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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Mefpar 500mg/450mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, heavy bleeding during periods, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis. It contains Mefenamic acid and Paracetamol which helps reduce mild to moderate pain and inflammation at the injured or damaged site. It may cause common side effects such as nausea, vomiting, indigestion, heartburn, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Consume Type :

ORAL

Return Policy :

Not Returnable

About Mefpar 500mg/450mg Tablet

Mefpar 500mg/450mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, heavy bleeding during periods, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body.

Mefpar 500mg/450mg Tablet contains two drugs, Mefenamic acid and Paracetamol. Mefpar 500mg/450mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

You are advised to take Mefpar 500mg/450mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Mefpar 500mg/450mg Tablet may cause common side effects such as nausea, vomiting, indigestion, heartburn, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Mefpar 500mg/450mg Tablet may cause dizziness, so drive only if you are alert. Avoid consuming alcohol with Mefpar 500mg/450mg Tablet as it could lead to increased dizziness and may increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Mefpar 500mg/450mg Tablet

Treatment of Pain, inflammation, osteoarthritis, and rheumatoid arthritis.

Directions for Use

Swallow Mefpar 500mg/450mg Tablet as a whole with a glass of water; do not chew or break the tablet/capsule.

Medicinal Benefits

Mefpar 500mg/450mg Tablet contains two Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Mefenamic acid and Paracetamol. Mefpar 500mg/450mg Tablet is used to treat pain, inflammation, migraine headache, period pain, heavy bleeding during periods, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis. Mefpar 500mg/450mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, prostaglandin. Prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

How Mefpar 500mg/450mg Tablet Works

Mefpar 500mg/450mg Tablet contains two drugs, Mefenamic acid and Paracetamol. Mefpar 500mg/450mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mefpar 500mg/450mg Tablet

  • Indigestion
  • Nausea
  • Diarrhoea
  • Heartburn
  • Vomiting

What if I have taken an overdose of Mefpar 500mg/450mg Tablet

Do not take more than the prescribed dose of Mefpar 500mg/450mg Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Do not take Mefpar 500mg/450mg Tablet if you are allergic to any of its contents; if you have severe heart, kidney or liver failure; or if you have suffered bleeding problems such as bleeding from the stomach or bowels while taking painkillers or if you have peptic ulcers or inflammatory bowel disease. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, dehydration, asthma, gastrointestinal bleeding, ulceration, perforation of the stomach and intestine, or liver and kidney problems. Consult your doctor if you are pregnant or breastfeeding. Mefpar 500mg/450mg Tablet may cause dizziness, so drive only if you are alert. Stop taking Mefpar 500mg/450mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Mefpar 500mg/450mg Tablet unless prescribed by the doctor.

Drug-Drug Interactions

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Mefenamic acidKetorolac
Critical
Mefenamic acidMeloxicam
Critical

Drug-Drug Interactions

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Mefenamic acidKetorolac
Critical
How does the drug interact with Mefpar 500mg/450mg Tablet:
Coadministration of Mefpar 500mg/450mg Tablet with Ketorolac can increase the risk or severity of gastric bleeding and ulcers.

How to manage the interaction:
Taking Mefpar 500mg/450mg Tablet with Ketorolac together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidMeloxicam
Critical
How does the drug interact with Mefpar 500mg/450mg Tablet:
Co-administration of Mefpar 500mg/450mg Tablet with Meloxicam together can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mefpar 500mg/450mg Tablet with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.
Mefenamic acidEtodolac
Severe
How does the drug interact with Mefpar 500mg/450mg Tablet:
Coadministration of Mefpar 500mg/450mg Tablet with Etodolac can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mefpar 500mg/450mg Tablet with Etodolac together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact the doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidFondaparinux
Severe
How does the drug interact with Mefpar 500mg/450mg Tablet:
Taking Mefpar 500mg/450mg Tablet with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Fondaparinux with Mefpar 500mg/450mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience bleeding or bruising, feeling dizzy or lightheaded, dark or bloody stools, headache, weakness contact your doctor right away. Do not stop using any medications without first talking to your doctor.
Mefenamic acidDalteparin
Severe
How does the drug interact with Mefpar 500mg/450mg Tablet:
Combining Mefpar 500mg/450mg Tablet with Dalteparin can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Although taking Dalteparin and Mefpar 500mg/450mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any signs like bleeding, bruising, swelling, vomiting, headache, dizziness, weakness, or blood in your urine or stool, make sure to contact your doctor right away. Do not stop using any medications without talking to a doctor.
Mefenamic acidFlurbiprofen
Severe
How does the drug interact with Mefpar 500mg/450mg Tablet:
Co-administration of Mefpar 500mg/450mg Tablet with Flurbiprofen can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mefpar 500mg/450mg Tablet with Flurbiprofen together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of dizziness, lightheadedness, unusual bleeding or bruising, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidCabozantinib
Severe
How does the drug interact with Mefpar 500mg/450mg Tablet:
Using cabozantinib together with Mefpar 500mg/450mg Tablet may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Mefpar 500mg/450mg Tablet and Cabozantinib, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms like blood clotting problems, excessive bleeding, or severe headaches, it's best to contact a doctor right away. They can help address any complications and provide the necessary support. Do not stop using any medications without talking to a doctor.
Mefenamic acidDasatinib
Severe
How does the drug interact with Mefpar 500mg/450mg Tablet:
Co-administration of Mefpar 500mg/450mg Tablet with Dasatinib can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mefpar 500mg/450mg Tablet with Dasatinib together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, lightheadedness, red or black tarry stools, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidEdoxaban
Severe
How does the drug interact with Mefpar 500mg/450mg Tablet:
Using Edoxaban together with Mefpar 500mg/450mg Tablet may increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Although taking Mefpar 500mg/450mg Tablet and Edoxaban together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these signs, it's important to contact a doctor right away - problems with bleeding, dizziness, black or tarry stools, severe headache, weakness, or vomiting. Do not stop using any medications without talking to a doctor.
Mefenamic acidNaproxen
Severe
How does the drug interact with Mefpar 500mg/450mg Tablet:
Coadministration of Mefpar 500mg/450mg Tablet with Naproxen can increase the risk or severity of stomach bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mefpar 500mg/450mg Tablet with Naproxen together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

  • Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

  • Acupuncture, massage and physical therapy may also be helpful.

  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANALGESICS

Mefpar 500mg/450mg Tablet Substitute

Substitutes safety advice
  • MEFNUM FORTE TABLET

    8.82per tablet
  • SPASMONIL FORTE TABLET

    3.55per tablet
  • Mefex FT 500mg/450mg Tablet

    3.42per tablet
  • Elagesic Fort 500 mg/450 mg Tablet

    3.78per tablet
  • Mefac Forte Tablet

    3.56per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Mefpar 500mg/450mg Tablet as it may cause increased dizziness. It can also increase the risk of stomach bleeding.

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Pregnancy

Caution

Please consult your doctor if you are pregnant or if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Please consult your doctor before taking Mefpar 500mg/450mg Tablet; your doctor will decide whether Mefpar 500mg/450mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Mefpar 500mg/450mg Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney problems or any concerns regarding this.

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Children

Caution

Please consult your doctor. Your doctor will prescribe the dose and duration based on your child's condition.

FAQs

Mefpar 500mg/450mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis.
Mefpar 500mg/450mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, prostaglandins. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.
Mefpar 500mg/450mg Tablet is used to reduce and relieve pain and inflammation associated with osteoarthritis and rheumatoid arthritis. Arthritis is tenderness and swelling in the joints.
Avoid taking Mefpar 500mg/450mg Tablet if you have stomach ulcers, bleeding problems, or heart problems. Talk to your doctor regarding your concerns; he/she may prescribe alternate medicine.
Diarrhoea might be a side-effect of Mefpar 500mg/450mg Tablet. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience severe diarrhea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Mefpar 500mg/450mg Tablet is used to relieve menstrual (period) pain and management of excessively heavy periods. Take Mefpar 500mg/450mg Tablet only as prescribed by the doctor.
Mefpar 500mg/450mg Tablet is generally prescribed for short-term use. Do not take Mefpar 500mg/450mg Tablet for longer durations as it might increase the risk of kidney problems and stomach bleeding.

Country of origin

India
Other Info - ME90722

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