Macrozide-500 Tablet is used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. Macrozide-500 Tablet does not work against infections caused by the virus, such as the common cold and flu.

Macrozide-500 Tablet contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of Macrozide-500 Tablet include muscle/joint pain, nausea, vomiting and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Macrozide-500 Tablet. Please tell your doctor if you are allergic to Macrozide-500 Tablet or its components. Inform your doctor beforehand if you have a history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and are undergoing dialysis. It is essential to let your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol along with Macrozide-500 Tablet as it might lead to liver problems.

Macrozide-500 Tablet contains 'Pyrazinamide', which is used to treat and prevent tuberculosis. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary to survive the TB bacteria. It is usually given in alone or combined with other antitubercular agents to treat tuberculosis.

• Muscle/joint pain

• Nausea

• Vomiting

• Loss of appetite

• Hepatitis, liver dysfunction

Brief your medical history to the doctor if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and are undergoing dialysis treatment before starting Macrozide-500 Tablet. Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since Macrozide-500 Tablet may affect vaccine's activity. Please consult your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother before starting Macrozide-500 Tablet. Avoid consuming alcohol along with Macrozide-500 Tablet as it might lead to liver problems. Store Macrozide-500 Tablet below 25°C away from direct sunlight.

Drug-Drug Interaction: Macrozide-500 Tablet may interact with gout medicine (probenecid, sulfinpyrazone) and oral contraceptives.

Drug-Food Interaction: Do not consume alcohol while taking Macrozide-500 Tablet as it could lead to increased liver damage.

Drug-Disease Interaction: Before using Macrozide-500 Tablet, let your doctor know if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and undergoing dialysis treatment.

• PROBENECID
• SULFINPYRAZONE

• Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.

• Foods rich in vitamin C, such as kiwi, broccoli and bell pepper, help improve the immune system.

• Avoid processed and fried foods.

• Warm ginger tea or warm soup can help in providing relief from the cough.

• Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.

• Quit smoking and avoid alcohol consumption.

• Let your doctor know that you are taking Macrozide-500 Tablet if you are undergoing any medical tests.

• Your doctor may advise liver enzymes and uric acid levels tests before you start treatment to make sure you can safely take Macrozide-500 Tablet.

• It is advised to undergo liver functioning tests to keep a check on your liver function.

• Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Macrozide-500 Tablet as it may make hormonal contraceptives such as the pill less effective.

Tuberculosis (TB): Tuberculosis is an infectious disease that affects the lungs, but it could also spread to other body parts such as kidneys, brain, spine and bone marrow. Tuberculosis is caused by a bacteria named Mycobacterium tuberculosis. It is a contagious disease which can spread to others through small droplets released into the air by a person suffering from tuberculosis. Symptoms include a cough that lasts for a few weeks, pain while coughing or normal breathing, unexplained fatigue, fever, night sweats, and loss of appetite and weight. People who smoke or consume alcohol, and people diagnosed with HIV and immune system problems are more likely at risk of developing active TB.