and rheumatoid arthritis.

How Musran ER 400 mg Tablet Works

Musran ER 400 mg Tablet works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Musran ER 400 mg Tablet

  • Stomach pain
  • Diarrhoea
  • Indigestion
  • Headache
  • Loss of appetite
  • Nausea
  • Vomiting

What if I have taken an overdose of Musran ER 400 mg Tablet

Do not take more than the prescribed dose of Musran ER 400 mg Tablet as it may cause overdose. The symptoms of overdose include stomach pain, nausea, vomiting, lack of energy, drowsiness, blood/black/tarry stools, vomit that is bloody or looks like coffee grounds or coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Musran ER 400 mg Tablet can increase your risk of fatal heart attack or stroke. So, if you have had any recent heart bypass surgery, do not use Musran ER 400 mg Tablet . Do not take Musran ER 400 mg Tablet if you are allergic to Etodolac, have severe heart failure or peptic ulcer, have suffered bleeding problems such as bleeding from stomach or bowels while taking any pain killers or you have liver or kidney problems. Inform your doctor before taking Musran ER 400 mg Tablet if you are taking medicines for high blood pressure and fluid retention. Consult your doctor before taking Musran ER 400 mg Tablet if you are pregnant or breast-feeding, your doctor will prescribe you Musran ER 400 mg Tablet only if the benefits outweigh the risks. Musran ER 400 mg Tablet causes drowsiness and dizziness, so drive only if you are alert. Musran ER 400 mg Tablet should not be given to children as the safety has not been established. Avoid consuming alcohol along with Musran ER 400 mg Tablet as it could lead to increased drowsiness and can increase the risk of stomach bleeding. Inform your doctor before taking Musran ER 400 mg Tablet if you suffer from fluid retention (swelling), high blood pressure, heart problems, asthma or breathing difficulties. Use of Musran ER 400 mg Tablet can make your skin very sensitive to sunlight which can even cause sunburn. So, whenever you step out of home try to apply sunscreen on your skin.

Drug-Drug Interactions

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EtodolacKetorolac
Critical
EtodolacMeloxicam
Critical

Drug-Drug Interactions

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EtodolacKetorolac
Critical
How does the drug interact with Musran ER 400 mg Tablet 10's:
Using ketorolac together with Musran ER 400 mg Tablet 10's may increase the risk of side effects in the gastrointestinal tract (inflammation, bleeding and ulceration).

How to manage the interaction:
Taking Musran ER 400 mg Tablet 10's with Ketorolac is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
EtodolacMeloxicam
Critical
How does the drug interact with Musran ER 400 mg Tablet 10's:
Co-administration of Musran ER 400 mg Tablet 10's with Meloxicam can raise the adverse consequences in the digestive system, including inflammation, bleeding, ulceration, and, in rare cases, perforation(rupture).

How to manage the interaction:
Taking Meloxicam with Musran ER 400 mg Tablet 10's is not recommended can result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness consult a doctor. Do not discontinue any medications without consulting a doctor.
EtodolacNaproxen
Severe
How does the drug interact with Musran ER 400 mg Tablet 10's:
Coadministration of Naproxen and Musran ER 400 mg Tablet 10's can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Naproxen and Musran ER 400 mg Tablet 10's together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EtodolacDeferasirox
Severe
How does the drug interact with Musran ER 400 mg Tablet 10's:
Taking Musran ER 400 mg Tablet 10's with Deferasirox can increase the risk of gastrointestinal bleeding.

How to manage the interaction:
Taking Deferasirox with Musran ER 400 mg Tablet 10's together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools, consult the doctor immediately. Do not stop taking any medication without consulting a doctor.
EtodolacIoversol
Severe
How does the drug interact with Musran ER 400 mg Tablet 10's:
Taking Ioversol and Musran ER 400 mg Tablet 10's can increase the risk of kidney damage.

How to manage the interaction:
There may be a possibility of interaction between Musran ER 400 mg Tablet 10's and Ioversol, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult your doctor immediately. Drink lots of fluid after the procedure to stay hydrated and flush the contrast agent out of your kidneys. Do not stop using any medications without talking to a doctor.
EtodolacIbrutinib
Severe
How does the drug interact with Musran ER 400 mg Tablet 10's:
Co-administration of Ibrutinib with Musran ER 400 mg Tablet 10's may increase the risk of bleeding.

How to manage the interaction:
Although taking Musran ER 400 mg Tablet 10's and Ibrutinib together can cause an interaction, it can be taken if a doctor has suggested it. However, If you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, a severe headache, and/or weakness, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
EtodolacEnoxaparin
Severe
How does the drug interact with Musran ER 400 mg Tablet 10's:
Taking Musran ER 400 mg Tablet 10's with Enoxaparin can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Co-administration of Musran ER 400 mg Tablet 10's with Enoxaparin can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs like difficulty with bleeding, bleeding, bruising, swelling, throwing up, headache, feeling lightheaded, weakness, or seeing blood in your urine or stools it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
EtodolacValdecoxib
Severe
How does the drug interact with Musran ER 400 mg Tablet 10's:
When valdecoxib is used with Musran ER 400 mg Tablet 10's, there is an increased risk of significant gastrointestinal toxicity (inflammation, bleeding, ulceration, and perforation).

How to manage the interaction:
Although taking Musran ER 400 mg Tablet 10's and Valdecoxib together can cause an interaction, it can be taken if a doctor has suggested it. If you're having any of these symptoms like stomach problems, inflammation, bleeding, or ulcers, it's important to let a doctor know right away. Do not discontinue any medications without consulting a doctor.
EtodolacFlurbiprofen
Severe
How does the drug interact with Musran ER 400 mg Tablet 10's:
Taking Flurbiprofen with Musran ER 400 mg Tablet 10's can increase the risk of side effects (inflammation, bleeding, ulceration, and rarely perforation).

How to manage the interaction:
Taking Musran ER 400 mg Tablet 10's with Flurbiprofen together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
EtodolacMipomersen
Severe
How does the drug interact with Musran ER 400 mg Tablet 10's:
Taking Musran ER 400 mg Tablet 10's and Mipomersen can increase the risk of liver issues.

How to manage the interaction:
Although taking Musran ER 400 mg Tablet 10's and Mipomersen together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

Habit Forming

No

Therapeutic Class

ANALGESICS

Musran ER 400 mg Tablet Substitute

Substitutes safety advice
  • Etova-ER 400 Tablet 10's

    17.33per tablet
  • Etova-400 Tablet 10's

    11.52per tablet
  • Etolgia-XR 400 Tablet 10's

    15.71per tablet
  • Etofree 400 Tablet 10's

    11.79per tablet
  • Etogesic Tablet 10's

    9.63per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Musran ER 400 mg Tablet . Alcohol intake along Musran ER 400 mg Tablet may cause increased drowsiness and drowsiness. It may also increase the risk of stomach bleeding. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Caution

Please consult your doctor before taking Musran ER 400 mg Tablet if you are pregnant, your doctor will prescribe you Musran ER 400 mg Tablet if the benefits outweigh the risks.

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Breast Feeding

Caution

It is not known whether Musran ER 400 mg Tablet passes into the mother’s milk. Please consult your doctor before taking Musran ER 400 mg Tablet if you are breast-feeding, your doctor will prescribe you Musran ER 400 mg Tablet if the benefits outweigh the risks.

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Driving

Caution

Musran ER 400 mg Tablet may cause drowsiness, dizziness or abnormal vision. Do not drive or operate heavy machinery if you feel dizzy or drowsy.

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Liver

Caution

Dose adjustment may be needed in patients with severe liver impairment. Please consult your doctor if you have liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with severe kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Musran ER 400 mg Tablet should not be used by children as the efficacy and safety has not been established.

FAQs

Musran ER 400 mg Tablet is used to treat mild to moderate pain in osteoarthritis and rheumatoid arthritis.
Musran ER 400 mg Tablet works by blocking the effect of chemical messengers (prostaglandin), thereby helping in reducing joint pain, stiffness, swelling and inflammation.
Diarrhoea might be a side-effect of Musran ER 400 mg Tablet . Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.
Musran ER 400 mg Tablet might cause stomach-upset, abdominal pain and indigestion. To prevent this take Musran ER 400 mg Tablet with or after food.
Do not take Musran ER 400 mg Tablet for longer durations or high doses as it may cause heart attack or stroke. Do not exceed the dose and duration prescribed by your doctor.
Do not overdose on Musran ER 400 mg Tablet or any medicine as it could lead to unpleasant side-effects. Take Musran ER 400 mg Tablet only as prescribed by your doctor. Rush to your nearest doctor as early as possible if you have overdosed on Musran ER 400 mg Tablet . Symptoms of overdose include nausea, vomiting, stomach pain, headache, blood in stools/faeces.
Yes, Musran ER 400 mg Tablet might affect certain test results like blood or urine tests. Inform your doctor that you are taking Musran ER 400 mg Tablet before undergoing any tests.
Yes, the use of Musran ER 400 mg Tablet can make the skin very sensitive to sunlight which can even cause sunburn. So, whenever you step out of home try to apply sunscreen on your skin.
Musran ER 400 mg Tablet can increase your risk of a fatal heart attack or stroke. If you have any recent heart bypass surgery, do not use Musran ER 400 mg Tablet .
Musran ER 400 mg Tablet may cause side effects such as diarrhoea, stomach pain, indigestion, loss of appetite, headache, nausea and vomiting. If these side effects persist or worsen, please consult your doctor.
Yes, Musran ER 400 mg Tablet is a pain-relieving medicine.
Musran ER 400 mg Tablet contains Etodolac. It belongs to the class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
No, Musran ER 400 mg Tablet is not a narcotic. It belongs to the class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs).
No, Musran ER 400 mg Tablet does not get you high. It does not lead to physical or psychological dependence and does not have the potential to be abused (drug-seeking behaviour). However, consult your doctor if you are not feeling well.
Patients who are allergic to Musran ER 400 mg Tablet or any of its ingredients, should avoid using Musran ER 400 mg Tablet . However, if you are using Musran ER 400 mg Tablet for the first time or if you are not aware of any allergy, please consult your doctor.
Prolonged use and high doses of Musran ER 400 mg Tablet may cause kidney problems, such as blood or protein in urine and pain during urination. Patients with impaired kidney function, heart failure, and hypertension (high blood pressure) are at risk of kidney problems. Patients taking medicines that cause excess urination (diuretics), or medicines which have significant impact on kidney function are also at higher risk of developing kidney problems. Additionally, Musran ER 400 mg Tablet can affect kidneys of patients who are over 65 years of age or who remain dehydrated. Thus, monitoring of kidney function is recommended for such patients.
Musran ER 400 mg Tablet may cause drowsiness and also dizziness and visual disturbances. However, not everyone taking Musran ER 400 mg Tablet will have these effects. If you experience these symptoms, avoid driving or operating heavy machinery.
Musran ER 400 mg Tablet is effective if used in the dose and duration prescribed by your doctor. Even if you see improvement in your condition, do not stop using Musran ER 400 mg Tablet too early as the symptoms may return or worsen.

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India.
Other Info - MUS0135

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