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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Medistat 0.5 mg Nasal Spray 5 ml is used to treat Seizure clusters (acute repetitive seizures). It contains Midazolam, which increases GABA activity (a chemical messenger in the brain). Thus, it suppresses the excessive and abnormal activity of nerve cells in the brain and controls Seizures. Common side effects of Medistat 0.5 mg Nasal Spray 5 ml are headache, drowsiness, runny nose, throat irritation, and nasal discomfort.
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Composition :

MIDAZOLAM-0.5MG

Manufacturer/Marketer :

Alteus Biogenics Pvt Ltd

Consume Type :

NASAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Medistat 0.5 mg Nasal Spray 5 ml

Medistat 0.5 mg Nasal Spray 5 ml belongs to a class of drugs called benzodiazepines used for the short-term treatment of seizure clusters. Seizure clusters are episodes of elevated seizure activity, defined as two or more seizures occurring within a 24-hour period. They are upsetting situations that can leave you feeling anxious, frustrated, or helpless.

Medistat 0.5 mg Nasal Spray 5 ml contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain). Thus, Medistat 0.5 mg Nasal Spray 5 ml suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Use Medistat 0.5 mg Nasal Spray 5 ml as prescribed and for the duration as your doctor has prescribed it for you based on your medical condition. Sometimes, it may cause side effects such as headache, drowsiness, runny nose, throat irritation, and nasal discomfort. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Midazolam or any other medicines, please tell your doctor. If you are pregnant, planning for pregnancy or are breastfeeding, please inform your doctor before taking Medistat 0.5 mg Nasal Spray 5 ml. Medistat 0.5 mg Nasal Spray 5 ml is not recommended for children below 12 years as the safety and effectiveness were not established. Avoid consumption of alcohol with Medistat 0.5 mg Nasal Spray 5 ml as it may cause increased drowsiness. Avoid driving or operating machinery until you know how Medistat 0.5 mg Nasal Spray 5 ml affects you. Avoid using Medistat 0.5 mg Nasal Spray 5 ml if you have acute narrow-angle glaucoma (eye problem). Do not take Medistat 0.5 mg Nasal Spray 5 ml with opioids until and unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma.

Uses of Medistat 0.5 mg Nasal Spray 5 ml

Treatment of Seizure clusters (acute repetitive seizures)

Directions for Use

Insert the tip of the bottle into a nostril while closing the other nostril and spray towards the sides of the nostril. Keep your head straight and breathe gently.

Medicinal Benefits

Medistat 0.5 mg Nasal Spray 5 ml contains Midazolam used to treat acute (sudden) repetitive fits. Medistat 0.5 mg Nasal Spray 5 ml increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thus, it suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

How Medistat 0.5 mg Nasal Spray 5 ml Works

Medistat 0.5 mg Nasal Spray 5 ml contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain). Thus, Medistat 0.5 mg Nasal Spray 5 ml suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Medistat 0.5 mg Nasal Spray 5 ml

  • Headache
  • Drowsiness
  • Runny nose
  • Throat irritation
  • Nasal discomfort

What if I have taken an overdose of Medistat 0.5 mg Nasal Spray 5 ml

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Medistat 0.5 mg Nasal Spray 5 ml may include agitation, changes in patterns and rhythms of speech, confusion, drowsiness, dullness, feeling of sluggishness, irritability, lack of coordination, loss of consciousness, loss of strength or energy, nervousness, nightmares, problems with muscle control or coordination, relaxed and calm feeling, restlessness, shakiness and unsteady walk, sleepiness, slurred speech, talkativeness, tiredness, trouble speaking, unsteadiness, unusual excitement, unusual weak feeling, and weakness. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are allergic to Midazolam or any other medicines, please tell your doctor. If you are pregnant, planning for pregnancy, or breastfeeding, please inform your doctor before using Medistat 0.5 mg Nasal Spray 5 ml. Medistat 0.5 mg Nasal Spray 5 ml is not recommended for children below 12 years as the safety and effectiveness were not established. Avoid consumption of alcohol with Medistat 0.5 mg Nasal Spray 5 ml as it may cause drowsiness. Avoid driving or operating machinery until you know how Medistat 0.5 mg Nasal Spray 5 ml affects you. Avoid using Medistat 0.5 mg Nasal Spray 5 ml if you have acute narrow-angle glaucoma (eye problem). Do not take Medistat 0.5 mg Nasal Spray 5 ml with opioids until and unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma. Get medical help immediately if you experience unusually excessive sleepiness or shallow or slowed breathing while using Medistat 0.5 mg Nasal Spray 5 ml.

Drug-Drug Interactions

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MidazolamCobicistat
Critical
MidazolamSodium oxybate
Critical

Drug-Drug Interactions

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MidazolamCobicistat
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Cobicistat and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Cobicistat and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamSodium oxybate
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Sodium oxybate and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Sodium oxybate and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamBoceprevir
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Boceprevir and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Boceprevir and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamCeritinib
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Taking ceritinib and Medistat 0.5 mg Nasal Spray 5 ml may significantly increase the blood levels and effects of Medistat 0.5 mg Nasal Spray 5 ml.

How to manage the interaction:
Although taking ceritinib and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MidazolamIdelalisib
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Idelalisib and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Idelalisib and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamMifepristone
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Co-administration of Mifepristone and Medistat 0.5 mg Nasal Spray 5 ml may significantly increase Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects, which increases the risk of side effects.

How to manage the interaction:
Although taking Mifepristone and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamTelaprevir
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Telaprevir and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Telaprevir and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamAmprenavir
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Co-administration of Amprenavir and Medistat 0.5 mg Nasal Spray 5 ml may significantly increase the blood levels and effects of Medistat 0.5 mg Nasal Spray 5 ml.

How to manage the interaction:
Although taking Amprenavir along with Medistat 0.5 mg Nasal Spray 5 ml can possibly lead to an interaction, they can be taken if a doctor advices them. In case of increased or prolonged drowsiness and breathing difficulties, consult a doctor. Do not stop using any medications without talking to a doctor.
MidazolamDelavirdine
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
The negative effects of Medistat 0.5 mg Nasal Spray 5 ml and Delavirdine might be increased when used together.

How to manage the interaction:
Taking Medistat 0.5 mg Nasal Spray 5 ml together Delavirdine may cause an interaction. They can, however, be taken if a doctor has prescribed them. Consult a doctor if you have any of the following symptoms: excessive sleepiness, dizziness, confusion, or weak or rapid breathing. Do not discontinue any medication without consulting a doctor.
MidazolamIndinavir
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Indinavir and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Indinavir and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise and maintain a healthy body weight.
  • Maintain a diet rich in fruits, vegetables and whole grains. Avoid fried foods, high-fat dairy products, pastries and processed foods, as they may worsen anxiety.
  • Follow a regular sleep pattern. Do not take a nap during day time.
  • Avoid watching tv and using mobiles or laptops just before bedtime.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Medistat 0.5 mg Nasal Spray 5 ml Substitute

Substitutes safety advice
  • Insed Nasal Spray 5 ml

    77.08per tablet
  • Midasiz 0.5 Nasal Spray 50 MDI

    7.88per tablet
  • Midaspray 0.5mg Nasal Spray 50 MDI

    6.41per tablet
  • Midacip Nasal Spray 5 ml

    73.71per tablet
  • Midazom 0.5 Nasal Spray 50 mdi

    8.05per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol with Medistat 0.5 mg Nasal Spray 5 ml as it may increase drowsiness.

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Pregnancy

Caution

If you are pregnant or planning for pregnancy, inform your doctor before using Medistat 0.5 mg Nasal Spray 5 ml. Babies born to mothers receiving Medistat 0.5 mg Nasal Spray 5 ml late in pregnancy may be at risk of feeding or breathing problems, withdrawal symptoms or dangerously low body temperature.

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Breast Feeding

Caution

Medistat 0.5 mg Nasal Spray 5 ml may be excreted in breast milk and may harm your baby. Therefore, discuss with your doctor the best way to feed your baby if you use Medistat 0.5 mg Nasal Spray 5 ml.

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Driving

Caution

Avoid driving or operating machinery until you know how Medistat 0.5 mg Nasal Spray 5 ml affects you.

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Liver

Consult your doctor

If you have liver problems, consult your doctor before using Medistat 0.5 mg Nasal Spray 5 ml.

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Kidney

Consult your doctor

If you have kidney diseases/conditions, consult your doctor before using Medistat 0.5 mg Nasal Spray 5 ml.

bannner image

Children

Unsafe

Medistat 0.5 mg Nasal Spray 5 ml is not recommended for children below 12 years as the safety and effectiveness were not established.

FAQs

Medistat 0.5 mg Nasal Spray 5 ml is used to treat Seizure clusters (acute repetitive seizures).
Medistat 0.5 mg Nasal Spray 5 ml contains Midazolam, which works by increasing the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thereby preventing fits by stabilizing the electrical activity of nerve cells in the brain.
If the seizure cluster continues after 10 minutes of the first dose, you can use the second dose of Medistat 0.5 mg Nasal Spray 5 ml if advised by your doctor. However, the second dose should be given in the other nostril. Do not use more than two doses to treat a seizure cluster.
You are not recommended to take Medistat 0.5 mg Nasal Spray 5 ml with opioids, alcohol or other central nervous system depressants as it may cause breathing problems, severe drowsiness or coma. Therefore, please consult your doctor before taking Medistat 0.5 mg Nasal Spray 5 ml with any other medicines.
You are not recommended to stop using Medistat 0.5 mg Nasal Spray 5 ml suddenly without consulting your doctor as it may cause withdrawal symptoms such as hallucinations, nervousness, shaking, muscle pain or cramps. Therefore, use Medistat 0.5 mg Nasal Spray 5 ml for as long as your doctor has prescribed it, and if you experience any difficulty while using Medistat 0.5 mg Nasal Spray 5 ml, please consult your doctor so that the dose may be reduced gradually.
Yes, Medistat 0.5 mg Nasal Spray 5 ml may cause physical dependence if used for prolonged periods. Therefore, use Medistat 0.5 mg Nasal Spray 5 ml only in the dose and for the duration as advised by your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Alteus Biogenics Pvt. Ltd., 14-B Dover Lane, Kolkata - 700029, WB, India.
Other Info - MED0864

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