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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Clofranil 25 Tablet is used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder. OCD is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions), leading to repetitive behaviours (compulsions). It contains Clomipramine, which works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain involved in regulating mood, behaviour and emotions. Thereby, relieves depression, lighten the mood and relieve anxiety symptoms such as fear and panic. It may cause side effects such as dizziness, headache, drowsiness, dry mouth, nausea, weight gain, increased sweating, constipation, shaking, blurred vision, erectile dysfunction or difficulty in urination.Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

CLOMIPRAMINE-25MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Clofranil 25 Tablet

Clofranil 25 Tablet belongs to a class of drugs called 'antidepressants' used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder. OCD is a mental disorder with symptoms such as excessive thoughts or ideas (obsessions), leading to repetitive behaviours (compulsions). Depression is a mood disorder associated with symptoms such as sadness and the inability to sleep properly or enjoy life as you used to do. Panic or anxiety disorder is linked to anxiety with sudden feelings of unnecessary fear or worries even when there is no danger in reality.

Clofranil 25 Tablet contains Clomipramine, which works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Clofranil 25 Tablet helps relieve depression, lighten the mood and relieve anxiety symptoms such as fear and panic.

Take Clofranil 25 Tablet with food as prescribed by your doctor and swallow whole with a glass of water. Do not break, crush or chew it. Your doctor will advise you how often you take Clofranil 25 Tablet based on your medical condition. Some people may experience dizziness, headache, drowsiness, dry mouth, nausea, weight gain, increased sweating, constipation, shaking, blurred vision, erectile dysfunction or difficulty in urination. Most of these side effects of Clofranil 25 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Clofranil 25 Tablet or any other medicines, please tell your doctor. Clofranil 25 Tablet is not recommended for children below 17 years of age. Avoid taking Clofranil 25 Tablet if you are pregnant, as it may cause harm to the foetus. Avoid breastfeeding while taking Clofranil 25 Tablet as it may be excreted in human milk and cause adverse effects in the baby. If you have any self-harming or suicidal thoughts before taking Clofranil 25 Tablet , inform your doctor as they may worsen in the initial days of taking Clofranil 25 Tablet .

Uses of Clofranil 25 Tablet

Treatment of Obsessive-compulsive disorder (OCD), Depression, Panic disorder, Anxiety disorder.

Directions for Use

Take Clofranil 25 Tablet with food or as advised by a doctor. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Medicinal Benefits

Clofranil 25 Tablet contains Clomipramine, an antidepressant used to treat obsessive-compulsive disorder (OCD), depression, and panic disorder. Clofranil 25 Tablet increases the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Clofranil 25 Tablet helps in relieving depression, lightening the mood and relieving anxiety symptoms such as fear and panic. Clofranil 25 Tablet , in combination with other medicines, may be used to treat cataplexy (a disorder that causes muscle weakness), which usually affects people suffering from narcolepsy (uncontrollable sleepiness during daytime).

How Clofranil 25 Tablet Works

Clofranil 25 Tablet contains Clomipramine, which works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain, which is involved in regulating mood, behaviour, and emotions. Thereby, Clofranil 25 Tablet helps relieve depression, lighten the mood and relieve anxiety symptoms such as fear and panic.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Clofranil 25 Tablet

  • Dizziness
  • Headache
  • Drowsiness
  • Dry mouth
  • Nausea
  • Weight gain
  • Increased sweating
  • Constipation
  • Shaking
  • Blurred vision
  • Erectile dysfunction
  • Difficulty in urination

What if I have taken an overdose of Clofranil 25 Tablet

Do not take more than the prescribed dose of Clofranil 25 Tablet as it may cause overdose. The symptoms of overdose include irregular heartbeats, low blood pressure, fits, drowsiness, muscle stiffness, restlessness, sweating, shortness of breath, dilated pupil or a decrease or absence of urine production. Severe overdose may lead to coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

If you are allergic to Clofranil 25 Tablet or any other medicines, please tell your doctor. Clofranil 25 Tablet is not recommended for children below 17 years of age. Avoid taking Clofranil 25 Tablet if you are pregnant as it may cause harm to the fetus. Avoid breastfeeding while taking Clofranil 25 Tablet as Clofranil 25 Tablet may be excreted in human milk and cause adverse effects in the baby. Therefore, please consult a doctor if you are pregnant, planning for pregnancy, or breastfeeding. Clofranil 25 Tablet should be used with caution in elderly patients as there is an increased risk of low sodium levels in the blood.  If you have any self-harming or suicidal thoughts before taking Clofranil 25 Tablet , inform your doctor as they may worsen in the initial days of taking Clofranil 25 Tablet . Do not take Clofranil 25 Tablet with monoamine oxidase inhibitors (MAOIs) such as moclobemide, tranylcypromine and phenelzine used to treat depression as it may cause severe adverse effects. Also, avoid taking Clofranil 25 Tablet with buprenorphine as it may cause a serious life-threatening condition. If you have fits, low blood pressure, mania, glaucoma, difficulty in urination, a blood disorder, hyperthyroidism (overactive thyroid gland), severe constipation, pheochromocytoma (tumor of the adrenal gland), low potassium levels in blood, kidney, liver, or heart problems, inform your doctor before taking Clofranil 25 Tablet .

Drug-Drug Interactions

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ClomipramineBepridil
Critical
ClomipramineSafinamide
Critical

Drug-Drug Interactions

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ClomipramineBepridil
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
When Clofranil 25 Tablet 10's is taken with Bepridil, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet 10's and Bepridil, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineSafinamide
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
Taking Safinamide with Clofranil 25 Tablet 10's can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Clofranil 25 Tablet 10's with Safinamide can possibly result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
ClomipramineSaquinavir
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
When Clofranil 25 Tablet 10's is taken with Saquinavir, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet 10's and Saquinavir, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineTranylcypromine
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
Taking tranylcypromine with Clofranil 25 Tablet 10's can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Clofranil 25 Tablet 10's with Tranylcypromine is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
ClomipramineProcarbazine
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
When Clofranil 25 Tablet 10's is taken with Procarbazine, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet 10's and Procarbazine, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipramineMoclobemide
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
When Clofranil 25 Tablet 10's is taken with Moclobemide, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet 10's and Moclobemide, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-contact a doctor immediately. Do not stop using any medications without a doctor's advice.
ClomipramineZiprasidone
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
Coadministration of Clofranil 25 Tablet 10's with Ziprasidone can increase the risk of irregular heat rhythm.

How to manage the interaction:
Taking Clofranil 25 Tablet 10's with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
ClomipramineSelegiline
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
Co-administration of Selegiline can increase the effects of Clofranil 25 Tablet 10's on serotonin levels (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Selegiline with Clofranil 25 Tablet 10's together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
ClomipramineThioridazine
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
When Thioridazine is taken with Clofranil 25 Tablet 10's, can increase the side effects.

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet 10's and Thioridazine, but it can be taken if prescribed by a doctor. If you notice any of these signs - like extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, fainting, seizure (convulsions), call a doctor right away. Do not stop using any medications without a doctor's advice.
ClomipraminePimozide
Critical
How does the drug interact with Clofranil 25 Tablet 10's:
When Clofranil 25 Tablet 10's is taken with Pimozide, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Clofranil 25 Tablet 10's and Pimozide, but it can be taken if prescribed by a doctor. If you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a diet rich in fruits, vegetables, and whole grains. Avoid fried foods, high-fat dairy products, pastries, and processed foods as they may worsen anxiety. Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.

  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in proper maintenance of neurotransmitters.

  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.

  • Exercising helps in the production of the body’s natural antidepressants. It also helps in relieving stress, improving mood, boosting self-esteem, and providing restful sleep.

  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.

  • Regularly attend therapy sessions.

  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.

  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIDEPRESSANT

Clofranil 25 Tablet Substitute

Substitutes safety advice
  • Clonil-25 Tablet 15's

    6.27per tablet
  • Clonil-25 Tablet 10's

    5.58per tablet
  • Clomip 25 mg Tablet 10's

    4.97per tablet
  • D.D. Pramine 25 Tablet 10's

    by AYUR

    6.26per tablet
  • Prumpin 25 mg Tablet 10's

    6.21per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol with Clofranil 25 Tablet as it may increase the risk of adverse effects such as drowsiness, blurred vision, or confusion.

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Pregnancy

Unsafe

Clofranil 25 Tablet is a Category C pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby. Therefore, please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Clofranil 25 Tablet as Clofranil 25 Tablet may be excreted in human milk and cause adverse effects in the baby. Therefore, please consult a doctor if you are a breastfeeding mother.

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Driving

Unsafe

Clofranil 25 Tablet may cause dizziness, tiredness, confusion, difficulty in concentrating or blurred vision. Therefore, avoid driving if you experience any of these symptoms after taking Clofranil 25 Tablet .

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Liver

Caution

Take Clofranil 25 Tablet with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

If you have any concerns regarding the use of Clofranil 25 Tablet in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Clofranil 25 Tablet is not recommended for children below 17 years of age, as the safety and effectiveness were not established. Please consult a doctor before using Clofranil 25 Tablet .

FAQs

Clofranil 25 Tablet is used to treat obsessive-compulsive disorder (OCD), depression, panic and anxiety disorder.
Clofranil 25 Tablet contains Clomipramine that works by increasing the activity of serotonin and noradrenaline (chemical messengers) in the brain that are involved in regulating mood, behavior, and emotions. Thereby, Clofranil 25 Tablet helps in relieving depression, lighten the mood and relieve anxiety symptoms such as fear and panic.
Yes, Clofranil 25 Tablet may be used to treat panic disorder by reducing fear. However, please consult a doctor before using Clofranil 25 Tablet .
You are not recommended to take Clofranil 25 Tablet with buprenorphine as co-administration of these medicines may lead to a severe condition called ‘serotonin syndrome’ and cause symptoms such as blurred vision, stomach cramps, fits, diarrhea, hallucination, extreme changes in blood pressure, confusion, excessive sweating, increased heart rate, fever, shivering or shaking, tremor, incoordination, muscle spasm or stiffness. However, please consult a doctor before taking Clofranil 25 Tablet with other medicines.
Yes, Clofranil 25 Tablet may cause self-harming or suicidal thoughts especially in patients aged less than 25 years or who have a history of self-harming thoughts. Therefore, please consult a doctor immediately if you experience any such thoughts while taking Clofranil 25 Tablet .
Clofranil 25 Tablet may cause impotence (inability to maintain an erection) in males and may decrease sexual desire (libido) in both men and women. However, if you experience any such problems while taking Clofranil 25 Tablet , please consult a doctor immediately.
It takes about 2 weeks or longer usually for Clofranil 25 Tablet to work. However, it is recommended to use Clofranil 25 Tablet for as long as your doctor has prescribed it for you.
Yes, Clofranil 25 Tablet may cause weight gain due to an increase in the appetite. Regular exercise and a healthy diet are recommended while taking Clofranil 25 Tablet to maintain proper body weight. However, if you notice any major changes in weight, please consult a doctor.
Yes, Clofranil 25 Tablet is safe if used as prescribed by your doctor. Do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects persist or worsen.
Clofranil 25 Tablet may cause side effects such as drowsiness, dizziness, constipation, erectile dysfunction, difficulty in urination, and dry mouth. If these side effects persist or worsen, please consult your doctor.
If you take an overdose of Clofranil 25 Tablet , you may experience symptoms such as irregular heartbeats, low blood pressure, fits, drowsiness, muscle stiffness, restlessness, sweating, shortness of breath, dilated pupil or a decrease or absence of urine production. Severe overdose may lead to coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.
No, do not stop taking Clofranil 25 Tablet without consulting your doctor as discontinuing suddenly may worsen your condition and also cause withdrawal symptoms such as vomiting, nausea, dizziness, headache, weakness, fever, sleep problems, and irritability. Therefore, take Clofranil 25 Tablet for duration advised by your doctor for best results. If you any of these side effects are bothering you, contact your doctor.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - CLO0024

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