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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Ketgen Tablet is an antifungal medicine used in the treatment of fungal infections such as blastomycosis, coccidioidomycosis, paracoccidioidomycosis, and histoplasmosis (lung infection caused by Histoplasma fungus). This medicine works by inhibiting the growth and multiplication of fungal cells that are responsible for the growth of infection-causing fungi.
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Composition :

KETOCONAZOLE-200MG

Manufacturer/Marketer :

Genees Pharmaceutical Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Ketgen Tablet

Ketgen Tablet belongs to a class of drugs called antifungals indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus). It is used only when other effective antifungal therapies are not available or tolerated and if potential benefits outweigh potential risks.

Ketgen Tablet contains Ketoconazole which works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

Take Ketgen Tablet as prescribed. Your doctor will advise you on how often you need to take Ketgen Tablet based on your medical condition. Some people may experience headache, nausea, stomach pain, and diarrhoea. Most of these side effects of Ketgen Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

If you are allergic to Ketoconazole or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, inform your doctor before taking Ketgen Tablet . Avoid breastfeeding while taking Ketgen Tablet as it may be excreted in breast milk. You are recommended to avoid alcohol consumption whilst on treatment with Ketgen Tablet . Ketgen Tablet is not recommended for children below 2 years of age. For children above 2 years, it is recommended to use only if the doctor has determined that the benefits outweigh the risks.

Uses of Ketgen Tablet

Treatment of Systemic fungal infections

Directions for Use

Take Ketgen Tablet with food to avoid stomach upset or take it as advised by the doctor. Swallow the whole tablet/capsule with a glass of water. Do not break, crush or chew it.

Medicinal Benefits

Ketgen Tablet is an antifungal used to treat severe fungal infections. It is used only when other effective antifungal therapies are not available or tolerated and if potential benefits outweigh potential risks. It destroys fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

How Ketgen Tablet Works

Ketgen Tablet contains Ketoconazole which works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Ketgen Tablet

  • Headache
  • Nausea
  • Stomach pain
  • Diarrhoea 

What if I have taken an overdose of Ketgen Tablet

Never take more than the prescribed dose. When Ketgen Tablet is used at high doses, it may, though unlikely, result in decreased testosterone levels, sperm production, and an issue with the adrenal glands (adrenal insufficiency). Seek emergency medical help if an overdose is suspected.

Drug Warnings

If you are allergic to Ketoconazole or any other medicines, please tell your doctor. If you are pregnant or planning for pregnancy, inform your doctor before taking Ketgen Tablet . Avoid breastfeeding while taking Ketgen Tablet as it may be excreted in breast milk. You are recommended to avoid alcohol consumption with Ketgen Tablet . If you have a loss of appetite, tiredness, stomach pain, vomiting, yellowing of skin or eyes, dark urine, or light-coloured stools, inform your doctor immediately as they might be symptoms of hepatotoxicity (liver damage). 

Drug-Drug Interactions

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KetoconazoleMethylergometrine
Critical
KetoconazoleMethylergometrine
Critical

Drug-Drug Interactions

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KetoconazoleMethylergometrine
Critical
How does the drug interact with Ketgen Tablet 10's:
Using Ketgen Tablet 10's with Methylergometrine can increase the concentration of Methylergometrine, which may lead to side effects.

How to manage the interaction:
Taking Ketgen Tablet 10's with Methylergometrine is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
KetoconazoleMethylergometrine
Critical
How does the drug interact with Ketgen Tablet 10's:
Using Ketgen Tablet 10's with Methylergometrine can increase the concentration of Methylergometrine, which may lead to side effects.

How to manage the interaction:
Taking Ketgen Tablet 10's with Methylergometrine can cause an interaction, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
KetoconazoleLomitapide
Critical
How does the drug interact with Ketgen Tablet 10's:
When Lomitapide is taken with Ketgen Tablet 10's, it may increase the risk of side effects.

How to manage the interaction:
Taking Ketgen Tablet 10's with Lomitapide is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor immediately. Do not stop using any medications without talking to the doctor.
KetoconazoleEplerenone
Critical
How does the drug interact with Ketgen Tablet 10's:
Coadministration of Ketgen Tablet 10's with Eplerenone can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Ketgen Tablet 10's with Eplerenone is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
KetoconazoleDronedarone
Critical
How does the drug interact with Ketgen Tablet 10's:
When Dronedarone is taken with Ketgen Tablet 10's, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Ketgen Tablet 10's with Dronedarone is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleIrinotecan
Critical
How does the drug interact with Ketgen Tablet 10's:
Using irinotecan together with Ketgen Tablet 10's can increase the risk of side effects.

How to manage the interaction:
Taking Ketgen Tablet 10's with Irinotecan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unexpected bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately.
KetoconazoleConivaptan
Critical
How does the drug interact with Ketgen Tablet 10's:
Using conivaptan together with Ketgen Tablet 10's may significantly increase the blood levels of conivaptan, which may increase the risk of side effects.

How to manage the interaction:
Taking Ketgen Tablet 10's with Conivaptan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures(fits), consult the doctor immediately. Do not discontinue any medication without consulting a doctor.
KetoconazoleLovastatin
Critical
How does the drug interact with Ketgen Tablet 10's:
Coadministration of Lovastatin with Ketgen Tablet 10's can increase the risk of liver damage, rhabdomyolysis (the breakdown of skeletal muscle tissue) which may lead to kidney damage.

How to manage the interaction:
Taking Ketgen Tablet 10's with Lovastatin is not recommended as it can cause an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms like unexplained muscular pain, tenderness, weakness, accompanied by fever, dark urine or unexpected bruising or bleeding, skin rash, itching, vomiting, yellowing of the skin or eyes, chills, joint pain, swelling, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
KetoconazoleRegorafenib
Critical
How does the drug interact with Ketgen Tablet 10's:
When Regorafenib is taken with Ketgen Tablet 10's, it can increase the levels of Regorafenib, which may lead to side effects.

How to manage the interaction:
Taking Regorafenib with Ketgen Tablet 10's is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleTolvaptan
Critical
How does the drug interact with Ketgen Tablet 10's:
When Tolvaptan is taken with Ketgen Tablet 10's, may increase the risk of side effects.

How to manage the interaction:
Taking Tolvaptan with Ketgen Tablet 10's is not recommended as it can lead to an interaction, it can be taken if prescribed by a doctor. However, if you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or its juice with Ketgen Tablet 10's may result in side effects such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, dark urine, light colored stools, and yellowing of the skin or eyes. Avoid consuming grapefruit, grapefruit juice, or any supplements that include grapefruit extract while taking Ketgen Tablet 10's.

Diet & Lifestyle Advise

  • Avoid high-risk areas such as renovated buildings, construction sites, pigeon or chick coops, and caves.
  • Wear a respiratory mask when there is a risk of exposure to spores.
  • People with a weak immune system are advised to avoid activities that involve close contact with dust or dirt including digging, yard work, and gardening.
  • Close windows and stay inside during dust storms.
  • Clean skin injuries well with soap and water to reduce the risk of developing a skin infection.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS - ORAL

Ketgen Tablet Substitute

Substitutes safety advice
  • Fungicide Tablet 10's

    47.52per tablet
  • Phytoral Tablet 10's

    46.08per tablet
  • Kenz Tablet 10's

    by AYUR

    21.60per tablet
  • Hyphoral Tablet 10's

    38.03per tablet
  • Ketocip 200 mg Tablet 10's

    21.78per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Ketgen Tablet as it may increase the risk of liver damage and cause adverse effects.

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Pregnancy

Caution

Ketgen Tablet is a Category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Unsafe

Ketgen Tablet may be excreted in breast milk. Therefore, it is recommended to avoid breastfeeding while taking Ketgen Tablet .

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Driving

Caution

Ketgen Tablet may cause dizziness or drowsiness. Therefore, drive only if you alert after taking Ketgen Tablet .

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Liver

Unsafe

Ketgen Tablet is contraindicated in patients with chronic or acute liver disease. Therefore, inform your doctor if you have any Liver diseases/conditions.

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Kidney

Caution

If you have any concerns regarding the use of Ketgen Tablet in patients with kiver diseases/conditions, consult a doctor.

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Children

Caution

Ketgen Tablet is not recommended for children below 2 years of age. For children above 2 years, it is recommended to use only if the doctor has determined that benefits outweigh risks.

FAQs

Ketgen Tablet belongs to a class of drugs called antifungals indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus).
Ketgen Tablet works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.
Ketgen Tablet is not recommended to treat fungal meningitis (fungal infection spreads to the brain and spinal cord) as it poorly penetrates into the cerebrospinal fluid. Therefore, inform your doctor if you have fungal meningitis so that appropriate medication may be prescribed.
You are recommended to avoid foods containing chocolate and caffeine such as cocoa beans, tea, coffee, cola and energy drinks while taking Ketgen Tablet as it may increase the adverse effects of caffeine such as drowsiness, nervousness or nausea.
You are not recommended to take Ketgen Tablet with simvastatin (lipid-lowering drug) as co-administration of these medicines may cause muscle problems. Therefore, please consult a doctor before taking Ketgen Tablet with other medicines.
No, you are not recommended to stop taking Ketgen Tablet without consulting your doctor as it may cause recurring infection. Therefore, take Ketgen Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Ketgen Tablet , please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Office No. G1, Bloom Paradise, S. No. 7/3D, B/H Bank of Maharashtra, Ambegaon Budruk, Pune, Maharashtra 411046
Other Info - KET0762

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