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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Mefedrot MR 500mg/2mg Tablet is used to provide relief from abdominal cramps due to the menstrual cycle. It contains Mefenamic acid and Tizanidine which work by blocking the chemical messengers that cause pain, relax the abdominal muscles and prevent muscle contractions. In some cases, this medicine may cause side effects such as nausea, vomiting, diarrhoea, indigestion, and weakness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Consume Type :

ORAL

Return Policy :

Not Returnable

About Mefedrot MR 500mg/2mg Tablet

Mefedrot MR 500mg/2mg Tablet belongs to a group of NSAID (Non-Steroidal Anti-Inflammatory Drug) medicines used to provide relief from abdominal cramps caused before and during the menstrual cycle. Abdominal cramps are throbbing pains in the lower abdomen due to the menstrual cycle every month in females. In some females, the pain and discomfort caused due to menstruation are so severe that they have to take some medicine to lower the pain intensity.

Mefedrot MR 500mg/2mg Tablet is a combination drug that contains 'mefenamic acid' and 'Tizanidine.' Mefenamic acid works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes, that make another chemical, 'prostaglandins' (PG) which are responsible for causing pain. Tizanidine works on the centres of the spinal cord and brain. This helps relax the intestine or stomach muscles and stops muscle contractions. Collectively, both of them help to relieve pain, bloating, cramps, and discomfort caused.

Take Mefedrot MR 500mg/2mg Tablet as prescribed. Depending on your medical condition, you are advised to take Mefedrot MR 500mg/2mg Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience common side effects, such as abdominal pain, nausea, vomiting, diarrhoea, indigestion, weakness, dry mouth, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please inform your doctor if you are allergic to Mefedrot MR 500mg/2mg Tablet or other medicines. Mefedrot MR 500mg/2mg Tablet can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, and perforation of the stomach and intestines. Do not take Mefedrot MR 500mg/2mg Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Mefedrot MR 500mg/2mg Tablet may cause drowsiness and dizziness, so drive with caution. Mefedrot MR 500mg/2mg Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol and Mefedrot MR 500mg/2mg Tablet as it could lead to increased drowsiness and dizziness; it might also increase stomach bleeding risk. Do not take other painkillers with Mefedrot MR 500mg/2mg Tablet unless prescribed by the doctor. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Mefedrot MR 500mg/2mg Tablet

Treatment of Abdominal cramps caused due to menstrual cycle.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Mefedrot MR 500mg/2mg Tablet is a combination drug that contains 'mefenamic acid' and 'Tizanidine.' Mefenamic acid belongs to a group of medicines called NSAID (Non-Steroidal Anti-Inflammatory Drug), used to relieve mild to moderate pain associated with period pain, symptoms of premenstrual syndrome (PMS), and management of excessively heavy periods. Mefedrot MR 500mg/2mg Tablet works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical, 'prostaglandins' (PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Tizanidine works in the centres of the spinal cord and brain. This helps relax the intestine or stomach muscles and stops muscle contractions. Collectively, both of them help to relieve pain, bloating, cramps, and discomfort caused.

How Mefedrot MR 500mg/2mg Tablet Works

Mefedrot MR 500mg/2mg Tablet is a combination drug that contains 'mefenamic acid' and 'Tizanidine.' Mefenamic acid works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes, that make another chemical, 'prostaglandins' (PG) which are responsible for causing pain. Tizanidine works on the centres of the spinal cord and brain. This helps relax the intestine or stomach muscles and stops muscle contractions. Collectively, both of them help to relieve pain, bloating, cramps, and discomfort caused.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mefedrot MR 500mg/2mg Tablet

  • Abdominal pain 
  • Nausea 
  • Vomiting 
  • Diarrhoea 
  • Indigestion
  • Heartburn
  • Weakness
  • Dryness in the mouth

What if I have taken an overdose of Mefedrot MR 500mg/2mg Tablet

Take Mefedrot MR 500mg/2mg Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Please inform your doctor if you are allergic to Mefedrot MR 500mg/2mg Tablet or other medicines. Mefedrot MR 500mg/2mg Tablet can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, and perforation of the stomach and intestines. Do not take Mefedrot MR 500mg/2mg Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Mefedrot MR 500mg/2mg Tablet may cause drowsiness and dizziness, so drive with caution. Mefedrot MR 500mg/2mg Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol and Mefedrot MR 500mg/2mg Tablet as it could lead to increased drowsiness and dizziness; it might also increase stomach bleeding risk. Do not take other painkillers with Mefedrot MR 500mg/2mg Tablet unless prescribed by the doctor. Keep your doctor informed about your health condition and medicines to rule out any side effects. Avoid taking Mefedrot MR 500mg/2mg Tablet with fluvoxamine and ciprofloxacin as it may cause adverse effects such as slurred speech, dizziness, weakness, confusion, low blood pressure, or drowsiness. You are advised not to take more than three doses of Mefedrot MR 500mg/2mg Tablet in a single day as too much of Mefedrot MR 500mg/2mg Tablet may cause liver damage. If you have low blood pressure or liver or kidney diseases, inform your doctor before taking Mefedrot MR 500mg/2mg Tablet.

Drug-Drug Interactions

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TizanidineZiprasidone
Critical
TizanidineFluvoxamine
Critical

Drug-Drug Interactions

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TizanidineZiprasidone
Critical
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
Co-administration of Mefedrot MR 500mg/2mg Tablet with Ziprasidone can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mefedrot MR 500mg/2mg Tablet with Ziprasidone is not recommended, as it can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
TizanidineFluvoxamine
Critical
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
Taking Fluvoxamine with Mefedrot MR 500mg/2mg Tablet it can increases the risk of side effects.

How to manage the interaction:
Although Fluvoxamine with Mefedrot MR 500mg/2mg Tablet is not recommended, but can be taken together if prescribed by a doctor. However, if you experience drowsiness, dizziness, low blood pressure, slurred speech, confusion, or severe weakness, contact your doctor immediately. Do not stop using any medications without consulting a doctor.
TizanidineCiprofloxacin
Critical
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
Coadministration of Ciprofloxacin and Mefedrot MR 500mg/2mg Tablet together can increase the risk of side effects.

How to manage the interaction:
Using Ciprofloxacin and Mefedrot MR 500mg/2mg Tablet together is avoided, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, weakness, sweating, or palpitations contact the doctor immediately. Do not discontinue any medications without consulting the doctor.
TizanidineSaquinavir
Critical
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
Combining Mefedrot MR 500mg/2mg Tablet with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Mefedrot MR 500mg/2mg Tablet with Saquinavir is not recommended, as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhoea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TizanidineDronedarone
Critical
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
Coadministration of Mefedrot MR 500mg/2mg Tablet with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Mefedrot MR 500mg/2mg Tablet with Dronedarone is generally avoided as it can result in an interaction, it can be taken when prescribed by a doctor. If you experience sudden dizziness, shortness of breath, palpitations, or chest pain, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TizanidineCisapride
Critical
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
Coadministration of Mefedrot MR 500mg/2mg Tablet with Cisapride can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Mefedrot MR 500mg/2mg Tablet with Cisapride is avoided as it can result in an interaction, it can be taken if your doctor has advised it. Contact your doctor immediately if you experience sudden dizziness, shortness of breath, palpitations, or vomiting. Do not discontinue any medications without consulting your doctor.
Mefenamic acidMeloxicam
Critical
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
Co-administration of Mefedrot MR 500mg/2mg Tablet with Meloxicam together can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mefedrot MR 500mg/2mg Tablet with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.
Mefenamic acidKetorolac
Critical
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
Coadministration of Mefedrot MR 500mg/2mg Tablet with Ketorolac can increase the risk or severity of gastric bleeding and ulcers.

How to manage the interaction:
Taking Mefedrot MR 500mg/2mg Tablet with Ketorolac together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
TizanidineHydrochlorothiazide
Severe
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
The combined use of Mefedrot MR 500mg/2mg Tablet and Hydrochlorothiazide can have additive effects in lowering your blood pressure.

How to manage the interaction:
Taking Mefedrot MR 500mg/2mg Tablet and Hydrochlorothiazide together can possibly result in an interaction, but they can be taken if advised by your doctor. However, if you experience any symptoms like headache, dizziness, lightheadedness, fainting, and changes in pulse or heart rate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
TizanidineIvabradine
Severe
How does the drug interact with Mefedrot MR 500mg/2mg Tablet:
Coadministration of Ivabradine with Mefedrot MR 500mg/2mg Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Ivabradine with Mefedrot MR 500mg/2mg Tablet together can result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Massages can also be helpful.
  • Avoid having too spicy and junk food and instead eat home-cooked food as it will help to lower contracting and make the job of the stomach easier.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes; instead, wear loose garments.
  • Rest well, and get plenty of sleep.
  • Stay hydrated, and drink plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS

Mefedrot MR 500mg/2mg Tablet Substitute

Substitutes safety advice
  • Mefcan TN 500mg/2mg Tablet

    6.30per tablet
  • Meftal MR Tablet 10's

    5.80per tablet
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Mefedrot MR 500mg/2mg Tablet as it may increase the risk of adverse effects.

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Pregnancy

Caution

Mefedrot MR 500mg/2mg Tablet belongs to pregnancy category C. Please consult your doctor before taking the Mefedrot MR 500mg/2mg Tablet if you are pregnant or planning for pregnancy. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown whether Mefedrot MR 500mg/2mg Tablet is excreted in human milk. Therefore, please consult a doctor if you are breastfeeding. Mefedrot MR 500mg/2mg Tablet is given to breastfeeding mothers only if the doctor thinks the benefits outweigh the risks.

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Driving

Caution

Mefedrot MR 500mg/2mg Tablet may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Mefedrot MR 500mg/2mg Tablet should not be given to children as safety and effectiveness were not established.

FAQs

Mefedrot MR 500mg/2mg Tablet is used to provide relief from abdominal cramps caused by the menstrual cycle.
Mefedrot MR 500mg/2mg Tablet is a combination drug that contains 'mefenamic acid' and 'Tizanidine.' Mefenamic acid works by blocking the effect of a chemical messenger in your body, which is responsible for causing pain. Tizanidine works in the centres of the spinal cord and brain. This helps relax the intestine or stomach muscles and stops muscle contractions. Collectively, both of them help to relieve pain, bloating, cramps, and discomfort caused.
Mefedrot MR 500mg/2mg Tablet is used to relieve menstrual (period) pain, premenstrual syndrome (PMS) symptoms, and management of excessively heavy periods. Take only as prescribed by the doctor.
You are not recommended to take Mefedrot MR 500mg/2mg Tablet with ciprofloxacin as Mefedrot MR 500mg/2mg Tablet contains Tizanidine. Co-administrating these two medicines may cause adverse effects such as slurred speech, dizziness, weakness, confusion, low blood pressure, and drowsiness. However, please consult a doctor before taking Mefedrot MR 500mg/2mg Tablet with other medicines.
Avoid taking Mefedrot MR 500mg/2mg Tablet if you have stomach ulcers as Mefedrot MR 500mg/2mg Tablet contains Mefenamine, which might increase the risk of stomach ulcers, perforation of the stomach and intestinal bleeding with higher doses.
Do not take Mefedrot MR 500mg/2mg Tablet if you are planning for pregnancy as Mefedrot MR 500mg/2mg Tablet might make it more difficult to get pregnant.
Diarrhoea might be a side-effect of Mefedrot MR 500mg/2mg Tablet. Drink plenty of fluids and eat food rich in fibre. Consult your doctor if you experience excessive diarrhoea or if you find blood in stools.

Country of origin

India
Other Info - ME53457

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