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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 12:38 PM IST
Lazid E Kit is used to treat HIV infection. It works by inhibiting the reverse transcriptase enzyme which is required for viral reproduction. In some cases, this medicine may cause side effects such as headache, tiredness, dizziness, drowsiness, vomiting, diarrhoea, insomnia, muscle damage, and low red blood cells. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Prescription drug

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Prescription drug
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Manufacturer/Marketer

Emcure Pharmaceuticals Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Lazid E Kit

Lazid E Kit belongs to the class of medications called ‘antiretroviral agents’ used to treat HIV infection. HIV is a virus that attacks the immune cells of the body leading to decreased immunity. It spreads through body fluids such as semen, vaginal fluid and blood. Symptoms include fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat that usually last for days to several weeks.

Lazid E Kit is a combination of three medicines: Efavirenz, zidovudine, and lamivudine. These drugs belong to a group of medicines called nucleoside analogue reverse transcriptase inhibitors. They work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. This effect helps to inhibit viral replication.

You should take this medicine exactly as prescribed by the doctor. Lazid E Kit may cause side effects such as headache, tiredness, dizziness, drowsiness, vomiting, diarrhea, insomnia, nightmare, muscle damage, and anemia (low number of red blood cells). Inform your doctor if any of these side effects persist or get worse.

It is not recommended to take Lazid E Kit if you are allergic to any contents of it. Before taking Lazid E Kit, inform your doctor if you have any liver disease, hepatitis B or C (liver infections), a history of mental illness, or are seriously overweight and have kidney disease. Inform your doctor if you are pregnant or breastfeeding. Lazid E Kit should not be given to children below 2 years of age. Lazid E Kit should be used with caution in elderly patients. Alcohol consumption may increase the risk of side effects. Lazid E Kit may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of Lazid E Kit

Treatment of HIV infection

Medicinal Benefits

Lazid E Kit belongs to the group of medicines called antiretroviral therapy (ART). Lazid E Kit contains efavirenz, zidovudine and lamivudine. These drugs belong to a group of medicines called nucleoside analogue reverse transcriptase inhibitors. They work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. Thereby preventing viral replication and controlling the infection. It helps in improving the quality of life of a patient with HIV.

 

Directions for Use

Take Lazid E Kit with food or after a meal as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lazid E Kit

  • Headache
  • Nausea
  • Dizziness
  • Drowsiness
  • Vomiting
  • Diarrhea
  • Insomnia
  • Muscle damage
  • Anemia

Drug Warnings

Inform your doctor if you develop persistent diarrhea or vomiting, as it may affect the effectiveness of Lazid E Kit. Lazid E Kit may cause pancreatitis (inflammation of the pancreas), so inform your doctor if you develop symptoms such as nausea (feeling sick), vomiting, or stomach pain. Lazid E Kit may lead to opportunistic infections (infections that occur frequently or severely in patients with weak immune systems), so inform your doctor immediately if you experience symptoms of infection such as muscle weakness, weakness beginning in the hands and feet that progress towards the trunk, palpitations (pounding heartbeat), and tremors. Lazid E Kit may destroy bone leading to symptoms such as joint stiffness or pain. It may also cause muscle pain, tenderness, or weakness. Lazid E Kit may also cause dizziness and abnormal heartbeat. Inform your doctor immediately if you notice any significant changes in the electrocardiogram (ECG). Do not take Lazid E Kit if you have severe liver disease, a slow heartbeat, or severe heart disease, a very low red blood cell count (anemia) or a very low white blood cell count (neutropenia). Speak with your doctor about the precautions to follow to avoid infecting other people as one can still pass on HIV while on this medicine, although the risk is somewhat lowered by antiretroviral therapy; it can spread through sexual contact with a person who already has the infection, or by transfer of infected blood. Lazid E Kit does not cure HIV infection. Lazid E Kit can make hormonal contraceptives less effective or less likely to work. So, use other effective methods for contraception, including a barrier form (cervical cap, condom, diaphragm, or contraceptive sponge) to prevent pregnancy while on Lazid E Kit and for at least 12 weeks after stopping treatment as advised by your doctor. Do not breast-feed while taking this medicine. Also, do not take Lazid E Kit with other medicines such as stavudine, used to treat HIV infection, ribavirin or ganciclovir to treat viral infections, rifampicin to treat bacterial infections, bepridil (used to treat heart disease), cisapride (used to treat heartburn), methadone (used to treat opiate addiction), St. John’s wort (Hypericum perforatum) (a herbal remedy used for depression and anxiety), flecainide, metoprolol (used to treat irregular heartbeat). Lazid E Kit is not recommended in pregnancy as could harm the unborn baby or cause birth defects. You may need frequent medical tests while on Lazid E Kit.

Drug Interactions

Drug-Drug Interactions:  Doxorubicin (medicine for cancer), ribavirin (used to treat chronic hepatitis C), stavudine(medication used to prevent and treat HIV/AIDS), emtricitabine (used to treat HIV infection), cladribine (used to treat hairy cell leukemia), bepridil (used to treat heart disease), cisapride (used to treat heartburn), methadone (used to treat opiate addiction), clomipramine (used to treat certain mental conditions).

Drug-Food Interactions: Lazid E Kit may have interaction with St.John’s wort (herbal supplement used to treat depression). Avoid smoking and alcohol consumption while on this medication.

Drug-Disease Interactions: Lazid E Kit should not be used in patients with liver disease, hepatitis B or C (liver infections), mental illness or psychosis, heart disease.

Drug-Drug Interactions Checker List

  • DOXORUBICIN
  • RIBAVIRIN
  • STAVUDINE
  • CLADRIBINE
  • BEPRIDIL
  • CISAPRIDE
  • METHADONE
  • CLOMIPRAMINE
  • EMTRICITABINE

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy and balanced diet. Eat vitamin and nutrient-rich food such as dark green, yellow, orange and red vegetables, and fruit as it helps to boost your immune system. Option for lean protein and whole grains.
  • Avoid eating raw meat and eggs. Consume properly boiled and cooked meat, poultry, or seafood.
  • Eat bland and low-fat foods and avoid spicy or oily foods if you experience nausea or vomiting.
  • Try to reduce emotional and physical stress by spending time with family or whatever makes you happy.
  • Drink more fluids and avoid alcoholic beverages to prevent dehydration. 
  • Wash your hands properly before and after eating.
  • Make sure you sleep at least 8 hours a day.

Special Advise

  • Lazid E Kit may still develop infections or other illnesses associated with HIV infection or AIDS. So, people taking Lazid E Kit should be carefully monitored throughout the treatment.
  • You can still infect other people while taking Lazid E Kit. So, use necessary precautions to avoid infecting others.
  • Lazid E Kit may cause abnormal liver function tests. So, regular monitoring of liver function is necessary while taking this medicine.

Disease/Condition Glossary

HIV (human immunodeficiency virus) is a virus that attacks the immune system, making the individual susceptible to other infections or illnesses. People with HIV experience flu-like symptoms such as fever, chills, rash, night sweats, muscle aches, tiredness, and sore throat. These symptoms usually last for days to several weeks. It spreads through body fluids such as semen, vaginal fluid and blood. If left untreated, this condition can lead to AIDS (Acquired Immunodeficiency Syndrome). It is a life-long condition and there is no definite cure for it.  However, it can be controlled by treating with antiretroviral agents.

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Alcohol

Caution

Consumption of alcohol may increase the risk of side-effects.

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Pregnancy

Caution

Lazid E Kit should be used with caution in pregnant women. It is given only if clinically needed and when benefits outweigh the risk. It can harm the unborn baby or cause birth defects if taken during pregnancy.

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Breast Feeding

Caution

If Lazid E Kit is prescribed during breastfeeding, the doctor may advise you to stop breastfeeding as this medicine can pass into breastmilk.

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Driving

Caution

Lazid E Kit may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Lazid E Kit should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Lazid E Kit should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Caution

Lazid E Kit is not recommended for use in children below 2 years. In children above 2 years of age, dose adjustments may be necessary.

Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - LAZ0023

Author Details

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FAQs

Lazid E Kit is used to treat HIV infection.
Lazid E Kit is a combination of three medicines: Efavirenz, zidovudine, and lamivudine. These three drugs work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. Thereby preventing viral replication and controlling the infection.
Lazid E Kit may cause side-effects such as abnormal dreams, difficulty concentrating, dizziness, blurred vision, whistling, ringing, aching muscles, difficulty in sleeping, hair loss, cough, feeling breathless. Inform your doctor if any of these side-effects persist or get worse.
Lazid E Kit doesn’t cure HIV infection. However, it helps to control the disease and prevent opportunistic infections.
Lazid E Kit may cause lactic acidosis (excess of lactic acid in the blood), a rare but a severe side effect, especially in women who are very obese. However, if you experience stomach pain, vomiting or nausea while taking Lazid E Kit, please consult a doctor immediately.
No, Lazid E Kit should be taken in the dose and duration as advised by the doctor. If you take it in more than the recommended dose, it might cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor.
If you miss a dose of Lazid E Kit, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
Do not stop taking Lazid E Kit without talking to your doctor. If you suddenly stop taking Lazid E Kit, you may experience confusion, fever, mental state changes or severe muscle stiffness. Your doctor will probably decrease your dose gradually depending upon your disease condition.

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