Grin-O Tablet SR is a combination medicine indicated to manage neuropathic pain associated with diabetic peripheral neuropathy and postherpetic neuralgia. Neuropathic pain is a chronic progressive nerve disease that causes nerve pain due to nerve damage or a malfunctioning nervous system. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, and evoked pain (pain caused by events usually not painful).

Grin-O Tablet SR is a combination of three drugs: Methylcobalamin (vitamin), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Methylcobalamin is a vitamin that aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Grin-O Tablet SR helps to treat neuropathic pain.

Take Grin-O Tablet SR as prescribed. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Grin-O Tablet SR may cause dizziness, sleepiness, nausea, blurred vision, peripheral oedema (swelling of the lower legs and hands), weight gain, and dry mouth. The majority of these side effects do not necessitate medical attention and will subside gradually over time. However, if you are experiencing these side effects regularly, you should consult your doctor.

Please do not take Grin-O Tablet SR if you are allergic to any of its ingredients. Consult your doctor before taking Grin-O Tablet SR if you are pregnant or breastfeeding. Grin-O Tablet SR may cause drowsiness and dizziness, so drive only if you are alert. Grin-O Tablet SR should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol along with Grin-O Tablet SR as it could lead to increased dizziness and sleepiness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Grin-O Tablet SR is a combination of three drugs: Methylcobalamin (a form of vitamin B), Nortriptyline (antidepressant), and Pregabalin (anti-convulsant). Grin-O Tablet SR is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, postherpetic neuralgia, spinal cord injury, etc. Methylcobalamin aids in producing myelin, a substance that protects nerve fibres and regenerates damaged nerve cells. Nortriptyline works by increasing nerve transmitters (serotonin and noradrenaline) in the brain, thereby reducing the pain messages arriving in the brain. Pregabalin reduces pain by interfering with pain messages travelling through the brain and down the spine. Together, Grin-O Tablet SR helps to treat neuropathic pain.

• Constipation
• Dry mouth
• Headache
• Feeling sleepy, tired or dizzy
• Diarrhoea

If you are allergic to any of the ingredients in Grin-O Tablet SR, do not consume it. Please do not stop taking Grin-O Tablet SR without first consulting your doctor, as this may result in withdrawal symptoms. If you are pregnant or breastfeeding, do not take Grin-O Tablet SR unless your doctor has prescribed it. Grin-O Tablet SR may cause drowsiness and dizziness, therefore drive only if you are alert. Grin-O Tablet SR is not recommended for children as safety and effectiveness have not been established. Avoid drinking alcohol while taking Grin-O Tablet SR as it may cause drowsiness and sleepiness. If you have suicidal thoughts, consult your doctor right away.

Drug-Drug Interactions: Grin-O Tablet SR may have interaction with antidepressant medications (e.g. duloxetine, sertraline, escitalopram), pain killer medications (e.g. codeine, hydrocodone, morphine, oxycodone, tramadol, acetaminophen), anti-convulsant medications (e.g. topiramate), anti-anxiety medications (e.g. alprazolam), sedative-hypnotics medications (e.g. zolpidem), antihistamine medications (e.g. diphenhydramine, cetirizine), muscle relaxant medications (e.g. cyclobenzaprine), antiemetic medications (e.g. ondansetron), and herbal medications to treat depression (e.g. St John's wort).

Drug-Food Interactions: Avoid alcohol consumption while taking Grin-O Tablet SR as it might cause increased drowsiness and sleepiness.

Drug-Disease Interactions: Use Grin-O Tablet SR with medical advice if you have had anticholinergic effects, cardiovascular disease, pheochromocytoma, acute myocardial infarction recovery, cardiovascular disease, depression, seizure disorders, drug dependence, suicidal tendency, angioedema, creatine kinase elevations, peripheral oedema, PR interval prolongation, bone marrow suppression, diabetes, renal/liver disease, schizophrenia/bipolar disorder, hyper/hypoglycemia, schizophrenia, thyroid disorders and urinary retention.

• DULOXETINE
• SERTRALINE
• ESCITALOPRAM
• CODEINE
• HYDROCODONE
• MORPHINE
• OXYCODONE
• TRAMADOL
• ACETAMINOPHEN
• TOPIRAMATE
• ALPRAZOLAM
• ZOLPIDEM
• DIPHENHYDRAMINE
• CETIRIZINE
• CYCLOBENZAPRINE
• ONDANSETRON
• ST JOHN'S WORT

• Include vitamin B and D-rich foods in your diet.

• Cayenne pepper should be included in your diet because it can help with neuropathic pain.

• Exercising regularly helps to improve overall health and combat pain.

• Rest well and get plenty of rest.

• Taking a warm bath can be very relaxing.

• Avoid smoking and drinking alcohol.

• Meditation and yoga can reduce stress, pain sensitivity and improve coping skills.

• Acupuncture, by stimulating pressure points, can be beneficial.

• Massages with essential oils can help increase circulation.

Grin-O Tablet SR contains Nortriptyline (antidepressant), which can lead to suicidal thoughts. Suicidal thoughts or behaviour should be closely monitored in people taking Grin-O Tablet SR. If you have suicidal thoughts, don't be afraid to talk to your doctor right away.

Neuropathic pain: Neuropathic pain is caused due to damaged sensory nerves. It is caused by chronic progressive nerve disease or due to infection or injury. The pain could be intermittent or continuous, which is felt as prickling, stabbing, tingling or burning sensation. A feeling of numbness and loss of sensations is also familiar with neuropathic pain. Usually, the body sends the pain signals when there is an injury, but with neuropathic pain, the pain is not triggered by an injury. The body unpromptedly sends the pain signals. Symptoms include spontaneous, untriggered pain, unpleasant feeling, shooting, burning or stabbing pain, difficulty resting or sleeping and evoked pain (pain caused by events usually not painful).