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  3. ISOKOXI 800MG

Written By Lakshmithulasi Yarragunta ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
ISOKOXI 800MG is used to treat tuberculosis (TB). It contains Isoniazid and Ethambutol which work by inhibiting the growth of tuberculosis-causing bacteria. In some cases, this medicine may cause side effects such as weakness, general discomfort, fatigue, loss of appetite, nausea or vomiting, dark urine, and vision problems. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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ISOKOXI 800MG, Pack of 10 TABLETS
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Composition :

ETHAMBUTOL-800MG + ISONIAZID-300MG

Manufacturer/Marketer :

Shreya Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About ISOKOXI 800MG

ISOKOXI 800MG belongs to the group of medications called ‘antituberculosis agents’ primarily used in the treatment of tuberculosis (TB). Tuberculosis is an infectious bacterial disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. ISOKOXI 800MG does not work against infections caused by the virus.

ISOKOXI 800MG contains Isoniazid and Ethambutol. They are bacteriostatic agents (stop the growth of bacteria) and have a similar mode of action. They work by preventing mycolic acid production (an enzyme produced by bacteria) essential for cell wall formation (protective coating). Thereby, bacteria get killed without a cell wall and burst due to disruption in their metabolism.

Take ISOKOXI 800MG exactly as prescribed by the doctor. ISOKOXI 800MG may cause side effects such as weakness, malaise (general discomfort), fatigue (feeling tired), loss of appetite, nausea or vomiting, dark urine, pale stools, jaundice (yellowing of the skin or whites of the eyes) and vision problems. Inform your doctor immediately if any of these side effects persist or get worse.

It is not recommended to take ISOKOXI 800MG if you are allergic to any contents of it. ISOKOXI 800MG is not recommended for patients with severe liver problems and sight problems. Before taking ISOKOXI 800MG, inform your doctor if you have kidney problems, epilepsy (fits), diabetes, alcohol abuse, psychosis, malnourishment, HIV infection, and extra-pulmonary TB (TB infection outside the lungs). ISOKOXI 800MG should be used with caution in pregnant and breastfeeding women. Dose adjustments may be required in children and elderly people. ISOKOXI 800MG may interact with alcohol and increase the risk of liver damage. ISOKOXI 800MG may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

Uses of ISOKOXI 800MG

Treatment of Tuberculosis

Directions for Use

Take ISOKOXI 800MG on an empty stomach preferably at least one hour before breakfast or snack or after two hours of a meal. or take it as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

ISOKOXI 800MG contains Isoniazid and Ethambutol, which is a fixed-dose combination used to treat tuberculosis (TB). Combination therapy reduces the development of drug resistance (reduction in the effectiveness of medication) as the bacteria causing TB develops drug resistance easily when monotherapy is given even for shorter periods. ISOKOXI 800MG helps to reduce the symptoms and control the disease effectively.

How ISOKOXI 800MG Works

ISOKOXI 800MG contains Isoniazid and Ethambutol. They are bacteriostatic agents (stop the growth of bacteria) and have a similar mode of action. They work by preventing mycolic acid production (an enzyme produced by bacteria) essential for cell wall formation (protective coating). Thereby, bacteria get killed without a cell wall and burst due to disruption in their metabolism.

Storage

Store in a cool and dry place away from sunlight

Side Effects of ISOKOXI 800MG

  • Weakness
  • Malaise (general discomfort)
  • Fatigue (feeling tired)
  • Loss of appetite
  • Nausea or vomiting
  • Dark urine
  • Pale stools
  • Jaundice (yellowing of the skin or whites of the eyes)
  • Vision problems

What if I have taken an overdose of ISOKOXI 800MG

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

It is advised to get your eyesight checked before taking ISOKOXI 800MG. If you notice any changes in your vision while using this medicine, stop taking this medicine and immediately inform your doctor. In most cases, the vision change is temporary and sight returns to normal. However, it might take a longer time for eyesight to recover in some cases or the change might be permanent. If you develop jaundice (yellowing of the skin and whites of the eyes), loss of appetite, nausea, vomiting, or malaise, inform your doctor immediately, as these effects may be a sign of hepatitis (liver disease). In these cases, the doctor may advise you to undergo liver function tests and provide the necessary treatment.

Drug-Drug Interactions

verifiedApollotooltip
IsoniazidLovastatin
Critical
IsoniazidRegorafenib
Critical

Drug-Drug Interactions

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IsoniazidLovastatin
Critical
How does the drug interact with ISOKOXI 800MG:
When Lovastatin is taken with ISOKOXI 800MG, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking ISOKOXI 800MG with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
IsoniazidRegorafenib
Critical
How does the drug interact with ISOKOXI 800MG:
When ISOKOXI 800MG is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with ISOKOXI 800MG is not recommended, it taken can be taken if prescribed by the doctor.
IsoniazidLomitapide
Critical
How does the drug interact with ISOKOXI 800MG:
When Lomitapide is taken with ISOKOXI 800MG, ISOKOXI 800MG may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking ISOKOXI 800MG with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
EthambutolKetoconazole
Severe
How does the drug interact with ISOKOXI 800MG:
Taking Ketoconazole with ISOKOXI 800MG can increase the risk of liver problems

How to manage the interaction:
Although there is an interaction, Ketoconazole can be taken with ISOKOXI 800MG if prescribed by the doctor. However, consult the doctor if you experience symptoms such as fever, joint pain or swelling, unusual bleeding or bruising, skin rash, nausea, vomiting, dark urine, skin or eye yellowing. Do not stop using any medications without talking to the doctor.
EthambutolVigabatrin
Severe
How does the drug interact with ISOKOXI 800MG:
Co-administration of Vigabatrin with ISOKOXI 800MG may increase the risk of serious side effects associated with vision loss, especially if used together for prolonged periods.

How to manage the interaction:
Co-administration of ISOKOXI 800MG with Vigabatrin can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
EthambutolLomitapide
Severe
How does the drug interact with ISOKOXI 800MG:
Taking Lomitapide and ISOKOXI 800MG together can increase the risk of liver problems.

How to manage the interaction:
Although taking ISOKOXI 800MG and Lomitapide together can cause an interaction, it can be taken if your doctor has suggested it. However, consult a doctor if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
EthambutolMipomersen
Severe
How does the drug interact with ISOKOXI 800MG:
Coadministration of mipomersen with ISOKOXI 800MG can increase the risk of liver problems.

How to manage the interaction:
Although taking ISOKOXI 800MG and Mipomersen together can cause an interaction, it can be taken if your doctor has suggested it. However, contact your doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting your doctor.
EthambutolTeriflunomide
Severe
How does the drug interact with ISOKOXI 800MG:
Coadministration of ISOKOXI 800MG with teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of ISOKOXI 800MG with Teriflunomide can result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting your doctor.
EthambutolLeflunomide
Severe
How does the drug interact with ISOKOXI 800MG:
Coadministration of ISOKOXI 800MG with Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although taking ISOKOXI 800MG with Leflunomide can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
IsoniazidHalothane
Severe
How does the drug interact with ISOKOXI 800MG:
When Halothane is taken with ISOKOXI 800MG, can increase the side affects of liver.

How to manage the interaction:
Co-administration of ISOKOXI 800MG with Halothane can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, appetite loss, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor right away. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Vitamin C-rich foods such as kiwi, broccoli, and bell pepper help improve the immune system.
  • Avoid processed and fried foods.
  • Stay hydrated. Drink plenty of fluids.
  • Warm ginger tea or warm soup can help in providing relief from cough.
  • Avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, and fish such as tuna, salmon, mackerel, wine, and beer.
  • Quit smoking and avoid alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTI- TUBERCULOSIS

ISOKOXI 800MG Substitute

Substitutes safety advice

  • Econex 800 mg Tablet 6's

    ₹12.08per tablet

  • Myconex 800mg Tablet 10's

    ₹14.13per tablet

  • THEMIBUTOL PLUS 800MG TABLET

    ₹3.02per tablet

  • Combunex 800 Tablet 10's

    ₹11.43per tablet

Product Substitutes

Info icon

Econex 800 mg Tablet 6's

₹72.5

MRP ₹80.5

Info icon

Myconex 800mg Tablet 10's

₹141.3

MRP ₹157

Info icon

THEMIBUTOL PLUS 800MG TABLET

₹30.24

MRP ₹33.6

Info icon

Combunex 800 Tablet 10's

₹114.3

MRP ₹127

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Alcohol

Caution

Consumption of alcohol may increase the risk of side-effects and worsen the condition.

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Pregnancy

Caution

ISOKOXI 800MG should be used with caution in pregnant women. It is given to pregnant women only if clinically needed when the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

ISOKOXI 800MG should be used with caution in breastfeeding mothers. It is given to breastfeeding mothers only when the benefits outweigh the risks.

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Driving

Caution

ISOKOXI 800MG may cause dizziness in some people. So, do not drive or operate heavy machinery if you are not fully alert.

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Liver

Caution

ISOKOXI 800MG is not recommended for patients with severe liver problems. In mild to moderate liver diseases, the dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

ISOKOXI 800MG should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

bannner image

Children

Caution

ISOKOXI 800MG should be used with caution in children. The dose may have to be adjusted based on age, body weight and healthy history of the child.

FAQs

ISOKOXI 800MG is used in the treatment of tuberculosis (TB).
ISOKOXI 800MG contains Isoniazid and Ethambutol. They are bacteriostatic agents (stop the growth of bacteria) and have a similar mode of action. They work by preventing mycolic acid production (an enzyme produced by bacteria) essential for cell wall formation (protective coating, which is necessary for bacteria's survival).
It is advised to take ISOKOXI 800MG on an empty stomach. So, you should take this medicine at least 30 minutes before a meal or after 2 hours of taking a meal for better absorption.
You are recommended to avoid foods and drinks containing histamine or tyramine such as cured meat, matured cheese, soya, fish such as tuna, salmon and mackerel, wine and beer as they may interact with ISOKOXI 800MG and cause adverse effects such as sweating, headache, dizziness, flushing (reddening of the skin) and uneven heartbeat.
ISOKOXI 800MG may cause side-effects such as weakness, malaise (general discomfort), fatigue (feeling tired), loss of appetite, nausea or vomiting, dark urine, pale stools, jaundice (yellowing of the skin or whites of the eyes) and vision problems. Inform your doctor immediately if any of these side-effects persist or get worse.
ISOKOXI 800MG may affect liver function, so it is not prescribed in patients with severe liver problems and alcohol abuse unless clinically needed. Also, do not consume excessive amounts of alcohol while using ISOKOXI 800MG as it may increase the risk of liver damage.
Yes, ethambutol in ISOKOXI 800MG may rarely cause vision problems like blurred/decreased vision, color blindness. Consult your doctor immediately if there is a problem in vision.
Yes, ISOKOXI 800MG can affect the action of birth control pills. ISOKOXI 800MG contains isoniazid and ethambutol, which can increase the breakdown of hormones in birth control pills, making them less effective. This could potentially result in an unwanted pregnancy. Please discuss with your doctor if you have any concerns.
No, do not stop taking ISOKOXI 800MG even if you feel better as it can result in the infection not being fully treated and potentially developing drug resistance. Therefore, complete the full course of treatment as prescribed by your doctor.
Yes, ISOKOXI 800MG can cause urine discolouration. As ISOKOXI 800MG contains isoniazid and ethambutol, which can lead to dark-coloured urine as a common but non-harmful side effect. If the discolouration persists, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

SHREYA HOUSE, 301/A, Pereira Hill Road, Andheri East, Mumbai - 400 099, India
Other Info - ISO0002

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Author Details

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Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.9139.pdf
  2. https://www.medicines.org.uk/emc/files/pil.5310.pdf
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