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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 10, 2024 | 7:20 PM IST

Megoal Trio 20mg/10mg/12.5mg Tablet is used to treat hypertension (high blood pressure). It works by relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. It reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Also, it removes extra water and certain electrolytes from the body and efficiently reduces blood pressure. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. In some cases, it may cause side effects such as headache, nausea, peripheral oedema (swelling of legs/hands), or dizziness in some cases. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Megoal Trio 20mg/10mg/12.5mg Tablet

Megoal Trio 20mg/10mg/12.5mg Tablet belongs to the class of medicines called hypertensives primarily used to treat hypertension (high blood pressure). Hypertension or high blood pressure is a chronic condition in which the blood's force against the artery wall is high. As a result, it leads to heart diseases, irregular heartbeat, and other complications.

Megoal Trio 20mg/10mg/12.5mg Tablet is a combination of three medicines, namely: Olmesartan medoxomil, Cilnidipine, and Chlorthalidone together help in lowering raised blood pressure effectively. Olmesartan medoxomil works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Cilnidipine blocks the activities of the calcium channels present in the blood vessels of the heart. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Chlorthalidone (diuretic) removes extra water, certain electrolytes from the body and efficiently reduces blood pressure. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.

Take Megoal Trio 20mg/10mg/12.5mg Tablet with food or as advised by the doctor. It should be swallowed whole with a glass of water. Do not chew, bite, or break it. Your doctor will advise you on the dose and duration based on your medical condition. You may experience headache, nausea, peripheral oedema (swelling of legs/hands), or dizziness in some cases. Most of these side effects of Megoal Trio 20mg/10mg/12.5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Let your doctor know about this, as it may cause a rise in blood pressure and increase the risk of getting stroke and heart diseases. Megoal Trio 20mg/10mg/12.5mg Tablet should be taken with caution in patients with chest pain (angina), kidney disease, heart failure, low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart). If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Megoal Trio 20mg/10mg/12.5mg Tablet can be prescribed accordingly. Do not use Megoal Trio 20mg/10mg/12.5mg Tablet if you cannot urinate,  are dehydrated, and increase fluid intake. Please inform your doctor if you are taking any other medicines or are allergic to this medicine. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.

Uses of Megoal Trio 20mg/10mg/12.5mg Tablet

Treatment of Hypertension (high blood pressure)

Medicinal Benefits

Megoal Trio 20mg/10mg/12.5mg Tablet is a combination of three medicines, namely: Olmesartan medoxomil, Clindipine, and Chlorthalidone, which together help in lowering raised blood pressure effectively. Olmesartan medoxomil works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Cilnidipine blocks the activities of the calcium channels present in the blood vessels of the heart. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. Chlorthalidone is a diuretic that removes extra water, certain electrolytes from the body and efficiently reduces blood pressure.

Side Effects of Megoal Trio 20mg/10mg/12.5mg Tablet

  • Dizziness
  • Headache
  • Peripheral oedema (swelling of legs/hands)
  • Flushing (skin reddening)
  • Rash
  • Taste change
  • Upset stomach

Directions for Use

Megoal Trio 20mg/10mg/12.5mg Tablet should be taken daily with food to allow its slow absorption and reduce the risk of sudden lowering of blood pressure. Swallow the whole tablet with a glass of water. Do not crush, chew, or break it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Megoal Trio 20mg/10mg/12.5mg Tablet should not be given to the people allergic to Megoal Trio 20mg/10mg/12.5mg Tablet, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, pregnant women or planning to get pregnant and breastfeeding women. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). Megoal Trio 20mg/10mg/12.5mg Tablet can pass into breast milk, but its effect on the baby is not known. So, it is better to tell your doctor if you are taking Megoal Trio 20mg/10mg/12.5mg Tablet and breastfeeding. Grapefruit juice and St. John's wort plant should not be consumed when taking Megoal Trio 20mg/10mg/12.5mg Tablet as it is contraindicated. Megoal Trio 20mg/10mg/12.5mg Tablet contain hydrochlorothiazide which can cause hypokalaemia (low potassium), hyponatremia (low sodium) and hypomagnesemia (low magnesium). So regular monitoring of electrolytes is required while taking treatment with Megoal Trio 20mg/10mg/12.5mg Tablet. Do not take Megoal Trio 20mg/10mg/12.5mg Tablet if you have low or no urine output, are allergic to other sulfonamide antibiotics, or are taking Aliskiren and have diabetes. Drinking alcohol while using Megoal Trio 20mg/10mg/12.5mg Tablet can cause you to have low blood pressure, so avoid intake of alcoholic beverages.

Therapeutic Class

ANTI- HYPERTENSIVES

Drug-Drug Interactions

verifiedApollotooltip
Olmesartan medoxomilAliskiren
Critical
chlorthalidoneCisapride
Critical

Drug-Food Interactions

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OLMESARTAN MEDOXOMIL-20MG+CILNIDIPINE-10MG+CHLORTHALIDONE-12.5MGPotassium rich foods
Moderate

Diet & Lifestyle Advise

  • Keep your weight under control with a BMI of 19.5-24.9.
  • Regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week, can help lower your raised blood pressure by about 5 mm of Hg.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products. 
  • Limit your intake of sodium chloride (table salt) to 2300 mg per day, or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, then only one serving for women and two servings is advisable. 
  • Quitting smoking is the best strategy to lower the risk of heart disease. 
  • Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques. 
  • Try to include heart-healthy omega-3 fatty acid-containing food drinks in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

What if I have taken an overdose of Megoal Trio 20mg/10mg/12.5mg Tablet

Do not take more than the prescribed dose of Megoal Trio 20mg/10mg/12.5mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.
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Alcohol

Unsafe

Megoal Trio 20mg/10mg/12.5mg Tablet can lower your blood pressure, causing dizziness and drowsiness. It can also cause orthostatic hypotension (a sudden fall in blood pressure while standing). So try to avoid taking Megoal Trio 20mg/10mg/12.5mg Tablet with alcoholic beverages.

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Pregnancy

Unsafe

Megoal Trio 20mg/10mg/12.5mg Tablet is pregnancy risk category D medicine which may cause harm to the fetus or unborn baby. So, when pregnancy is detected, discontinue Megoal Trio 20mg/10mg/12.5mg Tablet as soon as possible and consult the doctor.

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Breast Feeding

Caution

Megoal Trio 20mg/10mg/12.5mg Tablet passes into the breast milk, but its effect on the baby is not clear. Therefore, it is advisable to contact the doctor before intake of Megoal Trio 20mg/10mg/12.5mg Tablet.

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Driving

Unsafe

Megoal Trio 20mg/10mg/12.5mg Tablet may cause side effects, which could affect your ability to drive. Taking Megoal Trio 20mg/10mg/12.5mg Tablet may lower your blood pressure.

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Liver

Caution

Megoal Trio 20mg/10mg/12.5mg Tablet to be taken with caution, especially if you have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

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Kidney

Caution

Not recommended in patients with chronic kidney disease (severe renal impairment). Safety and effectiveness in patients with severe renal impairment have not been established.

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Children

Unsafe

Megoal Trio 20mg/10mg/12.5mg Tablet is not recommended in children. The safety and efficacy of Megoal Trio 20mg/10mg/12.5mg Tablet in children have not yet been established.

Country of origin

India
Other Info - ME60080

Author Details

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FAQs

Megoal Trio 20mg/10mg/12.5mg Tablet is used to treat high blood pressure. It works by relaxing blood vessels, reducing the heart's workload and making the heart more efficient at pumping blood throughout the body. It also removes extra water and certain electrolytes from the body and efficiently reduces blood pressure.
It is advised to continue your medicine even after your blood pressure is under control or becomes normal as blood pressure can shoot up at any time. If you have a persistent headache, please consult your doctor immediately.
Yes, Megoal Trio 20mg/10mg/12.5mg Tablet is contraindicated in people with known allergy to any of this medicine's components. It should be avoided in people with severe kidney or liver impairment and people with anuria (reduction or absence of urine). It should also be avoided in women who are in the second and third trimesters of their pregnancy.
Yes, Megoal Trio 20mg/10mg/12.5mg Tablet can cause dry mouth. Therefore, it is always advised to increase fluid intake while taking Megoal Trio 20mg/10mg/12.5mg Tablet. If you still feel excessively thirsty, please consult your doctor and advise for the best results of Megoal Trio 20mg/10mg/12.5mg Tablet.
It is unlikely that Megoal Trio 20mg/10mg/12.5mg Tablet affects fertility in men or women. However, some water pills like hydrochlorothiazide may lead to erectile dysfunction. There is not enough evidence to say for certain. For the best advice, consult your doctor.
Yes, Megoal Trio 20mg/10mg/12.5mg Tablet is known to cause ankle swelling. Please try to keep your feet up when sitting for long hours. If the problem persists, consult your doctor and do what is advised.
Yes, Megoal Trio 20mg/10mg/12.5mg Tablet can cause an upset stomach. So, it is preferred to take Megoal Trio 20mg/10mg/12.5mg Tablet with food to avoid it.
High blood pressure during pregnancy may cause eclampsia, which can be harmful to both baby and mother. Therefore, during pregnancy, you should have regular blood pressure monitoring.
Megoal Trio 20mg/10mg/12.5mg Tablet, if stopped abruptly, can lead to withdrawal symptoms. So, before stopping Megoal Trio 20mg/10mg/12.5mg Tablet, consult your doctor; your dose will be lowered gradually to avoid unpleasant side effects of Megoal Trio 20mg/10mg/12.5mg Tablet.
Megoal Trio 20mg/10mg/12.5mg Tablet and Cilacar 10 are medications used to treat high blood pressure (hypertension). Still, they differ in their composition and mechanism of action. Megoal Trio 20mg/10mg/12.5mg Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone. Whereas Cilacar 10 contains Cilnidipine.
Megoal Trio 20mg/10mg/12.5mg Tablet and Benlong 4 mg are medications used to treat high blood pressure (hypertension). Still, they differ in their active ingredients and mechanism of action. Megoal Trio 20mg/10mg/12.5mg Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone. Whereas Benlong 4 mg contains Benidipine.
Megoal Trio 20mg/10mg/12.5mg Tablet and Telma 40 are medications for treating high blood pressure (hypertension). Still, they differ in their composition and mechanism of action. Megoal Trio 20mg/10mg/12.5mg Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone. Whereas Telma 40 contains Telmisartan.
Megoal Trio 20mg/10mg/12.5mg Tablet and Ciplar tablet differ in their composition and mechanism of action. Megoal Trio 20mg/10mg/12.5mg Tablet contains Olmesartan medoxomil, Cilnidipine, and chlorthalidone, while the Ciplar tablet contains Propranolol.
Megoal Trio 20mg/10mg/12.5mg Tablet is a combination of three medicines, namely Olmesartan medoxomil, Cilnidipine, and Chlorthalidone, which help lower raised blood pressure effectively. Olmesartan medoxomil works by blocking the hormone angiotensin, thereby relaxing blood vessels. This allows the blood to flow more smoothly and the heart to pump more efficiently. Cilnidipine blocks the activities of the calcium channels present in the heart's blood vessels. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Chlorthalidone (diuretic) removes extra water and certain electrolytes from the body and efficiently reduces blood pressure. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.
Common side effects of Megoal Trio 20mg/10mg/12.5mg Tablet may include headache, nausea, peripheral oedema (swelling of legs/hands), or dizziness in some cases. Most of these side effects of Megoal Trio 20mg/10mg/12.5mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.
Megoal Trio 20mg/10mg/12.5mg Tablet can start showing its effect within one hour of its oral intake. However, it may take a few days to show its full effect, and this may vary from person to person.
Yes, Megoal Trio 20mg/10mg/12.5mg Tablet can generally be taken on an empty stomach. However, it's always best to follow your doctor's instructions or as mentioned on the medication label.
No, you should not take Megoal Trio 20mg/10mg/12.5mg Tablet or any other prescription medication on your own. Megoal Trio 20mg/10mg/12.5mg Tablet is a prescription medication used to treat high blood pressure. Consult with a healthcare professional before starting any new medication, including Megoal Trio 20mg/10mg/12.5mg Tablet, is essential. They can diagnose your condition accurately and prescribe the correct dosage.
No, you should not drink alcohol while taking this medication. Alcohol can increase the risk of side effects, such as dizziness and lightheadedness.
No, you should not drink grapefruit juice while taking this medication. Grapefruit juice can interact with this medication and increase the risk of side effects.
Megoal Trio 20mg/10mg/12.5mg Tablet may interact with certain medications. So, you should talk to your doctor before taking any over-the-counter medications, such as pain relievers or cold medications, while taking this medication.
Your doctor will monitor your blood pressure to evaluate if this medicine is effective. You may also experience less symptoms, such as headaches or dizziness.
The long-term effects of taking this medicine remain unclear. However, the majority of people who use this drug do not encounter any serious long-term negative effects.
Megoal Trio 20mg/10mg/12.5mg Tablet is a combination of three medicines, namely: Olmesartan medoxomil, Cilnidipine, and Chlorthalidone.
Megoal Trio 20mg/10mg/12.5mg Tablet is not recommended in children. The safety and efficacy of Megoal Trio 20mg/10mg/12.5mg Tablet in children have not yet been established.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
Megoal Trio 20mg/10mg/12.5mg Tablet is pregnancy risk category D medicine which may cause harm to the fetus or unborn baby. So, when pregnancy is detected, discontinue Megoal Trio 20mg/10mg/12.5mg Tablet as soon as possible and consult the doctor.

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