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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 10:52 AM IST

Imbruvica 140Mg Capsule is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr's macroglobulinaemia. It contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. Sometimes, Imbruvica 140Mg Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue.

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Composition

IBRUTINIB-140MG

Manufacturer/Marketer

Johnson & Johnson Pvt Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About Imbruvica 140Mg Capsule

Imbruvica 140Mg Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma (cancer affecting the lymph nodes), chronic lymphocytic leukaemia (cancer affecting white blood cells and lymph nodes), and waldenström's macroglobulinaemia (cancer affecting white blood cells).

Imbruvica 140Mg Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.

In some cases, Imbruvica 140Mg Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not take Imbruvica 140Mg Capsule if you are pregnant or breastfeeding. Consult the doctor immediately if you become pregnant during treatment with Imbruvica 140Mg Capsule . This medicine is not recommended for children as safety and effectiveness have not been established. Inform the doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Imbruvica 140Mg Capsule

Treatment of Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr's macroglobulinaemia

Medicinal Benefits

Imbruvica 140Mg Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia. This medicine may also be used to treat marginal zone lymphoma (cancer that begins in a type of white blood cells that normally fights infection) and chronic graft vs host disease (a complication of hematopoietic stem-cell transplant). Imbruvica 140Mg Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase (a protein in the body that helps cancer cells grow and survive). Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.

Directions for Use

Swallow the medicine as a whole with water; do not crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Imbruvica 140Mg Capsule

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Fatigue
  • Dizziness
  • Mouth sores

Drug Warnings

Do not take Imbruvica 140Mg Capsule if you are allergic to any of its components, if you are taking St. John's wort (herbal medicine) or if you are pregnant/breastfeeding. Inform the doctor if you have/had unusual bruising or bleeding, irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, kidney problems, or if you are due to undergo any surgery. Seek immediate medical attention if you experience symptoms of progressive multifocal leukoencephalopathy, a serious brain infection (trouble thinking, memory loss, sight loss, or difficulty walking), stroke (sudden confusion, numbness or weakness, trouble speaking, sight loss, loss of balance, or sudden severe headache), heart failure (breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs), rupture of the spleen (left abdominal pain, pain below the left rib cage or at the tip of left shoulder), infection (chills, fever, weakness, body aches, cold, flu symptoms, or confusion), or haemophagocytic lymphohistiocytosis, an inflammatory disorder (fever, bruising, swollen glands, or skin rash).

Drug Interactions

Drug-Drug Interactions: Inform the doctor if you are taking CYP3A inhibitors or inducers.

Drug-Food Interactions: Avoid taking grapefruit or Seville oranges (bitter oranges) or their juice, as they might increase the amount of ibrutinib in your blood.

Drug-Disease Interactions: Inform the doctor if you have an irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, or kidney problems.

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water.

Special Advise

  • Women of childbearing potential should use highly effective contraception during treatment and for three months after receiving the last dose.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Imbruvica 140Mg Capsule .
  • Your doctor may recommend tests to check liver function.
  • Drink plenty of water or other fluids while taking Imbruvica 140Mg Capsule .

Disease/Condition Glossary

Mantle cell lymphoma (MCL): Mantle cell lymphoma is a type of cancer that affects the lymph nodes. Symptoms include swelling of lymph nodes, fever, night sweats, weight loss, fatigue, nausea, vomiting, pain, bloating, and indigestion.

Chronic lymphocytic leukaemia (CLL): Chronic lymphocytic leukaemia is a type of cancer affecting white blood cells called lymphocytes that also involves the lymph nodes. Symptoms include swollen lymph nodes, easy bruising, and fatigue.

Waldenström's macroglobulinaemia (WM): Waldenström's macroglobulinaemia is a type of cancer that affects white blood cells called lymphocytes. Symptoms include anaemia (lack of red blood cells), frequent infections due to lack of white blood cells, swelling of lymph nodes, pain and discomfort.

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Alcohol

Consult your doctor

It is not known if alcohol affects Imbruvica 140Mg Capsule . However, avoid consumption of alcohol while on treatment with Imbruvica 140Mg Capsule as it may worsen your condition.

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Pregnancy

Unsafe

Ibrutinib belongs to pregnancy category D. Imbruvica 140Mg Capsule should not be used during pregnancy. Use effective contraception and avoid pregnancy during treatment with Imbruvica 140Mg Capsule .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Imbruvica 140Mg Capsule .

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Driving

Caution

Imbruvica 140Mg Capsule may cause dizziness and tiredness. Do not drive or operate machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

Avoid taking Imbruvica 140Mg Capsule if you have moderate or severe baseline liver impairment. Dose adjustment may be needed in patients with mild liver impairment. If you have a history of liver disease, inform the doctor.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before taking Imbruvica 140Mg Capsule .

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Children

Unsafe

Imbruvica 140Mg Capsule is not recommended for children as safety and effectiveness have not been established.

Country of origin

India

Manufacturer/Marketer address

Corporate Communications, Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Other Info - IMB0005

Author Details

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FAQs

Imbruvica 140Mg Capsule is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr’s macroglobulinaemia.
Imbruvica 140Mg Capsule works by blocking the action of an abnormal protein that helps cancer cells multiply. Thereby, it stops the spread of cancer cells.
Imbruvica 140Mg Capsule may make you bleed more easily. Therefore, consult the doctor if you are taking blood thinner medicines (heparin, warfarin), NSAIDs (aspirin, ibuprofen, naproxen), or supplements that may increase the risk of bleeding (flaxseed, vitamin E, fish oil).
Imbruvica 140Mg Capsule may affect the heart, especially if you already have heart diseases like heart failure, heart rhythm problems, diabetes, high blood pressure, or are of advanced age. Consult the doctor instantly if you experience symptoms of heart failure like breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs.

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