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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Grin-O 75 mg Tablet is a combination medicine used to manage diabetic neuropathy, neuropathic pain, and nutritional deficiencies. This medicine works by altering the nerve signals that cause pain and thereby protects nerve fibres. It helps provide a protective effect on the nerve tissues and the brain. You may experience common side effects like nausea, vomiting, diarrhoea, stomach upset, dizziness, and rash.
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Manufacturer/Marketer :

Gh Vision Care Life Sciences

Consume Type :

ORAL

Return Policy :

3 Days Returnable

Expires on or after :

Jan-27

About Grin-O 75 mg Tablet

Grin-O 75 mg Tablet is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).

Grin-O 75 mg Tablet is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Grin-O 75 mg Tablet helps to treat neuropathic pain.

Take Grin-O 75 mg Tablet as prescribed. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Grin-O 75 mg Tablet may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. The majority of these side effects do not necessitate medical attention and will subside gradually over time. However, if you are experiencing these side effects regularly, you should consult your doctor.

Please do not take Grin-O 75 mg Tablet if you are allergic to any of its ingredients. Consult your doctor before taking Grin-O 75 mg Tablet if you are pregnant or breastfeeding. Grin-O 75 mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Grin-O 75 mg Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Grin-O 75 mg Tablet as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Grin-O 75 mg Tablet

Treatment of Neuropathic pain

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Grin-O 75 mg Tablet is a combination of three drugs: Methylcobalamin (a form of vitamin B), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Grin-O 75 mg Tablet is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Grin-O 75 mg Tablet helps to treat neuropathic pain.

How Grin-O 75 mg Tablet Works

Grin-O 75 mg Tablet is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Grin-O 75 mg Tablet helps to treat neuropathic pain.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Grin-O 75 mg Tablet

  • Constipation
  • Dry mouth
  • Headache
  • Feeling sleepy, tired or dizzy
  • Diarrhoea

What if I have taken an overdose of Grin-O 75 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Grin-O 75 mg Tablet may include irregular heartbeats, severe drowsiness, vision problems, confusion, hallucinations, agitation, stiff muscles, overactive reflexes, vomiting, feeling hot or cold, feeling like you might pass out, seizures, or coma. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

If you are allergic to any of the ingredients in Grin-O 75 mg Tablet , do not consume it. Please do not stop taking Grin-O 75 mg Tablet without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Grin-O 75 mg Tablet unless your doctor has prescribed it. Grin-O 75 mg Tablet may cause drowsiness and dizziness, therefore drive only if you are alert. Grin-O 75 mg Tablet is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Grin-O 75 mg Tablet as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.

Drug-Drug Interactions

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NortriptylineLinezolid
Critical
NortriptylineTranylcypromine
Critical

Drug-Drug Interactions

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NortriptylineLinezolid
Critical
How does the drug interact with Grin-O 75 mg Tablet 10's:
Coadministration of Grin-O 75 mg Tablet 10's with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Grin-O 75 mg Tablet 10's with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineTranylcypromine
Critical
How does the drug interact with Grin-O 75 mg Tablet 10's:
Coadministration of Grin-O 75 mg Tablet 10's with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Grin-O 75 mg Tablet 10's with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
NortriptylineZiprasidone
Critical
How does the drug interact with Grin-O 75 mg Tablet 10's:
Coadministration of Grin-O 75 mg Tablet 10's with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Grin-O 75 mg Tablet 10's with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Grin-O 75 mg Tablet 10's:
Using Grin-O 75 mg Tablet 10's together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Grin-O 75 mg Tablet 10's is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
NortriptylinePotassium citrate
Critical
How does the drug interact with Grin-O 75 mg Tablet 10's:
Coadministration of Grin-O 75 mg Tablet 10's with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Grin-O 75 mg Tablet 10's with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineSelegiline
Critical
How does the drug interact with Grin-O 75 mg Tablet 10's:
Co-administration of Grin-O 75 mg Tablet 10's with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Grin-O 75 mg Tablet 10's with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineSafinamide
Critical
How does the drug interact with Grin-O 75 mg Tablet 10's:
Coadministration of Grin-O 75 mg Tablet 10's with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Grin-O 75 mg Tablet 10's with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
NortriptylineCyclobenzaprine
Severe
How does the drug interact with Grin-O 75 mg Tablet 10's:
Taking Cyclobenzaprine with Grin-O 75 mg Tablet 10's might raise serotonin hormone levels which can increase the risk of developing side effects.

How to manage the interaction:
Taking Cyclobenzaprine with Grin-O 75 mg Tablet 10's can possibly lead to an interaction. It can be taken if prescribed by doctor. However, if you experience fever, palpitations, excessive sweating, muscle spasm, or vomiting, contact a doctor immediately. Do not discontinue the medications without consulting a doctor.
NortriptylineFluoxetine
Severe
How does the drug interact with Grin-O 75 mg Tablet 10's:
Co-administration of Grin-O 75 mg Tablet 10's with Fluoxetine can reduce the metabolism and increase the levels of Grin-O 75 mg Tablet 10's in the body. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Grin-O 75 mg Tablet 10's with Fluoxetine together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, dry mouth, sleepiness, irritation, confusion, edema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineMirtazapine
Severe
How does the drug interact with Grin-O 75 mg Tablet 10's:
Using Grin-O 75 mg Tablet 10's together with mirtazapine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Grin-O 75 mg Tablet 10's with Mirtazapine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include vitamin B and D-rich foods in your diet.

  • Cayenne pepper should be included in your diet because it can help with neuropathic pain.

  • Exercising regularly helps to improve overall health and combat pain.

  • Rest well and get plenty of rest.

  • Taking a warm bath can be very relaxing.

  • Avoid smoking and drinking alcohol.

  • Meditation and yoga can reduce stress, pain sensitivity and improve coping skills.

  • Acupuncture, by stimulating pressure points, can be beneficial.

  • Massages with essential oils can help increase circulation.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Grin-O 75 mg Tablet Substitute

Substitutes safety advice
  • Nurodenz Tablet 10's

    by AYUR

    16.11per tablet
  • Pregatip-NT 75/10/750 Tablet 10's

    18.90per tablet
  • Pregateo-MNT 75 mg Tablet 10's

    21.51per tablet
  • Vantab-PN Tablet 10's

    16.20per tablet
  • Pregapress-Mnt Tablet 10'S

    by AYUR

    18.81per tablet
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Grin-O 75 mg Tablet as it may increase drowsiness and sleepiness.

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Pregnancy

Caution

If you're pregnant, don't take Grin-O 75 mg Tablet unless your doctor tells you to. Please consult your doctor if you have any concerns about this; your doctor will only prescribe if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of Grin-O 75 mg Tablet in breastfeeding/nursing mothers.

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Driving

Unsafe

Grin-O 75 mg Tablet causes drowsiness, sleepiness and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Unsafe

Grin-O 75 mg Tablet should not be given to children as the safety and efficacy have not been established.

FAQs

Grin-O 75 mg Tablet is used to treat neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia.
Grin-O 75 mg Tablet contains Methylcobalamin, Nortriptyline, and Pregabalin. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline alters the way nerves receive pain signals, thereby decreasing pain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Grin-O 75 mg Tablet helps to treat neuropathic pain.
Dry mouth could be a side-effect of Grin-O 75 mg Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Do not stop taking Grin-O 75 mg Tablet without consulting your doctor, as this could result in withdrawal symptoms. Continue taking Grin-O 75 mg Tablet for as long as prescribed to treat your condition effectively. If you experience any difficulty while taking Grin-O 75 mg Tablet , do not be afraid to speak with your doctor.
Grin-O 75 mg Tablet is used to treat diabetic neuropathy. Diabetic neuropathy is a condition that causes nerve damage due to high blood glucose levels. It primarily affects the nerves in the legs and feet.
Grin-O 75 mg Tablet may cause peripheral oedema. The swelling of the hands and lower legs are known as peripheral oedema. If you experience oedema, avoid sitting or standing for extended periods. Raise your legs by laying down and placing a pillow under them.

Country of origin

INDIA

Manufacturer/Marketer address

03, Ground Floor A-20 Teotoia Complex, Lane-4, Hardev Puri Delhi-110093
Other Info - GRI0033

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