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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Sep 30, 2024 | 4:52 PM IST

Megmabend Leo 400mg/150mg Tablet is used to treat parasitic worm infections. It contains albendazole and levamisole. Albendazole inhibits tubulin polymerization, causing metabolic disruption and energy depletion in the parasite, leading to immobilization. Levamisole suppresses the worm's muscle's enzyme activity, leading to paralysis and death; this eventually leads to the death of susceptible helminths and thus prevents the growth of parasitic infections.

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Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About Megmabend Leo 400mg/150mg Tablet

Megmabend Leo 400mg/150mg Tablet belongs to the class of medications called 'anthelmintics' used to treat parasitic worm infections. Parasitic worm infections are intestinal worm infections that are caused by the ingestion of contaminated food and water.

Megmabend Leo 400mg/150mg Tablet contains albendazole and levamisole. Albendazole works by inhibiting tubulin polymerization, causing metabolic disruption and energy depletion in the parasite, leading to immobilization. Levamisole works by suppressing the worm's muscle's enzyme activity, leading to paralysis and death. This eventually leads to the death of susceptible helminths and thus prevents the growth of parasitic infections.

Take Megmabend Leo 400mg/150mg Tablet as prescribed by your doctor. The common side-effects of Megmabend Leo 400mg/150mg Tablet are nausea, vomiting, indigestion, diarrhoea, metallic taste, headache, dizziness, and stomach pain. Most of these side effects do not require medical attention and resolve gradually over time. If any of the side effects persist or worsen, please consult your doctor.

Avoid taking Megmabend Leo 400mg/150mg Tablet if you are allergic to 'albendazole', 'levamisole', or any ingredients present in it. It may cause dizziness, so refrain from activities that require you to stay alert. Megmabend Leo 400mg/150mg Tablet is not recommended in pregnancy. Before taking Megmabend Leo 400mg/150mg Tablet, inform your doctor about your complete medical history.

Uses of Megmabend Leo 400mg/150mg Tablet

Treatment of Parasitic worm infections

Medicinal Benefits

Megmabend Leo 400mg/150mg Tablet contains 'Albendazole' and 'Levamisole', which belong to the class of medications called 'anthelmintics'. It is a broad-spectrum antibiotic used in the treatment of parasitic infections. It can kill the disease-causing worms and stop the spread of infection effectively. Albendazole interrupts the absorption of glucose by the worm, leading to energy depletion. Levamisole works by suppressing the enzyme activity in the worm's muscle; this leads to paralysis and death.

Directions for Use

Tablet: It is advised to swallow the tablet as a whole with water.Note: Those who have difficulty swallowing the tablets whole. The tablets should be crushed or chewed and consumed with a glass of water.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Megmabend Leo 400mg/150mg Tablet

  • Nausea
  • Vomiting
  • Indigestion
  • Diarrhea
  • Metallic taste
  • Headache
  • Dizziness
  • Stomach pain

Drug Warnings

Do not take Megmabend Leo 400mg/150mg Tablet if you are allergic to any component present in it; if you are unsure, check with your healthcare professional. Due to the risk of liver or bone marrow damage during albendazole therapy, blood counts and liver function tests should be performed regularly (at least once every two weeks). Albendazole may cause fetal damage; thus, women of reproductive age should begin medication after a negative pregnancy test. Women of reproductive age should avoid becoming pregnant while taking Megmabend Leo 400mg/150mg Tablet or within one month of completing therapy. Megmabend Leo 400mg/150mg Tablet should be taken with food.

Drug Interactions

Drug-Drug Interactions: Megmabend Leo 400mg/150mg Tablet may interact with chemotherapy drugs (e.g. cladribine), antipsychotic medication (e.g. clozapine), live vaccinations (e.g. BCG vaccine, dengue vaccine, zoster vaccine)

Drug-Food Interactions: Alcohol consumption should be avoided.

Drug-Disease Interactions: Megmabend Leo 400mg/150mg Tablet should be used with caution in patients with myelosuppression (bone marrow suppression), hepatobiliary dysfunction (liver and biliary disease), neurological disorder (Intracranial Hypertension, Seizures), and renal dysfunction.

Drug-Drug Interactions Checker List

  • CLADRIBINE
  • CLOZAPINE
  • BCG VACCINE
  • DENGUE VACCINE
  • ZOSTER VACCINE

Habit Forming

No

Diet & Lifestyle Advise

  • Regularly wash your child's hands with soap and water.
  • Avoid giving raw fish and meat.
  • Thoroughly cook meat before eating.
  • Wash all fruits and vegetables properly before consuming them.
  • Wash or reheat food that has been around for a long time.
  • Avoid contact with soil that may be contaminated with faeces.
  • Avoid keeping foods open in the markets as they can be contaminated.
  • Drink boiled and purified water.

Disease/Condition Glossary

Parasitic worm infections: Parasitic worms are also called intestinal worms or helminths. They live in and feed on the hosts, leading to weakness and diseases. Common types of intestinal worms are roundworms and flatworms, such as tapeworms and flukes. Worm infections could occur due to consuming contaminated water, food, or soil, contact with contaminated faeces, poor sanitization, or poor hygiene. Symptoms of worm infections include abdominal pain, diarrhoea, nausea, vomiting, gas, bloating, fatigue, unexplained weight loss, and dysentery (bloody stools).

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Alcohol

Caution

Megmabend Leo 400mg/150mg Tablet may interact with alcohol and worsen your condition. So, consumption of alcohol should be avoided.

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Pregnancy

Caution

Megmabend Leo 400mg/150mg Tablet should not be used in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Megmabend Leo 400mg/150mg Tablet.

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Breast Feeding

Safe if prescribed

Megmabend Leo 400mg/150mg Tablet is considered safe to be used in breastfeeding. However, consult your doctor before taking Megmabend Leo 400mg/150mg Tablet.

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Driving

Caution

Megmabend Leo 400mg/150mg Tablet may cause dizziness, so do not drive or operate heavy machinery until you are alert.

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Liver

Caution

In patients with hepatic dysfunction, Albendazole has been demonstrated to induce aplastic anaemia, agranulocytosis, and bone marrow suppression. Hence, Megmabend Leo 400mg/150mg Tablet should be used with caution in patients with liver disease. Dose adjustments may be necessary. So, discuss with your doctor before receiving Megmabend Leo 400mg/150mg Tablet if you have a history of liver diseases/conditions.

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Kidney

Consult your doctor

Limited data is available. If you have kidney problems, inform your doctor before taking Megmabend Leo 400mg/150mg Tablet.

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Children

Safe if prescribed

Megmabend Leo 400mg/150mg Tablet should be used in children only if clinically needed. Please consult your child's doctor for more information.

Country of origin

India
Other Info - ME12603

Author Details

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FAQs

Megmabend Leo 400mg/150mg Tablet is used to treat Parasitic worm infections.
Megmabend Leo 400mg/150mg Tablet is a combination of two drugs, albendazole and Levamisole. It is used to treat certain parasite infections. It kills the parasite by preventing it from using glucose and, therefore, diminishing its energy reserves. It also paralyzes the insect, causing it to die.
Combining these two drugs may offer an effective solution for Parasitic worm infections.
Megmabend Leo 400mg/150mg Tablet is not an antibiotic. It is an anthelmintics medication used to treat parasitic worm infections in the stomach and intestine.
Common symptoms of intestinal worms are stomach or abdominal pain, diarrhoea, nausea, vomiting, gas formation, bloating, fatigue and unexplained weight.

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