Mefera 500 mg/450 mg Tablet is used for the treatment of pain, inflammation, migraine headache, period pain, heavy bleeding during periods, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis. Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body.

Mefera 500 mg/450 mg Tablet contains two drugs, Mefenamic acid and Paracetamol. Mefera 500 mg/450 mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, fewer prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

You are advised to take Mefera 500 mg/450 mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Mefera 500 mg/450 mg Tablet may cause common side effects such as nausea, vomiting, indigestion, heartburn, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Mefera 500 mg/450 mg Tablet may cause dizziness, so drive only if you are alert. Avoid consuming alcohol with Mefera 500 mg/450 mg Tablet as it could lead to increased dizziness and may increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Mefera 500 mg/450 mg Tablet contains two Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Mefenamic acid and Paracetamol. Mefera 500 mg/450 mg Tablet is used to treat pain, inflammation, migraine headache, period pain, heavy bleeding during periods, muscle pain, tooth pain, joint pain, pain after surgery, ear pain, fever, flu, osteoarthritis, and rheumatoid arthritis. Mefera 500 mg/450 mg Tablet blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, prostaglandin. Prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site.

• Indigestion
• Nausea
• Diarrhoea
• Heartburn
• Vomiting

Do not take Mefera 500 mg/450 mg Tablet if you are allergic to any of its contents; if you have severe heart, kidney or liver failure; or if you have suffered bleeding problems such as bleeding from the stomach or bowels while taking painkillers or if you have peptic ulcers or inflammatory bowel disease. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, dehydration, asthma, gastrointestinal bleeding, ulceration, perforation of the stomach and intestine, or liver and kidney problems. Consult your doctor if you are pregnant or breastfeeding. Mefera 500 mg/450 mg Tablet may cause dizziness, so drive only if you are alert. Stop taking Mefera 500 mg/450 mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Mefera 500 mg/450 mg Tablet unless prescribed by the doctor.

Drug-Drug Interactions: Mefera 500 mg/450 mg Tablet may interact with pain killers (aspirin, ibuprofen, celecoxib, diclofenac, naproxen), anti-gout (probenecid), immunosuppressants (cyclosporine, tacrolimus), anticoagulants (warfarin, heparin), anti-rheumatoid (methotrexate), anti-HIV (zidovudine), anti-depressant (duloxetine, lithium, fluoxetine, sertraline), steroid medication (mifepristone), anti-emetic (metoclopramide, domperidone), anti-cancer (imatinib), and bile acid sequestrants (cholestyramine).

Drug-Food Interactions: Avoid alcohol consumption while taking Mefera 500 mg/450 mg Tablet as it might cause increased dizziness and risk of stomach bleeding.

Drug-Disease Interactions: Inform your doctor if you have peptic ulcers, bleeding disorders, asthma, fluid retention, gastrointestinal toxicity, rash, renal toxicity, thrombosis, anaemia, heart failure, liver toxicity, high blood pressure, platelet aggregation inhibition, or hyperkalemia (high potassium levels).

• ASPIRIN
• IBUPROFEN
• CELECOXIB
• DICLOFENAC
• NAPROXEN
• PROBENECID
• CYCLOSPORINE
• TACROLIMUS
• WARFARIN
• HEPARIN
• METHOTREXATE
• ZIDOVUDINE
• DULOXETINE
• LITHIUM
• FLUOXETINE
• SERTRALINE
• MIFEPRESTONE
• METOCLOPRAMIDE
• DOMPERIDONE
• IMATINIB
• CHOLESTYRAMINE

• Physical activity helps strengthen muscles and relieves joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.

• Performing yoga may also help in improving joint flexibility and pain management.

• Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.

• Get adequate sleep, as resting the muscles can help reduce inflammation and swelling.

• De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.

• Acupuncture, massage and physical therapy may also be helpful.

• Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.

• Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.

• Avoid smoking and alcohol consumption.

Pain: Pain is a symptom triggered by the nervous system, causing uncomfortable sensations in the body. Pain may be dull or sharp; it might be constant or may come and go. The tolerance level of pain might vary from person to person. Pain can be generalised (overall body aches) or localized (affecting a specific area of the body). The common causes of pain include headache, muscle strain, cramps, cuts, bone fractures, and arthritis.

Osteoarthritis: It is a joint disease in which the two ends of the joints come together due to the breakdown of a protective covering called cartilage. Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Symptoms include pain, stiffness, inflammation and tenderness.

Rheumatoid arthritis: It is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage. Symptoms of rheumatoid arthritis include pain, swelling, stiffness, deformities and loss of joint function.