Karzine 100mg Tablet is used in the treatment of schizophrenia or psychosis and bipolar disorder (manic depression). Besides this, it is also used to treat nausea and vomiting, anxiety before surgery, and chronic hiccups (involuntary spasms of the diaphragm). Schizophrenia is characterized by hallucinations symptoms (seeing or hearing things that are not real) and delusions (wrong beliefs). Manic episodes of excitement or depression characterize bipolar disorder. Karzine 100mg Tablet prevents the occurrence of these symptoms. 

Karzine 100mg Tablet contains ‘Chlorpromazine’, which is an antipsychotic drug. It acts by blocking dopamine, a neurotransmitter present in the brain responsible for developing schizophrenia and bipolar disorder symptoms. Karzine 100mg Tablet rebalances dopamine to improve thinking, mood and behaviour. It also blocks the other natural substances receptors in the brain, such as histamine and muscarinic receptors, thereby preventing nausea and vomiting.

Take Karzine 100mg Tablet as prescribed by your doctor. You are advised to take Karzine 100mg Tablet as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as sleepiness, orthostatic hypotension (sudden lowering of blood pressure on standing), dry mouth, abnormality of voluntary movements, weight gain, urinary retention, constipation, muscle stiffness, and tremor. Most of these side effects of Karzine 100mg Tablet do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

Do not take Karzine 100mg Tablet if you are allergic to Chlorpromazine or any other ingredients present in it. Before taking Karzine 100mg Tablet, talk to your doctor if you or your family have a history of blood clots, stroke or heart disease or if you are above 65 years and have a history of dementia (memory loss). Karzine 100mg Tablet is not recommended during pregnancy as it may affect the unborn baby. Tell your doctor if you are breastfeeding before taking Karzine 100mg Tablet. It is not recommended for use in children under 1 year of age. Please do not stop taking Karzine 100mg Tablet without your doctor’s advice, as it may lead to withdrawal symptoms.

Karzine 100mg Tablet works by helping to restore the balance of certain natural substances in the brain. The key action of Karzine 100mg Tablet is to block the dopamine receptors (D2) in the brain and correct dopamine's overactivity. Altogether, Karzine 100mg Tablet may help decrease hallucinations and help you think more clearly and positively about yourself, feel less agitated and take a more active part in everyday life. On the other hand, it also blocks histamine H1 and muscarinic M1 receptors in the vomiting centre, thereby preventing nausea and vomiting.

• Sleepiness
• Orthostatic hypotension (sudden lowering of blood pressure on standing)
• Dry mouth
• Weight gain
• Urinary retention
• Constipation
• Muscle stiffness
• Tremor

Do not take Karzine 100mg Tablet if you are allergic (hypersensitive) to any ingredients present in it. Please consult your doctor before taking Karzine 100mg Tablet if you are pregnant, planning to conceive and breastfeeding. The use of Karzine 100mg Tablet should be avoided in children and adolescents whose signs and symptoms suggest Reye’s syndrome (confusion, swelling in the brain, and liver damage). Elderly patients (above 65 years) with dementia-related psychosis (memory loss) treated with antipsychotic drugs increased the risk of death. Do not abruptly stop taking the medication, as it may cause withdrawal symptoms, especially suicidal thoughts in young adults. Before taking Karzine 100mg Tablet, talk to your doctor if you have a history of blood clots, alcohol or drug abuse, fits (seizures), Parkinson's disease, hypothyroidism (reduced activity of the thyroid gland), stroke or heart diseases, myasthenia gravis (a condition where muscles become easily tired and weak leading to difficulty breathing) and glaucoma (increased pressure in the eye).

Drug-drug interactions: Karzine 100mg Tablet may interact with antidepressants (citalopram, escitalopram, bupropion), medicines for Parkinson’s disease (levodopa), antiepileptic ( carbamazepine, phenobarbital), medicines control heartbeat (amiodarone, disopyramide, quinidine), medicines used to calm emotion and mental disorder (olanzapine, prochlorperazine) antihypertensive (clonidine, guanethidine, propranolol), antibiotic (moxifloxacin) and medication used to treat mental illness (lithium).

Drug-food interactions: Karzine 100mg Tablet may interact with grapefruit and alcohol and increase the risk of side-effects.

Drug-disease interactions: Karzine 100mg Tablet should be used with caution in patients with heart problems such as QT prolongation (heart rhythm problem), acute alcohol abuse, central nervous system (CNS), depression, dementia, stroke, seizures, diabetes and liver problems.

• CITALOPRAM
• ESCITALOPRAM
• BUPROPION
• LEVODOPA
• CARBAMAZEPINE
• PHENOBARBITAL
• AMIODARONE
• DISOPYRAMIDE
• QUINIDINE
• OLANZAPINE
• PROCHLORPERAZINE
• CLONIDINE
• GUANETHIDINE
• PROPRANOLOL
• MOXIFLOXACIN
• LITHIUM

• Monitor your mood. Keep track of your mood regularly, including factors such as sleep, medicine and activities that can impact your mood. 

• Exercise daily. It can also avoid the weight gain that can be a side effect of bipolar medication.

• Practice calming techniques such as meditation and deep breathing exercises.

• Get some sleep. Having enough sleep will help to stabilize your mood.

• Eat a healthy diet. Certain foods may affect your mood more than others. Consider keeping a food log to track what you eat and how certain foods make you feel. Talk to your doctor or nutritionist about foods that may help stabilize your mood.

• Stay optimistic. It will take time for your symptoms to improve after you start bipolar therapy, but you will feel relaxed knowing that you will get better and that the worst is most definitely behind you.
  

• A person should take a healthy diet that includes lots of fruits and vegetables, lean meats, skinless poultry, nuts, fish, whole grains, plant-based oils and low-fat dairy products will help to keep a person in good health and avoid the chances of nausea and vomiting.

• One should avoid taking greasy or oily foods as this food triggers nausea and vomiting.

• Eat cool foods instead of hot and spicy foods.

• Include clear broths, non-fat yoghurt, fruit juice, sherbet, and sports drinks for fluid make up, which has got lost due to vomiting.

• Geriatric patients with dementia-related psychosis treated with Karzine 100mg Tablet are at an increased risk of death. Please consult your doctor before taking Karzine 100mg Tablet.

• Your doctor may advise you to regularly check your blood glucose levels, as Karzine 100mg Tablet can affect the levels of sugar in your blood.

Schizophrenia (psychosis): It is a mental illness in which brain information processing is affected. Patients with schizophrenia develop symptoms such as hallucinations (seeing or hearing unreal things), delusions (false beliefs) and withdrawal from society. They lose the ability to differentiate reality from false beliefs. Schizophrenia and bipolar disorder may occur due to genetic factors, alcohol or drug abuse, or mental trauma. Schizophrenia may also occur due to brain injuries or diseases.

Bipolar disorder: Patients with bipolar disorders have mood swings ranging from manic episodes of heightened excitement to severe depression. It may occur due to genetic factors, alcohol or drug abuse and mental trauma.