Toldin 400 Tablet is used to treat mild to moderate pain in osteoarthritis and rheumatoid arthritis. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering (cartilage). Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage.

Toldin 400 Tablet works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Take Toldin 400 Tablet with or after food. You are advised to take Toldin 400 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as stomach pain, diarrhoea, indigestion, headache, loss of appetite, nausea and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you should talk to your doctor if you experience these side effects persistently.

Consult your doctor before taking Toldin 400 Tablet if you are pregnant or breastfeeding; your doctor will prescribe Toldin 400 Tablet only if the benefits outweigh the risks. Toldin 400 Tablet may cause drowsiness and dizziness, so drive with caution. Toldin 400 Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Toldin 400 Tablet as it could lead to increased drowsiness and dizziness. It could also increase the risk of stomach bleeding.

Toldin 400 Tablet works by blocking the effect of a chemical messenger in the body, known as cyclo-oxygenase (COX) enzymes that make another chemical prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Thus, Toldin 400 Tablet helps treat pain associated with osteoarthritis and rheumatoid arthritis.

• Stomach pain
• Diarrhoea
• Indigestion
• Headache
• Loss of appetite
• Nausea
• Vomiting

Toldin 400 Tablet can increase your risk of fatal heart attack or stroke. So, if you have had any recent heart bypass surgery, do not use Toldin 400 Tablet . Do not take Toldin 400 Tablet if you are allergic to Etodolac, have severe heart failure or peptic ulcer, have suffered bleeding problems such as bleeding from stomach or bowels while taking any pain killers or you have liver or kidney problems. Inform your doctor before taking Toldin 400 Tablet if you are taking medicines for high blood pressure and fluid retention. Consult your doctor before taking Toldin 400 Tablet if you are pregnant or breast-feeding, your doctor will prescribe you Toldin 400 Tablet only if the benefits outweigh the risks. Toldin 400 Tablet causes drowsiness and dizziness, so drive only if you are alert. Toldin 400 Tablet should not be given to children as the safety has not been established. Avoid consuming alcohol along with Toldin 400 Tablet as it could lead to increased drowsiness and can increase the risk of stomach bleeding. Inform your doctor before taking Toldin 400 Tablet if you suffer from fluid retention (swelling), high blood pressure, heart problems, asthma or breathing difficulties. Use of Toldin 400 Tablet can make your skin very sensitive to sunlight which can even cause sunburn. So, whenever you step out of home try to apply sunscreen on your skin.

Drug-Drug Interactions: Toldin 400 Tablet may have interaction with ibuprofen, naproxen, aspirin and diclofenac (used to relieve pain), duloxetine and escitalopram (used to treat depression), metoprolol (used to treat high blood pressure), warfarin (blood thinner), digoxin (used for heart problems), lithium (used for mental illness), quinolone antibiotics  (used to treat bacterial infections), cyclosporine (used after transplantation), mifepristone (used to induce abortion) and drugs used to treat high blood pressure and fluid retention.

Drug-Food Interactions: Avoid consuming alcohol along with Toldin 400 Tablet as it could lead to increased drowsiness and dizziness. It could also increase the risk of stomach bleeding.

Drug-Disease Interactions: Inform your doctor if you have heart failure, fluid retention (oedema), asthma, gastrointestinal ulcer/bleeding, high blood pressure, hyperkalemia (high levels of potassium), thrombosis (formation of clots), anaemia (low red blood cells), kidney and liver problems.

• IBUPROFEN
• NAPROXEN
• ASPIRIN
• DICLOFENAC
• DULOXETINE
• ESCITALOPRAM
• METOPROLOL
• WARFARIN
• DIGOXIN
• LITHIUM
• CYCLOSPORINE
• MIFEPRISTONE

• Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
• Performing yoga may also help in improving joint flexibility and pain management.
• Maintain healthy weight by performing regular low-strain exercises and eating healthy food.
• Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
• Follow heat or cold therapy, apply a cold or hot compress on the joints for 15-20minutes regularly.
• Acupuncture, massage and physical therapy may also be helpful.
• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

Toldin 400 Tablet should be taken with caution in patients with gastric problems like gastritis and peptic ulcers. Please consult your doctor if you have any concerns regarding this.

Osteoarthritis: It is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering of cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms of osteoarthritis include pain, stiffness, inflammation and tenderness. The main reason for osteoarthritis is age, the older you are, the more likely you could get osteoarthritis, thus known as degenerative disease, meaning that the joints wear out as a person ages. Other reasons include a past injury such as torn cartilage, dislocated joints and ligament injuries.

Rheumatoid arthritis: It is an auto-immune disease (the body’s immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function.