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  3. Macprox DP 500 Tablet 10's

Macprox DP 500 Tablet 10's, Pack of 10 TabletS
Macprox DP 500 Tablet 10's, Pack of 10 TabletS
Macprox DP 500 Tablet 10's, Pack of 10 TabletS
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Veda Maddala , M Pharmacy

MACPROX DP 500MG TABLET is used to treat migraine headaches. Besides this, it can also be used to reduce pain in rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). It contains Naproxen and Domperidone, which works by reducing certain chemical substances (prostaglandins) that cause pain and swelling. Also, it prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre in the brain. It may cause common side effects such as dryness of the mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

DOMPERIDONE-10MG + NAPROXEN-500MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About MACPROX DP 500MG TABLET

MACPROX DP 500MG TABLET belongs to the group of medications called analgesics. It treats migraine headaches. Besides this, it can also be used to reduce pain in rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). Migraine is a condition characterized by intense headaches. Pain is a symptom that occurs due to various underlying conditions.

MACPROX DP 500MG TABLET is a combination of two drugs: Naproxen and Domperidone. Naproxen works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that produces certain chemical substances such as prostaglandins that cause pain and swelling. Domperidone is an antiemetic agent which prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain.

Take MACPROX DP 500MG TABLET as prescribed by your doctor. You are advised to take MACPROX DP 500MG TABLET for as long as your doctor has prescribed it for you based on your medical condition. Common side-effects of MACPROX DP 500MG TABLET are dryness of the mouth, abdominal pain, constipation, drowsiness, dizziness, visual disturbances, hearing problems and headache. Consult your doctor if you feel any discomfort.

Before taking the MACPROX DP 500MG TABLET , let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. If you are pregnant or breastfeeding, please tell your doctor so that your doctor will weigh the benefits and any potential risks before prescribing it to you. Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to pain killers. Patients with age above 65 years, pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ;ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases or bleeding disorders should use MACPROX DP 500MG TABLET only when prescribed by a doctor.

Uses of MACPROX DP 500MG TABLET

MACPROX DP 500MG TABLET is used in the treatment of migraine headache, pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain). The detailed uses of MACPROX DP 500MG TABLET are as follows:
•Effective Pain Relief: MACPROX DP 500MG TABLET is commonly prescribed to alleviate moderate to severe pain, including headaches, dental pain, menstrual cramps, and postoperative discomfort. It works by blocking the production of chemicals responsible for inflammation and pain.
•Powerful Anti-inflammatory Action: With its active ingredient naproxen, MACPROX DP 500MG TABLET helps reduce inflammation associated with conditions like osteoarthritis and rheumatoid arthritis, providing relief from joint pain and swelling.
•Fever Management: MACPROX DP 500MG TABLET is also effective in lowering fever across various conditions, offering relief and aiding the body's recovery process.
•Relief for Muscle Pain: Whether due to exercise, strains, or injuries, MACPROX DP 500MG TABLET can help alleviate muscle pain, improving comfort and mobility.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

MACPROX DP 500MG TABLET is a combination of naproxen and domperidone. Naproxen is an anti-inflammatory (reduce inflammation) and analgesic (reduce pain) agent. It inhibits the synthesis of prostaglandins, which are inflammatory mediators, thereby reducing pain and inflammation. Domperidone acts by enhancing gastric peristalsis (movements) to empty stomach. Easy movement of food through the stomach helps in relieving nausea and vomiting. It blocks the dopamine receptors present at the chemoreceptor trigger zone (responsible for regulating nausea and vomiting).

How MACPROX DP 500MG TABLET Works

MACPROX DP 500MG TABLET is a combination of two drugs: Naproxen and Domperidone. Naproxen works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that produces certain chemical substances such as prostaglandins that cause pain and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of MACPROX DP 500MG TABLET

  • Abdominal pain

  • Constipation

  • Indigestion

  • Flatulence

  • Dry mouth

  • Glossitis (inflammation of the tongue)

  • Diarrhoea

  • Drowsiness

  • Dizziness

  • Headache

  • Vision problems

  • Hearing problems

What if I have taken an overdose of MACPROX DP 500MG TABLET

Do not take more than the prescribed dose of MACPROX DP 500MG TABLET as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Inform your doctor if you are taking any of the anticoagulants (warfarin), other NSAIDs (ibuprofen, ketorolac), corticosteroids (prednisolone), antidepressants (citalopram, fluoxetine, paroxetine, duloxetine, venlafaxine), or any other dietary or herbal supplements. Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as naproxen may increase the risk of heart attack or stroke and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, older in age, alcoholic or have multiple diseases. The risk of having a heart attack increases if you smoke, or you or your family has a history of heart failure, stroke, or hypertension. Call for medical help immediately, if you experience chest pain, shortness of breath, blood in the stool or dark stools, heartburn, or any other abnormal signs.

Drug-Drug Interactions

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NaproxenKetorolac
Critical
NaproxenCidofovir
Critical

Drug-Drug Interactions

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NaproxenKetorolac
Critical
How does the drug interact with Macprox DP 500 Tablet:
Coadministration of Ketorolac with Macprox DP 500 Tablet can increase the risk or severity of gastric bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac with Macprox DP 500 Tablet together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
NaproxenCidofovir
Critical
How does the drug interact with Macprox DP 500 Tablet:
Taking cidofovir with Macprox DP 500 Tablet may increase the risk or severity of kidney problems

How to manage the interaction:
Taking Macprox DP 500 Tablet with Cidofovir is generally avoided as it can possibly result in an interaction. You should seek immediate medical attention if you develop signs and symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
NaproxenMeloxicam
Critical
How does the drug interact with Macprox DP 500 Tablet:
Co-administration of Macprox DP 500 Tablet with Meloxicam can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Meloxicam with Macprox DP 500 Tablet is not advised as it can possibly result in an interaction, it can be taken if your doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness.
DomperidoneClarithromycin
Severe
How does the drug interact with Macprox DP 500 Tablet:
Coadministration of Macprox DP 500 Tablet with Clarithromycin can increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Macprox DP 500 Tablet and Clarithromycin, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
DomperidoneHalofantrine
Severe
How does the drug interact with Macprox DP 500 Tablet:
Coadministration of Macprox DP 500 Tablet with Halofantrine can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Macprox DP 500 Tablet and Halofantrine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneMizolastine
Severe
How does the drug interact with Macprox DP 500 Tablet:
Combining Mizolastine with Macprox DP 500 Tablet can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although taking Macprox DP 500 Tablet and Mizolastine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DomperidoneCitalopram
Severe
How does the drug interact with Macprox DP 500 Tablet:
Coadministration of Macprox DP 500 Tablet with Citalopram can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Macprox DP 500 Tablet and Citalopram together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneNefazodone
Severe
How does the drug interact with Macprox DP 500 Tablet:
Coadministration of Macprox DP 500 Tablet with Nefazodone can increase the blood levels of Macprox DP 500 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Macprox DP 500 Tablet and Nefazodone, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneRitonavir
Severe
How does the drug interact with Macprox DP 500 Tablet:
Coadministration of Macprox DP 500 Tablet with Ritonavir can increase the blood levels of Macprox DP 500 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Macprox DP 500 Tablet and Ritonavir, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneToremifene
Severe
How does the drug interact with Macprox DP 500 Tablet:
Coadministration of Macprox DP 500 Tablet with Toremifene can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Macprox DP 500 Tablet and Toremifene together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Drink plenty of fluids to avoid gastrointestinal problems.

  • Avoid triggers that can increase your migraine headache.

  • Take enough rest.

  • Acupuncture, massage and physical therapy may also be helpful.

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listen to soothing music.

  • Avoid smoking and alcohol consumption.

  • Performing yoga may also help in improving joint flexibility and pain management.

  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.

Habit Forming

No

Therapeutic Class

ANALGESICS

MACPROX DP 500MG TABLET Substitute

Substitutes safety advice

  • Naxdom 500 Tablet 15's

    by Others

    ₹10.26per tablet

  • Napra-D 500 Tablet 10's

    by Others

    ₹11.61per tablet

  • Xenadom 500 Tablet 10's

    by Others

    ₹10.17per tablet

  • Domstal NP-500 mg Tablet 10's

    by AYUR

    ₹7.92per tablet

  • Naprodom 500 Tablet 10's

    by Others

    ₹10.13per tablet

Product Substitutes

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Alcohol

Caution

It is advised not to take alcohol as MACPROX DP 500MG TABLET can cause dizziness or drowsiness.

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Pregnancy

Caution

MACPROX DP 500MG TABLET should be used in pregnant women only if clinically needed, and the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

MACPROX DP 500MG TABLET should be used in breastfeeding mothers only if the benefits outweigh the risks.

bannner image

Driving

Unsafe

It is unsafe to drive after taking MACPROX DP 500MG TABLET as it impacts your ability to drive or operate machinery.

bannner image

Liver

Caution

Limited information was available for the use of MACPROX DP 500MG TABLET in patients suffering from liver impairment. Please consult your doctor if you have any concerns regarding using MACPROX DP 500MG TABLET in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Kidney

Caution

Limited information was available for the use of MACPROX DP 500MG TABLET in patients suffering from kidney impairment. Please consult your doctor if you have any concerns regarding using MACPROX DP 500MG TABLET in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Caution

MACPROX DP 500MG TABLET should be used in children below 12 years of age only when prescribed by a child specialist.

FAQs

MACPROX DP 500MG TABLET is used to treat migraine headaches, pain associated with conditions like rheumatoid arthritis, gout and dysmenorrhea (menstrual pain).

Naproxen works by inhibiting the cyclo-oxygenase (COX) enzyme in the body, which creates chemical compounds such as prostaglandins, which induce pain and swelling. Domperidone is an antiemetic that blocks certain receptors (such as dopamine and serotonin) that stimulate the brain's vomiting centre (chemoreceptor trigger zone - CTZ).

MACPROX DP 500MG TABLET cannot permanently cure migraine. It can provide relief from pain and headache.

MACPROX DP 500MG TABLET on prolonged or frequent use can cause liver or kidney problems. Therefore, it should be only used for a duration as prescribed by the doctor.

Arthritis is a chronic condition of joints with pain and inflammation. MACPROX DP 500MG TABLET does not cure arthritis but relieves symptoms of arthritis-like joint pain, swelling and stiffness.

Yes, MACPROX DP 500MG TABLET may increase the risk of heart problems such as heart attack and stroke, especially when used in high doses or for a prolonged duration. It is advised to inform your doctor if you have any of these conditions or have a history of heart problems or stroke before taking the MACPROX DP 500MG TABLET .

Dry mouth may be caused by Domperidone in MACPROX DP 500MG TABLET . Chew a sugar-free sweet or sugar-free gum.

Yes, MACPROX DP 500MG TABLET is a painkiller. It contains Naproxen, a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce pain and inflammation, while Domperidone helps manage nausea, which is common in migraines. Besides this, it can also be used to reduce pain in gout, rheumatoid arthritis, and dysmenorrhea (menstrual pain).

MACPROX DP 500MG TABLET usually starts working within 30-60 minutes after oral intake. However, the exact time may vary based on individual response and medical condition. Always consult your doctor for personalized guidance and proper usage.

To ensure safe and effective treatment, it's helpful to know that MACPROX DP 500MG TABLET may have a potential impact on blood pressure, but with proper monitoring, you can minimize risks. By working closely with your healthcare provider, you can enjoy the benefits of MACPROX DP 500MG TABLET while maintaining healthy blood pressure. Open communication with your doctor is key to a successful treatment plan.

MACPROX DP 500MG TABLET is a combination medication that pairs a nonsteroidal anti-inflammatory drug (NSAID) with an antiemetic and prokinetic agent. This combination helps relieve pain and prevents nausea, improving overall comfort.

The side effects of MACPROX DP 500MG TABLET include dryness of the mouth, constipation, abdominal pain, drowsiness, dizziness, visual disturbances, hearing problems and headache. Most of these side effects do not require medical attention and gradually resolve over time. However, please consult your doctor if any symptoms persist or worsen.

You should consult your doctor before stopping MACPROX DP 500MG TABLET , even if your migraine is relieved. It is generally used as needed for migraine attacks, but stopping suddenly without medical advice may not be ideal. Follow the dosage instructions provided by your doctor and complete the entire treatment course to treat your medical condition effectively.

Yes, MACPROX DP 500MG TABLET may cause diarrhoea, a common side effect. If you experience this symptom, drink plenty of water to stay hydrated, take probiotics, avoid spicy, fatty, or dairy foods, and limit caffeine intake to manage diarrhoea.

To ensure a safe and effective treatment experience with MACPROX DP 500MG TABLET , it's essential to be aware of certain contraindications. By knowing these guidelines, you can minimize risks and maximize benefits. MACPROX DP 500MG TABLET is not recommended for individuals with NSAID hypersensitivity, NSAID-induced asthma, or severe allergic reactions, as well as during pregnancy, especially after 30 weeks, and in cases of severe liver impairment, heart conditions, or significant electrolyte disturbances. Additionally, caution is advised for patients with gastrointestinal bleeding, obstruction, or prolactin-releasing pituitary tumours and when taking QT-prolonging drugs or potent CYP3A4 inhibitors. By working closely with your healthcare provider, you can navigate these guidelines and enjoy a successful treatment outcome.

Yes, prolonged or frequent use of MACPROX DP 500MG TABLET may cause kidney damage as it contains Naproxen, an NSAID, which can affect kidney function, especially with long-term use. Therefore, it should only be used as a doctor prescribes to minimize the risk.

No, you should not take a higher than the recommended dose of MACPROX DP 500MG TABLET , as it may cause serious side effects like irregular heartbeat, drowsiness, extreme tiredness, nausea, stomach pain, and breathing difficulties. If you accidentally take more than the prescribed dose, seek immediate medical attention.

MACPROX DP 500MG TABLET should be stored in a cool, dry place away from sunlight. Keep it out of sight and reach of children.

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0330

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Author Details

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Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Apr 14, 2025 | 11:24 AM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a681029.html
  2. https://www.drugs.com/uk/domperidone-10mg-film-coated-tablets-leaflet.html
  3. https://www.nhs.uk/medicines/naproxen/
  4. https://www.nhs.uk/medicines/domperidone/
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