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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Last Updated Oct 9, 2024 | 10:52 AM IST

Bdbrut Capsule is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr's macroglobulinaemia. It contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. Sometimes, Bdbrut Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue.

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Prescription drug

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Composition

IBRUTINIB-140MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-26

for this medicine

About Bdbrut Capsule

Bdbrut Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma (cancer affecting the lymph nodes), chronic lymphocytic leukaemia (cancer affecting white blood cells and lymph nodes), and waldenström's macroglobulinaemia (cancer affecting white blood cells).

Bdbrut Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.

In some cases, Bdbrut Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.

Do not take Bdbrut Capsule if you are pregnant or breastfeeding. Consult the doctor immediately if you become pregnant during treatment with Bdbrut Capsule . This medicine is not recommended for children as safety and effectiveness have not been established. Inform the doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Bdbrut Capsule

Treatment of Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr's macroglobulinaemia

Medicinal Benefits

Bdbrut Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia. This medicine may also be used to treat marginal zone lymphoma (cancer that begins in a type of white blood cells that normally fights infection) and chronic graft vs host disease (a complication of hematopoietic stem-cell transplant). Bdbrut Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase (a protein in the body that helps cancer cells grow and survive). Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.

Directions for Use

Swallow the medicine as a whole with water; do not crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Bdbrut Capsule

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Fatigue
  • Dizziness
  • Mouth sores

Drug Warnings

Do not take Bdbrut Capsule if you are allergic to any of its components, if you are taking St. John's wort (herbal medicine) or if you are pregnant/breastfeeding. Inform the doctor if you have/had unusual bruising or bleeding, irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, kidney problems, or if you are due to undergo any surgery. Seek immediate medical attention if you experience symptoms of progressive multifocal leukoencephalopathy, a serious brain infection (trouble thinking, memory loss, sight loss, or difficulty walking), stroke (sudden confusion, numbness or weakness, trouble speaking, sight loss, loss of balance, or sudden severe headache), heart failure (breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs), rupture of the spleen (left abdominal pain, pain below the left rib cage or at the tip of left shoulder), infection (chills, fever, weakness, body aches, cold, flu symptoms, or confusion), or haemophagocytic lymphohistiocytosis, an inflammatory disorder (fever, bruising, swollen glands, or skin rash).

Drug Interactions

Drug-Drug Interactions: Inform the doctor if you are taking CYP3A inhibitors or inducers.

Drug-Food Interactions: Avoid taking grapefruit or Seville oranges (bitter oranges) or their juice, as they might increase the amount of ibrutinib in your blood.

Drug-Disease Interactions: Inform the doctor if you have an irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, or kidney problems.

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water.

Special Advise

  • Women of childbearing potential should use highly effective contraception during treatment and for three months after receiving the last dose.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Bdbrut Capsule .
  • Your doctor may recommend tests to check liver function.
  • Drink plenty of water or other fluids while taking Bdbrut Capsule .

Disease/Condition Glossary

Mantle cell lymphoma (MCL): Mantle cell lymphoma is a type of cancer that affects the lymph nodes. Symptoms include swelling of lymph nodes, fever, night sweats, weight loss, fatigue, nausea, vomiting, pain, bloating, and indigestion.

Chronic lymphocytic leukaemia (CLL): Chronic lymphocytic leukaemia is a type of cancer affecting white blood cells called lymphocytes that also involves the lymph nodes. Symptoms include swollen lymph nodes, easy bruising, and fatigue.

Waldenström's macroglobulinaemia (WM): Waldenström's macroglobulinaemia is a type of cancer that affects white blood cells called lymphocytes. Symptoms include anaemia (lack of red blood cells), frequent infections due to lack of white blood cells, swelling of lymph nodes, pain and discomfort.

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Alcohol

Consult your doctor

It is not known if alcohol affects Bdbrut Capsule . However, avoid consumption of alcohol while on treatment with Bdbrut Capsule as it may worsen your condition.

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Pregnancy

Unsafe

Ibrutinib belongs to pregnancy category D. Bdbrut Capsule should not be used during pregnancy. Use effective contraception and avoid pregnancy during treatment with Bdbrut Capsule .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Bdbrut Capsule .

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Driving

Caution

Bdbrut Capsule may cause dizziness and tiredness. Do not drive or operate machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

Avoid taking Bdbrut Capsule if you have moderate or severe baseline liver impairment. Dose adjustment may be needed in patients with mild liver impairment. If you have a history of liver disease, inform the doctor.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before taking Bdbrut Capsule .

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Children

Unsafe

Bdbrut Capsule is not recommended for children as safety and effectiveness have not been established.

Country of origin

India

Manufacturer/Marketer address

407-408, Sharda Chambers, New Marine Lines, Mumbai 400 020 (Maharashtra), New Marine Lines, Marine Lines, Mumbai, Maharashtra 400020
Other Info - BDB0002

Author Details

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FAQs

Bdbrut Capsule is used to treat Mantle cell lymphoma, chronic lymphocytic leukaemia, and Waldenstr’s macroglobulinaemia.
Bdbrut Capsule works by blocking the action of an abnormal protein that helps cancer cells multiply. Thereby, it stops the spread of cancer cells.
Bdbrut Capsule may make you bleed more easily. Therefore, consult the doctor if you are taking blood thinner medicines (heparin, warfarin), NSAIDs (aspirin, ibuprofen, naproxen), or supplements that may increase the risk of bleeding (flaxseed, vitamin E, fish oil).
Bdbrut Capsule may affect the heart, especially if you already have heart diseases like heart failure, heart rhythm problems, diabetes, high blood pressure, or are of advanced age. Consult the doctor instantly if you experience symptoms of heart failure like breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs.

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