Isordil 5 Sublingual Tablet belongs to the class of blood pressure-lowering medications called ‘nitrate vasodilators’ used in the prevention of angina (heart-related chest pain) or heart failure. Angina pectoris (angina) is chest pain occurring due to reduced blood flow to the heart (coronary artery disease). It occurs when the blood vessels supplying the heart are blocked or narrowed.

Isordil 5 Sublingual Tablet contains ‘isosorbide dinitrate’, which works by dilating, relaxing, and widening the constricted blood vessels, thereby increasing the blood and oxygen supply to the heart. Thus, it effectively helps prevent the risk of future heart attack and stroke in the future, especially in high blood pressure patients. 

Take Isordil 5 Sublingual Tablet as prescribed. Your doctor will advise you on how often you take Isordil 5 Sublingual Tablet based on your medical condition. The common side-effects of Isordil 5 Sublingual Tablet are headache (during initial days of therapy) and flushing (reddening of the skin, especially the face). These side effects usually disappear without requiring medical attention. However, consult your doctor immediately if these effects persist or worsen.

Do not take it if you are allergic to ‘isosorbide dinitrate’ or any of its ingredients. Do not use in patients with severe heart failure, severe hypotension (low blood pressure), bleeding in the brain, severe dehydration, heart valve problems, progressive heart failure due to chronic lung disease, severe anemia (low levels of iron), and severe hypoxemia (low levels of oxygen in the blood). Inform your doctor if you have an underactive thyroid gland, glaucoma (an eye condition), or head injury. Inform your doctor if you are taking other prescription or non-prescription medicines, especially medicines used to treat erectile dysfunction in men. Isordil 5 Sublingual Tablet contains lactose, so inform your doctor if you have an intolerance to some sugars. Also, inform your doctor if you are pregnant or breastfeeding.

Isordil 5 Sublingual Tablet contains ‘isosorbide dinitrate’, which is a ‘nitrate’ and a vasodilator. It acts by dilating and relaxing the constricted blood vessels due to increased blood pressure (hypertension). This effect helps in improving the blood and oxygen supply to the heart, thus decreasing the risk of angina or heart-related chest pain. Thus, Isordil 5 Sublingual Tablet prevents the risk of chest pain in heart conditions like coronary artery disease.

• Headache
• Flushing (redness of the skin, especially the face)
• Low blood pressure
• Dizziness

Do not take Isordil 5 Sublingual Tablet if you are allergic to ‘isosorbide dinitrate’ or its contents. Do not take it if you have severe low blood pressure, bleeding or increased pressure in the brain, severe dehydration, heart valve problems, inflammation of the heart wall, high blood pressure due to long-term lung disease, and severe anemia. Before taking Isordil 5 Sublingual Tablet , inform your doctor if you have glaucoma (increased pressure in the eye), glucose 6 phosphate dehydrogenase deficiency (a type of anemia), underactive thyroid (hypothyroidism), kidney or liver problems, head injury, hypothermia (low body temperature), or intolerance to some sugars. This medicine should not be used with medicines used for erectile dysfunction like sildenafil or tadalafil. Inform your doctor if you are pregnant or breastfeeding.

Drug-Drug interactions: Isordil 5 Sublingual Tablet should not be used with organic nitrate drugs used to treat erectile dysfunction (sildenafil, vardenafil, tadalafil, and avanafil) and medicine used to treat pulmonary hypertension (riociguat), medicines to treat high blood pressure (norepinephrine), phenothiazines, and antiallergic medications.

Drug-Food interactions: Intake of foods containing high amounts of sodium should be reduced. 

Drug-Disease interactions: Isordil 5 Sublingual Tablet use is contraindicated in conditions such as acute myocardial infarction or congestive heart failure, severe hypotension (low blood pressure), severe anemia, bleeding in the brain, and severe dehydration.

• TADALAFIL
• SILDENAFIL
• VARDENAFIL
• AVANAFIL
• RIOCIGAUT
• NOREPINEPHRINE

• Eat plenty of fresh fruits and vegetables. Choose whole grains rather than refined or polished grains. Choose lean proteins, such as skinless chicken and fish. Choose non-fat or low-fat dairy products.
• Do not take food containing high levels of sodium (salt).
• Drink plenty of fluids to prevent dehydration. 
• Maintain a normal weight. Shed excess weight by exercising regularly for at least 30 min a day.
• Manage stress.
• Limit alcohol intake and quit smoking.

• Isordil 5 Sublingual Tablet may cause orthostatic hypotension (low blood pressure when standing). So, do not suddenly rise from a sitting or lying position. 
• You may develop tolerance to Isordil 5 Sublingual Tablet over time, meaning that the same dose may be less effective next time. To avoid this, follow the prescribed dosing schedule.
• Keep all appointments. Your doctor will monitor your condition during the follow-up visits while taking this medication. 

Angina pectoris: It is the medical term for heart-related chest pain. It occurs when there is a reduction in blood supply to the heart due to the blockage of one or more arteries (coronary heart disease). Patients with angina often explain chest pain as squeezing, tightening, or pressure in the chest. Other symptoms can be dizziness, sweating, heartburn, and difficulty breathing.