Mario 25mg Tablet belongs to a class of drugs called 'antidepressants' used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder. OCD is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions), leading to repetitive behaviours (compulsions). Depression is a mood disorder associated with symptoms such as sadness and the inability to sleep properly or enjoy life as you used to do. Panic or anxiety disorder is linked to anxiety with sudden feelings of unnecessary fear or worries even when there is no danger in reality.

Mario 25mg Tablet contains Clomipramine, which works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Mario 25mg Tablet helps relieve depression, lighten the mood and relieve anxiety symptoms such as fear and panic.

Take Mario 25mg Tablet with food as prescribed by your doctor and swallow whole with a glass of water. Do not break, crush or chew it. Your doctor will advise you how often you take Mario 25mg Tablet based on your medical condition. Some people may experience dizziness, headache, drowsiness, dry mouth, nausea, weight gain, increased sweating, constipation, shaking, blurred vision, erectile dysfunction or difficulty in urination. Most of these side effects of Mario 25mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Mario 25mg Tablet or any other medicines, please tell your doctor. Mario 25mg Tablet is not recommended for children below 17 years of age. Avoid taking Mario 25mg Tablet if you are pregnant, as it may cause harm to the foetus. Avoid breastfeeding while taking Mario 25mg Tablet as it may be excreted in human milk and cause adverse effects in the baby. If you have any self-harming or suicidal thoughts before taking Mario 25mg Tablet, inform your doctor as they may worsen in the initial days of taking Mario 25mg Tablet.

Mario 25mg Tablet contains Clomipramine, an antidepressant used to treat obsessive-compulsive disorder (OCD), depression, and panic disorder. Mario 25mg Tablet increases the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Mario 25mg Tablet helps in relieving depression, lightening the mood and relieving anxiety symptoms such as fear and panic. Mario 25mg Tablet, in combination with other medicines, may be used to treat cataplexy (a disorder that causes muscle weakness), which usually affects people suffering from narcolepsy (uncontrollable sleepiness during daytime).

• Dizziness
• Headache
• Drowsiness
• Dry mouth
• Nausea
• Weight gain
• Increased sweating
• Constipation
• Shaking
• Blurred vision
• Erectile dysfunction
• Difficulty in urination

If you are allergic to Mario 25mg Tablet or any other medicines, please tell your doctor. Mario 25mg Tablet is not recommended for children below 17 years of age. Avoid taking Mario 25mg Tablet if you are pregnant as it may cause harm to the fetus. Avoid breastfeeding while taking Mario 25mg Tablet as Mario 25mg Tablet may be excreted in human milk and cause adverse effects in the baby. Therefore, please consult a doctor if you are pregnant, planning for pregnancy, or breastfeeding. Mario 25mg Tablet should be used with caution in elderly patients as there is an increased risk of low sodium levels in the blood.  If you have any self-harming or suicidal thoughts before taking Mario 25mg Tablet, inform your doctor as they may worsen in the initial days of taking Mario 25mg Tablet. Do not take Mario 25mg Tablet with monoamine oxidase inhibitors (MAOIs) such as moclobemide, tranylcypromine and phenelzine used to treat depression as it may cause severe adverse effects. Also, avoid taking Mario 25mg Tablet with buprenorphine as it may cause a serious life-threatening condition. If you have fits, low blood pressure, mania, glaucoma, difficulty in urination, a blood disorder, hyperthyroidism (overactive thyroid gland), severe constipation, pheochromocytoma (tumor of the adrenal gland), low potassium levels in blood, kidney, liver, or heart problems, inform your doctor before taking Mario 25mg Tablet.

Drug-Drug Interaction: Mario 25mg Tablet may have interaction with antiparkinson drugs (selegiline, levodopa), antibiotics (pentamidine, rifampicin), antipsychotic drugs (pimozide), opioid pain killers (buprenorphine, morphine, codeine), blood thinners (warfarin), monoamine oxidase inhibitors used to treat depression (moclobemide, phenelzine, tranylcypromine), antidepressants (fluoxetine, fluvoxamine, amitriptyline, sertraline, venlafaxine, dothiepin, maprotiline), antimanic drug (lithium), anticonvulsants  (phenytoin, carbamazepine, phenobarbital, valproate), painkillers (aspirin), antacids (cimetidine), water tablets (furosemide), anti-allergic drug (terfenadine), medicines used to treat high blood pressure (betanidine, reserpine, guanethidine, clonidine), heart-related medicines (isoprenaline, amiodarone, quinidine, disopyramide, procainamide, epinephrine, diltiazem, verapamil), HIV drugs (ritonavir, indinavir).

Drug-Food Interaction: Avoid grapefruit, grapefruit juice, and cranberry juice as they may interact with Mario 25mg Tablet and increase the levels of Mario 25mg Tablet in the body, leading to more adverse effects. Also, avoid intake of alcohol while taking Mario 25mg Tablet as it may increase side effects such as drowsiness, blurred vision, or confusion.

Drug-Disease Interaction: If you have fits, low blood pressure, mania, glaucoma, difficulty in urination, a blood disorder, hyperthyroidism (overactive thyroid gland), severe constipation, pheochromocytoma (tumour of the adrenal gland), low potassium levels in the blood, kidney, liver or heart problems, inform your doctor before taking Mario 25mg Tablet.

• SELEGILINE
• LEVODOPA
• PENTAMIDINE
• RIFAMPICIN
• PIMOZIDE
• BUPRENORPHINE
• MORPHINE
• CODEINE
• WARFARIN
• MOCLOBEMIDE
• PHENELZINE
• TRANYLCYPROMINE
• FLUVOXAMINE
• FLUOXETINE
• AMITRIPTYLINE
• SERTRALINE
• VENLAFAXINE
• DOTHIEPIN
• LITHIUM
• PHENYTOIN
• CARBAMAZEPINE
• PHENOBARBITAL
• VALPROATE
• ASPIRIN
• CIMETIDINE
• FUROSEMIDE
• TERFENADINE
• RESERPINE
• GUANETHIDINE
• CLONIDINE
• ISOPRENALINE
• AMIODARONE
• QUINIDINE
• DISOPYRAMIDE
• PROCAINAMIDE
• EPINEPHRINE
• DILTIAZEM
• VERAPAMIL
• RITONAVIR
• INDINAVIR
• MAPROTILINE
• BETANIDINE

• Maintain a diet rich in fruits, vegetables, and whole grains. Avoid fried foods, high-fat dairy products, pastries, and processed foods as they may worsen anxiety. Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.

• Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in proper maintenance of neurotransmitters.

• Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.

• Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosting self-esteem, and providing restful sleep.

• Perform meditation and yoga. This helps in relieving stress and provides relaxation.

• Regularly attend therapy sessions.

• Follow a regular sleep pattern to improve the amount and quality of sleep you get.

• Avoid smoking and alcohol consumption.

• Regular blood tests are recommended while taking Mario 25mg Tablet to monitor liver and heart functioning.

• Regular dental check-ups are also advised while taking Mario 25mg Tablet as it may cause dry mouth, which may increase the risk of tooth decay.

Obsessive-compulsive disorder (OCD): It is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions) leading to repetitive behaviours (compulsions).

Depression: It is a mood disorder associated with symptoms such as sadness, inability to sleep properly, or enjoy life as you used to do. Depression can also influence some chronic health conditions and relationships. The exact cause of depression is unknown, but it may be associated with mental problems, trauma, family history, drug use, and medical conditions.

Panic disorder: It is linked to anxiety with sudden feelings of fear when there is no danger in reality.