How does Macrozide-1000 Tablet work?

Macrozide-1000 Tablet contains 'Pyrazinamide.' It is bactericidal and works by stopping the growth of Mycobacterium tuberculosis, a bacteria that causes tuberculosis.

In which conditions should I avoid Macrozide-1000 Tablet?

Macrozide-1000 Tablet is not recommended for use in the medical history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and undergoing dialysis treatment. Please let your doctor know if you have any other medical problems before starting Macrozide-1000 Tablet.

I am undergoing vaccination for typhoid this week, can I use Macrozide-1000 Tablet?

Macrozide-1000 Tablet can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Macrozide-1000 Tablet if you are undergoing any vaccinations.

Can I take Macrozide-1000 Tablet with food?

It is advised to take Macrozide-1000 Tablet 30 minutes before food or 2 hours after food. Please consult your doctor for more information.

Why should I avoid Macrozide-1000 Tablet in gout?

Macrozide-1000 Tablet gets converted in the body to Pyrazinoic acid that blocks the excretion of urates (salt form of uric acid) by the kidneys. Increased blood levels of uric acid (hyperuricemia) causes pain, swelling, redness and stiffness in joints (gout). Hence, Macrozide-1000 Tablet should be avoided if you have a history of gout.

What is Macrozide-1000 Tablet?

Macrozide-1000 Tablet is an antibiotic that belongs to the group of anti-tuberculosis (TB) drugs. It is used for the treatment of tuberculosis which is an infectious disease that mainly affects lungs but can also impact other parts of the body.

Is Macrozide-1000 Tablet bactericidal?

Yes, Macrozide-1000 Tablet is bactericidal. It works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria that is responsible for causing tuberculosis.

How does Macrozide-1000 Tablet cause hyperuricemia and gout?

Macrozide-1000 Tablet causes hyperuricemia and gout by inhibiting the renal excretion of uric acid, which can lead to the precipitation or worsening of gout. It should be used with caution in individuals with hyperuricemia or a history of gout.

What are the side effects of Macrozide-1000 Tablet?

The side effects of Macrozide-1000 Tablet include nausea, vomiting, muscle/joint pain, nausea and loss of appetite. Consult the doctor if any of these symptoms persist or worsen.

Macrozide-1000 Tablet 6's

Written By Veda Maddala , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Macrozide-1000 Tablet is used to treat and prevent tuberculosis. It contains Pyrazinamide which converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria. It may cause common side effects such as muscle/joint pain, nausea, vomiting and loss of appetite. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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About Macrozide-1000 Tablet

Macrozide-1000 Tablet is used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. Macrozide-1000 Tablet does not work against infections caused by the virus, such as the common cold and flu.

Macrozide-1000 Tablet contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of Macrozide-1000 Tablet include muscle/joint pain, nausea, vomiting and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Macrozide-1000 Tablet. Please tell your doctor if you are allergic to Macrozide-1000 Tablet or its components. Inform your doctor beforehand if you have a history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and are undergoing dialysis. It is essential to let your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol along with Macrozide-1000 Tablet as it might lead to liver problems.

Uses of Macrozide-1000 Tablet

Treatment of Tuberculosis (TB).

Directions for Use

Swallow Macrozide-1000 Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Macrozide-1000 Tablet contains 'Pyrazinamide', which is used to treat and prevent tuberculosis. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary to survive the TB bacteria. It is usually given in alone or combined with other antitubercular agents to treat tuberculosis.

How Macrozide-1000 Tablet Works

Macrozide-1000 Tablet contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Macrozide-1000 Tablet

Muscle/joint pain
Nausea
Vomiting
Loss of appetite
Hepatitis, liver dysfunction

What if I have taken an overdose of Macrozide-1000 Tablet

Do not take more than the prescribed dose of Macrozide-1000 Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Brief your medical history to the doctor if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and are undergoing dialysis treatment before starting Macrozide-1000 Tablet. Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since Macrozide-1000 Tablet may affect vaccine's activity. Please consult your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother before starting Macrozide-1000 Tablet. Avoid consuming alcohol along with Macrozide-1000 Tablet as it might lead to liver problems. Store Macrozide-1000 Tablet below 25°C away from direct sunlight.

Drug-Drug Interactions

PyrazinamideLomitapide

Severe

PyrazinamideRifampicin

Severe

Drug-Drug Interactions

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PyrazinamideLomitapide

Severe

How does the drug interact with Macrozide-1000 Tablet 6's:
Co-administration of Lomitapide with Macrozide-1000 Tablet 6's may increase in the risk or severity of liver problems.

How to manage the interaction:
Although taking Lomitapide and Macrozide-1000 Tablet 6's together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.

PyrazinamideRifampicin

Severe

How does the drug interact with Macrozide-1000 Tablet 6's:
Taking rifampicin together with Macrozide-1000 Tablet 6's can cause liver problems.

How to manage the interaction:
Although there is an interaction between Macrozide-1000 Tablet 6's and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience fever, rash, less desire to eat, nausea, vomiting, fatigue, right upper abdominal pain, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

PyrazinamideLeflunomide

Severe

How does the drug interact with Macrozide-1000 Tablet 6's:
Co-administration of leflunomide with Macrozide-1000 Tablet 6's may increase the risk or severity of liver problems.

How to manage the interaction:
Although taking Leflunomide and Macrozide-1000 Tablet 6's together can cause an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

PyrazinamideKetoconazole

Severe

How does the drug interact with Macrozide-1000 Tablet 6's:
Co-administration of Ketoconazole with Macrozide-1000 Tablet 6's may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Macrozide-1000 Tablet 6's together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.

PyrazinamideTeriflunomide

Severe

How does the drug interact with Macrozide-1000 Tablet 6's:
Co-administration of Teriflunomide with Macrozide-1000 Tablet 6's may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Teriflunomide and Macrozide-1000 Tablet 6's together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
Foods rich in vitamin C, such as kiwi, broccoli and bell pepper, help improve the immune system.
Avoid processed and fried foods.
Warm ginger tea or warm soup can help in providing relief from the cough.
Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.
Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS

Macrozide-1000 Tablet Substitute

Pirazide-1000mg Tablet 10's
by AYUR
₹8.36per tablet
Pyzina 1000 Tablet 10's
₹9.90per tablet
P-Zide 1000 Tablet 10's
by AYUR
₹11.00per tablet

Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Macrozide-1000 Tablet. Alcohol intake, along with Macrozide-1000 Tablet, may cause increased liver damage. Please consult your doctor for more information.

Pregnancy

Caution

Macrozide-1000 Tablet should be used with caution during pregnancy. Please consult your doctor before taking Macrozide-1000 Tablet if you are pregnant or planning to conceive.

Breast Feeding

Caution

Macrozide-1000 Tablet is not recommended for use during breastfeeding since it is excreted into the breast milk and may harm a nursing baby. Please consult your doctor if you are a breastfeeding mother.

Driving

Caution

It is not known if Macrozide-1000 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to drive or operate machinery.

Liver

Caution

Macrozide-1000 Tablet is not recommended in patients with severe liver damage. Please consult your doctor since Macrozide-1000 Tablet should be used with caution in patients with liver impairment/liver disease. Regular monitoring of the liver with liver function tests is also advised.

Kidney

Caution

Please consult your doctor since Macrozide-1000 Tablet should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.

Children

Caution

Macrozide-1000 Tablet is recommended in children below 12 years of age only after doctor's advice.

FAQs

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.

Other Info - MAC0038

Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Macrozide-1000 Tablet Substitute

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