apollo
0
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 30, 2024 | 5:51 AM IST

Insugrip-M 500 Tablet is used in the treatment of Type 2 diabetes mellitus. It works by making the pancreas produce insulin and less glucagon and also by helps the body to make better use of the insulin it has. You must continue following the diet and exercise recommended for you whilst on treatment with this medicine. It is not a substitute for insulin. It may cause common side effects such as hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycemia, you should not miss meals and also should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Read more
18 people bought
in last 30 days
Prescription drug

Whats That

tooltip
Prescription drug
 Trailing icon
Consult Doctor

Synonym

METFORMIN HYDROCHLORIDE+VILDAGLIPTIN

Manufacturer/Marketer

Ultra Biotech Formulations

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Insugrip-M 500 Tablet

Insugrip-M 500 Tablet is a combination drug of Vildagliptin (DPP-4 inhibitor) and Metformin (Biguanides) belongs to the class of anti-diabetic. Type 2 diabetes mellitus used to be known as 'non-insulin-dependent diabetes mellitus (NIDDM)' or 'maturity-onset diabetes. Type 2 diabetes develops if the body does not produce enough insulin or when your body's insulin does not work as well as it should. It can also develop if the body produces too much glucagon. Insulin is a substance which helps to lower the level of sugar in your blood, especially after meals. Insugrip-M 500 Tablet is another substance which triggers the production of sugar by the liver, causing the blood sugar to rise. The pancreas makes both of these substances.

Insugrip-M 500 Tablet helps to control the blood sugar level. It works by making the pancreas produce insulin and less glucagon (effect of vildagliptin) and also by helping the body to make better use of the insulin it has (effect of metformin). You must continue following the diet and exercise recommended for you whilst on treatment with Insugrip-M 500 Tablet . Insugrip-M 500 Tablet is not a substitute for insulin. It is not used to treat type 1 diabetes (where your body does not produce insulin) or diabetic ketoacidosis.

Insugrip-M 500 Tablet should be taken with food to avoid an upset stomach. Insugrip-M 500 Tablet should be taken at the same time of the day each time for best results. For better advice, your doctor will decide what dose should be taken, which can change quickly depending on your condition. The most common side effect of Insugrip-M 500 Tablet is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycemia, you should not miss meals and also should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

Insugrip-M 500 Tablet should not be stopped even if you feel better without consulting your doctor as sugar levels change. If you stop taking Insugrip-M 500 Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Insugrip-M 500 Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or planning to get pregnant or breastfeed.

Uses of Insugrip-M 500 Tablet

Treatment of Type 2 Diabetes Mellitus

Medicinal Benefits

Insugrip-M 500 Tablet helps your pancreas produce more insulin, effectively utilise insulin, and decrease the excess sugar that your liver makes. It helps control the rise of blood sugar levels in your body after a meal. Insugrip-M 500 Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Insugrip-M 500 Tablet

  • Low blood sugar
  • Nausea
  • Headache
  • Shaking or quivering
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Loss of appetite
  • Joint pain
  • Tiredness
  • Constipation
  • Swollen hands
  • Ankle or feet (oedema)

Drug Warnings

Insugrip-M 500 Tablet should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Insugrip-M 500 Tablet , might develop a rare but serious condition called lactic acidosis. In this condition, there is too much lactic acid accumulated in the blood that can damage the working of your liver and kidney required for the elimination of excess lactic acid from the blood. Before you start taking Insugrip-M 500 Tablet , tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 level. Insugrip-M 500 Tablet , when used with insulin, may extremely lower the blood sugar level leading to hypoglycaemia condition, which can be fatal. In this case, your doctor may adjust the dose by lowering the dose of insulin or Insugrip-M 500 Tablet . Prolonged intake of Insugrip-M 500 Tablet may lower your thyroid-stimulating hormone (TSH); hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. The use of Insugrip-M 500 Tablet should be stopped for a short time before having an X-ray procedure.

Drug Interactions

Drug-Drug Interactions: Insugrip-M 500 Tablet interacts with pain killers (aspirin, ibuprofen, and celecoxib), high blood pressure-lowering pills (nifedipine, captopril, enalapril, lisinopril), thyroid hormones (thyroxine), antacid (cimetidine) or certain medicines affecting the nervous system.

Drug-Food Interactions: Intake of excessive alcoholic beverages may increase the chance of life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Insugrip-M 500 Tablet .

Drug-Disease Interactions: People affected with heart diseases (like congestive heart failure and myocardial infarction), vitamin B12 deficiency, and alcoholism should avoid intake of Insugrip-M 500 Tablet .

Drug-Drug Interactions Checker List

  • RANOLAZINE
  • CIMETIDINE
  • NIFEDIPINE
  • ENALAPRIL
  • LOSARTAN
  • DICLOFENAC

Habit Forming

No

Diet & Lifestyle Advise

  • Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.

  • Eat at regular intervals. Do not take a long gap between a meal or snack.
  • Monitor your blood sugar level regularly, especially when there are lots of fluctuations.
  • Invest at least 150 minutes of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise weekly.
  • Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
  • Replace refined carbohydrates-containing foods with whole grain foods and increase the intake of fruits, veggies, and other fibre-enriched foods.
  • Limit saturated fat (or hidden intake fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega-3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
  • Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
  • Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, cheese, etc.).
  • Keep your blood pressure as normal (140/90) as possible as it reduces the risk of cardiovascular diseases in diabetes patients.

Special Advise

Contact your doctor immediately if you have nausea, vomiting, kussmaul breathing  (laboured and deep), and generalised weakness which are symptoms of Lactic acidosis, a very rare but serious metabolic complication. 

Disease/Condition Glossary

Type 2 diabetes is a condition where the body is unable to make sufficient insulin, or the insulin that it makes doesn't work properly or is utilized by our body. This can cause high blood sugar levels (hyperglycaemia). Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. There may be weight gain in some cases, while in rare cases, weight loss may be observed. The complication of type 2 diabetes also includes neuropathy (nerve problems), nephropathy (kidney problems), retinopathy (damaged retina of eyes or blindness), loss of limbs, sexual dysfunction, and an increase in the chance of heart attack or stroke.

bannner image

Alcohol

Unsafe

It is best to avoid alcohol while taking medication.

bannner image

Pregnancy

Caution

Please consult your doctor for advice before using Insugrip-M 500 Tablet .

bannner image

Breast Feeding

Caution

Please consult your doctor for advice before using Insugrip-M 500 Tablet .

bannner image

Driving

Caution

Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking these medications you should not drive or operate any machinery or vehicles.

bannner image

Liver

Caution

If u have or had history or evidence of any liver-related diseases, please consult the doctor before taking the medicine.

bannner image

Kidney

Caution

If u have or had history or evidence of any kidney-related diseases, please consult the doctor before taking the medicine.

bannner image

Children

Caution

It is advisable to consult a doctor before using it.

Country of origin

India

Manufacturer/Marketer address

1/2284, Ram Nagar, Delhi-110032
Other Info - INS0352

Author Details

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Insugrip-M 500 Tablet is an antidiabetic medicine used in addition to diet and exercise to improve control of blood glucose (sugar) levels in adults with type 2 diabetes.
Insugrip-M 500 Tablet help to control the level of sugar in the blood. The substance vildagliptin works by making the pancreas produce more insulin and less glucagon. The substance metformin works by helping the body to make better use of insulin. This medicine has been shown to reduce blood sugar, which may help to prevent complications from your diabetes.
If you have symptoms like increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sores healing, and frequent infections, contact doctor as it can be a condition of type 2 diabetes.
In case you feel that your blood sugar level is going down and you are feeling weak, immediately eat sugar candies or drink sugary beverages. It will help to balance the blood sugar level in your body. So, it is advisable to keep sugar candies with you.
No. Insugrip-M 500 Tablet is only prescribed for the treatment of type 2 diabetes also called as 'non-insulin-dependent diabetes'.
Type 2 diabetes is a common form of diabetes in which the blood sugar-lowering hormone called insulin produced by the body does not function properly. Due to this, the blood glucose level increases, and symptoms such as frequent urination, increased thirst, and increased hunger start. Diabetes, if left untreated or not treated properly, can cause long-term complications such as nerve damage, kidney damage, eye damage, foot problems, and also poses a high risk of developing heart diseases.
Continue taking your medicine for as long as your doctor tells you to. Your doctor will check your progress to make sure the medicine is working and will discuss with you how long your treatment should continue. Do not stop taking Insugrip-M 500 Tablet unless your doctor tells you to.
The medicine should be swallowed as a whole with water. Do not crush, break or chew it.
Include a diet rich in fruits, vegetables and whole grains like brown rice, whole wheat, oats, barley, and quinoa. Non-fat or low-fat dairy and proteins like chicken, lean meats, nuts, beans, tofu, lentils, eggs, fish, and turkey can also be included.
Do not stop taking Insugrip-M 500 Tablet on your own as it might cause an increase in blood sugar levels. Consult the doctor if you have any difficulty while taking the medicine.
Insugrip-M 500 Tablet contains two anti-diabetic medicines, Vildagliptin (DPP-4 inhibitor) and Metformin (biguanides) which help manage blood glucose levels.
Take Insugrip-M 500 Tablet as advised by the doctor. It can be taken in the morning and evening with or just after food. Taking Insugrip-M 500 Tablet with food helps lower the risk of stomach upset.
Insugrip-M 500 Tablet may cause side effects such as nausea, headache, shaking or quivering, vomiting, diarrhoea, abdominal pain, loss of appetite, joint pain, tiredness, constipation, and oedema.
Insugrip-M 500 Tablet may cause hypoglycaemia (low blood glucose levels), which is characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin. Regularly monitor blood glucose levels and consume glucose tablets, juice or candy if you experience these symptoms.
Insugrip-M 500 Tablet may cause side effects such as nausea and vomiting. If you experience these symptoms eat smaller meals more often and avoid hard-to-digest food. Take small, frequent sips of water or any other fluids. Consult the doctor if the condition persists or worsens.
Insugrip-M 500 Tablet is contraindicated in people who are allergic to any of its components. It is not recommended for people with uncontrolled diabetes, ketoacidosis, severely reduced kidney function, severe infection, heart failure, or serious blood circulation problems.
Insugrip-M 500 Tablet should be stored at room temperature (below 30°C). Keep it away from the reach and sight of children.
Insugrip-M 500 Tablet is an anti-diabetic medicine used to treat type 2 diabetes mellitus, also known as noninsulin-dependent diabetes mellitus.
Insugrip-M 500 Tablet may cause lactic acidosis (a very rare, but very serious side effect in which lactic acid builds up in the blood), particularly if your kidneys are not working properly. The risk of developing lactic acidosis is also increased with uncontrolled diabetes, prolonged fasting or alcohol intake, serious infections, dehydration, liver problems and any medical conditions in which a part of the body has a reduced supply of oxygen (such as acute severe heart disease). Consult the doctor if you notice symptoms of lactic acidosis like abdominal pain, vomiting, muscle cramps, difficulty breathing, reduced body temperature and heartbeat, and a general feeling of not being well with severe tiredness.
Insugrip-M 500 Tablet may interfere with the absorption of vitamin B12 leading to its deficiency on long-term use. Consult the doctor if you notice signs of vitamin B12 deficiency like pale/yellow skin, headache, fatigue, anaemia, and depression.
Yes, it is safe to use Insugrip-M 500 Tablet if prescribed by the doctor. Insugrip-M 500 Tablet has a good safety profile with robust glucose-lowering efficacy.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Add to Cart