Mefedrot MR 500mg/2mg Tablet belongs to a group of NSAID (Non-Steroidal Anti-Inflammatory Drug) medicines used to provide relief from abdominal cramps caused before and during the menstrual cycle. Abdominal cramps are throbbing pains in the lower abdomen due to the menstrual cycle every month in females. In some females, the pain and discomfort caused due to menstruation are so severe that they have to take some medicine to lower the pain intensity.

Mefedrot MR 500mg/2mg Tablet is a combination drug that contains 'mefenamic acid' and 'Tizanidine.' Mefenamic acid works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes, that make another chemical, 'prostaglandins' (PG) which are responsible for causing pain. Tizanidine works on the centres of the spinal cord and brain. This helps relax the intestine or stomach muscles and stops muscle contractions. Collectively, both of them help to relieve pain, bloating, cramps, and discomfort caused.

Take Mefedrot MR 500mg/2mg Tablet as prescribed. Depending on your medical condition, you are advised to take Mefedrot MR 500mg/2mg Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience common side effects, such as abdominal pain, nausea, vomiting, diarrhoea, indigestion, weakness, dry mouth, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please inform your doctor if you are allergic to Mefedrot MR 500mg/2mg Tablet or other medicines. Mefedrot MR 500mg/2mg Tablet can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, and perforation of the stomach and intestines. Do not take Mefedrot MR 500mg/2mg Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Mefedrot MR 500mg/2mg Tablet may cause drowsiness and dizziness, so drive with caution. Mefedrot MR 500mg/2mg Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol and Mefedrot MR 500mg/2mg Tablet as it could lead to increased drowsiness and dizziness; it might also increase stomach bleeding risk. Do not take other painkillers with Mefedrot MR 500mg/2mg Tablet unless prescribed by the doctor. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Mefedrot MR 500mg/2mg Tablet is a combination drug that contains 'mefenamic acid' and 'Tizanidine.' Mefenamic acid belongs to a group of medicines called NSAID (Non-Steroidal Anti-Inflammatory Drug), used to relieve mild to moderate pain associated with period pain, symptoms of premenstrual syndrome (PMS), and management of excessively heavy periods. Mefedrot MR 500mg/2mg Tablet works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical, 'prostaglandins' (PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the COX enzymes' effect, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Tizanidine works in the centres of the spinal cord and brain. This helps relax the intestine or stomach muscles and stops muscle contractions. Collectively, both of them help to relieve pain, bloating, cramps, and discomfort caused.

• Abdominal pain 
• Nausea 
• Vomiting 
• Diarrhoea 
• Indigestion
• Heartburn
• Weakness
• Dryness in the mouth

Please inform your doctor if you are allergic to Mefedrot MR 500mg/2mg Tablet or other medicines. Mefedrot MR 500mg/2mg Tablet can increase the risk of fatal heart attack or stroke, gastrointestinal bleeding, ulceration, and perforation of the stomach and intestines. Do not take Mefedrot MR 500mg/2mg Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Mefedrot MR 500mg/2mg Tablet may cause drowsiness and dizziness, so drive with caution. Mefedrot MR 500mg/2mg Tablet should not be given to children as safety and efficacy have not been established. Avoid consuming alcohol and Mefedrot MR 500mg/2mg Tablet as it could lead to increased drowsiness and dizziness; it might also increase stomach bleeding risk. Do not take other painkillers with Mefedrot MR 500mg/2mg Tablet unless prescribed by the doctor. Keep your doctor informed about your health condition and medicines to rule out any side effects. Avoid taking Mefedrot MR 500mg/2mg Tablet with fluvoxamine and ciprofloxacin as it may cause adverse effects such as slurred speech, dizziness, weakness, confusion, low blood pressure, or drowsiness. You are advised not to take more than three doses of Mefedrot MR 500mg/2mg Tablet in a single day as too much of Mefedrot MR 500mg/2mg Tablet may cause liver damage. If you have low blood pressure or liver or kidney diseases, inform your doctor before taking Mefedrot MR 500mg/2mg Tablet.

Drug-Drug Interactions: Mefedrot MR 500mg/2mg Tablet may have interaction with pain killers (aspirin, ibuprofen, celecoxib, diclofenac, naproxen), anti-gout (probenecid), immunosuppressants (cyclosporine, tacrolimus), anticoagulants (warfarin, heparin), anti-rheumatoid (methotrexate), anti-HIV (zidovudine), anti-depressant (duloxetine, lithium, fluoxetine, sertraline), steroid medication (mifepristone), anti-allergic drugs (diphenhydramine, cetirizine), an anti-anxiety drug (alprazolam), sedative-hypnotic drug (zolpidem), bronchodilator (albuterol), antibiotic (ciprofloxacin).

Drug-Food Interactions: Avoid alcohol consumption while taking Mefedrot MR 500mg/2mg Tablet as it might cause increased dizziness and risk of stomach bleeding.

Drug-Disease Interactions: Mefedrot MR 500mg/2mg Tablet may have interactions with patients having peptic ulcers, bleeding disorders, asthma, fluid retention, gastrointestinal toxicity, rash, renal toxicity, thrombosis, anaemia, heart failure, liver toxicity, high blood pressure, platelet aggregation inhibition, and hyperkalemia (high potassium levels).

• ASPIRIN
• IBUPROFEN
• CELECOXIB
• DICLOFENAC
• NAPROXEN
• PROBENECID
• CYCLOSPORINE
• TACROLIMUS
• WARFARIN
• HEPARIN
• METHOTREXATE
• ZIDOVUDINE
• DULOXETINE
• LITHIUM
• FLUOXETINE
• SERTRALINE
• MIFEPRISTONE
• DIPHENHYDRAMINE
• CETIRIZINE
• ALPRAZOLAM
• ZOLPIDEM
• ALBUTEROL
• CIPROFLOXACIN

• Massages can also be helpful.
• Avoid having too spicy and junk food and instead eat home-cooked food as it will help to lower contracting and make the job of the stomach easier.
• Avoid freezing and hot temperatures.
• Avoid wearing tight-fitting clothes; instead, wear loose garments.
• Rest well, and get plenty of sleep.
• Stay hydrated, and drink plenty of water.

Regular blood tests are recommended to monitor liver functioning while taking Mefedrot MR 500mg/2mg Tablet.

Abdominal cramps: Abdominal cramps are the throbbing pains in the lower abdomen due to menstruation every month in females. Menstruation is the release of blood in females in the fertilization of the egg that does not take place. In some females, the pain and discomfort caused due to menstruation are so severe that they have to take some medicine to lower the pain intensity. It generally occurs one to two days before the menses and lasts till the day menses are over.