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Written By ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Nov 30, 2024 | 3:18 PM IST

Lomcap 40 Capsule is used to treat Brain Tumors and Hodgkin's Disease. It contains Lomustine, which belongs to the alkylating agent’s class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. Common side effects of this medication may include nausea, vomiting, headache, visual disturbances, blindness, disorientation, lack of energy, loss of control, and difficulty talking.

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Prescription drug

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Composition

LOMUSTINE-40MG

Manufacturer/Marketer

GLS Pharma Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Lomcap 40 Capsule

Lomcap 40 Capsule is an anti-cancer medicine used in the treatment of brain tumors. A tumor is defined as the formation of solid mass tissue due to the abnormal growth of cells. Lomcap 40 Capsule is used in the treatment of primary and metastatic brain tumors along with appropriate surgical or radiotherapeutic procedures. A brain tumor is a serious condition where the cells (cancerous or non-cancerous) grow abnormally in the brain. Lomcap 40 Capsule is also used in the treatment of Hodgkin’s Disease when used in combination with other chemotherapies.

Lomcap 40 Capsule contains Lomustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

Lomcap 40 Capsule may cause certain side effects, such as nausea, vomiting, headache, visual disturbances, blindness, disorientation, lack of energy, loss of control, and difficulty talking. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Lomcap 40 Capsule should be taken as prescribed by your doctor. Do not take more than the recommended dose of medicine.

Lomcap 40 Capsule should be avoided if you are allergic to it or any other components present in it. Lomcap 40 Capsule may cause pulmonary toxicity, delayed myelosuppression, pulmonary fibrosis, nephrotoxicity, and hepatotoxicity in some patients. Hence, careful monitoring should be done during the entire treatment. This medicine is known to cause embryo-fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. It is unknown whether Lomcap 40 Capsule is suitable for children's use. Hence, please consult your doctor or paediatrician for information on children's use. Breastfeeding should be discontinued in nursing mothers during the treatment. Lomcap 40 Capsule should only be taken once in 6 weeks as taking more than the recommended dose can cause serious life-threatening problems. Hence, talk to your doctor or pharmacist before starting the treatment.

Uses of Lomcap 40 Capsule

Lomcap 40 Capsule is used in the treatment of Brain Tumors and Hodgkin's Disease

Medicinal Benefits

Lomcap 40 Capsule contains Lomustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

Directions for Use

Take Lomcap 40 Capsule as prescribed by your doctor. Do not take more than the prescribed dose of medicine, as it can cause fatal toxicity. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine. This medicine should be taken on an empty stomach 30 minutes before food or at least 2 hours after food. For children who cannot swallow the medicine as a whole, open the capsule and add the powder to a very small amount (1 teaspoon) of applesauce/ice cream and make your child eat all the mixture.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lomcap 40 Capsule

  • Nausea
  • Dizziness
  • Headache
  • Vomiting
  • Lack of energy
  • Visual disturbances
  • Loss of balance
  • Difficulty talking
  • Decreased platelet count
  • Blindness

Drug Warnings

Lomcap 40 Capsule should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. This medicine can cause a severe decrease in the number of blood cells in your bone marrow. A decrease in the number of blood cells in your body may cause certain symptoms and increase the risk of developing a serious infection or bleeding. Before administration, inform your doctor if you have liver/kidney disease, blood disorders, or respiratory conditions. Lomcap 40 Capsule may cause pulmonary toxicity, delayed myelosuppression, pulmonary fibrosis, secondary malignancies, nephrotoxicity, and hepatotoxicity in some patients. Hence, careful monitoring should be done during the entire treatment. Lomcap 40 Capsule is known to cause embryo-fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. Breastfeeding should be discontinued in nursing mothers during the treatment. Lomcap 40 Capsule should be given in children only if prescribed by the paediatrician. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects. Lomcap 40 Capsule may cause visual disturbances as a side effect. Hence, avoid driving vehicles or operating machines until you can see clearly. Lomcap 40 Capsule should be taken once in 6 weeks only. Hence, talk to your doctor or pharmacist before starting the treatment.

Drug Interactions

Drug-Drug Interactions: Lomcap 40 Capsule may interact with live vaccines, monoclonal antibodies (certolizumab, baricitinib, adalimumab ), antifungal drugs (ketoconazole), antipsychotic drug (clozapine), antirheumatic drug (leflunomide), etc.

Drug-Food Interactions: Avoid alcohol consumption and smoking. 

Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease and pulmonary disorders before taking Lomcap 40 Capsule .

Drug-Drug Interactions Checker List

  • CHOLERA VACCINE
  • TYPHOID VACCINE
  • ZIDOVUDINE
  • ABACAVIR

Habit Forming

No

Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Special Advise

  • A blood test should be performed, such as LFT, RFT, and PFT, to check for liver/kidney function and pulmonary function.
  • Weekly blood tests should be done during the treatment course to check for CBC (Complete blood count).
  • Lomcap 40 Capsule should not be taken more than the prescribed dose as it can lead to fatal toxicities and death.
  • Lomcap 40 Capsule should always be taken on an empty stomach only to avoid nausea.
  • The patient's stool, urine and vomit should be discarded carefully by the caregiver. Gloves should be worn to avoid any contamination.

Disease/Condition Glossary

Brain Tumors: A tumor is defined as the formation of solid mass tissue due to the abnormal growth of cells. A brain tumor is a serious condition where the cells (cancerous or non-cancerous) grow abnormally in the brain. There are different types of brain tumors which can be either benign (non-cancerous) or malignant (cancerous). Lomcap 40 Capsule is used in the treatment of primary (a tumor that starts in any part of the brain) and metastatic (cancer cells which spread to other organs of the body) brain tumors.

Hodgkin’s Disease: Hodgkin’s disease or lymphoma is a blood cancer of a certain type of cells called WBCs, specifically lymphocytes. Lymphocytes normally help control infection and maintain the body's normal immunity. However, in a cancerous state, there is an abnormal multiplication of these blood cells, causing many problems such as fatigue, fever, loss of appetite, itching, night sweats and lymph node swelling.

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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Lomcap 40 Capsule to prevent serious adverse effects.

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Pregnancy

Unsafe

Lomcap 40 Capsule is not recommended for use in pregnancy as it may harm your fetus. If you are pregnant or planning pregnancy, inform your doctor before taking Lomcap 40 Capsule .

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Breast Feeding

Unsafe

Avoid breastfeeding your child while on treatment with Lomcap 40 Capsule as it causes serious side effects to the baby.

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Driving

Unsafe

Lomcap 40 Capsule may cause visual disturbances as a side effect. Avoid driving vehicles or operating machines until you are alert.

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Liver

Caution

Lomcap 40 Capsule may cause hepatotoxicity. If you have a pre-existing or a history of liver disease, inform your doctor before taking Lomcap 40 Capsule . Your liver function should be monitored carefully before, during and after the treatment with Lomcap 40 Capsule .

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Kidney

Caution

Lomcap 40 Capsule and its metabolites are known to be largely eliminated via the kidney, and the risk of adverse responses to this medicine may be higher in patients with impaired renal function. It may cause nephrotoxicity with progressive renal failure and a decrease in kidney size. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor before taking Lomcap 40 Capsule .

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Children

Caution

Please consult a doctor. Your child's doctor may recommend this medicine based on the age, body weight and disease condition of your child.

Country of origin

India

Manufacturer/Marketer address

F-30, Phase-1, Okhla Industrial Estate, New Delhi - 110020, INDIA
Other Info - LOM0114

FAQs

Lomcap 40 Capsule is used to treat Brain Tumors and Hodgkin's Disease.
Lomcap 40 Capsule contains Lomustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.
Lomcap 40 Capsule may cause or worsen pulmonary toxicity, myelosuppression, nephrotoxicity and hepatotoxicity. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any adverse effects/interactions.
Lomcap 40 Capsule is effective in treating brain tumours and Hodgkin's lymphoma (a rare type of blood cancer that affects the lymphatic system). However, its effectiveness can vary depending on the type and stage of cancer, how the body responds to the medication, and whether it is used alone or in combination with other anti-cancer drugs. Always follow your doctor's instructions, as proper dosing and monitoring are crucial for maximizing its effectiveness.
Lomcap 40 Capsule does not work immediately. It may take several weeks or months to see the full effect of the treatment as the drug gradually slows the growth of cancer cells. Your doctor will monitor your progress and adjust your treatment plan accordingly.
Lomcap 40 Capsule has a long half-life, typically 16 to 48 hours, meaning it can remain in your body for several days. However, its effects can last longer, as it works in the body for weeks.
If you miss a dose of Lomcap 40 Capsule , take it as soon as you remember unless it is almost time for your next dose. In that case, skip the missed dose and take your next dose at the usual time. Do not take two doses at once to make up for a missed dose. Always follow your doctor's instructions for dosing.
Lomcap 40 Capsule may cause common side effects, such as nausea, vomiting, headache, visual disturbances, blindness, disorientation, lack of energy, loss of control, and difficulty talking in some individuals. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Before taking Lomcap 40 Capsule , it's important to share your medical history and current medications with your doctor. If you have any allergies, liver or kidney problems, or breathing issues, be sure to let them know. Lomcap 40 Capsule can lower your blood count, making you more prone to infections or bleeding, and may cause vision problems, so be careful when driving or operating machinery. Additionally, if you're pregnant or breastfeeding, inform your doctor, and children should only take Lomcap 40 Capsule under a paediatrician's care. Typically taken every 6 weeks, be sure to consult your doctor or pharmacist before starting treatment.
Yes, women can use Lomcap 40 Capsule only if recommended by a doctor. Lomcap 40 Capsule is a chemotherapy drug, and its use may require special considerations for women, particularly those who are pregnant, breastfeeding, or planning to become pregnant. This is because it can harm the developing foetus or be passed to the baby through breast milk. Always consult with your doctor before using Lomcap 40 Capsule . Your doctor will evaluate the benefits and risks before prescribing it and may monitor you for any side effects.

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